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41. 发明申请

WO2002103458A1 IMAGE REPLICATION SYSTEM 审中-公开
标题翻译：图像复制系统
公开(公告)号：WO2002103458A1
公开(公告)日：2002-12-27
申请号：PCT/GB2002/002827
申请日：2002-06-19
申请人： HOLOGRAPHIC IMAGING LLC , SMITH, Mark, Anthony, Gleeson , MILLER, Richard, Jonathan , STANLEY, Maurice
发明人： SMITH, Mark, Anthony, Gleeson , MILLER, Richard, Jonathan , STANLEY, Maurice
IPC分类号： G03H1/04
CPC分类号： G03H1/02 , G02B6/4298 , G02F1/133553 , G03H1/2294 , G03H1/30 , G03H2001/0216 , G03H2001/0224 , G03H2001/306 , G03H2223/16 , G03H2223/24 , G03H2225/25 , G03H2225/52 , G03H2225/60
摘要： The present invention relates, in one aspect to an image replication system comprising a light guide (2), a light source (8) arranged to direct emitted light into a first end (2a) of a light guide (2), a reflective spatial light modulator (6) and focussing means (16). In a preferred embodiment, the light guide (2) is in the form of an elongate glass rod having first and second parallel polygonal end faces (2a, 2b) which are parallel to the long axis of the rod, the rod having a uniform polygonal cross section along its length. The spatial light modulator (6) is optically coupled to the second end face (2b) of the light guide (2) and the focussing means (16) is arranged to receive light reflected back through the rod from the spatial light modulator (6), whereby to form multiple images of said spatial light modulator in an image plane (18).
摘要翻译：本发明在一个方面涉及一种图像复制系统，其包括光导（2），被布置成将发射的光引导到光导（2）的第一端（2a）中的光源（8），反射空间光调制器（6）和聚焦装置（16）。在优选实施例中，导光体（2）呈细长玻璃棒的形式，具有平行于杆的长轴的第一和第二平行的多边形端面（2a，2b），该杆具有均匀的多边形横截面沿其长度。空间光调制器（6）光学耦合到光导（2）的第二端面（2b），并且聚焦装置（16）布置成接收来自空间光调制器（6）的反射回穿过杆的光，，从而在图像平面（18）中形成所述空间光调制器的多个图像。

42. 发明申请

WO2016034851A1 ELEVATED INTRACRANIAL PRESSURE TREATMENT 审中-公开
标题翻译：高级治疗压力治疗
公开(公告)号：WO2016034851A1
公开(公告)日：2016-03-10
申请号：PCT/GB2015/052453
申请日：2015-08-25
申请人： THE UNIVERSITY OF BIRMINGHAM
发明人： SINCLAIR, Alex
IPC分类号： A61K38/26 , C07K14/605 , A61P25/00
CPC分类号： A61K38/26 , C07K14/57563 , C07K14/605
摘要： Provided is an incretin, or analogue thereof, an incretin receptor agonist, an incretin enhancer, or any combination thereof, for use in a method of reducing elevated intracranial pressure (ICP) in a subject. Methods of reducing elevated ICP in a subject may comprise administering an incretin,or analogue thereof, an incretin receptor agonist, an incretin enhancer, or any combination thereof to the subject. The elevated ICP may be associated with idiopathic intracranial hypertension (IIH), secondary pseudotumour cerebri, hydrocephalus, normal pressure hydrocephalus, raised intracranial pressure secondary to a brain tumour, meningitis, brain trauma, brain injury, and venous sinus thrombosis.
摘要翻译：提供一种肠降血糖素或其类似物，用于降低受试者的颅内压升高（ICP）的方法中的肠降血糖素受体激动剂，肠降征素增强剂或其任何组合。减少受试者体内升高的ICP的方法可包括将肠降血糖素或其类似物，肠降血候素受体激动剂，肠降征素增强子或其任何组合施用于受试者。升高的ICP可能与特发性颅内高压（IIH），继发性假瘤脑，脑积水，正常压力脑积水，脑肿瘤继发性升高的颅内压，脑膜炎，脑外伤，脑损伤和静脉窦血栓形成有关。

43. 发明申请

WO2016009185A1 METHOD TO OPERATE A HYDRAULIC PRESS FOR METAL SHEET FORMING 审中-公开
标题翻译：用于金属片形成的液压印刷的方法
公开(公告)号：WO2016009185A1
公开(公告)日：2016-01-21
申请号：PCT/GB2015/052018
申请日：2015-07-13
申请人： IMPRESSION TECHNOLOGIES LIMITED
发明人： ADAM, George J.S. , BRAZIER, Mark W. , FOSTER, Alistair D.
IPC分类号： C22F1/04 , B21D22/20 , C21D9/46 , C21D1/673
CPC分类号： B21D22/208 , B21D35/005 , C21D1/673 , C22F1/04 , C22F1/06
摘要： The invention is a process for forming a metal alloy component comprising: heating a metal alloy sheet blank to at least its Solution Heat Treatment temperature at a heating station; transferring the heated sheet blank to a press; initiating formation of a component by closing the press dies at a first speed then completing the formation by closing the press dies at a second speed, said second speed being slower than the first; and holding the formed component in the dies during cooling of the formed component.
摘要翻译：本发明是一种形成金属合金成分的方法，包括：在加热站加热金属合金板坯至少其溶液热处理温度; 将加热的板坯转移到压机上; 通过以第一速度关闭压模来启动部件的形成，然后通过以第二速度关闭压模完成形成，所述第二速度比第一速度慢; 并且在形成的部件的冷却期间将形成的部件保持在模具中。

44. 发明申请

WO2015185915A1 WASTE MANAGEMENT 审中-公开
标题翻译：废物管理
公开(公告)号：WO2015185915A1
公开(公告)日：2015-12-10
申请号：PCT/GB2015/051604
申请日：2015-06-02
申请人： CHINOOK END-STAGE RECYCLING LIMITED
发明人： CHALABI, Rifat Al , PERRY, Ophneil Henry , LI, Ke
IPC分类号： F01K23/06
CPC分类号： F01K23/067 , F01K13/003 , F01K13/02 , F01K25/14 , H02K7/1815 , H02K7/1823 , Y02E20/18
摘要： The present invention relates to a method for producing steam, the method comprising: (a) passing waste gas through a first boiler to produce steam having a first temperature, and cooled waste gas; (b) removing contaminants from the cooled waste gas to produce clean waste gas; (c) passing the steam having a first temperature through a second boiler; and (d) burning at least a portion of the clean waste gas in the second boiler to produce steam having a second temperature, the second temperature being higher than the first temperature. The method is particularly suited to efficiently generating high temperature, high pressure steam derived from the pyrolysis/gasification of organic waste.
摘要翻译：本发明涉及一种生产蒸汽的方法，该方法包括：（a）使废气通过第一锅炉产生具有第一温度的蒸汽和冷却的废气; （b）从冷却的废气中除去污染物以产生清洁的废气; （c）将具有第一温度的蒸汽通过第二锅炉; 和（d）在第二锅炉中燃烧清洁废气的至少一部分，以产生具有第二温度的蒸汽，第二温度高于第一温度。该方法特别适用于有效地产生源自有机废物的热解/气化的高温高压蒸汽。

45. 发明申请

WO2015185914A1 METHOD AND APPARATUS FOR CLEANING GAS ENGINE 审中-公开
标题翻译：清洁气体发动机的方法和装置
公开(公告)号：WO2015185914A1
公开(公告)日：2015-12-10
申请号：PCT/GB2015/051603
申请日：2015-06-02
申请人： CHINOOK END-STAGE RECYCLING LIMITED
发明人： CHALABI, Rifat Al , PERRY, Ophneil Henry , LI, Ke
IPC分类号： F02B77/04
CPC分类号： F02B77/04 , F02M25/10 , F02M25/12 , Y02T10/121
摘要： The present invention relates to a method of cleaning a surface within a gas engine, the method comprising: passing ozone through an inlet to the engine and over the surface, reacting the ozone with any organic contaminants on the surface, and removing the reacted contaminants and any residual ozone from an outlet from the engine as a gaseous exhaust. The method is particularly suited to cleaning sensitive or delicate apparatus such as pre-combustion portions of a gas engine.
摘要翻译：本发明涉及一种清洁燃气发动机内表面的方法，该方法包括：将臭氧通过入口通向发动机和表面，使臭氧与表面上的任何有机污染物反应，并除去反应的污染物和来自发动机出口的残留臭氧作为气体排气。该方法特别适用于清洁气体发动机的预燃部分的敏感或精密装置。

46. 发明申请

WO2015181547A1 IMPROVED MOLECULAR DETECTION SYSTEM 审中-公开
标题翻译：改进的分子检测系统
公开(公告)号：WO2015181547A1
公开(公告)日：2015-12-03
申请号：PCT/GB2015/051545
申请日：2015-05-28
申请人： THE UNIVERSITY OF BIRMINGHAM
发明人： DAFFORN, Timothy , HICKS, Matthew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/6816 , C12Q1/6844 , G01N21/77 , G01N2021/7769 , C12Q2523/101 , C12Q2523/303
摘要： A molecular sensor that utilises dichroism can be used to identify the presence of a target nucleic acid molecule in a sample, for example during or after amplification reactions such as PCR/thermocyling reactions and isothermal reactions. A sensor element for use in the molecular sensor may comprise an alignable scaffold/receptor complex, the receptor of said complex comprising a nucleic acid sequence which is complementary to at least a portion of a target nucleic acid molecule.
摘要翻译：可以使用利用二色性的分子传感器来鉴定样品中靶核酸分子的存在，例如在扩增反应期间或之后，例如PCR /热沉反应和等温反应。用于分子传感器的传感器元件可以包含可对齐的支架/受体复合物，所述复合物的受体包含与靶核酸分子的至少一部分互补的核酸序列。

47. 发明申请

WO2015140571A1 ATRIAL FIBRILLATION THERAPY 审中-公开
标题翻译： ATRIAL FIBRILLATION治疗
公开(公告)号：WO2015140571A1
公开(公告)日：2015-09-24
申请号：PCT/GB2015/050828
申请日：2015-03-20
申请人： THE UNIVERSITY OF BIRMINGHAM
发明人： KIRCHHOF, Paulus , FABRITZ, Larissa , SYEDA, Fahima
IPC分类号： G01N33/68 , A61K31/00
CPC分类号： C12Q1/6883 , A61K31/138 , A61K31/18 , A61K31/4458 , A61K45/06 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N2800/326 , A61K2300/00
摘要： Provided is a method of facilitating the determination of treatment of a subject displaying atrial fibrillation, the method comprising determining a level of pitx2c expression in a sample from the subject and selecting a treatment based upon the level of pitx2c expression. Treatment with a sodium channel blocker may be selected if the level of pitx2c expression is determined to be reduced or below a predetermined threshold. Also provided are an assay system and a kit for use in the methods of the invention.
摘要翻译：提供了一种有利于确定显示心房颤动的受试者的治疗的方法，所述方法包括确定来自受试者的样品中pitx2c表达的水平，并基于pitx2c表达的水平选择治疗。如果确定pitx2c表达水平降低或低于预定阈值，则可以选择用钠通道阻断剂进行治疗。还提供了用于本发明方法的测定系统和试剂盒。

48. 发明申请

WO2015128643A1 ANTIMICROBIAL SURFACE 审中-公开
标题翻译：抗微生物表面
公开(公告)号：WO2015128643A1
公开(公告)日：2015-09-03
申请号：PCT/GB2015/050544
申请日：2015-02-25
申请人： THE UNIVERSITY OF BIRMINGHAM
发明人： STAMBOULIS, Artemis , DE COGAN, Felicity Jane , SCHOTT, Robert
IPC分类号： C07K14/47 , C07K17/14 , C12N15/62 , A61L27/54
CPC分类号： C07K7/08 , A01N25/08 , A01N47/44 , A61L27/54 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/606 , A61L2420/02 , C07K14/001 , C07K14/4723 , C07K17/08 , C07K17/14 , C07K2319/20
摘要： The invention relates to an antimicrobial surface, in particular a surface functionalised with a peptide comprising an antimicrobial moiety. The invention comprises a surface functionalised with a peptide comprising an antimicrobial moiety and a binder moiety, wherein the peptide is immobilized on the surface by electrostatic interactions between the binder moiety and the surface. Further provided is a medical device, a peptide and a method for the immobilization of a peptide.
摘要翻译：本发明涉及抗微生物表面，特别是用包含抗微生物部分的肽进行功能化的表面。本发明包括用包含抗微生物部分和粘合剂部分的肽官能化的表面，其中通过粘合剂部分和表面之间的静电相互作用将肽固定在表面上。还提供了用于固定肽的医疗装置，肽和方法。

49. 发明申请

WO2015079244A1 IRON COMPLEXING AGENT AND USES THEREOF IN THE TREATMENT AND PREVENTION OF COLORECTAL CANCER 审中-公开
标题翻译：铁复合剂及其在治疗和预防癌症中的应用
公开(公告)号：WO2015079244A1
公开(公告)日：2015-06-04
申请号：PCT/GB2014/053529
申请日：2014-11-28
申请人： THE UNIVERSITY OF BIRMINGHAM
发明人： TSELEPIS, Chris , FOSSEY, John S. , BYRAVAN, Rama
IPC分类号： C08B15/00 , A61K47/48 , C08B37/08 , C08B37/00 , C08L1/08 , C08L5/04 , C08L5/06 , C08L5/08
CPC分类号： A61K47/4823 , A61K9/0053 , A61K31/192 , A61K31/4196 , A61K47/61 , C08B15/00 , C08B37/003 , C08B37/0045 , C08B37/0084 , C08L1/08 , C08L5/04 , C08L5/06 , C08L5/08
摘要： A complex comprising a non-absorbable portion attached to an iron chelator moiety, a composition comprising the complex and the use of the complex in the treatment of colorectal cancer. In one embodiment the non-absorbable portion is a polymer such as a polysaccharide, including chitosan, chitin, cellulose or pectin. In one embodiment the iron chelator moiety comprises at least one functional group selected from catechol, hydroxamate or carboxylate, or any combination thereof.
摘要翻译：包含连接到铁螯合剂部分的不可吸收部分的复合物，包含所述复合物的组合物和所述复合物在治疗结肠直肠癌中的用途。在一个实施方案中，不可吸收部分是诸如多糖的聚合物，包括壳聚糖，壳多糖，纤维素或果胶。在一个实施方案中，铁螯合剂部分包含至少一种选自儿茶酚，异羟肟酸酯或羧酸酯的官能团，或其任何组合。

50. 发明申请

WO2015022501A1 POWER SYSTEM CONTROL 审中-公开
标题翻译：电力系统控制
公开(公告)号：WO2015022501A1
公开(公告)日：2015-02-19
申请号：PCT/GB2014/052432
申请日：2014-08-08
申请人： THE UNIVERSITY OF BIRMINGHAM
发明人： ZHANG, Xiao-Ping , YANG, Xuan
IPC分类号： H02J13/00 , G01R19/25
CPC分类号： H02J13/0013 , G01R19/2513 , Y02B70/3216 , Y02B90/2607 , Y02E60/728 , Y02E60/74 , Y04S10/265 , Y04S10/30 , Y04S20/221 , Y04S40/12
摘要： The present invention relates to a method of controlling power flows and/or voltages in a power system. The method comprises monitoring conditions of voltage and/or current at a set of system locations for a scanning cycle of synchronised measurements. The scanning cycle comprises a series of time steps in which instantaneous sample measurements of voltage and/or current are taken. The monitoring provides data comprising the instantaneous sample measurements for a complete scanning cycle. A transient state estimation is determined based on the data for two or more sequential time steps. The transient state estimation includes an estimation of a non-sinusoidal voltage or current waveform caused by a disturbance to the power system. The method further includes forming a snapshot that includes instantaneous voltages, current flows and power flows of the power system. The method further includes making an adjustment to mitigate the effect of the disturbance. The invention also resides in a power system comprising a plurality of synchronised measurement units at locations in the power system. Each measurement unit is configured to obtain sample data over a synchronised scanning cycle comprising a series of time steps in which instantaneous sample measurements of voltages and/or currents are taken, and to transmit the instantaneous sample data for a complete scanning cycle after completion of the cycle. A transient state estimator is configured to receive and analyse the sample data to determine a transient state estimation based on the data for two or more sequential time steps. The transient state estimation includes an estimation of a non-sinusoidal voltage or current waveform caused by a disturbance to the power system. At least one power device adjusts an amount of power supplied to and/or drawn from the power system to mitigate the effect of the disturbance.
摘要翻译：本发明涉及一种控制电力系统中的功率流和/或电压的方法。该方法包括在同步测量的扫描周期中监视一组系统位置处的电压和/或电流的条件。扫描周期包括一系列时间步骤，其中采用电压和/或电流的瞬时采样测量。该监视提供包括完整扫描周期的瞬时采样测量的数据。基于两个或更多个连续时间步长的数据确定瞬态状态估计。瞬态状态估计包括由对电力系统的干扰引起的非正弦电压或电流波形的估计。该方法还包括形成包括电力系统的瞬时电压，电流和功率流的快照。该方法还包括进行调整以减轻干扰的影响。本发明还涉及一种在电力系统中的位置处包括多个同步测量单元的电力系统。每个测量单元被配置为在同步的扫描周期上获得采样数据，该扫描周期包括一系列时间步长，其中采用电压和/或电流的瞬时采样测量，并且在完成扫描周期之后将瞬时采样数据传送到完整的扫描周期周期。瞬态状态估计器被配置为接收和分析样本数据，以基于两个或更多个连续时间步长的数据来确定瞬态状态估计。瞬态状态估计包括由对电力系统的干扰引起的非正弦电压或电流波形的估计。至少一个电力设备调整供应给电力系统和/或从电力系统抽取的电力量以减轻干扰的影响。

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