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41. 发明申请

WO2008063190A3 PRECURSORS FOR FORMATION OF COPPER SELENIDE, INDIUM SELENIDE, COPPER INDIUM DISELENIDE, AND/OR COPPER INDIUM GALLIUM DISELENIDE FILMS 审中-公开
标题翻译：用于形成硒化铜，硒化铟，铜铟二硒化物和/或铜铟镓二硒化物膜的前体
公开(公告)号：WO2008063190A3
公开(公告)日：2008-11-20
申请号：PCT/US2006060757
申请日：2006-11-09
申请人： MIDWEST RESEARCH INST , CURTIS CALVIN J , MIEDANER ALEXANDER , VAN HEST MAIKEL , GINLEY DAVID S
发明人： CURTIS CALVIN J , MIEDANER ALEXANDER , VAN HEST MAIKEL , GINLEY DAVID S
IPC分类号： B05D3/02 , B05D5/12
CPC分类号： H01L31/0322 , B82Y30/00 , C23C18/1204 , Y02E10/541
摘要： Liquid-based precursors for formation of Copper Selenide, Indium Selenide, Copper Indium Diselenide, and/or copper Indium Galium Diselenide include copper-organoselenides, particulate copper selenide suspensions, copper selenide ethylene diamine in liquid solvent, nanoparticlulate indium selenide suspensions, and indium selenide ethylene diamine coordination compounds in solvent. These liquid-based precursors can be deposited in liquid form onto substrates and treated by rapid thermal processing to form crystalline copper selenide and indium selenide films.
摘要翻译：用于形成硒化铜，硒化铟，铜铟二硒化物和/或铜铟硒二硒化物的基于液体的前体包括铜 - 有机硒化物，硒化铜微粒悬浮液，硒化铜乙二胺在液体溶剂中，硒化纳米硒化物悬浮液和硒化铟乙二胺配位化合物的溶剂。这些基于液体的前体可以以液体形式沉积在基底上并通过快速热处理来处理以形成结晶硒化铜和硒化铟薄膜。

42. 发明申请

WO2008133638A2 XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS FOR ETHANOL PRODUCTION 审中-公开
标题翻译：用于乙醇生产的XYLOSE-ZYMOMONAS的XYLITOL合成突变体
公开(公告)号：WO2008133638A2
公开(公告)日：2008-11-06
申请号：PCT/US2007020950
申请日：2007-09-28
申请人： DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
发明人： VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
CPC分类号： C12N1/22 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism.lt also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
摘要翻译：用葡萄糖 - 果糖氧化还原酶基因的遗传修饰工程改造了一种利用木糖的酵母菌菌株，导致GFOR酶活性的降低。工程化的菌株表现出木糖代谢产物的减少，这是木糖代谢的有害副产物。在过程相关条件下，混合糖发酵过程中还会消耗更多的木糖并产生更多的乙醇。

43. 发明申请

WO2008051349A3 IMPROVED ETHANOL PRODUCT I ON IN FERMENTATION OF MIXED SUGARS CONTAINING XYLOSE IN THE PRESENCE OF SUGAR ALCOHOLS 审中-公开
标题翻译：改进的乙醇产品I在糖乳液存在下发酵中含有XYLOSE的混合糖
公开(公告)号：WO2008051349A3
公开(公告)日：2008-08-07
申请号：PCT/US2007020946
申请日：2007-09-28
申请人： DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , LI XU , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
发明人： VIITANEN PAUL V , MCCUTCHEN CAROL M , LI XU , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
IPC分类号： C12N1/00
CPC分类号： C12N1/20 , C12P7/065 , C12R1/01 , Y02E50/16 , Y02E50/17
摘要： Xylose-utilizing Z. mobilis strains were found to have improved ethanol production when grown in medium containing mixed sugars including xylose if sorbitol or mannitol was included in the medium. The effect was seen in concentrations of mixed sugars where no growth lag period occurs, as well as in higher sugars concentrations.
摘要翻译：当发现含木糖的运动发酵单胞菌菌株在含有木糖的混合糖的培养基中生长时，如果在培养基中包含山梨糖醇或甘露醇，则发现其具有改善的乙醇生产。在没有生长滞后期的混合糖的浓度以及较高的糖浓度下观察到效果。

44. 发明申请

WO2007143247A3 CLONING AND CHARACTERIZATION OF L-ARABINOSE TRANSPORTERS FROM NON-CONVENTIONAL YEAST 审中-公开
标题翻译：来自非常规YEAST的L-阿拉伯糖输送机的克隆和表征
公开(公告)号：WO2007143247A3
公开(公告)日：2008-02-21
申请号：PCT/US2007064418
申请日：2007-03-20
申请人： MIDWEST RESEARCH INST , KNOSHAUG ERIC , JARVIS ERIC , SINGH ARJUN , FRANDEN MARY ANN , ZHANG MIN
发明人： KNOSHAUG ERIC , JARVIS ERIC , SINGH ARJUN , FRANDEN MARY ANN , ZHANG MIN
IPC分类号： C12N15/00 , C12N1/00
CPC分类号： C12P7/08 , C07K14/39
摘要： Two genes from non-conventional yeast encode arabinose transporters. These arabinose transporters are capable of transporting arabinose across the cell membrane. These genes may be expressed heterologously in a host that is not otherwise capable of taking up significant amounts of arabinose from the environment of use. Methods are disclosed to use such genetically engineered hosts to ferment pentose such as arabinose, to produce ethanol.
摘要翻译：来自非常规酵母的两个基因编码阿拉伯糖转运蛋白。这些阿拉伯糖转运蛋白能够将阿拉伯糖输送到细胞膜上。这些基因可以在不能从使用环境中占据大量阿拉伯糖的宿主中异源表达。公开了使用这种基因工程的宿主来发酵戊糖如阿拉伯糖的方法以产生乙醇。

45. 发明申请

WO2005040170A8 Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto 审中-公开
标题翻译：吡咯并苯并二氮杂衍生物，包含其的组合物及其相关方法
公开(公告)号：WO2005040170A8
公开(公告)日：2006-05-11
申请号：PCT/US2004035050
申请日：2004-10-22
申请人： VISHNUVAJ-JALA RAO B , LIU PAUL S , SNADER KENNETH M , THURSTON DAVID , HOWARD PHILIP W , HSIAO LUKE Y , TURNER GREGORY , US GOVERNMENT , SPIROGEN LTD , STARKS ASS , MIDWEST RESEARCH INST
发明人： VISHNUVAJ-JALA RAO B , LIU PAUL S , SNADER KENNETH M , THURSTON DAVID , HOWARD PHILIP W , HSIAO LUKE Y , TURNER GREGORY
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Disclosed are compounds of Formula (I) wherein X, Y, R 1 -R 7 , T 1 , T 2 , Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.
摘要翻译：公开了式（I）的化合物，其中X，Y，R 1 -R 7，T 1，T 2， SUP>，Z和p如本文所述; 包含式（I）化合物和载体的药物组合物; 抑制细胞生长的方法，该方法包括以有效抑制生长的量施用式（I）化合物; 一种治疗哺乳动物癌症的方法，该方法包括以有效治疗癌症的量施用式（I）化合物; 治疗细胞的病毒，寄生或细菌感染的方法，所述方法包括以有效治疗病毒，寄生或细菌感染的量施用式（I）化合物; 和制备本文所述的式（I）化合物的方法。

46. 发明申请

WO2005017436A3 TABBED TRANSFER FINS FOR AIR-COOLED HEAT EXCHANGER 审中-公开
标题翻译：用于空气冷却热交换器的换热片
公开(公告)号：WO2005017436A3
公开(公告)日：2005-04-07
申请号：PCT/US2004021317
申请日：2004-07-01
申请人： MIDWEST RESEARCH INST , KUTSCHER CHARLES F , KOZUBAL ERIC JOSEPH
发明人： KUTSCHER CHARLES F , KOZUBAL ERIC JOSEPH
IPC分类号： B21D53/08 , F28F20060101 , F28F1/32 , F28F13/12
CPC分类号： F28F1/325 , B21D53/04 , F28F13/12 , F28F2240/00
摘要： Heat transfer fins (110), and heat exchangers (100) incorporating such fins (110), enhancing heat transfer with acceptable pressure drop increase. The fins (110) include tabs or secondary fins bent upward and downward from the fin body at a selected bend angle. All or a majority of the tabs are aligned with a simple flow path or with local flow paths for cooling air adjacent the fins (110) to minimize turbulence and pressure drop. The tabs are planar and generally aligned parallel to the simple flow path or local flow paths and are arranged so as to serve as a plurality of sites for starting new boundary layers by offsetting the tabs such that downstream tabs are not shadowed by upstream tabs. The tabs have a height sufficiently large to extend the tabs out into boundary layers on the fin (110). The tabs provide more uniform flow over fins (110) and shrink wake size behind tubes (120).
摘要翻译：传热翅片（110）和包含这种翅片（110）的热交换器（100），增强了可接受的压降增加的热传递。散热片（110）包括以翅片本体以选定的弯曲角度向上和向下弯曲的凸片或二次散热片。所有或大部分翼片与简单的流动路径对准，或者与用于冷却与翅片（110）相邻的冷却空气的局部流动路线对齐，以最小化湍流和压降。突片是平面的并且大致对齐于平行于简单流动路径或局部流动路径，并且被布置成用作多个位置，用于通过偏移突起来启动新的边界层，使得下游突出部不被上游突出部遮蔽。突片具有足够大的高度，以将突出部延伸到翅片（110）上的边界层中。翼片提供在鳍（110）上更均匀的流动并且在管（120）后面收缩尾巴尺寸。

47. 发明申请

WO2004078919A3 SUPERACTIVE CELLULASE FORMULATION USING CELLOBIOHYDROLASE-1 FROM PENICILLIUM FUNICULOSUM 审中-公开
标题翻译：使用来自P FROM ING ING ING OH ASE ASE ASE ASE UM UM UM UM UM UM UM UM UM UM UM
公开(公告)号：WO2004078919A3
公开(公告)日：2005-04-07
申请号：PCT/US0306172
申请日：2003-02-27
申请人： MIDWEST RESEARCH INST , ADNEY WILLIAM S , BAKER JOHN O , DECKER STEPHEN R , CHEN YAT-CHEN , HIMMEL MICHAEL E , DING SHI-YOU
发明人： ADNEY WILLIAM S , BAKER JOHN O , DECKER STEPHEN R , CHEN YAT-CHEN , HIMMEL MICHAEL E , DING SHI-YOU
IPC分类号： A23L11/20 , C12N20060101 , C12N9/42
CPC分类号： C12N9/2437 , C12Y302/01004 , C12Y302/01091
摘要： Purified cellobiohydrolase I (glycosyl hydrolase family 7 (Cel7A) enzymes from Penicillium funiculosum demonstrate a high level of specific performance in comparison to other Cel7 family member enzymes when formulated with purified E1cd endoglucanase from A. cellulolyticus and tested on pretreated corn stover. This result is true of the purified native enzyme, as well as recombinantly expressed enzyme, for example, that enzyme expressed in a non-native Aspergillus host. In a specific example, the specific performance of the formulation using puriified recombinant Cel7A from Penicillium funiculosum expressed in A. awamori is increased by more than 200% when compared to a formulation using purified Cel7A from Trichoderma reesei.
摘要翻译：与其他Cel7家族成员酶相比，纯化的纤维二糖水解酶I（糖基水解酶家族7（Cel7A））来自A. cellulolyticus的纯化E1cd内切葡聚糖酶，并与预处理的玉米秸秆进行了测试，结果表明：纯化的天然酶，以及重组表达的酶，例如在非天然曲霉属宿主中表达的酶。在一个具体实例中，使用在A.A中表达的来自Penicillium funiculosum的纯化重组Cel7A的制剂的具体性能。与使用来自里氏木霉的纯化Cel7A的制剂相比，泡盛曲增加超过200％。

48. 发明申请

WO2004093524A2 OXYGEN-RESISTANT HYDROGENASES AND METHODS FOR DESIGNING AND MAKING SAME 审中-公开
标题翻译：耐氧化氢及其设计和制造方法
公开(公告)号：WO2004093524A2
公开(公告)日：2004-11-04
申请号：PCT/US2004011830
申请日：2004-04-16
申请人： MIDWEST RESEARCH INST , KING PAUL , GHIRARDI MARIA L , SEIBERT MICHAEL
发明人： KING PAUL , GHIRARDI MARIA L , SEIBERT MICHAEL
IPC分类号： C12N9/02 , A01G
CPC分类号： C12N9/0067 , C12N9/001
摘要： The invention provides oxygen-resistant iron-hydrogenases ([Fe]-hydrogenases) for use in the production of H2. Methods used in the design and engineering of the oxygen-resistant [Fe]-hydrogenases are disclosed, as are the methods of transforming and culturing appropriate host cells with the oxygen-resistant [Fe]-hyrdogenases. Finally, the invention provides methods for utilizing the transformed, oxygen insensitive, host cells in the bulk production of H2 in a light catalyzed reaction having water as the reactant.
摘要翻译：本发明提供用于生产H2的耐氧铁 - 氢化酶（[Fe] - 氢化酶）。还公开了用于氧耐受[Fe] - 氢化酶的设计和工程中的方法，以及用耐氧[Fe] - 生成酶转化和培养合适的宿主细胞的方法。最后，本发明提供了在具有水作为反应物的轻催化反应中，在大量生产H 2中利用转化的，不对氧不敏感的宿主细胞的方法。

49. 发明申请

WO03008767A3 MIXED WORKING FLUID POWER SYSTEM WITH INCREMENTAL VAPOR GENERATION 审中-公开
标题翻译：具有增量蒸气发生的混合工作流体动力系统
公开(公告)号：WO03008767A3
公开(公告)日：2003-08-28
申请号：PCT/US0122773
申请日：2001-07-19
申请人： MIDWEST RESEARCH INST , BHARATHAN DESIKAN , HASSANI VAHAB
发明人： BHARATHAN DESIKAN , HASSANI VAHAB
IPC分类号： F01K25/06
CPC分类号： F01K25/065
摘要： A power generating system (110) comprising a heat source (116) and an incremental vapor generator system (112) operatively associated with the heat source (116). The incremental vapor generator system (112) includes a first heating section (136) and a second heating section (138). The first heating section (136) receives a mixed working fluid (114) and generates a first heated working fluid stream comprising a vapor portion (120) and a liquid portion. The second heating section (138) is operatively associated with the first heating section (136) and receives the liquid portion from the first heated working fluid stream. The second heating section (138) generates a second heated working fluid system stream comprising a vapor portion (122). An energy conversion device (126) operatively associated with the incremental vapor generator system (112) converts into useful work heat energy contained in the vapor portion (120, 122) of the first and second heated working fluid streams.
摘要翻译：一种发电系统（110），包括热源（116）和可操作地与热源（116）关联的增量蒸汽发生器系统（112）。增量式蒸气发生器系统（112）包括第一加热部分（136）和第二加热部分（138）。第一加热部分（136）接收混合的工作流体（114）并且产生包括蒸气部分（120）和液体部分的第一加热的工作流体流。第二加热部分（138）与第一加热部分（136）可操作地相关联并从第一加热的工作流体流接收液体部分。第二加热部分（138）产生包括蒸汽部分（122）的第二加热的工作流体系统流。与增量式蒸汽发生器系统（112）可操作地相关联的能量转换装置（126）转换成包含在第一和第二加热的工作流体流的蒸汽部分（120,122）中的有用功的热能。

50. 发明申请

WO0232852A3 SYNTHESIS OF ACID ADDITION SALT OF DELTA-AMINOLEVULINIC ACID FROM 5-BROMO LEVULINIC ACID ESTERS 审中-公开
标题翻译：从五溴胞苷酸酯中合成含有氨基酸的酸的添加盐
公开(公告)号：WO0232852A3
公开(公告)日：2003-06-05
申请号：PCT/US0132401
申请日：2001-10-16
申请人： MIDWEST RESEARCH INST
发明人： MOEN LUC
IPC分类号： C07C227/08 , C07C229/22
CPC分类号： C07C227/08 , C07C229/22
摘要： A process of preparing an acid addition salt of delta-aminolevulinc acid comprising: dissolving a lower alkyl 5-bromolevulinate and hexamethylenetetramine in a solvent selected from the group consisting of water, ethyl acetate, chloroform, acetone, ethanol, tetrahydrofuran and acetonitrile, to form a quaternary ammonium salt of the lower alkyl 5-bromolevulinate; and hydrolyzing the quatenary ammonium salt with an inorganic acid to form an acid addition salt of delta-aminolevulinic acid.
摘要翻译：一种制备δ-氨基乙酰丙酸的酸加成盐的方法，包括：将5-溴戊酰丙酸低级烷基酯和六亚甲基四胺溶解在选自水，乙酸乙酯，氯仿，丙酮，乙醇，四氢呋喃和乙腈的溶剂中形成 5-溴戊酰丙酸低级烷基酯的季铵盐; 并用无机酸水解季铵盐，形成δ-氨基乙酰丙酸的酸加成盐。

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