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    • 1. 发明申请
    • PHOTOCURABLE POLYMER WITH A COMB-LIKE STRUCTURE
    • 具有类似结构的可光聚合物
    • WO2015040513A1
    • 2015-03-26
    • PCT/IB2014/063728
    • 2014-08-06
    • FONDAZIONE FILARETE PER LE BIOSCIENZE E L'INNOVAZIONEUNIVERSITA' DEGLI STUDI DI MILANO
    • GERGES, IriniLENARDI, CristinaMARTELLO, FedericoPISTIS, ValentinaTAMPLENIZZA, MargheritaTOCCHIO, Alessandro
    • C08F265/04C08J3/075C08F265/10C08F299/00C12N5/00
    • C08F265/04C08F265/10C08F299/00C08J3/075C08J3/24C08J2333/04C08J2333/26
    • The present invention relates to a synthetic polymeric precursor with a comb-like or hyper- branched structure, which is capable of carrying out an irreversible in situ sol-gel transition by photo- cross-linking, under conditions which are compatible with a biological organism, to produce hydrogels, which is capable of acting as biocompatible and biodegradable tridimensional matrices suitable to the in vitro, and in vivo encapsulation and transport of: cells; drugs; peptides; proteins, and growth factors. In particular, the invention relates to a photocurable polymeric precursor, which can be administered in vivo by injection or minimally invasive surgical approaches, said- polymeric precursor being composed of: (i) an acrylic oligomer of formula (II) : which is obtained by random co-polymerization of an acrylic monomer of formula (III) : CH 2 =C (R 2 ) -CO-OR-R 1 -OH (III) wherein the functional group R 1 is a C 1 -C 6 alkylene, preferably C 2 alkylene; wherein the R 2 functional group is H or a C 1 -C 4 alkylene, preferably C 1 alkylene together with an acrylic co-monomer or acrylamide of formula ( IV) : CH 2 =C(R 3 ) -CO-X-R 4 -YH (IV) wherein the functional group R 3 is H or a C 1 -C 4 alkylene, preferably C 1 alkylene; wherein the R 4 functional group is a C 1 -C 6 alkylene, preferably C3 alkylene; X is 0 or NH; Y is NH or S; such co- polymerization occurs in the presence of a chain transfer agent, preferably 2-mercaptoethanol, on said acrylic oligomer being grafted (ii) side chains composed of linear poly (amidoamine) s, an end of which side chains is bounded to said acrylic oligomer, while the free end terminates with an acrylamide group.
    • 本发明涉及具有梳状或超支化结构的合成聚合物前体,其能够在与生物有机体相容的条件下通过光交联进行不可逆的原位溶胶 - 凝胶转变 ,以产生水凝胶,其能够用作适于体外和体内包封和运输细胞的生物相容性和可生物降解的三维基质; 药物; 肽; 蛋白质和生长因子。 特别地,本发明涉及可以通过注射或微创手术方法在体内施用的光固化聚合物前体,所述聚合物前体由以下组成:(i)式(II)的丙烯酸低聚物:其通过 式(III)的丙烯酸单体的无规共聚:CH2 = C(R2)-CO-OR-R1-OH(Ⅲ)其中官能团R1是C1-C6亚烷基,优选C2亚烷基; 其中R 2官能团是H或C 1 -C 4亚烷基,优选C 1亚烷基与丙烯酸共聚单体或式(Ⅳ)的丙烯酰胺:CH2 = C(R3)-CO-X-R4-YH(Ⅳ),其中 官能团R3是H或C1-C4亚烷基,优选C1亚烷基; 其中R4官能团是C1-C6亚烷基,优选C3亚烷基; X为0或NH; Y是NH或S; 这种共聚发生在链转移剂(优选2-巯基乙醇)存在下,所述丙烯酸低聚物被接枝(ii)由直链聚酰胺胺组成的侧链,其侧链与所述丙烯酸 低聚物,而自由端用丙烯酰胺基团终止。