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41. 发明申请

WO2004055158A3 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗性多肽，编码其的核酸及其使用方法
公开(公告)号：WO2004055158A3
公开(公告)日：2005-08-04
申请号：PCT/US0331817
申请日：2003-10-07
申请人： CURAGEN CORP , ANDERSON DAVID , VOSS EDWARD , KHRAMTSOV NIKOLAI , GUO XIAOJIA SASHA , RIEGER DANIEL , LI LI , SMITHSON GLENNDA , KEKUDA RAMESH , MEZES PETER
发明人： ANDERSON DAVID , VOSS EDWARD , KHRAMTSOV NIKOLAI , GUO XIAOJIA SASHA , RIEGER DANIEL , LI LI , SMITHSON GLENNDA , KEKUDA RAMESH , MEZES PETER
IPC分类号： A61K38/00 , C07K14/47 , C12N9/00 , C12N9/64 , C07H14/00
CPC分类号： C07K14/47 , A61K38/00 , C12N9/00
摘要： Disclosed herein are novel nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的新型核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体突变体或片段。载体宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法也包括在内。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

42. 发明申请

WO2004015060A3 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗性多肽，编码其的核酸及其使用方法
公开(公告)号：WO2004015060A3
公开(公告)日：2004-10-07
申请号：PCT/US0224492
申请日：2002-08-02
申请人： CURAGEN CORP , ANDERSON DAVID W , BOLDOG FERENC L , CASMAN STACIE J , EDINGER SHLOMIT R , GANGOLLI ESHA A , GERLACH VALERIE L , GORMAN LINDA , GUO XIAOJIA , KHRAMTSOV NIKOLAI V , LI LI , MACDOUGALL JOHN R , PENA CAROL E A , PEYMAN JOHN A , PATTURAJAN MEERA , SHIMKETS RICHARD A , SMITHSON GLENNDA , SPYTEK KIMBERLY A , VERNET CORINE A M , VOSS EDWARD Z , ZHONG MEI
发明人： ANDERSON DAVID W , BOLDOG FERENC L , CASMAN STACIE J , EDINGER SHLOMIT R , GANGOLLI ESHA A , GERLACH VALERIE L , GORMAN LINDA , GUO XIAOJIA , KHRAMTSOV NIKOLAI V , LI LI , MACDOUGALL JOHN R , PENA CAROL E A , PEYMAN JOHN A , PATTURAJAN MEERA , SHIMKETS RICHARD A , SMITHSON GLENNDA , SPYTEK KIMBERLY A , VERNET CORINE A M , VOSS EDWARD Z , ZHONG MEI
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N15/12 , C07K14/00 , C12N15/11 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

43. 发明申请

WO2004070817A2 METHOD OF ELIMINATING RESIDUAL CARBON FROM FLOWABLE OXIDE FILL 审中-公开
标题翻译：从可流动氧化物膜中消除残留碳的方法
公开(公告)号：WO2004070817A2
公开(公告)日：2004-08-19
申请号：PCT/US2004003236
申请日：2004-02-04
申请人： MICRON TECHNOLOGY INC , LI LI , LI WEIMIN
发明人： LI LI , LI WEIMIN
IPC分类号： C23C16/04 , C23C16/40 , C23C16/56 , H01L21/316 , H01L21/762 , H01L21/3065 , H01L21/3105
CPC分类号： H01L21/02126 , C23C16/045 , C23C16/401 , C23C16/56 , H01L21/02164 , H01L21/02211 , H01L21/02216 , H01L21/02271 , H01L21/02282 , H01L21/0234 , H01L21/31612 , H01L21/31633 , H01L21/76224
摘要： Methods of forming an oxide layer such as high aspect ratio trench isolations, and treating the oxide substrate to remove carbon, structures formed by the method, and devices and systems incorporating the oxide material are provided.
摘要翻译：提供形成氧化物层的方法，例如高纵横比沟槽隔离，以及处理氧化物衬底以除去碳，通过该方法形成的结构，以及结合氧化物材料的器件和系统。

44. 发明申请

WO02081498A9 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白质和编码相同的核酸
公开(公告)号：WO02081498A9
公开(公告)日：2003-12-24
申请号：PCT/US0210780
申请日：2002-04-03
申请人： CURAGEN CORP , GUO XIAOJIA , KEKUDA RAMESH , MILLER CHARLES E , MALYANKAR URIEL M , SPYTEK KIMBERLY A , PATTURAJAN MEERA , LIU XIAOHONG , GUSEV VLADIMIR Y , LI LI , VERNET CORINE A M
发明人： GUO XIAOJIA , KEKUDA RAMESH , MILLER CHARLES E , MALYANKAR URIEL M , SPYTEK KIMBERLY A , PATTURAJAN MEERA , LIU XIAOHONG , GUSEV VLADIMIR Y , LI LI , VERNET CORINE A M
IPC分类号： C07K14/47 , C07K14/54 , C07K14/705 , C07K14/82 , C12N9/10 , C12N9/12 , C12N15/113 , C12Q1/68 , A61K38/00 , C07H21/04 , C12N1/20 , C12N5/08
CPC分类号： C12N15/113 , C07K14/47 , C07K14/5421 , C07K14/705 , C07K14/82 , C12N9/1051 , C12N9/1211 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12Y204/0115
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
摘要翻译：本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态。更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。

45. 发明申请

WO03052061A3 NOVEL HUMAN PROTEINS, POLYNUCLEOTIDES ENCODING THEM AND METHODS OF USING THE SAME 审中-公开
标题翻译：新的人类蛋白质，编码它们的多核苷酸及其使用方法
公开(公告)号：WO03052061A3
公开(公告)日：2003-10-16
申请号：PCT/US0238821
申请日：2002-12-03
申请人： CURAGEN CORP , ALSOBROOK JOHN P II , ANDERSON DAVID W , BOLDOG FERENC L , BURGESS CATHERINE E , CATTERTON ELINA , EDINGER SHLOMIT R , GORMAN LINDA , GUO XIAOJIA , JI WEIZHEN , KEKUDA RAMESH , LI LI , PATTURAJAN MEERA , RIEGER DANIEL K , SHENOY SURESH G , SPYTEK KIMBERLY A , VERNET CORINE A M , VOSS EDWARD Z , ZHONG MEI
发明人： ALSOBROOK JOHN P II , ANDERSON DAVID W , BOLDOG FERENC L , BURGESS CATHERINE E , CATTERTON ELINA , EDINGER SHLOMIT R , GORMAN LINDA , GUO XIAOJIA , JI WEIZHEN , KEKUDA RAMESH , LI LI , PATTURAJAN MEERA , RIEGER DANIEL K , SHENOY SURESH G , SPYTEK KIMBERLY A , VERNET CORINE A M , VOSS EDWARD Z , ZHONG MEI
IPC分类号： A61K38/00 , C07K14/47 , C12N9/00 , C07K14/00 , A61K38/17
CPC分类号： C07K14/47 , A61K38/00 , C12N9/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using the same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及对多肽特异的新多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。还包括载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法。本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

46. 发明申请

WO03064629A2 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗性多肽，编码其的核酸及其使用方法
公开(公告)号：WO03064629A2
公开(公告)日：2003-08-07
申请号：PCT/US0303402
申请日：2003-02-03
申请人： CURAGEN CORP , ALVAREZ ENRIQUE , EDINGER SHLOMIT R , GANGOLLI ESHA A , GERLACH VALERIE L , GORMAN LINDA , GUO XIAOJIA , JI WEIZHEN , KEKUDA RAMESH , LI LI , MILLER CHARLES E , PADIGARU MURALIDHARA , PATTURAJAN MEERA , RASTELLI LUCA , RIEGER DANIEL K , SHENOY SURESH G , SHIMKETS RICHARD A , SPYTEK KIMBERLY A , ZHONG MEI
发明人： ALVAREZ ENRIQUE , EDINGER SHLOMIT R , GANGOLLI ESHA A , GERLACH VALERIE L , GORMAN LINDA , GUO XIAOJIA , JI WEIZHEN , KEKUDA RAMESH , LI LI , MILLER CHARLES E , PADIGARU MURALIDHARA , PATTURAJAN MEERA , RASTELLI LUCA , RIEGER DANIEL K , SHENOY SURESH G , SHIMKETS RICHARD A , SPYTEK KIMBERLY A , ZHONG MEI
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/14 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P5/38 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P41/00 , A61P43/00 , C07K14/47 , C07K14/715 , C07K14/82 , C07K16/18 , C07K16/28 , C07K16/32 , C07K16/40 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , C12N
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifcally bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法也包括在内。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

47. 发明申请

WO0230974A3 PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：蛋白质和核酸编码相同
公开(公告)号：WO0230974A3
公开(公告)日：2003-04-17
申请号：PCT/US0131922
申请日：2001-10-12
申请人： CURAGEN CORP , GROSSE WILLIAM M , ALSOBROOK JOHN P II , LEPLEY DENISE M , BURGESS CATHERINE E , MISHRA VISHNU , KEKUDA RAMESH , LI LI , PADIGARU MURALIDHARA , SHIMKETS RICHARD A , ZERHUSEN BRYAN D , SPYTEK KIMBERLY A , EDINGER SHLOMIT , GERLACH VALERIE , MACDOUGALL JOHN , MILLET ISABELLE , STONE DAVID , GUNTHER ERIK , ELLERMAN KAREN
发明人： GROSSE WILLIAM M , ALSOBROOK JOHN P II , LEPLEY DENISE M , BURGESS CATHERINE E , MISHRA VISHNU , KEKUDA RAMESH , LI LI , PADIGARU MURALIDHARA , SHIMKETS RICHARD A , ZERHUSEN BRYAN D , SPYTEK KIMBERLY A , EDINGER SHLOMIT , GERLACH VALERIE , MACDOUGALL JOHN , STONE DAVID , GUNTHER ERIK , ELLERMAN KAREN
IPC分类号： A61K48/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K14/81 , C12N1/21 , C12N9/12 , C12N15/12 , C12N15/54 , A61K38/00 , C07K16/18 , C07K16/42 , C12N15/70 , C12Q1/68 , G01N33/577 , G01N33/68
CPC分类号： C12N9/12 , A61K48/00 , C07K14/47 , C07K14/4741 , C07K14/70571 , C07K14/70596 , C07K14/78 , C07K14/8139
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

48. 发明申请

WO02098900A3 NOVEL HUMAN PROTEINS, POLYNUCLEOTIDES ENCODING THEM AND METHODS OF USING THE SAME 审中-公开
标题翻译：新的人类蛋白质，编码它们的多核苷酸及其使用方法
公开(公告)号：WO02098900A3
公开(公告)日：2003-02-20
申请号：PCT/US0217558
申请日：2002-06-04
申请人： CURAGEN CORP , ZERHUSEN BRYAN D , KEKUDA RAMESH , SPYTEK KIMBERLY A , SHENOY SURESH G , MILLER CHARLES E , HJALT TORD , GERLACH VALERIE L , BAUMGARTNER JASON C , GUO XIAOJIA , GANGOLLI ESHA A , VERNET CORINE A M , PADIGARU MURALIDHARA , LI LI , PENA CAROL E A , GORMAN LINDA , ANDERSON DAVID W , EDINGER SHLOMIT R , PATTURAJAN MEERA , STONE DAVID J
发明人： ZERHUSEN BRYAN D , KEKUDA RAMESH , SPYTEK KIMBERLY A , SHENOY SURESH G , MILLER CHARLES E , HJALT TORD , GERLACH VALERIE L , BAUMGARTNER JASON C , GUO XIAOJIA , GANGOLLI ESHA A , VERNET CORINE A M , PADIGARU MURALIDHARA , LI LI , PENA CAROL E A , GORMAN LINDA , ANDERSON DAVID W , EDINGER SHLOMIT R , PATTURAJAN MEERA , STONE DAVID J
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12N1/21 , C07K14/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00
摘要： Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
摘要翻译：公开了编码它们的多肽和核酸。还公开了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

49. 发明申请

WO0155179A3 NUCLEIC ACIDS ENCODING POLYPEPTIDES WITH HOMOLOGY TO OLFACTORY RECEPTORS 审中-公开
标题翻译：核糖核酸编码多肽与同种异体受体的同源性
公开(公告)号：WO0155179A3
公开(公告)日：2002-03-14
申请号：PCT/US0102849
申请日：2001-01-29
申请人： CURAGEN CORP , PRAYAGA SUDHIRDAS K , PADIGARU MURALIDHAR , SPYTEK KIMBERLY A , LI LI , TCHERNEV VELIZAR T , VERNET CORINE A M , PEYMAN JOHN A , MACDOUGALL JOHN
发明人： PRAYAGA SUDHIRDAS K , PADIGARU MURALIDHAR , SPYTEK KIMBERLY A , LI LI , TCHERNEV VELIZAR T , VERNET CORINE A M , PEYMAN JOHN A , MACDOUGALL JOHN
IPC分类号： A61K38/00 , C07K14/705 , C07K16/28 , C12Q1/68
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00
摘要： The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译：本发明提供新的分离的NOVX多核苷酸和由NOVX多核苷酸编码的多肽。还提供免疫特异性结合NOVX多肽或NOVX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。本发明另外提供了其中使用NOVX多肽，多核苷酸和抗体来检测和治疗广泛的病理状态以及其它用途的方法。

50. 发明申请

WO2012094138A3 SEAMLESS SCALING OF ENTERPRISE APPLICATIONS 审中-公开
标题翻译：无缝缩放企业应用程序
公开(公告)号：WO2012094138A3
公开(公告)日：2012-11-22
申请号：PCT/US2011065755
申请日：2011-12-19
申请人： ALCATEL LUCENT , LI LI , WOO THOMAS
发明人： LI LI , WOO THOMAS
IPC分类号： G06F9/50
CPC分类号： G06F9/5061 , G06F9/5011
摘要： Various exemplary embodiments relate to a method of scaling resources of a computing system, the method comprising. The method may include: setting a threshold value for a metric of system performance; determining an ideal resource load for at least one resource based on the threshold value for the metric; distributing a system work load among the computing system resources; and adjusting the number of resources based on the system work load, the ideal resource load, and a current number of resources. Various exemplary embodiments also relate to a computing system for scaling cloud resources. The computing system may include: internal resources; a load balancer; a performance monitor; a communication module; a job dispatching module; and a controller. Various exemplary embodiments also relate to a method of detecting dynamic bottlenecks during resource scaling using a resource performance metric and a method of detecting scaling choke points using historical system performance metric.
摘要翻译：各种示例性实施例涉及一种缩放计算系统的资源的方法，所述方法包括：该方法可以包括：为系统性能度量设置阈值; 基于该度量的阈值确定至少一个资源的理想资源负载; 在系统资源中分配系统工作量; 并根据系统工作量，理想资源负载和当前资源数量调整资源数量。各种示例性实施例还涉及用于缩放云资源的计算系统。该计算系统可以包括：内部资源; 负载平衡器; 性能监视器; 通信模块; 一个工作调度模块; 和一个控制器。各种示例性实施例还涉及使用资源性能度量来检测资源缩放期间的动态瓶颈的方法以及使用历史系统性能度量来检测缩放阻塞点的方法。

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