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31. 发明申请

WO2011028754A1 VASCULAR PROSTHESIS WITH STRESS RELIEF SLOTS 审中-公开
标题翻译：具有应力消除位置的血管扩张
公开(公告)号：WO2011028754A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047449
申请日：2010-09-01
申请人： NOVOSTENT CORPORATION , LEOPOLD, Eric, W. , MARTIN, Gerald, Ray , YU, Eric, Hsiang , LUBINSKI, Alexander, Arthur , WALDO, Michael, C. , CHENG, Christopher, P.
发明人： LEOPOLD, Eric, W. , MARTIN, Gerald, Ray , YU, Eric, Hsiang , LUBINSKI, Alexander, Arthur , WALDO, Michael, C. , CHENG, Christopher, P.
IPC分类号： A61F2/82
CPC分类号： A61F2/92 , A61F2/885 , A61F2/91 , A61F2210/0076 , A61F2220/0041 , A61F2220/0058 , A61F2230/0017 , A61F2230/0021
摘要： A vascular prosthesis comprises generally tubular body placeable in contracted and expanded states and has an axial length and a circumferential dimension in the expanded state. The body includes a series of circumferential elements having first lengths. First and second connectors have connector lengths and join alternating ends of adjacent circumferential elements. The first length plus the connector lengths joined thereto equal a total circumferential length. Each connector length is between 2.5% and 25% of the total circumferential length. Adjacent circumferential elements and connectors extending therefrom are separated by a stress relief slot having a relief slot length of more than 50% and less than 95% of the total circumferential length. The stress relief slots have narrow width portions over a majority of the relief slot lengths, the narrow width portions having lateral dimensions of no greater than about 3 mm.
摘要翻译：血管假体包括可收缩和膨胀状态的大体管状体，并且在扩张状态下具有轴向长度和周向尺寸。主体包括一系列具有第一长度的周向元件。第一和第二连接器具有连接器长度并且连接相邻周向元件的交替端部。第一长度加上连接到其上的连接器长度等于总圆周长度。每个连接器长度在总圆周长度的2.5％和25％之间。相邻的圆周元件和从其延伸的连接器由应力释放槽分隔开，该释放槽的释放槽长度大于总圆周长度的50％且小于95％。应力消除槽在大部分释放槽长度上具有窄的宽度部分，窄的宽度部分具有不大于约3mm的横向尺寸。

32. 发明申请

WO2011019546A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2011019546A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/044244
申请日：2010-08-03
申请人： WILLIAM COOK EUROPE APS , COOK INCORPORATED , RASMUSSEN, Erik , OEHLENSCHLAEGER, Bent , JENSEN, Kim, Moegelvang , PETERSEN, Jesper, Schade
发明人： RASMUSSEN, Erik , OEHLENSCHLAEGER, Bent , JENSEN, Kim, Moegelvang , PETERSEN, Jesper, Schade
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2002/075 , A61F2002/8483 , A61F2210/0014 , A61F2220/0058 , A61F2220/0075 , A61F2310/00023
摘要： A stent graft (10) includes a tubular graft element (12) to which there are attached a plurality of stent rings (14). The stent rings (14) are formed of a plurality of stent struts (16) arranged in a zig-zag arrangement with alternating peaks (18) and valleys (20). The end-most stent (22) is located at the proximal end (24) of the graft tube (12). Between adjacent peaks (18) of the end-most stent (22), there is provided a series of bridging elements (28). These are preferably formed of Nitinol wire and to be substantially more flexible than the stent struts (14). The bridging elements (28) extend in the region of graft material between adjacent stent peaks (18) and are attached to the graft material, for example by suturing. The bridging elements (28) are substantially more flexible than the stent ring (22) and therefore impart little opening force on the graft material in comparison to the force produced by the stent ring (22). However, the bridging elements (28) impart enough force on the flaps (26) of graft material between the peaks (18) of the stent ring (28) keep these flaps (26) open, that is against the vessel wall. The bridging elements (28) can provide integral barbs (30).
摘要翻译：支架移植物（10）包括管状移植物元件（12），其上附接有多个支架环（14）。支架环（14）由布置成具有交替的峰（18）和谷（20）的之字形布置的多个支架支柱（16）形成。最终的支架（22）位于移植管（12）的近端（24）处。在最终支架（22）的相邻峰（18）之间，提供一系列桥接元件（28）。这些优选由镍钛诺丝形成，并且比支架支柱（14）基本上更具柔性。桥接元件（28）在相邻支架顶部（18）之间的移植材料区域中延伸并且例如通过缝合附接到移植物材料。桥接元件（28）比支架环（22）大得多的柔性，因此与支架环（22）产生的力相比，在接枝材料上施加很小的打开力。然而，桥接元件（28）在支架环（28）的峰（18）之间的移植材料的翼片（26）上赋予足够的力，使得这些翼片（26）打开，即抵靠血管壁。桥接元件（28）可以提供整体倒钩（30）。

33. 发明申请

WO2011002996A2 APPARATUS AND METHOD FOR REPLACING A DISEASED CARDIAC VALVE 审中-公开
标题翻译：用于更换已泄漏的心脏瓣膜的装置和方法
公开(公告)号：WO2011002996A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040786
申请日：2010-07-01
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： NAVIA, Jose L. , CHEN, Ji-Feng , GAO, Shengqiang , DAVIS, Brian L. , STUCKE, Samantha
IPC分类号： A61F2/24 , A61M29/00 , A61M29/02
CPC分类号： A61F2/243 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005
摘要： An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the main body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.
摘要翻译：用于置换患病心脏瓣膜的设备可从径向收缩构型移动到径向扩张构型。该设备包括可膨胀支撑构件和固定在其中的人工瓣膜。主体部分在第一端部和第二端部之间延伸并且包括外圆周表面，围绕圆周表面延伸的周向轴线以及通过可扩张区域彼此间隔开的多个翼构件。每个翼部件包括第一和第二端部以及在端部之间延伸的柔性中间部分。第二端部与主体部分一体地形成。第一端部部分与周向轴线相邻并且在径向收缩构造中与外周表面基本齐平。第一端部在径向扩展结构中基本径向延伸到外圆周表面。

34. 发明申请

WO2010117680A1 SUTURELESS VALVE PROSTHESES AND DEVICES AND METHODS FOR DELIVERY 审中-公开
标题翻译： SUTELELESS VALVE PROSTHESES AND DEVICES AND METHODS FOR DELIVERY
公开(公告)号：WO2010117680A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/028843
申请日：2010-03-26
申请人： CARDIOVANTAGE MEDICAL, INC. , ZHANG, Ji
发明人： ZHANG, Ji
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2436 , A61F2/966 , A61F2002/9517 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2230/0054 , A61F2230/0067 , A61F2250/006
摘要： A valve prosthesis, implantation device, and methods for use are provided. The implantation device utilizes moveable ciaspers for both positioning and anchoring the valve prosthesis Alternative designs of the devices allow different methods for minimally invasive implantation of a sutureless valve prosthesis, including transapical and transcatheter approaches Also provided is a delivery device for delivery of a medical prostheses though minimally invasive means. The valve prosthesis is comprised of a support frame (892) with attached leaflets and a valve clasper (880) that can be attached to the support frame to fix the prostestis in the pockets of the coronary sinus.
摘要翻译：提供了一种阀门假体，植入装置和使用方法。植入装置利用可移动的缝线来定位和锚定瓣膜假体装置的替代设计允许不同的方法用于无缝隙的假体的微创植入，包括经皮和经导管方法。还提供了用于递送医疗假体的递送装置，微创手段。瓣膜假体包括具有附接小叶的支撑框架（892）和可以附接到支撑框架以将前列腺固定在冠状窦口袋中的阀夹（880）。

35. 发明申请

WO2010086460A9 STENT FOR THE POSITIONING AND ANCHORING OF A VALVULAR PROSTHESIS IN AN IMPLANTATION SITE IN THE HEART OF A PATIENT 审中-公开
标题翻译：用于在患者心脏的植入部位定位和锚定瓣膜假体的支架
公开(公告)号：WO2010086460A9
公开(公告)日：2010-09-23
申请号：PCT/EP2010052429
申请日：2010-02-25
申请人： JENAVALVE TECHNOLOGY INC , STRAUBINGER HELMUT , JUNG JOHANNES , GIRARD MICHAEL S , MAYER ARNULF
发明人： STRAUBINGER HELMUT , JUNG JOHANNES , GIRARD MICHAEL S , MAYER ARNULF
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0023 , A61F2230/0054
摘要： The present invention relates to a stent (10) for the positioning and anchoring of a valvular prosthesis (100) in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis (100) fastened to a stent (10) will occur relative the stent (10) in the implanted state of the stent (10), even given the peristaltic motion of the heart, the stent (10) according to the invention comprises at least one fastening portion (11, 11a) via which the valvular prosthesis (100) is connectable to the stent (10). The stent (10) further comprises positioning arches (15a, 15b, 15c) and retaining arches (16a, 16b, 16c), whereby at least one positioning arch (15a, 15b, 15c) is connected to at least one retaining arch (16a, 16b, 16c).
摘要翻译：本发明涉及一种用于将瓣膜假体（100）定位和锚定在患者心脏中的植入部位中的支架（10）。具体而言，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内部假体的可扩张支架。为了确保在支架（10）的植入状态下相对于支架（10）不发生固定到支架（10）的瓣膜假体（100）的纵向移位，即使给予心脏的蠕动运动，根据本发明的支架（10）包括至少一个紧固部分（11,11a），瓣膜假体（100）可通过该紧固部分（11,11a）连接到支架（10）。支架（10）还包括定位弧（15a，15b，15c）和保持弧（16a，16b，16c），由此至少一个定位弧（15a，15b，15c）连接到至少一个保持弧，16b，16c）。

36. 发明申请

WO2010099209A1 LOW PROFILE SUPPORT FRAME AND RELATED INTRALUMINAL MEDICAL DEVICES 审中-公开
标题翻译：低配置支持框架和相关的内科医疗设备
公开(公告)号：WO2010099209A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/025245
申请日：2010-02-24
申请人： COOK INCORPORATED , PAUL, Ram, H. , CHAMBERS, Sean, D. , MCINTOSH, Charles, L. , AGNEW, Charles, W.
发明人： PAUL, Ram, H. , CHAMBERS, Sean, D. , MCINTOSH, Charles, L. , AGNEW, Charles, W.
IPC分类号： A61F2/24 , A61F2/86
CPC分类号： A61F2/2418 , A61F2/01 , A61F2/2412 , A61F2/2475 , A61F2/848 , A61F2/86 , A61F2/88 , A61F2002/016 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2230/0013 , A61F2230/0021
摘要： A low profile support frame (10) for use as an or in an expandable intraluminal medical device includes first (12) and second (14) wire members that define arcuate paths having opposing curves. Connectors (20,22) join the wire members, and barbs can be disposed on the connectors. The support frame has radially compressed and radially expanded configurations. When the support frame is in the radially expanded configuration, substantially no portion of the support frame is disposed on a first transverse axis of the frame opposite one end of the frame and substantially no portion of the frame is disposed on a second transverse axis of the frame opposite the other end of the frame. The support frame can be used as an intraluminal medical device by itself or as a component in a medical device that includes other components, such as a stent, prosthetic valve, occluder, or filter.
摘要翻译：用作可扩展管腔内医疗装置中的或在可扩展的管腔内医疗装置中的低调支撑框架（10）包括限定具有相对曲线的弓形路径的第一（12）和第二（14）线构件。连接器（20,22）连接线构件，倒钩可以设置在连接器上。支撑框架具有径向压缩和径向扩张的构造。当支撑框架处于径向展开构型时，支撑框架的基本上没有部分设置在与框架的一端相对的框架的第一横向轴线上，并且基本上没有框架的任何部分设置在框架的第二横向轴线上框架与框架的另一端相对。支撑框架可以作为管腔内医疗装置本身或作为包括其它部件（例如支架，假体瓣膜，封堵器或过滤器）的医疗装置中的部件使用。

37. 发明申请

WO2009055723A3 STENT SEGMENTS AXIALLY CONNECTED BY THIN FILM 审中-公开
标题翻译：由薄膜轴向连接的STENT分段
公开(公告)号：WO2009055723A3
公开(公告)日：2010-08-26
申请号：PCT/US2008081192
申请日：2008-10-24
申请人： CORDIS CORP , RICE CAROLYN , BONSIGNORE CRAIG
发明人： RICE CAROLYN , BONSIGNORE CRAIG
IPC分类号： A61F2/82 , B23P13/04
CPC分类号： A61F2/07 , A61F2/844 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/072 , A61F2002/075 , A61F2220/005 , A61F2220/0058 , A61F2250/0023 , Y10T29/49982 , Y10T29/49995
摘要： In accordance with the present invention, there is provided a stent for insertion into a vessel of a patient. The stent has a front and back open ends and a longitudinal axis extending therebetween. The stent has a plurality of adjacent hoops that are held in alignment with the longitudinal axis between the front and back open ends by a thin film tube. The hoops are attached to either the inner or outer surface of the thin film tube. The stent is compressed into a first smaller diameter for insertion into the vessel with a delivery tube and a second larger diameter for deployment into the vessel. The inventive stent can be retracted into the delivery tube if it is improperly deployed.
摘要翻译：根据本发明，提供一种用于插入患者血管的支架。支架具有前后开口端和在其间延伸的纵向轴线。支架具有多个相邻的箍，其通过薄膜管保持在前开口端和后开口端之间的纵向轴线对准。箍连接到薄膜管的内表面或外表面。支架被压缩成第一较小的直径，以便用输送管插入血管，第二较大的直径用于展开到血管中。如果不适当地展开，本发明的支架可以缩回到输送管中。

38. 发明申请

WO2010088467A1 PREFORM FOR AND AN ENDOLUMINAL PROSTHESIS 审中-公开
标题翻译：预制体及腔内假体
公开(公告)号：WO2010088467A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/022515
申请日：2010-01-29
申请人： COOK INCORPORATED , FARAG, Jacqueline , FRYE, Mark, R. , MACATANGAY, Edwin, E. , MELSHEIMER, Jeffry, S.
发明人： FARAG, Jacqueline , FRYE, Mark, R. , MACATANGAY, Edwin, E. , MELSHEIMER, Jeffry, S.
IPC分类号： A61F2/06 , A61F2/88
CPC分类号： A61F2/04 , A61F2/07 , A61F2/88 , A61F2/89 , A61F2002/075 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2250/0007 , A61F2250/0039 , Y10T29/49826
摘要： An endoluminal device (1210) may include a tubular graft (1212) extending in a longitudinal direction, where the graft has an inner surface forming a lumen extending a length of the graft. An elongate member (1214) may be attached to the graft in a circumferentially and longitudinally extending manner such that the elongate member forms a series of longitudinally spaced apart turns, each turn extending substantially around a circumference of the graft. The elongate member may torsion the graft in at least the circumferential direction and cause the graft to form circumferentially and longitudinally extending folds (1215, 1217) in the portions of the graft disposed between longitudinally adjacent turns of the elongate member.
摘要翻译：腔内设备（1210）可以包括在纵向方向上，其中，所述接枝具有内表面形成延伸的移植物的长度的内腔延伸的管状移植物（1212）。细长构件（1214）可在周向和纵向延伸的方式被附接到移植物，使得所述细长构件形成一系列纵向间隔开的匝数，每转一圈基本上围绕移植物的外周延伸。细长构件可以扭转接枝在至少圆周方向，并导致移植物，以形成在设置在细长构件的纵向相邻匝之间的移植物的部分周向和纵向延伸的褶皱（1215年，1217）。

39. 发明申请

WO2010034287A3 JOINT IMPLANT 审中-公开
标题翻译：关节植入物
公开(公告)号：WO2010034287A3
公开(公告)日：2010-07-15
申请号：PCT/DE2009001283
申请日：2009-09-10
申请人： TAURUS GMBH & CO KG , BLEISTEIN FRANK
发明人： BLEISTEIN FRANK
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61F2002/30375 , A61F2002/30387 , A61F2002/30434 , A61F2002/30448 , A61F2002/30451 , A61F2002/30504 , A61F2002/30604 , A61F2002/3063 , A61F2002/30632 , A61F2002/30841 , A61F2002/3093 , A61F2002/30932 , A61F2002/30935 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2220/005 , A61F2220/0058
摘要： Joint implant (1) comprising an upper and a lower implant part (2, 3), which are connected to each other by at least one joint, wherein a top side of the upper implant part and a bottom side of the lower implant part can be placed against bones to be connected to each other in an articulated manner and supported, wherein the upper and/or the lower implant parts each comprise a portion of the joint region providing the joint, and wherein a connecting means (4) is provided which connects the upper and lower implant parts to each other to form a combined assembly, while enabling movement of the joint. Each of the upper and/or lower implant parts comprises a contact part (5, 8) which faces the respective bone and can be attached thereto and which provides the top or bottom side of the implant, and further comprises a joint part (6, 9) which can be attached to the contact part and comprises the joint region of the implant part. As an alternative, or in addition, the connecting means (4) extends substantially parallel to the longitudinal axis of the implant and is mounted in a holder (26, 27) of the joint region of the upper and/or lower implant parts, said holder being open on the side facing the bone, wherein the holder can be covered at least partially or at least substantially fully by a cover element which can be displaced transversely to the longitudinal axis of the implant.
摘要翻译：关节植入物（1）具有上部和下部植入件部分（2,3），它们通过至少一个接合，相互连接，其中，具有上表面和分别在铰接方式的骨头被接合具有底表面的下植入物部分上植入部可放置并支撑是，与上和/或下植入物部分各自具有关节提供关节运动区域的一部分，并且其中，一连接装置设置（4），其连接所述上部和下部的植入物部分，以形成一个连贯的组装和允许关节运动到一起。每个上和/或下植入物部分具有面向，在系统的此可定义的部分的相应的骨（5,8），其中提供所述植入物的上侧或下侧，并且还包括附接到所述安装部分接合部分（6,9 ），其包括植入物部分的铰链区。可替换地或附加地，连接装置（4）基本上平行于所述植入物的纵向轴线并在骨侧支撑在上和/或下植入部的铰链区的开放座（26，27），所述插座由一个横向移动到覆盖元件至少部分的所述植入物的纵向轴线或基本上是至少完全覆盖。

40. 发明申请

WO2010051121A1 MULTI-LAYER DEVICE WITH GAP FOR TREATING A TARGET SITE AND ASSOCIATED METHOD 审中-公开
标题翻译：具有用于处理目标位置的多层设备和相关方法
公开(公告)号：WO2010051121A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/058747
申请日：2009-09-29
申请人： AGA MEDICAL CORPORATION , KARINIEMI, Ryan , HEIDNER, Matthew, C. , OSLUND, John
发明人： KARINIEMI, Ryan , HEIDNER, Matthew, C. , OSLUND, John
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2/95 , A61F2/966 , A61F2002/072 , A61F2220/005 , A61F2220/0058
摘要： Embodiments of the present invention provide medical devices and methods for treating a target site within the body. For example, a medical device includes a multi-layered structure comprising an inner layer disposed within an outer layer, wherein each of the inner and outer layers has respective inner and outer surfaces. The multi-layered structure further comprises at least offset located between the inner and outer layers or formed in the inner and/or outer layers to define at least one gap therebetween such that a majority of the outer surface of the inner layer is spaced apart from the inner surface of the outer layer. The multi-layered structure is configured to be deployed within a lumen such that at least a portion of the outer layer is configured to engage the lumen and the at least one gap is configured to promote thrombosis between the inner and outer layers.
摘要翻译：本发明的实施例提供用于治疗身体内的靶部位的医疗装置和方法。例如，医疗装置包括多层结构，其包括设置在外层内的内层，其中每个内层和外层具有相应的内表面和外表面。多层结构还包括位于内层和外层之间的至少偏移，或者形成在内层和/或外层中，以在其间限定至少一个间隙，使得内层的大部分外表面与外层的内表面。所述多层结构构造成部署在内腔中，使得所述外层的至少一部分被配置为接合所述内腔，并且所述至少一个间隙构造成促进内层和外层之间的血栓形成。

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