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41. 发明申请

WO2011010965A1 METHOD OF USING AN ESTABLISHED CELL LINE FOR GLIOMA THERAPY 审中-公开
标题翻译：使用建立细胞系进行GLIOMA治疗的方法
公开(公告)号：WO2011010965A1
公开(公告)日：2011-01-27
申请号：PCT/SG2010/000274
申请日：2010-07-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , ZHAO, Ying
发明人： WANG, Shu , ZHAO, Ying
IPC分类号： C12N5/16 , C12N5/095
CPC分类号： C12N5/0695 , C12N2501/385
摘要： The present invention relates to a method of generating pluripotent cells that show enhanced tumor-specific migration, isolated pluripotent cells with enhanced tumor-specific migration and pharmaceutical uses thereof.
摘要翻译：本发明涉及产生显示增强的肿瘤特异性迁移的多能细胞的方法，具有增强的肿瘤特异性迁移的分离的多能细胞及其药物用途。

42. 发明申请

WO2009014702A2 METHOD OF CANCER TREATMENT WITH ANTAGONISTS OF FAS INHIBITORS 审中-公开
标题翻译：癌症治疗方法与FAS抑制剂的拮抗剂
公开(公告)号：WO2009014702A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/008914
申请日：2008-07-23
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SAMANIEGO, Felipe , WANG, Suizhao , WANG, Shu
发明人： SAMANIEGO, Felipe , WANG, Suizhao , WANG, Shu
IPC分类号： A61K38/17 , A61P35/00 , A61P35/02 , A61P37/00 , A61P39/00
CPC分类号： A61K38/1709 , A61K38/10 , A61K38/162 , A61K38/1774 , A61K48/00 , C07K14/70539 , C07K14/82 , C12N15/1135 , C12N15/1138 , C12N2310/14 , C12N2799/027
摘要： In one embodiment, the present invention relates to a method of treating a cancer characterized by inhibition of Fas-mediated apoptosis, comprising administering to a patient suffering from the cancer a pharmaceutically-effective amount of a composition comprising a peptide that competitively antagonizes at least one protein-Fas binding selected from the group consisting of herpes virus 8 protein Kl binding to Fas, CD74 binding to Fas, and pi 00 binding to Fas. In a further embodiment, the peptide is selected from the group consisting of peptides having from about 15 to about 35 amino acid residues and comprising at least a portion of the immunoglobulin domain of Kl, peptides having from about 15 to about 35 amino acid residues and comprising at least fifteen consecutive amino acid residues among positions 50-120 of CD74, LVTLLLAGQ ATT A YFL YQQQ, LYQQQGRLDKLTVTSQNLQL, QNLQLENLRMKLPKPPKPVS, and PKPVSKMRMATPLLMQALPM. In another embodiment, the present invention relates to a method of treating a disease characterized by unwanted apoptosis in a mammal, comprising transfecting a cell of the mammal with a nucleic acid molecule encoding CD74. The present invention also relates to the compositions referred to above and their use in manufacture of medicaments for treatment of the diseases described herein.
摘要翻译：在一个实施方案中，本发明涉及治疗特征在于抑制Fas介导的细胞凋亡的癌症的方法，其包括向患有癌症的患者施用药物有效量的组合物，所述组合物包含竞争性拮抗至少一种蛋白质-Fas结合选自结合Fas的疱疹病毒8蛋白K1，与Fas结合的CD74，以及结合Fas的pi 00。在另一个实施方案中，肽选自具有约15至约35个氨基酸残基并且包含至少一部分Kl免疫球蛋白结构域的肽，具有约15至约35个氨基酸残基的肽，以及包括CD74的位置50-120中的至少十五个连续氨基酸残基，LVTLLLAGQ ATT A YFL YQQQ，LYQQQGRLDKLTVTSQNLQL，QNLQLENLRMKLPKPPKPVS和PKPVSKMRMATPLLMQALPM。在另一个实施方案中，本发明涉及治疗哺乳动物特征在于不希望的细胞凋亡的疾病的方法，包括用编码CD74的核酸分子转染哺乳动物细胞。本发明还涉及上述组合物及其在制备用于治疗本文所述疾病的药物中的用途。

43. 发明申请

WO2008118100A1 METHOD OF ENHANCING MIGRATION OF NEURAL PRECURSOR CELLS 审中-公开
标题翻译：增强神经前体细胞迁移的方法
公开(公告)号：WO2008118100A1
公开(公告)日：2008-10-02
申请号：PCT/SG2008/000089
申请日：2008-03-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , JURVANSUU, Jaana
发明人： WANG, Shu , JURVANSUU, Jaana
IPC分类号： C12N15/00 , C12Q1/68 , A61P25/00
CPC分类号： C07K14/47
摘要： There is provided methods relating to enhancing migration of a neural precursor cell by augmenting levels of TMEM18 protein in the neural precursor cell. Such methods may be used in the treatment of disorders, including treatment of a glioma or a neurodegenerative disorder.
摘要翻译：提供了通过增加神经前体细胞中TMEM18蛋白的水平来增强神经前体细胞迁移的方法。这些方法可用于治疗疾病，包括治疗神经胶质瘤或神经变性疾病。

44. 发明申请

WO2006101457A1 NOVEL NEURAL CELL SPECIFIC PROMOTER AND BACULOVIRUS AND METHOD FOR GENE DELIVERY 审中-公开
标题翻译：新型神经细胞特异性促进剂和细菌病毒和基因交付方法
公开(公告)号：WO2006101457A1
公开(公告)日：2006-09-28
申请号：PCT/SG2006/000067
申请日：2006-03-22
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , WANG, Chao Yang
发明人： WANG, Shu , WANG, Chao Yang
IPC分类号： C12N15/866 , C12N5/10 , C12N15/67 , C12N15/861
CPC分类号： C12N15/86 , A01K2267/0331 , C07K14/4746 , C12N2710/14143 , C12N2750/14143 , C12N2830/008
摘要： [00247] There is provided a novel hybrid promoter region that utilizes a neural specific promoter and an enhancer element, in one embodiment from a viral promoter, located upstream or downstream of the neural-specific promoter. The novel promoter can be used to create a viral vector, including a baculovirus vector, useful for gene delivery to neural cells.
摘要翻译：在一个实施方案中，提供了位于神经特异性启动子上游或下游的病毒启动子的新型杂合启动子区，其利用神经特异性启动子和增强子元件。新型启动子可用于产生病毒载体，包括可用于神经细胞基因递送的杆状病毒载体。

45. 发明申请

WO2016209919A1 MODEL-BASED OPERATION CONTROL OF A SPARK IGNITED INTERNAL COMBUSTION ENGINE 审中-公开
标题翻译：火箭喷射内燃机的基于模型的操作控制
公开(公告)号：WO2016209919A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/038700
申请日：2016-06-22
申请人： WANG, Shu , PRUCKA, Robert Gary , DOURRA, Hussein , PRUCKA, Michael , ZHU, Qilun
发明人： WANG, Shu , PRUCKA, Robert Gary , DOURRA, Hussein , PRUCKA, Michael , ZHU, Qilun
IPC分类号： F02D35/02 , F02D41/14 , F02P5/15 , F02D41/00
CPC分类号： F02P5/15 , F02D35/024 , F02D35/028 , F02D41/0062 , F02D41/1401 , F02D41/1406 , F02D41/1448 , F02D2041/1417 , F02D2041/1433 , G05B15/02 , Y02T10/46
摘要： Systems and methods of controlling operation of a vehicle engine are provided. For instance, one example aspect of the present disclosure is directed to determining a spark timing associated with a combustion engine. For instance, a combustion phasing target to be implemented by a combustion engine can be received. A spark timing associated with the combustion engine can be determined based at least in part on the combustion phasing target. The spark timing can be determined based at least in part on an optimization comprising one or more iterations determined during an engine cycle. The spark timing is determined based at least in part on a combustion phasing prediction model determined based at least in part on at least one of laminar flame speed, residual gas mass, or turbine intensity.
摘要翻译：提供了一种控制车辆发动机的操作的系统和方法。例如，本公开的一个示例性方面涉及确定与内燃机相关联的火花正时。例如，可以接收由内燃机实施的燃烧定相目标。可以至少部分地基于燃烧定相目标来确定与内燃机相关联的火花正时。可以至少部分地基于包括在发动机循环期间确定的一个或多个迭代的优化来确定火花正时。至少部分地基于至少部分地基于层状火焰速度，残余气体质量或涡轮强度中的至少一个确定的燃烧定相预测模型来确定火花正时。

46. 发明申请

WO2010043466A1 CONTROL CIRCUIT WITH FAST RECOVERY 审中-公开
标题翻译：快速恢复控制电路
公开(公告)号：WO2010043466A1
公开(公告)日：2010-04-22
申请号：PCT/EP2009/062075
申请日：2009-09-17
申请人： STMICROELECTRONICS SA , WANG, Shu
发明人： WANG, Shu
IPC分类号： H02M3/157 , H02M3/156
CPC分类号： H02M3/157 , H02M3/156 , H02M2001/0012
摘要： The invention concerns a control circuit arranged to generate a control signal (V c ) for controlling at least one transistor of a switched mode power supply (SMPS, 102) during first, second and third successive time periods based on a feedback voltage (V F ), wherein during the first and third time periods the control circuit is adapted to regulate the output voltage of the SMPS to a first voltage level, and during the second time period the control circuit is adapted to control the SMPS to output a low voltage, the control circuit having a memory (304) adapted to store an indication of the control signal generated by the control circuit at the end of the first time period, wherein the control circuit is adapted to output a control signal based on the stored indication at the start of the third time period.
摘要翻译：本发明涉及一种控制电路，其被布置为基于反馈电压（VF）产生用于在第一，第二和第三连续时间段期间控制开关模式电源（SMPS，102）的至少一个晶体管的控制信号（Vc）其中在所述第一和第三时间段期间，所述控制电路适于将所述SMPS的输出电压调节到第一电压电平，并且在所述第二时间段期间，所述控制电路适于控制所述SMPS以输出低电压，所述控制电路具有适于在第一时间段结束时存储由控制电路产生的控制信号的指示的存储器（304），其中控制电路适于基于在开始时存储的指示输出控制信号第三个时期。

47. 发明申请

WO2006078221A1 METHOD OF DELIVERY OF NUCLEIC ACIDS TO PERIPHERAL NEURONS 审中-公开
标题翻译：将核酸递送至外周神经元的方法
公开(公告)号：WO2006078221A1
公开(公告)日：2006-07-27
申请号：PCT/SG2005/000015
申请日：2005-01-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , WANG, Xu
发明人： WANG, Shu , WANG, Xu
IPC分类号： C12N15/64 , C12N15/87
CPC分类号： A61K48/0075 , A61K48/00 , C12N2799/025 , C12N2799/026 , C12N2830/008
摘要： The invention provides for methods for delivering a nucleic acid into a peripheral neuron by identifying a target neuron in a dorsal root ganglion and intrathecally delivering a vector comprising the nucleic acid to the dorsal root ganglion neuron. The nucleic acid may encode a neurotrophic factor that may be used to treat a peripheral neuropathy or, in conjunction with a nerve guide conduit, to treat a transected peripheral nerve.
摘要翻译：本发明提供了通过鉴定背根神经节中的目标神经元并将包含核酸的载体鞘内递送至背根神经节神经元来将核酸递送至周围神经元的方法。核酸可以编码可用于治疗周围神经病变的神经营养因子，或者与神经导管结合治疗横切的周围神经。

48. 发明申请

WO2005100577A1 METHOD FOR GENE DELIVERY TO NEURONAL CELLS 审中-公开
标题翻译：用于基因递送至神经细胞的方法
公开(公告)号：WO2005100577A1
公开(公告)日：2005-10-27
申请号：PCT/SG2004/000089
申请日：2004-04-14
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , WANG, Shu , YING, Li
发明人： WANG, Shu , YING, Li
IPC分类号： C12N15/866
CPC分类号： C12N15/86 , A61K47/6901 , A61K48/0075 , C12N2710/14143
摘要： The present invention relates to the use of axonal transport to deliver a baculorivus vector to a target neuronal cell by administering the vector to a site that is remote from the target cell. Such delivery allows for tracing of neuronal pathways and further a baculorivus vector may be used to deliver therapeutic gene to a target neuronal which may otherwise be not readily accessible, for the treatment of a neuronal disorder in a subject.
摘要翻译：本发明涉及轴突转运的用途，其通过将该载体施用于远离靶细胞的位点而将杆状病毒载体递送至目标神经元细胞。这种递送允许追踪神经元途径，此外，可以使用杆状病毒载体将治疗基因递送至否则不容易获得的靶神经元，用于治疗受试者的神经元病症。

49. 发明申请

WO2004092324A2 METHODS AND COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDES USING LIGHT HARVESTING MULTICHROMOPHORES 审中-公开
标题翻译：使用光收集多色素检测和分析多核苷酸的方法和组合物
公开(公告)号：WO2004092324A2
公开(公告)日：2004-10-28
申请号：PCT/US2003/026989
申请日：2003-08-26
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BAZAN, Guillermo, C. , GAYLORD, Brent, S. , WANG, Shu
发明人： BAZAN, Guillermo, C. , GAYLORD, Brent, S. , WANG, Shu
IPC分类号： C12N
CPC分类号： C12Q1/6834 , C12Q1/6813 , C12Q1/6818 , C12Q1/6825 , Y10T436/143333 , C12Q2565/107 , C12Q2563/107 , C12Q2523/313
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
摘要翻译：提供了用于测定靶多核苷酸的样品的方法，组合物和制品。将怀疑含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器多核苷酸接触。传感器多核苷酸包含用于从激发的多色素载体接收能量的信号发色团，并在靶多核苷酸存在下增加发射。这些方法可以多路复用形式使用。还提供了包含用于执行这些方法的试剂的试剂盒。

50. 发明申请

WO2007037639A2 A METHOD AND APPARATUS OF PREPROCESSING FOR FREQUENCY DOMAIN SIGNAL PROCESSING 审中-公开
标题翻译：用于频域信号处理的预处理方法和装置
公开(公告)号：WO2007037639A2
公开(公告)日：2007-04-05
申请号：PCT/KR2006/003900
申请日：2006-09-28
申请人： LG ELECTRONICS INC.
发明人： WANG, Shu
IPC分类号： H04Q7/38 , H04L27/26
CPC分类号： H04B1/7105 , H04B1/712 , H04B2201/70701 , H04B2201/709727 , H04J13/00 , H04L25/022 , H04L25/0226
摘要： A method of transmitting at least one packet in a wireless mobile communication system is disclosed. More specifically, the method includes transmitting at least one pilot symbol, at least one data symbol, and at least one null symbol, wherein the at least one null symbol is transmitted between transmission of the pilot symbol and the data symbol.
摘要翻译：公开了一种在无线移动通信系统中发送至少一个分组的方法。更具体地说，该方法包括发送至少一个导频符号，至少一个数据符号和至少一个空符号，其中在导频符号的传输和数据符号之间传送至少一个空符号。

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