专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

WO1997034625A1 CYSTATIN B MUTANTS 审中-公开
公开(公告)号：WO1997034625A1
公开(公告)日：1997-09-25
申请号：PCT/US1997004332
申请日：1997-03-19
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , HELSINKI UNIVERSITY LICENSING, LTD. , MYERS, Richard, M. , COX, David, R. , PENNACCHIO, Len, A. , LEHESJOKI, Anna-Elina , DE LA CHAPELLE, Albert
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , HELSINKI UNIVERSITY LICENSING, LTD.
IPC分类号： A61K38/17
CPC分类号： C07K14/8139 , Y10S435/81
摘要： An isolated nucleic acid molecule, wherein the molecule contains: (1) a first sequence consisting of human cystatin B genomic DNA as set forth in figure 3 (SEQ ID NO:1); (2) a second sequence, wherein said second sequence is a subsequence of said first sequence, is at least 10 nucléotides in length, and is not present in human cystatin B cDNA; (3) a third sequence in which at least one nucleotide of said first or second sequences is replaced by a different nucleotide; or (4) a fourth sequence complementary to any of said first, second or third sequences; with the proviso that (i) if said molecule is an RNA molecule, U replaces T in said sequence of said molecule, and (ii) said third sequence is at least 95 % identical to said first or second sequence.
摘要翻译：一种分离的核酸分子，其中所述分子包含：（1）由图3（SEQ ID NO：1）所示的人半胱氨酸蛋白酶抑制剂B基因组DNA组成的第一序列; （2）第二序列，其中所述第二序列是所述第一序列的亚序列，长度为至少10个核苷酸，并且不存在于人半胱氨酸蛋白酶抑制剂B cDNA中; （3）第三序列，其中所述第一或第二序列的至少一个核苷酸被不同的核苷酸替代; 或（4）与所述第一，第二或第三序列中的任一个互补的第四序列; 条件是（i）如果所述分子是RNA分子，则U代替所述分子的所述序列中的T，和（ii）所述第三序列与所述第一或第二序列至少95％相同。

42. 发明申请

WO1997030587A1 DNA VACCINATION FOR INDUCTION OF SUPPRESSIVE T CELL RESPONSE 审中-公开
标题翻译：用于诱导抑制性T细胞应答的DNA疫苗
公开(公告)号：WO1997030587A1
公开(公告)日：1997-08-28
申请号：PCT/US1997002837
申请日：1997-02-24
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , STEINMAN, Lawrence , WAISMAN, Ari
IPC分类号： A01N43/04
CPC分类号： C07K14/7051 , A61K38/00 , A61K2039/51
摘要： A pro-inflammatory T response is specifically prevented by the injection into a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells expressing the variable region produce Th2 cytokines, including IL-4. A pro-inflammatory T cell response directed to an autoantigen is shown to be suppressed by DNA vaccination. The suppressive vaccination further reduced the inflammatory effect of T cells reactive against epitopes of the autoantigen not recognized by the variable region used for vaccination.
摘要翻译：通过注射到编码T细胞受体的可变区的DNA的接收者来特异性地预防促炎T反应。响应于接种，表达可变区的T细胞产生Th2细胞因子，包括IL-4。针对自身抗原的促炎T细胞应答被DNA接种抑制。抑制性疫苗接种进一步降低了用于疫苗接种的可变区未识别的自身抗原表位的T细胞的抗炎作用。

43. 发明申请

WO1997027213A1 METHODS FOR SCREENING FOR TRANSDOMINANT EFFECTOR PEPTIDES AND RNA MOLECULES 审中-公开
标题翻译：用于筛选转运蛋白效应肽和RNA分子的方法
公开(公告)号：WO1997027213A1
公开(公告)日：1997-07-31
申请号：PCT/US1997001048
申请日：1997-01-23
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , NOALN, Garry, P. , ROTHENBERG, S., Michael
IPC分类号： C07K01/04
CPC分类号： C12N15/1082 , C07K1/047 , C12N15/1034 , C12N15/1079 , C12N15/86 , C12N2740/13043 , C12N2799/027 , C12N2830/00 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , C12Q1/6811 , C12Q1/6897 , C12Q1/70 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/5041 , G01N33/5044 , G01N33/5064 , G01N33/68 , G01N33/6803 , G01N2500/00 , G01N2510/00
摘要： Methods and compositions for screening for transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
摘要翻译：提供了用于筛选来自随机化池的活细胞内选择的跨主效效应肽和RNA分子的方法和组合物。

44. 发明申请

WO1997020218A1 CALCIUM CHANNEL MODULATOR COMPOSITIONS AND METHODS 审中-公开
标题翻译：钙通道调节剂组合物和方法
公开(公告)号：WO1997020218A1
公开(公告)日：1997-06-05
申请号：PCT/US1996019002
申请日：1996-11-27
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , TSIEN, Richard, W. , BEZPROZVANNY, Ilya , SCHELLER, Richard, H.
IPC分类号： G01N33/566
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/705 , G01N2500/10
摘要： A syntaxin-derived composition containing a peptide capable of shifting the steady-state inactivation curve of a voltage-dependent calcium ion channel in the hyperpolarized direction, a method of selectively inhibiting the opening of voltage-dependent calcium ion channels associated with neurotransmitter release, and screening method of identifying a compound capable of modulating the opening of voltage-dependent calcium ion channels.
摘要翻译：含有能够在超极化方向上移动电压依赖性钙离子通道的稳态失活曲线的肽的引发蛋白衍生物组合物，选择性抑制与神经递质释放相关的依赖于电压的钙离子通道的打开方法，以及鉴定能够调节电压依赖性钙离子通道开放的化合物的筛选方法。

45. 发明申请

WO1997013251A1 GATED RECORDING OF HOLOGRAMS USING RARE-EARTH DOPED FERROELECTRIC MATERIALS 审中-公开
标题翻译：使用稀土掺杂的电解材料进行埋藏记录
公开(公告)号：WO1997013251A1
公开(公告)日：1997-04-10
申请号：PCT/US1996015816
申请日：1996-10-02
申请人： SRI INTERNATIONAL , IBM CORPORATION , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： SRI INTERNATIONAL , IBM CORPORATION , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , BAI, Yu, Sheng , KACHRU, Ravinder , HESSELINK, Lambertus , MACFARLANE, Roger, M.
IPC分类号： G11C13/04
CPC分类号： B82Y10/00 , G11B7/0065 , G11B7/243 , G11B7/2433 , G11C13/042
摘要： Rare earth doped ferroelectric materials are disclosed as reversible holographic recording medium (25) for use in two-photon recording systems. Such rare earth elements provide long-lived electronic states intermediate the ferroelectric material's valence and conduction bands. In some cases, these rare earth intermediate states have a sufficiently long life that low-power continuous wave ("cw") lasers (1) can be used to record interference patterns on them. Thus, two-photon holographic recording systems are also disclosed which do not require high-power, short pulse length, mode-locked or Q-switched lasers. Rather, the disclosed holographic recording systems employ cw lasers such as diode lasers. The rare earth dopants include praseodymium, neodymium, dysprosium, holmium, erbium, and thulium. These dopants provide ions having 4f excited states that give rise to absorptions in the near infra-red and visible spectral regions and typically have lifetimes on the order of 0.1 to 1 milliseconds. The disclosed two-photon holographic recording systems provide for absorption of a first photon which excites electrons of a holographic recording medium to a rare-earth intermediate state. Thereafter, upon absorption of a second photon, the electrons are promoted to the medium's conduction band where they are arranged according to the interference pattern provided by the recording system.
摘要翻译：稀土掺杂的铁电材料被公开为用于双光子记录系统的可逆全息记录介质（25）。这种稀土元素在铁电材料的价带和导带之间提供长寿命的电子态。在某些情况下，这些稀土中间体具有足够长的寿命，可以使用低功率连续波（“cw”）激光器（1）来记录干涉图案。因此，还公开了不需要大功率，短脉冲长度，锁模或Q开关激光器的双光子全息记录系统。相反，所公开的全息记录系统采用诸如二极管激光器之类的cw激光器。稀土掺杂剂包括镨，钕，镝，钬，铒和。。这些掺杂剂提供具有4f激发态的离子，其在近红外和可见光谱区域中产生吸收，并且通常具有0.1至1毫秒量级的寿命。所公开的双光子全息记录系统提供了将全息记录介质的电子激发到稀土中间状态的第一光子的吸收。此后，在吸收第二光子时，电子被提升到介质的导带，它们根据由记录系统提供的干涉图案排列。

46. 发明申请

WO1997012689A1 FLUID DROP EJECTOR AND METHOD 审中-公开
标题翻译：流体喷射器和方法
公开(公告)号：WO1997012689A1
公开(公告)日：1997-04-10
申请号：PCT/US1996014717
申请日：1996-09-11
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , KHURI-YAKUB, Brutus, Thomas , LEVIN, Laurent
IPC分类号： B05B17/06
CPC分类号： B05B17/0607 , B05B17/0646 , B41J2/14201 , B41J2/1607 , B41J2/1628 , B41J2/1629 , B41J2/1634 , B41J2/1635 , B41J2002/1437 , B41J2202/15 , Y10S977/837 , Y10S977/86 , Y10S977/869 , Y10S977/872 , Y10S977/887
摘要： An improved fluid drop ejector is disclosed which includes one wall comprising a thin elastic membrane (13) having an orifice defining a nozzle and means (17) responsive to electrical signals for deflecting the membrane to eject drops of fluid from said nozzle.
摘要翻译：公开了一种改进的液滴喷射器，其包括一个壁，该壁包括具有限定喷嘴的孔口的薄弹性膜（13）和响应于电信号的装置（17），用于偏转膜以从所述喷嘴喷射液体滴。

47. 发明申请

WO1997012244A1 METHODS FOR DETERMINING T-CELL PROFILES OF IMMUNOCOMPROMISED SUBJECTS 审中-公开
标题翻译：用于确定免疫组织化学物质的T细胞谱的方法
公开(公告)号：WO1997012244A1
公开(公告)日：1997-04-03
申请号：PCT/US1996015460
申请日：1996-09-26
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , ROEDERER, Mario , RABIN, Ronald , HERZENBERG, Leonore, A. , HERZENBERG, Leonard, A.
IPC分类号： G01N33/53
CPC分类号： G01N33/5008 , G01N33/505 , G01N33/5094 , G01N33/56972
摘要： A method of screening drugs for efficacy to stimulate the production of naive T-cells in a subject is disclosed. The method involves obtaining a blood sample before and after the administration of a drug to the subject. The T-cells are then isolated from both samples respectively. Next, the number of naive T-cells in each population is determined by reacting the T-cells with at least two antibodies selectively reactive with naive T-cell surface proteins. Then the drugs efficacy is identified by determining if the number of naive T-cells in the T-cell population collected after drug administration is significantly greater than the number in the pre-administration population.
摘要翻译：公开了一种筛选用于刺激受试者中初始T细胞产生的功效的药物的方法。该方法包括在向受试者施用药物之前和之后获得血液样品。然后分别从两个样品中分离出T细胞。接下来，通过使T细胞与初始T细胞表面蛋白选择性反应的至少两种抗体反应来确定每个群体中初始T细胞的数量。然后通过确定药物给药后收集的T细胞群中的初始T细胞的数量是否明显大于给药前群体中的数量来鉴定药物功效。

48. 发明申请

WO1997007200A1 ADULT OLIGODENDROCYTE PRECURSOR CELL COMPOSITIONS AND METHODS 审中-公开
标题翻译：成人OLIGODENDROCYTE前体细胞组合物和方法
公开(公告)号：WO1997007200A1
公开(公告)日：1997-02-27
申请号：PCT/US1996013279
申请日：1996-08-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , BARRES, Barbara, A.
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
IPC分类号： C12N05/00
CPC分类号： C12N5/0623 , A61K35/12 , C12N2500/32 , C12N2501/13 , C12N2501/135
摘要： A substantially pure culture of adult oligodendrocyte precursor (progenitor) cells is disclosed. Also disclosed are methods of purifying and culturing/expanding adult oligodendrocyte precursor cells from a suspension of cells, and methods of differentiating perinatal oligodendrocyte precursor cells from oligodendrocyte precursor cells.
摘要翻译：公开了基本上纯的成体少突胶质细胞前体（祖细胞）培养物。还公开了从细胞悬液中纯化和培养/培养/扩增成年少突胶质细胞前体细胞的方法，以及从少突胶质细胞前体细胞分化围产期少突胶质细胞前体细胞的方法。

49. 发明申请

WO1997005158A1 COMPOSITIONS, TREATMENTS, AND DIAGNOSTICS FOR SCHISTOSOMIASIS AND RELATED DISEASES 审中-公开
标题翻译：组织病理学和相关疾病的组合物，治疗和诊断
公开(公告)号：WO1997005158A1
公开(公告)日：1997-02-13
申请号：PCT/US1995009400
申请日：1995-07-25
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MANSOUR, Tag, E.
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
IPC分类号： C07K01/00
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/43559 , C12N2799/026 , Y02A50/423
摘要： Compositions and methods are provided for the detection and treatment of Schistosoma parasites. These compositions and methods are based on nucleic acid and amino acid sequences of Schistosoma phosphofructokinase.
摘要翻译：提供组成和方法用于血吸虫寄生虫的检测和治疗。这些组合物和方法基于血吸虫磷酸果糖激酶的核酸和氨基酸序列。

50. 发明申请

WO1996039750A1 RADIO FREQUENCY SIGNAL RECEPTION USING FREQUENCY SHIFTING BY DISCRETE-TIME SUB-SAMPLING DOWN-CONVERSION 审中-公开
标题翻译：通过离散次采样下变频使用频率移位的无线电频率接收
公开(公告)号：WO1996039750A1
公开(公告)日：1996-12-12
申请号：PCT/US1996009311
申请日：1996-06-06
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , SHEN, David, H. , HWANG, Chien-Meen , LUSIGNAN, Bruce, B. , WOOLEY, Bruce, A.
IPC分类号： H04B01/26
CPC分类号： H04B1/0025 , H03D7/00 , H04B1/0003 , H04B1/26
摘要： An RF communications receiver permits greater integration on standard silicon chips and consumes less power than previous receivers. Sub-sampling and discrete-time signal processing techniques are used to frequency down-convert, filter, amplify, and select a desired analog RF channel. A sample-and-hold circuit (81) sub-samples the desired analog RF channel of carrier frequency fc, thereby down-converting it to a discrete-time image signal of frequency fi. Successive down-sampling, (99. 1) anti-alias filtering, (95.1) and amplification of the discrete-time image signal yields a low-frequency discrete-time signal containing a down-converted channel of frequency fk. The low-frequency discrete-time signal is then digitized, (87) filtered, (91) and demodulated (93) to reveal its baseband information content.
摘要翻译： RF通信接收器允许在标准硅芯片上实现更大的集成，并且比以前的接收机消耗更少的功率。子采样和离散时间信号处理技术用于降频，滤波，放大和选择所需的模拟RF信道。采样和保持电路（81）对载波频率fc的期望的模拟RF信道进行子采样，从而将其下变频到频率fi的离散时间图像信号。（99. 1）抗混叠滤波（95.1）和离散时间图像信号的放大产生包含频率为fk的下变频信道的低频离散时间信号。然后将低频离散时间信号数字化，（87）滤波，（91）和解调（93）以显示其基带信息内容。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式