专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

WO1996011712A2 CELL-SPECIFIC GENE DELIVERY VEHICLES 审中-公开
标题翻译：细胞特异性基因递送车辆
公开(公告)号：WO1996011712A2
公开(公告)日：1996-04-25
申请号：PCT/US1995014621
申请日：1995-10-11
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , KAYYEM, Jon, F. , MEADE, Thomas, J. , FRASER, Scott, E.
发明人： CALIFORNIA INSTITUTE OF TECHNOLOGY
IPC分类号： A61K47/48
CPC分类号： A61K49/146 , A61K47/645 , A61K49/085 , Y10S977/808 , Y10S977/927 , Y10S977/93
摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
摘要翻译：描述了能够特异性结合并进入靶细胞的递送载体，递送许多生理剂，特别是顺磁离子用于细胞的磁共振成像（MRI）。递送载体包含具有与具有净负电荷的另一个聚合物分子络合的净正电荷的聚合物分子。细胞靶向部分和生理剂，包括造影剂和治疗剂，连接到一个或两个聚合物分子。在一个实施方案中，具有净负电荷的聚合物分子是核酸。因此，递送载体可以用于其中用于基因治疗的核酸和用于MRI对比的药剂共同转运到特定细胞的临床方案，允许核酸递送的医学成像监测。

42. 发明申请

WO2011133896A1 COMBINATIONS INCLUDING CRY3AA AND CRY6AA PROTEINS TO PREVENT DEVELOPMENT OF RESISTANCE IN CORN ROOTWORMS (DIABROTICA SPP.) 审中-公开
标题翻译：包括CRY3AA和CRY6AA蛋白的组合，以防止CORN ROOTWORMS（DIABROTICA SPP。）中的抗性发展
公开(公告)号：WO2011133896A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033622
申请日：2011-04-22
申请人： DOW AGROSCIENCES LLC , NARVA, Kenneth, E. , MEADE, Thomas , FENCIL, Kristin, J. , LI, Huarong , HEY, Timothy, D. , WOOSLEY, Aaron, T. , OLSON, Monica, Britt
发明人： NARVA, Kenneth, E. , MEADE, Thomas , FENCIL, Kristin, J. , LI, Huarong , HEY, Timothy, D. , WOOSLEY, Aaron, T. , OLSON, Monica, Britt
IPC分类号： A01H5/00 , C12N5/04 , A01N37/18
CPC分类号： C12N15/8286 , A01G22/00 , A01H5/10 , A01N37/18 , A01N43/50 , B32B1/02 , B65D85/00 , C07K14/325 , Y02A40/162 , Y10T428/13
摘要： The subject invention relates in part to Cry3Aa in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry3Aa and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm ( Diabrotica spp.) population. Included within the subject invention are plants producing these insecticidal Cry proteins, which are useful to mitigate concern that a corn rootworm population could develop that would be resistant to either of these insecticidal protein systems alone. Plants (and acreage planted with such plants) that produce these two insecticidal protein systems are included within the scope of the subject invention. The subject invention also relates in part to combinations of Cry3Aa and Cry6Aa proteins "triple-stacked" or "multi- stacked" with another insecticidal protein(s) such as a Cry6Aa protein or binary Cry34/35 proteins. Thus, such embodiments target rootworms with three modes of action. Transgenic plants, including corn, comprising a cry6Aa gene and a cry3Aa gene are included within the scope of the subject invention.
摘要翻译：本发明部分地涉及Cry3Aa与Cry6Aa的组合。本发明部分地涉及令人惊奇的发现，即Cry3Aa和Cry6Aa的组合可用于防止由玉米根虫（Diabrotica spp。）种群发展抗性（仅针对任一杀虫蛋白质系统）。本发明中包括的是产生这些杀虫Cry蛋白质的植物，其可用于减轻玉米根虫群体可能发展的担忧，这些玉米根虫群可以单独抗这些杀虫蛋白系统。产生这两种杀虫蛋白质系统的植物（和种植有这种植物的种植面包括在本发明的范围内）。本发明还部分涉及Cry3Aa和Cry6Aa蛋白质“三叠层”或“多堆叠”与另一种杀虫蛋白如Cry6Aa蛋白或二元Cry34 / 35蛋白的组合。因此，这样的实施例以三种作用模式来针对根虫。包含cry6Aa基因和cry3Aa基因的包含玉米的转基因植物包括在本发明的范围内。

43. 发明申请

WO2011084634A1 USE OF VIP3AB IN COMBINATION WITH CRY1CA FOR MANAGEMENT OF RESISTANT INSECTS 审中-公开
标题翻译：使用VIP3AB与CRY1CA联合治疗耐药性
公开(公告)号：WO2011084634A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060835
申请日：2010-12-16
申请人： DOW AGROSCIENCES LLC , MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , WOOSLEY, Aaron, T. , BURTON, Stephanie, L.
发明人： MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , WOOSLEY, Aaron, T. , BURTON, Stephanie, L.
IPC分类号： A01H5/00 , A61K36/899
CPC分类号： A01N37/46 , A01G22/00 , A01N63/02 , C12N15/8286 , Y02A40/162 , A01N65/00
摘要： The subject invention includes methods and plants for controlling fall army worm lepidopteran insects, said plants comprising a V1p3Ab insecticidal protein and a Cry1Ca insecticidal protein, and various combinations of other proteins comprising this pair of proteins, to delay or prevent development of resistance by the insects.
摘要翻译：本发明包括用于控制秋季军体虫体鳞翅目昆虫的方法和植物，所述植物包含V1p3Ab杀虫蛋白和Cry1Ca杀虫蛋白，以及包含该对蛋白质的其它蛋白质的各种组合，以延迟或预防昆虫的抗性发展。

44. 发明申请

WO2011084631A1 USE OF CRY1AB IN COMBINATION WITH CRY1BE FOR MANAGEMENT OF RESISTANT INSECTS 审中-公开
标题翻译： CRY1AB与CRY1BE联合用于治疗耐药性的使用
公开(公告)号：WO2011084631A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060830
申请日：2010-12-16
申请人： DOW AGROSCIENCES LLC , MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , WOOSLEY, Aaron, T. , BURTON, Stephanie, L.
发明人： MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , WOOSLEY, Aaron, T. , BURTON, Stephanie, L.
IPC分类号： C12N15/82
CPC分类号： C12N15/8286 , A01N63/02 , A01N65/00 , Y02A40/162 , A01N2300/00
摘要： The subject invention includes methods and plants for controlling European corn borer and/or fall armyworm insects, said plants comprising a Cry1Ab insecticidal protein and a Cry1Be insecticidal protein, and various combinations of other proteins comprising this pair of proteins, to delay or prevent development of resistance by the insects.
摘要翻译：本发明包括用于控制欧洲玉米螟虫和/或秋季粘虫的方法和植物，所述植物包含Cry1Ab杀虫蛋白和Cry1Be杀虫蛋白，以及包含该对蛋白质的其它蛋白质的各种组合，以延迟或预防昆虫的抵抗力。

45. 发明申请

WO2011084629A1 USE OF CRY1DA IN COMBINATION WITH CRY1CA FOR MANAGEMENT OF RESISTANT INSECTS 审中-公开
标题翻译：使用CRY1DA与CRY1CA联合治疗耐药性
公开(公告)号：WO2011084629A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060828
申请日：2010-12-16
申请人： DOW AGROSCIENCES LLC , MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , WOOSLEY, Aaron, T. , BURTON, Stephanie, L.
发明人： MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , WOOSLEY, Aaron, T. , BURTON, Stephanie, L.
IPC分类号： C12N15/82
CPC分类号： C12N15/8286 , A01N63/02 , Y02A40/162 , A01N65/00
摘要： The subject invention includes methods and plants for controlling fall armyworm lepidopteran insects, said plants comprising a Cry1Da insecticidal protein and a Cry1Ca insecticidal protein, and various combinations of other proteins comprising this pair of proteins, to delay or prevent development of resistance by the insects.
摘要翻译：本发明包括用于控制秋季粘虫鳞翅目昆虫的方法和植物，所述植物包含Cry1Da杀虫蛋白和Cry1Ca杀虫蛋白，以及包含该对蛋白质的其它蛋白质的各种组合，以延迟或预防昆虫的抗性发展。

46. 发明申请

WO2011075586A1 INSECTICIDAL PROTEIN COMBINATIONS FOR CONTROLLING FALL ARMYWORM AND EUROPEAN CORN BORER, AND METHODS FOR INSECT RESISTANCE MANAGEMENTS 审中-公开
标题翻译：用于控制退伍军人和欧洲玉米螟的杀虫蛋白组合，以及防御性管理方法
公开(公告)号：WO2011075586A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/060812
申请日：2010-12-16
申请人： DOW AGROSCIENCES LLC , MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , BURTON, Stephanie, L.
发明人： MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , BURTON, Stephanie, L.
IPC分类号： A01H5/00 , A01H1/00 , A01P7/00
CPC分类号： C12N15/8286 , A01N63/02 , Y02A40/162 , A01N65/00 , A01N2300/00
摘要： The subject invention relates in part to stacking certain Cry genes along with Cry 1Fa to result in products that are more durable and less prone towards insects developing resistance towards the activity of any of the toxins (such as Cry 1Fa) by itself. Embodiments of the Cry 1F stacking partners include Cry2Aa, Cry 1I, and Cry 1E. These stacks can be used to control FAW and/or ECB as described herein.
摘要翻译：本发明部分地涉及将某些Cry基因与Cry1Fa一起堆叠以产生更耐用的产物，并且较不易于昆虫对任何毒素（例如Cry 1Fa）的活性产生抗性。 Cry 1F堆叠伙伴的实施方案包括Cry2Aa，Cry1I和Cry1E。这些堆叠可以用于控制如本文所述的一汽和/或ECB。

47. 发明申请

WO2011075585A1 COMBINED USE OF VIP3AB AND CRY1FA FOR MANAGEMENT OF RESISTANT INSECTS 审中-公开
标题翻译：联合使用VIP3AB和CRY1FA进行耐药性管理
公开(公告)号：WO2011075585A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/060810
申请日：2010-12-16
申请人： DOW AGROSCIENCES LLC , MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , WOOSLEY, Aaron, T. , BURTON, Stephanie, L.
发明人： MEADE, Thomas , NARVA, Kenneth , STORER, Nicholas, P. , SHEETS, Joel, J. , WOOSLEY, Aaron, T. , BURTON, Stephanie, L.
IPC分类号： A01H5/00 , A01H1/00 , A01P7/00
CPC分类号： C12N15/8286 , A01N63/02 , Y02A40/162 , A01N65/00 , A01N2300/00
摘要： The subject invention includes methods and plants for controlling lepidopteran insects, said plants comprising a Vip3Ab insecticidal protein in combination with a Cry 1Fa insecticidal protein to delay or prevent development of resistance by the insect(s).
摘要翻译：本发明包括用于控制鳞翅目昆虫的方法和植物，所述植物包含与Cry 1Fa杀虫蛋白结合的Vip3Ab杀虫蛋白，以延迟或防止昆虫发生抗性。

48. 发明申请

WO2010111257A2 TARGETED SCHIFF BASE COMPLEXES 审中-公开
标题翻译：目标SCHIFF基础复合体
公开(公告)号：WO2010111257A2
公开(公告)日：2010-09-30
申请号：PCT/US2010/028299
申请日：2010-03-23
申请人： NORTHWESTERN UNIVERSITY , HARNEY, Allison, S. , LEE, Jiyoun , MEADE, Thomas, J. , LABONNE, Carole, B.
发明人： HARNEY, Allison, S. , LEE, Jiyoun , MEADE, Thomas, J. , LABONNE, Carole, B.
IPC分类号： A61K31/7135
CPC分类号： C07K19/00 , A61K31/7135 , C07H23/00
摘要： The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof.
摘要翻译：本发明提供目标希夫碱配合物。特别地，本发明提供了配置成抑制靶向蛋白质的活性的生物聚合物靶向过渡金属络合物，其合成方法及其药物组合物及其用途。

49. 发明申请

WO2008073828A3 COMPOSITIONS AND METHODS FOR MAGNETIC RESONANCE IMAGING CONTRAST AGENTS 审中-公开
标题翻译：磁共振成像对比剂的组合物和方法
公开(公告)号：WO2008073828A3
公开(公告)日：2008-09-25
申请号：PCT/US2007086796
申请日：2007-12-07
申请人： UNIV NORTHWESTERN , KARFELD LINDSAY S , BULL STEVE R , BARRON ANNELISE EMILY , MEADE THOMAS J
发明人： KARFELD LINDSAY S , BULL STEVE R , BARRON ANNELISE EMILY , MEADE THOMAS J
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/14 , A61K49/085 , A61K49/1803
摘要： The present application provides for compositions and methods of creating and applying contrast agents that find use in magnetic resonance imaging (MRI). In particular, contrast agents that comprise monodisperse, protein polymer backbones capable of chelating multiple paramagnetic ions resulting in high relaxivity for use in enhancing MRI signal intensity.
摘要翻译：本申请提供了产生和应用在磁共振成像（MRI）中使用的造影剂的组合物和方法。特别地，包含能够螯合多个顺磁离子的单分散蛋白质聚合物主链的造影剂，导致用于增强MRI信号强度的高弛豫度。

50. 发明申请

WO2006094161A2 NEW SOURCES FOR, AND TYPES OF, INSECTICIDALLY ACTIVE PROTEINS, AND POLYNUCLEOTIDES THAT ENCODE THE PROTEINS 审中-公开
标题翻译：新的来源和类型的杀虫活性蛋白质和编码蛋白质的多核苷酸
公开(公告)号：WO2006094161A2
公开(公告)日：2006-09-08
申请号：PCT/US2006/007524
申请日：2006-03-02
申请人： DOW AGROSCIENCES LLC , LARRINUA, Ignacio, M. , MERLO, Donald, J. , WOOSLEY, Aaron, Todd , HEY, Timothy, D. , MEADE, Thomas , BURTON, Stephanie, Love
发明人： LARRINUA, Ignacio, M. , MERLO, Donald, J. , WOOSLEY, Aaron, Todd , HEY, Timothy, D. , MEADE, Thomas , BURTON, Stephanie, Love
IPC分类号： C12N15/82 , C07K14/195 , C07K14/37
CPC分类号： C07K14/195 , A01N63/00 , A01N63/04 , C07K14/20 , C07K14/21 , C07K14/37 , C07K16/14 , C07K2319/00 , Y10S530/858
摘要： The subject invention provides exciting new sources for surprising, new types of toxin complex ("TC") proteins. The subject invention includes these new classes and types of TC proteins. The subject invention also includes polynucleotides that encode the subject proteins. The subject invention further provides vectors and cells comprising these polynucleotides. The subject invention also provides novel methods of controlling insects. The subject invention relates in part to the surprising discovery that new types of TC proteins can be obtained from a widely diverse phylogenetic spectrum of organisms including, most notably and surprisingly, eukaryotic fungus.
摘要翻译：本发明为令人惊奇的新型毒素复合物（“TC”）蛋白质提供令人兴奋的新来源。本发明包括这些新类型和TC蛋白。本发明还包括编码受试蛋白的多核苷酸。本发明进一步提供了包含这些多核苷酸的载体和细胞。本发明还提供了控制昆虫的新方法。本发明部分地涉及令人惊奇的发现，即可以从广泛多样的生物学系统发育谱获得新型TC蛋白质，包括最引人注目和令人惊讶的是真核真菌。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式