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1. 发明申请

WO03076584A8 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO03076584A8
公开(公告)日：2004-05-21
申请号：PCT/US0306951
申请日：2003-03-06
申请人： CURAGEN CORP , ALSOBROOK JOHN P II , BURGESS CATHERINE E , EDINGER SHLOMIT R , GERLACH VALERIE L , JI WEIZHEN , KEKUDA RAMESH , LI LI , MACDOUGALL JOHN R , MILLER CHARLES E , MILLET ISABELLE , PATTURAJAN MEERA , PENA CAROL E A , RIEGER DANIEL K , SCIORE PAUL , SHENOY SURESH G , SMITHSON GLENNDA , SPYTEK KIMBERLY A , STONE DAVID J , VOSS EDWARD Z , ZHONG MEI
发明人： ALSOBROOK JOHN P II , BURGESS CATHERINE E , EDINGER SHLOMIT R , GERLACH VALERIE L , JI WEIZHEN , KEKUDA RAMESH , LI LI , MACDOUGALL JOHN R , MILLER CHARLES E , MILLET ISABELLE , PATTURAJAN MEERA , PENA CAROL E A , RIEGER DANIEL K , SCIORE PAUL , SHENOY SURESH G , SMITHSON GLENNDA , SPYTEK KIMBERLY A , STONE DAVID J , VOSS EDWARD Z , ZHONG MEI
IPC分类号： A61K38/00 , C07K14/47 , C12N
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

2. 发明申请

WO2004013732A3 DYNAMICALLY ANALYZING A MOBILE OBJECT 审中-公开
标题翻译：动态分析移动对象
公开(公告)号：WO2004013732A3
公开(公告)日：2004-04-29
申请号：PCT/US0324126
申请日：2003-07-31
申请人： UNIV IOWA RES FOUND , SOLL DAVID R , VOSS EDWARD R
发明人： SOLL DAVID R , VOSS EDWARD R
IPC分类号： G06T15/70 , G06K9/46
CPC分类号： G06T17/00 , G06K9/00127 , G06K9/6253 , G06T7/0012 , G06T2200/24 , G06T2207/10056 , G06T2207/30024
摘要： A system and method for dynamically analyzing a mobile object provides (100) a computerized method that includes obtaining a plurality of digital representations of the mobile object, establishing a first and second processing stations in a session, processing the digital representations on the first processing station, processing in parallel the digital representations on the second processing station to compute a plurality of parameters representing a motility or morphology of the mobile object, and displaying a graphical reconstruction of the mobile object. In one implementation, the computerized method further includes establishing one or more control panels to control various functionalities of the first and second processing stations. In another implementation, the computerized method further includes preserving the first and second processing stations in a session.
摘要翻译：一种用于动态分析移动对象的系统和方法提供（100）一种计算机化方法，其包括获得所述移动对象的多个数字表示，在会话中建立第一和第二处理站，处理所述第一处理站上的数字表示，并行地处理第二处理站上的数字表示，以计算表示移动对象的运动或形态的多个参数，以及显示移动对象的图形重构。在一个实现中，计算机化方法还包括建立一个或多个控制面板以控制第一和第二处理站的各种功能。在另一实现中，计算机化方法还包括在会话中保留第一和第二处理站。

3. 发明申请

WO03088150A9 RECONSTRUCTION AND MOTION ANALYSIS OF AN EMBRYO 审中-公开
标题翻译：胚胎的重建和运动分析
公开(公告)号：WO03088150A9
公开(公告)日：2004-04-15
申请号：PCT/US0310863
申请日：2003-04-09
申请人： UNIV IOWA RES FOUND , HEID PAUL J , VOSS EDWARD R , SOLL DAVID R
发明人： HEID PAUL J , VOSS EDWARD R , SOLL DAVID R
IPC分类号： G06K9/00 , G06T7/00 , G06T7/20 , G06T17/20 , G06T15/00
CPC分类号： G06T7/0012 , G06K9/0014 , G06T7/20 , G06T7/571 , G06T17/20 , G06T2207/10056 , G06T2207/30004 , G06T2207/30024 , G06T2210/41
摘要： In an embodiment, a method includes receiving a number of optical sections of different parts of an embryo over time along a Z-axis through differential interference contrast microscopy. The method also includes outlining a perimeter of the number of parts of the embryo within the number of optical sections. Additionally, the method includes generating a three-dimensional faceted image of the number of parts based on the outlined perimeter. The method includes reconstructing, separately, a four-dimensional image of a growth of the different parts of the embryo over time based on the three-dimensional facet image of the number of parts.
摘要翻译：在一个实施例中，一种方法包括通过微分干涉对比显微镜在Z轴上接收随时间的胚胎不同部分的多个光学部分。该方法还包括在光学部分的数目内概述胚胎的部分数量的周长。另外，该方法包括基于概述的周长生成多个零件的三维刻面图像。该方法包括基于部件数量的三维小平面图像分别重建胚胎不同部分随时间的生长的四维图像。

4. 发明申请

WO2003076642A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白质和编码相同的核酸
公开(公告)号：WO2003076642A2
公开(公告)日：2003-09-18
申请号：PCT/US2002/024459
申请日：2002-08-02
申请人： CURAGEN CORPORATION , ZERHUSEN, Bryan, D. , PATTURAJAN, Meera , KEKUDA, Ramesh , MILLER, Charles, E. , RIEGER, Daniel, K. , PENA, Carol, E., A. , SHIMKETS, Richard, A. , LI, Li , BERGHS, Constance , ZHONG, Mei , CASMAN, Stacie, J. , VOSS, Edward, Z. , BOLDOG, Ferenc, L. , PADIGARU, Muralidhara , SMITHSON, Glennda , SHENOY, Suresh, G. , JI, Weizhen , GORMAN, Linda , VERNET, Corine, A., M. , LEITE, Mario, W. , GUO, Xiaojia , ANDERSON, David, W. , SPYTEK, Kimberly, A. , GERLACH, Valerie, L. , BURGESS, Catherine, E. , KHRAMTSOV, Nikolai, V. , ORT, Tatiana , ELLERMAN, Karen , RASTELLI, Luca , AGEE, Michele, L. , CHAUDHURI, Amitabha , CHANT, John, S. , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew , GANGOLLI, Esha, A. , GIOT, Loic , OOI, Chean, Eng , ROTHENBERG, Mark, E. , SPADERNA, Steven, K. , HJALT, Tord , LIU, Xiaohong , TAUPIER, Raymond, J., Jr. , CATTERTON, Elina
发明人： ZERHUSEN, Bryan, D. , PATTURAJAN, Meera , KEKUDA, Ramesh , MILLER, Charles, E. , RIEGER, Daniel, K. , PENA, Carol, E., A. , SHIMKETS, Richard, A. , LI, Li , BERGHS, Constance , ZHONG, Mei , CASMAN, Stacie, J. , VOSS, Edward, Z. , BOLDOG, Ferenc, L. , PADIGARU, Muralidhara , SMITHSON, Glennda , SHENOY, Suresh, G. , JI, Weizhen , GORMAN, Linda , VERNET, Corine, A., M. , LEITE, Mario, W. , GUO, Xiaojia , ANDERSON, David, W. , SPYTEK, Kimberly, A. , GERLACH, Valerie, L. , BURGESS, Catherine, E. , KHRAMTSOV, Nikolai, V. , ORT, Tatiana , ELLERMAN, Karen , RASTELLI, Luca , AGEE, Michele, L. , CHAUDHURI, Amitabha , CHANT, John, S. , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew , GANGOLLI, Esha, A. , GIOT, Loic , OOI, Chean, Eng , ROTHENBERG, Mark, E. , SPADERNA, Steven, K. , HJALT, Tord , LIU, Xiaohong , TAUPIER, Raymond, J., Jr. , CATTERTON, Elina
IPC分类号： C12Q
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态。更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。本发明进一步公开了诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

5. 发明申请

WO2003050245A3 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
公开(公告)号：WO2003050245A3
公开(公告)日：2003-06-19
申请号：PCT/US2002/038594
申请日：2002-12-03
申请人： CURAGEN CORPORATION , ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHILLAKURU, Rajeev, A. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , JEFFERS, Michael, E. , JI, Weizhen , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , MURPHEY, Ryan , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SMITHSON, Glennda , STARLING, Gary , TAUPIER, Raymond, J., Jr. , VOSS, Edward, Z. , ZHONG, Haihong , ZHONG, Mei
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHILLAKURU, Rajeev, A. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , JEFFERS, Michael, E. , JI, Weizhen , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , MURPHEY, Ryan , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SMITHSON, Glennda , STARLING, Gary , TAUPIER, Raymond, J., Jr. , VOSS, Edward, Z. , ZHONG, Haihong , ZHONG, Mei
IPC分类号： C07K14/435
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

6. 发明申请

WO2003050245A2 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗用多肽，编码核酸及使用方法
公开(公告)号：WO2003050245A2
公开(公告)日：2003-06-19
申请号：PCT/US2002/038594
申请日：2002-12-03
申请人： CURAGEN CORPORATION , ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHILLAKURU, Rajeev, A. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , JEFFERS, Michael, E. , JI, Weizhen , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , MURPHEY, Ryan , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SMITHSON, Glennda , STARLING, Gary , TAUPIER, Raymond, J., Jr. , VOSS, Edward, Z. , ZHONG, Haihong , ZHONG, Mei
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHILLAKURU, Rajeev, A. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , JEFFERS, Michael, E. , JI, Weizhen , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , MURPHEY, Ryan , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SMITHSON, Glennda , STARLING, Gary , TAUPIER, Raymond, J., Jr. , VOSS, Edward, Z. , ZHONG, Haihong , ZHONG, Mei
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00 , C12N9/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及对多肽特异的新多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。还包括载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法。本发明进一步公开了诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

7. 发明申请

WO2003040329A3 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
公开(公告)号：WO2003040329A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/035535
申请日：2002-11-05
申请人： CURAGEN CORPORATION , ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHANT, John, S. , CHAPOVAL, Andrei , CHAUDHURI, Amitabha , EDINGER, Shlomit, R. , EISEN, Andrew , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GUO, Xiaojia , JI, Weizhen , KHRAMTSOV, Nikolai, V. , LEITE, Mario, W. , LI, Li , MEZES, Peter, S. , MILLET, Isabelle , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E.A. , RASTELLI, Luca , RIEGER, Daniel, K. , QUINN SENGER, Kerry, E. , SMITHSON, Glennda , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , STONE, David, J. , TWOMLOW, Nancy , VERNET, Corine, A. M. , VOSS, Edward, Z. , ZERHUSEN, Bryan, D. , ZHONG, Mei
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHANT, John, S. , CHAPOVAL, Andrei , CHAUDHURI, Amitabha , EDINGER, Shlomit, R. , EISEN, Andrew , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GUO, Xiaojia , JI, Weizhen , KHRAMTSOV, Nikolai, V. , LEITE, Mario, W. , LI, Li , MEZES, Peter, S. , MILLET, Isabelle , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E.A. , RASTELLI, Luca , RIEGER, Daniel, K. , QUINN SENGER, Kerry, E. , SMITHSON, Glennda , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , STONE, David, J. , TWOMLOW, Nancy , VERNET, Corine, A. M. , VOSS, Edward, Z. , ZERHUSEN, Bryan, D. , ZHONG, Mei
IPC分类号： C12N9/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

8. 发明申请

WO2003023001A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白和核酸编码相同
公开(公告)号：WO2003023001A2
公开(公告)日：2003-03-20
申请号：PCT/US2002/028538
申请日：2002-09-09
申请人： CURAGEN CORPORATION , AGEE, Michele, L. , ALSOBROOK, John, P., II , ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , CHANT, John, S. , CHAUDHURI, Amitabha , CRABTREE, Julie , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew, J. , ELLERMAN, Karen , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GIOT, Loic , GORMAN, Linda , GUO, Xiaojia , GUSEV, Vladimir, Y. , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai, V. , LEACH, Martin, D. , LEPLEY, Denise, M. , LI, Li , LIU, Xiaohong , MALYANKAR, Uriel, M. , MILLER, Charles, E. , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , TAUPIER, Raymond, J., Jr. , TWOMLOW, Nancy , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZERHUSEN, Bryan, D. , ZHONG, Mei
发明人： AGEE, Michele, L. , ALSOBROOK, John, P., II , ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , CHANT, John, S. , CHAUDHURI, Amitabha , CRABTREE, Julie , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew, J. , ELLERMAN, Karen , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GIOT, Loic , GORMAN, Linda , GUO, Xiaojia , GUSEV, Vladimir, Y. , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai, V. , LEACH, Martin, D. , LEPLEY, Denise, M. , LI, Li , LIU, Xiaohong , MALYANKAR, Uriel, M. , MILLER, Charles, E. , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , TAUPIER, Raymond, J., Jr. , TWOMLOW, Nancy , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZERHUSEN, Bryan, D. , ZHONG, Mei
IPC分类号： C12N
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/00
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗的广泛病理状态。更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

9. 发明申请

WO2003004687A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白和核酸编码相同
公开(公告)号：WO2003004687A2
公开(公告)日：2003-01-16
申请号：PCT/US2002/021361
申请日：2002-07-03
申请人： CURAGEN CORPORATION , ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , EDINGER, Shlomit , EISEN, Andrew, J. , ELLERMAN, Karen , GERLACH, Valerie , GORMAN, Linda , GUO, Xiaojia , JEFFERS, Michael , KEKUDA, Ramesh , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , RASTELLI, Luca , SHENOY, Suresh , SHIMKETS, Richard, A. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , STONE, David, J. , TAUPIER, Raymond, J., Jr. , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZHONG, Mei
发明人： ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , EDINGER, Shlomit , EISEN, Andrew, J. , ELLERMAN, Karen , GERLACH, Valerie , GORMAN, Linda , GUO, Xiaojia , JEFFERS, Michael , KEKUDA, Ramesh , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , RASTELLI, Luca , SHENOY, Suresh , SHIMKETS, Richard, A. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , STONE, David, J. , TAUPIER, Raymond, J., Jr. , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZHONG, Mei
IPC分类号： C12Q
CPC分类号： C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态。更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。本发明还公开了与疾病相关的治疗性小分子。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

10. 发明申请

WO2003004618A2 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗性多肽，编码其的核酸及其使用方法
公开(公告)号：WO2003004618A2
公开(公告)日：2003-01-16
申请号：PCT/US2002/021360
申请日：2002-07-03
申请人： CURAGEN CORPORATION , ANDERSON, David, W. , BOLDOG, Ferenc, L. , CASMAN, Stacie, J. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , LI, Li , MALYANKAR, Uriel, M. , PATTURAJAN, Meera , PEYMAN, John, A. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , VERNET, Corine, A., M. , VOSS, Edward, Z.
发明人： ANDERSON, David, W. , BOLDOG, Ferenc, L. , CASMAN, Stacie, J. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , LI, Li , MALYANKAR, Uriel, M. , PATTURAJAN, Meera , PEYMAN, John, A. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , VERNET, Corine, A., M. , VOSS, Edward, Z.
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

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