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41. 发明申请

WO2010144293A1 SYNTHESIS OF TELCAGEPANT AND INTERMEDIATES THEREOF 审中-公开
标题翻译：电泳组合物及其中间体的合成
公开(公告)号：WO2010144293A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/037148
申请日：2010-06-03
申请人： MERCK SHARP & DOHME CORP. , XU, Feng , DESMOND, Richard , HOERRNER, R. Scott , HUMPHREY, Guy, R. , ITOH, Tetsuji , JOURNET, Michel , YOSHIKAWA, Naoki , ZACUTO, Michael, J.
发明人： XU, Feng , DESMOND, Richard , HOERRNER, R. Scott , HUMPHREY, Guy, R. , ITOH, Tetsuji , JOURNET, Michel , YOSHIKAWA, Naoki , ZACUTO, Michael, J.
IPC分类号： C07D401/00
CPC分类号： C07D223/12 , C07C201/12 , C07C205/44 , C07C237/20 , C07D401/04
摘要： Disclosed is an efficient synthesis for the manufacture of the caprolactam intermediate (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one: Formula and salts thereof, and an efficient preparation of telcagepant using the caprolactam intermediate.
摘要翻译：公开了用于制备己内酰胺中间体（3R，6S）-3-氨基-6-（2,3-二氟苯基）-1-（2,2,2-三氟乙基）氮杂环庚烷-2-酮的有效合成：式和其盐，以及使用己内酰胺中间体的有效制备telcagepant。

42. 发明申请

WO2010042759A2 GABA CONJUGATES AND METHODS OF USE THEREOF 审中-公开
标题翻译： GABA结合物及其使用方法
公开(公告)号：WO2010042759A2
公开(公告)日：2010-04-15
申请号：PCT/US2009/060058
申请日：2009-10-08
申请人： KYPHIA PHARMACEUTICALS, INC. , XU, Feng
发明人： KYPHIA PHARMACEUTICALS, INC. , XU, Feng
IPC分类号： C07C229/00 , A61K31/675 , A61K31/191 , A61P25/00
CPC分类号： A61K47/48023 , A61K9/0019 , A61K9/0053 , A61K31/16 , A61K31/19 , A61K31/191 , A61K31/192 , A61K31/195 , A61K31/197 , A61K31/675 , A61K45/06 , A61K47/54 , C07C271/22 , C07C2601/14
摘要： In one aspect, the present invention provides a composition of a covalent conjugate of a GABA analog with a drug. In another aspect, the present invention provides methods for treating pain and neurological disorders using the conjugates of GABA analogs.
摘要翻译：一方面，本发明提供了GABA类似物与药物的共价缀合物的组合物。另一方面，本发明提供使用GABA类似物的缀合物治疗疼痛和神经障碍的方法。

43. 发明申请

WO2008052044A2 USE OF FORMS OF PROPOFOL FOR TREATING DISEASES ASSOCIATED WITH OXIDATIVE STRESS 审中-公开
标题翻译：用于治疗与氧化应激相关的疾病的丙泊酚的使用
公开(公告)号：WO2008052044A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/082365
申请日：2007-10-24
申请人： XENOPORT, INC. , VIRSIK, Peter A. , XU, Feng
发明人： VIRSIK, Peter A. , XU, Feng
IPC分类号： A61K31/05 , A61P3/00 , A61P9/00 , A61P25/00 , A61P11/06 , A61P1/16
CPC分类号： A61K31/05
摘要： Methods of treating diseases associated with oxidative stress such as metabolic diseases, cardiovascular diseases, neurological diseases, liver diseases, and pulmonary diseases in a patient comprising orally administering a therapeutically effective amount of forms of propofol that provide a high oral bioavailability of propofol are disclosed.
摘要翻译：公开了在患者中治疗与代谢疾病，心血管疾病，神经系统疾病，肝脏疾病和肺部疾病有关的疾病相关疾病的方法，包括口服给予丙泊酚的高口服生物利用度的治疗有效量的丙泊酚形式。

44. 发明申请

WO2008011091A1 METHOD AND SYSTEM FOR HIGHLIGHTING AND ADDING COMMENTARY TO NETWORK WEB PAGE CONTENT 审中-公开
标题翻译：用于对网络页面内容的注释和添加评论的方法和系统
公开(公告)号：WO2008011091A1
公开(公告)日：2008-01-24
申请号：PCT/US2007/016349
申请日：2007-07-19
申请人： LUCENT TECHNOLOGIES INC. , REN, Tim, Jing Hui , XU, Feng
发明人： REN, Tim, Jing Hui , XU, Feng
IPC分类号： G06F17/30
CPC分类号： G06F17/30899 , G06F17/241
摘要： An enhanced web page content search system is implemented on or as part of a web browser application (e.g., as a "plug-in") for highlighting and adding commentary to web page content displayed on a terminal. The system includes a user interface and a search engine, and provides enhanced search functionality, e.g., flexible formatting, data-type, and other search options. After a user accesses a website and enters search criteria, the search engine conducts a search of the accessed website content. The search results are highlighted at the same time. The user is provided with options for navigating through the search results (e.g., a search index), for adding selected displayed content to the search results and/or for removing selected search results, and for adding comments to the web page content. The highlighted and/or commented web page (including the original web page content and structure) is stored locally for subsequent retrieval and use.
摘要翻译：增强的网页内容搜索系统在网页浏览器应用程序（例如，作为“插件”）上或作为一部分实现，用于突出显示和添加对终端上显示的网页内容的评论。该系统包括用户界面和搜索引擎，并且提供增强的搜索功能，例如灵活的格式化，数据类型和其他搜索选项。在用户访问网站并输入搜索条件之后，搜索引擎对所访问的网站内容进行搜索。搜索结果同时突出显示。向用户提供用于浏览搜索结果（例如，搜索索引）的选项，用于将所选择的显示的内容添加到搜索结果和/或用于移除所选择的搜索结果，以及用于向网页内容添加评论。突出显示和/或评论的网页（包括原始网页内容和结构）存储在本地以供后续检索和使用。

45. 发明申请

WO2005023204A2 AROMATIC PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：丙泊酚的组合物及其用途
公开(公告)号：WO2005023204A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/030999
申请日：2004-09-09
申请人： XENOPORT, INC. , GALLOP, Mark, A. , XU, Feng
发明人： GALLOP, Mark, A. , XU, Feng
IPC分类号： A61K
CPC分类号： C07C271/28
摘要： Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post- chemotherapy or post-operative surgery nausea and vomiting are disclosed herein.
摘要翻译：丙泊酚的前药，制备丙泊酚前药的方法，丙泊酚前药的药物组合物和使用异丙酚前药的方法及其药物组合物治疗或预防疾病或障碍，如偏头痛头痛和化疗后或术后手术恶心和呕吐。

46. 发明申请

WO2004072090A1 PROCESS FOR PREPARING BRANCHED RIBONUCLEOSIDES FROM 1, 2-ANHYDRORIBOFURANOSE INTERMEDIATES 审中-公开
标题翻译：从1,2-二氢呋喃糖醛酸中间体制备分支的核糖核酸酶的方法
公开(公告)号：WO2004072090A1
公开(公告)日：2004-08-26
申请号：PCT/US2004/003469
申请日：2004-02-06
申请人： MERCK & CO. INC. , XU, Feng , BIO, Matthew, M. , COWDEN, Cameron, J. , SAVARY, Kimberly, A. , WILLIAMS, John, M. , YANG, Chunhua , WATERS, Majorie, See
发明人： XU, Feng , BIO, Matthew, M. , COWDEN, Cameron, J. , SAVARY, Kimberly, A. , WILLIAMS, John, M. , YANG, Chunhua , WATERS, Majorie, See
IPC分类号： C07H1/00
CPC分类号： C07D487/04 , C07H1/00 , C07H19/048 , C07H19/14 , Y02P20/55
摘要： A process is provided for the preparation of branched-chain ribonucleosides of formula (I) from the 1,2- anhydro derivatives of fomula (II). The compounds of fomula (I) are inhibitors of HCV polymerase useful in the treatment of HCV infection.
摘要翻译：提供了从式（II）的1,2-脱水衍生物制备式（I）的支链核糖核苷的方法。（I）化合物是用于治疗HCV感染的HCV聚合酶抑制剂。

47. 发明申请

WO2018226563A1 MICRONEEDLE PATCHES FOR TRANSDERMAL DELIVERY 审中-公开
公开(公告)号：WO2018226563A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/035812
申请日：2018-06-04
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , XU, Feng
发明人： XU, Feng , AHMED, Mohamed R. , RAJADAS, Jayakumar , SUN, Wenchao , INAYATHULLAH NAZIR AHMED, Mohammed
IPC分类号： A61M5/00 , B32B37/16
CPC分类号： A61M37/0015 , A45D34/00 , A45D34/04 , A45D37/00 , A45D40/00 , A45D40/26 , A45D2200/00 , A45D2200/10 , A61B5/0082 , A61B5/01 , A61B5/411 , A61B10/0035 , A61K9/0097 , A61L31/125 , A61M5/3298 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2205/3306 , A61M2205/3368 , A61M2210/0606
摘要： Embodiment provided herein are directed to microneedle patches for agent application on a mammal skin. The microneedle patch may comprise a patch scaffold having a surface, and a plurality of microneedles disposed on the surface. Each of the microneedles may be capable of piercing the skin 50 µm to 1000 µm deep, and comprises a composite material comprising polyvinylpyrrolidone (PVP) and one or more additional copolymers selected from the group consisting of maltose, leucine, and dileucine.

48. 发明申请

WO2014150639A1 PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES 审中-公开
标题翻译：制备BETA 3激动剂和中间体的方法
公开(公告)号：WO2014150639A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/023858
申请日：2014-03-12
申请人： MERCK SHARP & DOHME CORP. , XU, Feng , LIU, Zhuqing , DESMOND, Richard , PARK, Jeonghan , KALININ, Alexei , KOSJEK, Birgit , STROTMAN, Hallena , LI, Hongmei , MONCECCHI, Johannah
发明人： XU, Feng , LIU, Zhuqing , DESMOND, Richard , PARK, Jeonghan , KALININ, Alexei , KOSJEK, Birgit , STROTMAN, Hallena , LI, Hongmei , MONCECCHI, Johannah
IPC分类号： A61K31/40
CPC分类号： C07D487/04 , C07C215/30 , C07D207/08 , C07D207/12 , C12P17/10
摘要： The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
摘要翻译：该应用涉及如下更详细描述的用于制备式I-7的β3激动剂和可用于制备这些激动剂的中间体化合物的有效和经济的方法。本公开涉及使用酮还原酶（KRED）生物催化剂酶和使用生物催化剂的方法制备β-3激动剂和中间体的方法。

49. 发明申请

WO2013062878A1 PROCESS FOR MAKING BETA 3 ANGONISTS AND INTERMEDIATES 审中-公开
标题翻译：制作BETA 3对角线和中间线的过程
公开(公告)号：WO2013062878A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/061249
申请日：2012-10-22
申请人： MERCK SHARP & DOHME CORP. , YASUDA, Nobuyoshi , LIU, Zhuqing , ZHONG, Yong-Li , CHUNG, John, Y. L. , DUNN, Robert, F. , MALONEY, Kevin, M. , CAMPOS, Kevin , HOERRNER, R. Scott , LYNCH, Joseph , XU, Feng , CLEATOR, Edward , GIBSON, Andrew , KEEN, Stephen , LIEBERMAN, Dave , YOSHIKAWA, Naoki
发明人： YASUDA, Nobuyoshi , LIU, Zhuqing , ZHONG, Yong-Li , CHUNG, John, Y. L. , DUNN, Robert, F. , MALONEY, Kevin, M. , CAMPOS, Kevin , HOERRNER, R. Scott , LYNCH, Joseph , XU, Feng , CLEATOR, Edward , GIBSON, Andrew , KEEN, Stephen , LIEBERMAN, Dave , YOSHIKAWA, Naoki
IPC分类号： A61K31/497
CPC分类号： C07D207/09 , C07D207/08 , C12P17/10
摘要： The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:.
摘要翻译：本发明涉及通过多步反应制备式I-11化合物的方法：

50. 发明申请

WO2012075963A1 METHODS FOR PRODUCING A FERMENTATION PRODUCT FROM LIGNOCELLULOSE-CONTAINING MATERIAL 审中-公开
标题翻译：从含有木质素的材料生产发酵产品的方法
公开(公告)号：WO2012075963A1
公开(公告)日：2012-06-14
申请号：PCT/CN2011/083773
申请日：2011-12-09
申请人： NOVOZYMES A/S , COFCO , SINOPEC , HUANG, Hongzhi , WANG, Yun , CHEN, Ye , XU, Feng , REN, Haiyu
发明人： HUANG, Hongzhi , WANG, Yun , CHEN, Ye , XU, Feng , REN, Haiyu
IPC分类号： C12P19/00 , C12P13/04 , C12P7/00 , C12P5/00 , C08B15/00 , C08B1/00
CPC分类号： C08B1/003 , C08H8/00 , C10L1/023 , C12P7/10 , C12P7/14 , C12P19/02 , C12P19/14 , C12P2201/00 , C12P2203/00 , C13K1/02 , C13K13/002 , C13K13/007 , Y02E50/16
摘要： The present invention provides a method for producing a fermentation product from lignocellulose-containing material, a method for converting lignocellulose-containing material into a hydrolyzate comprising mono- and oligo-saccharides, and a method for treating lignocellulose-containing material, all of which comprise the step of mixing an acid pre-treated lignocellulose-containing material and an alkaline pre-treated lignocellulose-containing material. The present invention further provides a fermentation product made according to the method for producing a fermentation product.
摘要翻译：本发明提供了一种用于从含木素纤维素的材料生产发酵产物的方法，将含木素纤维素的材料转化为包含单糖和寡糖的水解产物的方法，以及用于处理含木素纤维素的材料的方法，所述方法包括混合酸预处理的含木素纤维素材料和碱性预处理的含木素纤维素的材料的步骤。本发明还提供根据发酵产物的制造方法制造的发酵产物。

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