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31. 发明申请

WO2014070204A1 TUMID IMPLANT AND PUMP 审中-公开
标题翻译： TUMID植入和泵
公开(公告)号：WO2014070204A1
公开(公告)日：2014-05-08
申请号：PCT/US2012/063499
申请日：2012-11-05
申请人： EMPIRE TECHNOLOGY DEVELOPMENT LLC
发明人： BROMER, Nicholas
IPC分类号： A61F2/38
CPC分类号： A61F2/30721 , A61B17/562 , A61F2/30 , A61F2/30756 , A61F2/32 , A61F2/38 , A61F2/3872 , A61F2002/30548 , A61F2002/30581 , A61F2002/30754 , A61F2002/485 , A61F2250/0003
摘要： Technologies related to tumid implants and pumps are generally described. In some examples, a tumid implant device may comprise an enclosed sack membrane adapted to fit between bones in a joint. Articulation of the joint may cause a first layer of the membrane to move through a first boundary section into a second layer of the membrane, while the second layer moves through a second boundary section into the first layer. A working fluid may be disposed inside the sack membrane, and a reservoir may optionally be coupled to the membrane via a gate. The working fluid may be expelled from the sack membrane into the reservoir, and may re-enter the sack membrane from the reservoir in response to changes in pressure in the joint. The working fluid may be conducted into the reservoir or sack membrane by a pump, and several artery pump designs are disclosed.
摘要翻译：与肿瘤植入物和泵相关的技术通常被描述。在一些示例中，肿瘤植入装置可以包括适于装配在关节中的骨之间的封闭袋袋。关节的关节可能导致膜的第一层通过第一边界部分移动到膜的第二层中，而第二层通过第二边界部分移动到第一层中。工作流体可以设置在袋状膜内部，并且储存器可以可选地通过栅极耦合到膜。工作流体可以从袋膜排出到储存器中，并且可以响应于接头中的压力变化而从储存器重新进入袋膜。工作流体可以通过泵传送到储存器或袋式膜中，并且公开了几种动脉泵设计。

32. 发明申请

WO2013033447A2 RESILIENT INTERPOSITIONAL ARTHROPLASTY DEVICE 审中-公开
标题翻译：灵活的插入性手术装置
公开(公告)号：WO2013033447A2
公开(公告)日：2013-03-07
申请号：PCT/US2012053207
申请日：2012-08-30
申请人： GROTZ R THOMAS
发明人： GROTZ R THOMAS
IPC分类号： A61F2/20 , A61L27/14 , A61L27/54 , A61L27/58
CPC分类号： A61F2/3859 , A61B17/0642 , A61F2/30756 , A61F2/3872 , A61F2002/30062 , A61F2002/30563 , A61F2002/30578 , A61F2002/30581 , A61F2002/30688 , A61F2002/30754 , A61F2002/3863 , A61L27/18 , A61L27/34 , A61L27/3817 , A61L27/3834 , A61L27/3852 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/602 , A61L2300/64 , A61L2400/10 , A61L2430/06 , A61L2430/24 , C08L75/04 , C08L67/04
摘要： This disclosure is directed to a resilient interpositional arthroplasty implant for application into a joint to pad cartilage defects, cushion, and replace or restore the articular surface, which may preserve joint integrity, reduce pain and improve function. The implant may endure variable joint compressive and shear forces and cyclic loads. The implant may repair, reconstruct, and regenerate joint anatomy, and thereby improve upon joint replacement alternatives. The walls of this invention may capture, distribute and hold living cells until aggregation and hyaline cartilage regrowth occurs. The implant may be deployed into debrided joint spaces, molding and conforming to surrounding structures with sufficient stability so as to enable immediate limb use after outpatient surgery. Appendages of the implant may repair or reconstruct tendons or ligaments, and menisci by interpositional inflatable or compliant polymer arthroplasties that promote anatomic joint motion.
摘要翻译：本公开涉及一种弹性插入关节置换植入物，用于施加到关节中以抵消软骨缺损，缓冲和替换或恢复关节表面，这可以保持关节完整性，减轻疼痛和改善功能。植入物可以承受可变的关节压缩和剪切力和循环载荷。植入物可以修复，重建和再生关节解剖结构，从而改善关节置换替代方案。本发明的壁可以捕获，分布和保持活细胞直到聚集并发生透明软骨再生长。植入物可以部署到清创的关节空间中，以足够的稳定性模制和符合周围结构，以便在门诊手术后立即使用肢体。植入物的附属物可以修复或重建肌腱或韧带，以及通过内插充气或顺应性聚合物关节置换来促进解剖关节运动的半月板。

33. 发明申请

WO2012134647A2 METHODS AND DEVICES FOR THE TREATMENT OF INTERVERTEBRAL DISCS DISORDERS 审中-公开
标题翻译：用于治疗椎间盘疾病的方法和装置
公开(公告)号：WO2012134647A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/024810
申请日：2012-02-13
申请人： WARSAW ORTHOPEDIC, INC. , LEE, Elaine
发明人： LEE, Elaine
IPC分类号： A61F2/44 , A61B17/70 , A61L27/54 , A61L27/52
CPC分类号： A61F2/441 , A61F2002/30064 , A61F2002/30581 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61K9/0019 , A61K9/08 , A61K47/26 , A61L27/50 , A61L27/54 , A61L2430/38
摘要： Devices for the treatment of intervertebral discs are described. The devices, when implanted into the nucleus pulposus of an intervertebral disc, are specifically configured with an inert outer layer and an inner layer containing at least one chemonucleolysis agent so as to provide a delayed and controlled release of the chemonucleolysis agent from the inner layer into the disc. The implant can be an elongated solid body having a tapered or rounded insertion end having at least one therapeutic agent in the inner layer of the implant surrounded by an outer layer of inert material.
摘要翻译：描述了用于治疗椎间盘的装置。当植入到椎间盘的髓核中时，所述装置具体地配置有惰性外层和含有至少一种化学核分解剂的内层，以便提供化学内核分解剂从内层的延迟和受控释放到光盘。植入物可以是具有锥形或圆形插入端的细长固体，植入物的内层中具有至少一种治疗剂，该植入物的内层被外层惰性材料包围。

34. 发明申请

WO2012061627A1 ANATOMIC TOTAL DISC REPLACEMENT 审中-公开
标题翻译：解剖总盘替换
公开(公告)号：WO2012061627A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/059203
申请日：2011-11-03
申请人： CARPENTER, Clyde T.
发明人： CARPENTER, Clyde T.
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/3094 , A61F2/441 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30013 , A61F2002/30019 , A61F2002/30075 , A61F2002/30092 , A61F2002/30133 , A61F2002/30433 , A61F2002/30462 , A61F2002/30467 , A61F2002/30484 , A61F2002/30563 , A61F2002/30578 , A61F2002/30579 , A61F2002/30581 , A61F2002/30604 , A61F2002/30611 , A61F2002/30616 , A61F2002/30774 , A61F2002/30784 , A61F2002/30787 , A61F2002/3083 , A61F2002/30831 , A61F2002/30841 , A61F2002/30952 , A61F2002/4495 , A61F2002/4625 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00047 , A61F2310/00053 , A61F2310/00131 , A61F2310/00604 , A61F2310/00796 , A61F2310/00976
摘要： An artificial spinal disc prosthesis (20) that can be implanted to replace a damaged natural spinal disc. A nucleus (60) of compressible elastomeric material is surrounded by a winding (70) of a slender strand of flexible tension-bearing material oriented at a pitch angle (71) relative to a central axis. The winding (70) interconnects fingers (72) on an end plate (40) with fingers (74) on an end plate (42). The orientation of the winding (70) provides the prosthesis (20) a limited amount of freedom of movement and flexibility. A pair of end caps (32 and 34) of the disc prosthesis (20) include angulated grooves (94, 96, and 98) that allow for insertion of the prosthesis (20) between vertebral bodies from any of several directions. Special fasteners (36, 38) provide protruding points (93) useful in anchoring the prosthesis (20).
摘要翻译：可植入人造脊椎假体（20），以替代受损的天然脊椎盘。可压缩弹性体材料的核心（60）由相对于中心轴线以倾斜角度（71）定向的柔性张力轴承材料的细长股线的绕组（70）围绕。绕组（70）将端板（40）上的指状物（72）与端板（42）上的指状物（74）互连。绕组（70）的取向为假体（20）提供了有限的移动自由度和柔性。椎间盘假体（20）的一对端盖（32和34）包括允许假体（20）从多个方向中的任何一个方向插入到椎体之间的有角度的凹槽（94,96和98）。特殊紧固件（36,38）提供用于锚固假体（20）的突出点（93）。

35. 发明申请

WO2011159999A1 SPINE DISC REPLACEMENT WITH COMPLIANT ARTICULATING CORE 审中-公开
标题翻译：脊椎椎间盘替换与合适的关节核
公开(公告)号：WO2011159999A1
公开(公告)日：2011-12-22
申请号：PCT/US2011/040857
申请日：2011-06-17
申请人： SYNTHES USA, LLC , SYNTHES GMBH , KOCH, David , RICHTER, Joern , BERGER, Roger , KRAFT, Marcus
发明人： KOCH, David , RICHTER, Joern , BERGER, Roger , KRAFT, Marcus
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61F2/4611 , A61F2002/30009 , A61F2002/30014 , A61F2002/30448 , A61F2002/30581 , A61F2002/30583 , A61F2002/30586 , A61F2002/30588 , A61F2002/30677 , A61F2002/30841 , A61F2310/00017 , A61F2310/00023 , A61F2310/00179
摘要： An intervertebral implant can include a pair of endplates between which is coupled a bag that is filled or is fillable with small beads or particles having smooth exterior geometries. The bead sack implant allows for articulation about various centers of rotation without a predefined neutral position.
摘要翻译：椎间植入物可以包括一对端板，在其之间连接有填充或可填充有小珠粒或具有光滑外观几何形状的颗粒的袋子。珠袋植入允许关于各种旋转中心的关节，而没有预定义的中立位置。

36. 发明申请

WO2011073351A2 PARTIAL HIP PROSTHESIS 审中-公开
标题翻译：部分呕吐症状
公开(公告)号：WO2011073351A2
公开(公告)日：2011-06-23
申请号：PCT/EP2010/069977
申请日：2010-12-16
申请人： TEPIC, Slobodan
发明人： TEPIC, Slobodan
IPC分类号： A61F2/34 , A61F2/36 , A61F2/32
CPC分类号： A61F2/3601 , A61B17/1668 , A61F2/3603 , A61F2/4607 , A61F2002/30327 , A61F2002/30332 , A61F2002/30354 , A61F2002/30581 , A61F2002/30673 , A61F2002/30738 , A61F2002/3085 , A61F2002/30909 , A61F2002/30934 , A61F2002/3623 , A61F2002/365 , A61F2002/3692 , A61F2220/0033 , A61F2250/0039 , A61F2310/0058
摘要： The invention reduces friction and wear in partial hip prosthesis by combining optimized geometry of the articulation and surface treatment of the prosthetic component. The acetabulum is reamed to the bone. One of the articulating surfaces - either that of the reamed acetabulum, or that of the femoral head prosthesis is a-spherical so that a fluid-filled gap is formed at the area of major load transfer. The fluid-filled gap is sealed by an annular area of contact, over which the concave and the convex components are congruent. The preferred surface treatment is by diamond-like coating, which results in very low coefficient of friction and high abrasion resistance against the bone. The prosthetic head is fixed to the femur by either a conventional stem, a perforated shell, or a femoral neck prosthesis screwed onto the femur so that it is partially covered by bone and partially exposed on the medial-inferior aspect, where it abuts the reamed cortex of the calcar region.
摘要翻译：本发明通过组合铰接的优化几何形状和假体部件的表面处理来减少部分髋关节假体中的摩擦和磨损。髋臼被植入骨骼。其中一个关节表面 - 铰链髋臼或股骨头假体的铰链表面都是球形的，从而在主负荷转移区域形成流体填充间隙。流体填充的间隙由环形接触区域密封，凹部和凸部分在该区域上是一致的。优选的表面处理是通过类金刚石涂层，这导致非常低的摩擦系数和对骨骼的高耐磨性。假体头部通过常规的杆，穿孔的外壳或螺纹固定在股骨上的股骨颈假体固定到股骨上，使得它被部分地被骨覆盖并且部分地暴露在内侧的方面，其中它邻接延伸钙质区皮层。

37. 发明申请

WO2010126915A1 PROSTHETIC INTERVERTEBRAL DISCS IMPLANTABLE BY MINIMALLY INVASIVE SURGICAL TECHNIQUES 审中-公开
标题翻译：通过微创外科手术植入的前列腺切除术
公开(公告)号：WO2010126915A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/032633
申请日：2010-04-27
申请人： SPINAL KINETICS, INC. , WESTROM, Elizabeth V. , REO, Michael L.
发明人： WESTROM, Elizabeth V. , REO, Michael L.
IPC分类号： A61F2/44
CPC分类号： A61F2/4611 , A61F2/0095 , A61F2/30742 , A61F2/441 , A61F2/442 , A61F2/4425 , A61F2002/30014 , A61F2002/30075 , A61F2002/30092 , A61F2002/30448 , A61F2002/30451 , A61F2002/30462 , A61F2002/30563 , A61F2002/30579 , A61F2002/30581 , A61F2002/30594 , A61F2002/30616 , A61F2002/30736 , A61F2002/3082 , A61F2002/30836 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2210/0014 , A61F2210/0061 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2250/0018 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179
摘要： The described devices are bound spinal implants that may be surgically implanted into the spine to replace damaged or diseased discs using a posterior, lateral, or postero-lateral approach. The discs are prosthetic devices that approach or mimic the physiological motion and reaction of the natural disc.
摘要翻译：所描述的装置是绑定的脊柱植入物，其可以被外科手术植入脊柱中，以使用后部，外侧或后外侧方法来替换损伤的或患病的椎间盘。椎间盘是接近或模仿天然椎间盘的生理运动和反应的假体装置。

38. 发明申请

WO2010068725A2 LOCKABLE EXPANDING SPINE CAGE 审中-公开
标题翻译：可伸缩的脊柱
公开(公告)号：WO2010068725A2
公开(公告)日：2010-06-17
申请号：PCT/US2009/067446
申请日：2009-12-10
申请人： INNVOTEC SURGICAL, INC. , KADABA, Murali , SIMPSON, Philip, J. , ASHLEY, John, E. , GILLESPIE, Walter, Dean , GROTZ, Thomas , MANSFIELD, George, A., III , MATSUURA, David, G. , PRETTI, Rudy
发明人： KADABA, Murali , SIMPSON, Philip, J. , ASHLEY, John, E. , GILLESPIE, Walter, Dean , GROTZ, Thomas , MANSFIELD, George, A., III , MATSUURA, David, G. , PRETTI, Rudy
IPC分类号： A61F2/44 , A61B17/70
CPC分类号： A61F2/44 , A61F2/30742 , A61F2/442 , A61F2/4455 , A61F2002/30079 , A61F2002/3008 , A61F2002/30133 , A61F2002/30365 , A61F2002/30405 , A61F2002/30476 , A61F2002/30484 , A61F2002/30499 , A61F2002/30505 , A61F2002/30514 , A61F2002/30522 , A61F2002/30525 , A61F2002/3055 , A61F2002/30579 , A61F2002/30581 , A61F2002/30589 , A61F2002/30601 , A61F2002/30841 , A61F2002/482 , A61F2002/485 , A61F2210/009 , A61F2220/0025 , A61F2220/0033 , A61F2230/0015 , A61F2250/0007 , A61F2250/0069 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023
摘要： A spinal implant which is configured to be deployed between adjacent vertebral bodies. The implant has at least one extendable support element with a retracted configuration to facilitate deployment of the implant and an extended configuration so as to expand the implant and effectively distract the disc space, stabilize the motion segments and eliminate pathologic spine motion. Angular deformities can also be corrected, and natural curvatures restored. Preferably, the implant has a minimal dimension in its unexpanded state that is smaller than the dimensions of the neuroforamen through which it typically passes to be deployed within the intervertebral space. The implant is provided with a locking system preferably having a plurality of locking elements to lock the implant in an extended configuration. Bone engaging anchors also may be provided to ensure secure positioning.
摘要翻译：脊柱植入物，其构造成部署在相邻的椎体之间。植入物具有至少一个具有缩回构型的可延伸的支撑元件，以便于植入物的展开和延伸构造，以便扩大植入物并有效地分散椎间盘空间，稳定运动节段并消除病理脊柱运动。角度畸形也可以被修正，自然曲率恢复。优选地，植入物在其未展开状态下具有小于其通常通过以在椎间空间内展开的神经孔的尺寸的最小尺寸。植入物设置有锁定系统，优选地具有多个锁定元件以将植入物锁定在延伸构造中。也可以提供骨接合锚，以确保安全的定位。

39. 发明申请

WO2009070199A1 CARBOXYMETHYLCELLULOSE POLYETHYLENE GLYCOL COMPOSITIONS FOR MEDICAL USES 审中-公开
标题翻译：羧甲纤维素聚乙二醇用于医疗用途的组合物
公开(公告)号：WO2009070199A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/012529
申请日：2008-11-05
申请人： FZIOMED, INC. , FALCONE, Samuel J. , BERG, Richard A.
发明人： FALCONE, Samuel J. , BERG, Richard A.
IPC分类号： A61K47/00
CPC分类号： A61L27/20 , A61F2/441 , A61F2002/30062 , A61F2002/30224 , A61F2002/30242 , A61F2002/30581 , A61F2002/30677 , A61F2002/3068 , A61F2002/4435 , A61F2002/444 , A61F2002/448 , A61F2210/0004 , A61F2230/0071 , A61F2250/0068 , A61K47/60 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/042 , A61L31/06 , A61L31/14 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2400/06 , A61L2400/10 , A61L2430/02 , A61L2430/38 , C08B11/20 , C08J3/246 , C08J2301/08 , C08J2471/00 , C08L1/286 , Y10T428/2982 , C08L1/28
摘要： Compositions comprising carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS via an addition reaction In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS In other embodiments, bi-functional PEG molecules are attached to adjacent CPSs, thereby forming a covalently cross-linked composition A PEG can be linked to the CPS by way of an ether linkage or by way of an ester linkage, and in still further embodiments, PEG molecule(s) can be attached to CPS molecule(s) by way of both ether and ester linkages PEG/CMC compositions can include multi-branch and/or a multi-arm PEG Compositions having desired viscoelastic properties can be used as space-filling materials, load-bearing materials, anti-adhesion compositions for drug delivery vehicles or for lubrication of tissues and medical instruments.
摘要翻译：提供包含羧甲纤维素（CMC）和聚乙二醇（PEG）的羧基多糖（CPS）的组合物，其中PEG是通过加成反应与CPS共价连接的PEG-环氧化物。在某些实施方案中，PEG附着于仅一个CPS，形成装饰的CPS在其它实施方案中，双功能PEG分子连接到相邻的CPS，从而形成共价交联的组合物。PEG可以通过醚键或通过酯键与CPS连接，并且在另外的实施方案中，PEG分子可以通过醚键和酯键连接到CPS分子。PEG / CMC组合物可以包括多支和/或具有所需粘弹性的多臂PEG组合物可以是用作空间填充材料，承载材料，用于药物递送载体的抗粘合组合物或用于组织和医疗仪器的润滑。

40. 发明申请

WO2007028096A3 PROSTHETIC INTERVERTEBRAL DISCS 审中-公开
标题翻译： PROSTHETIC INTERVERTEBRAL DISC
公开(公告)号：WO2007028096A3
公开(公告)日：2009-05-22
申请号：PCT/US2006034358
申请日：2006-08-31
申请人： SPINAL KINETICS INC , GITTINGS DARIN C , REO MICHAEL L , ROBINSON JANINE C , ASHLEY JOHN E , KOSKE NICHOLAS C , RICHMAN ROXANNE L , WISTROM ELIZABETH V , CHEE URIEL H
发明人： GITTINGS DARIN C , REO MICHAEL L , ROBINSON JANINE C , ASHLEY JOHN E , KOSKE NICHOLAS C , RICHMAN ROXANNE L , WISTROM ELIZABETH V , CHEE URIEL H
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61F2/30742 , A61F2/3094 , A61F2/442 , A61F2002/30009 , A61F2002/30014 , A61F2002/30075 , A61F2002/30133 , A61F2002/30168 , A61F2002/30179 , A61F2002/30224 , A61F2002/30331 , A61F2002/30387 , A61F2002/30462 , A61F2002/30471 , A61F2002/305 , A61F2002/30523 , A61F2002/3055 , A61F2002/30563 , A61F2002/30566 , A61F2002/30576 , A61F2002/30579 , A61F2002/30581 , A61F2002/30586 , A61F2002/30594 , A61F2002/30662 , A61F2002/30884 , A61F2002/30889 , A61F2002/30897 , A61F2002/30899 , A61F2002/30971 , A61F2002/4415 , A61F2002/443 , A61F2002/444 , A61F2002/448 , A61F2002/4495 , A61F2002/4677 , A61F2002/485 , A61F2210/0061 , A61F2220/0025 , A61F2220/0033 , A61F2220/0075 , A61F2220/0091 , A61F2230/0015 , A61F2230/0043 , A61F2230/0058 , A61F2230/0069 , A61F2250/0018 , A61F2250/0028
摘要： Prosthetic intervertebral discs, systems including such prosthetic intervertebral discs, and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components, construction, and other features of the discs.
摘要翻译：描述了假体椎间盘，包括这种假体椎间盘的系统及其使用方法。主体假体盘包括由可压缩的芯构件分开的上端板和下端板。主体假体椎板在垂直方向上显示出刚度，扭转刚度，屈曲平面中的弯曲刚度和前平面中的弯曲刚度，其中这些特征的程度可以通过调整部件，结构和其他特征来独立地控制光盘。

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