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31. 发明申请

WO2010047956A1 AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS 审中-公开
标题翻译：阿莫洛林粉红素浓缩激素受体-1拮抗剂
公开(公告)号：WO2010047956A1
公开(公告)日：2010-04-29
申请号：PCT/US2009/059924
申请日：2009-10-08
申请人： BRISTOL-MYERS SQUIBB COMPANY , DEVASTHALE, Pratik , WASHBURN, William, N. , WANG, Wei , HERNANDEZ, Andres , AHMAD, Saleem , ZHAO, Guohua
发明人： DEVASTHALE, Pratik , WASHBURN, William, N. , WANG, Wei , HERNANDEZ, Andres , AHMAD, Saleem , ZHAO, Guohua
IPC分类号： C07D487/04 , A61K31/4015 , A61P3/00
CPC分类号： C07D487/04
摘要： The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula (I) including all pharmaceutically acceptable salts and stereoisomers thereof: wherein A is a monocyclic aryl or monocyclic heteroaryl; W is a direct bond, -0-, or -N(R 6 )-, provided that if W is a direct bond, D must be a cyclic amine that is attached to A via the nitrogen atom of said cyclic amine; D is a direct bond, substituted or unsubstituted C 1 to C 4 alkyl, substituted or unsubstituted C 3 to C 7 cycloalkyl, cycloalkylalkyl, or a 4 to 6 membered cyclic amine; B and E are independently N or CH provided that both are not CH;
摘要翻译：本申请提供了包括其所有药学上可接受的盐和立体异构体的根据式（I）的所有立体异构体，溶剂化物，前药和药学上可接受的形式的化合物：其中A是单环芳基或单环杂芳基; W是直接键，-O-或-N（R6） - ，条件是如果W是直接键，则D必须是通过所述环胺的氮原子连接到A的环胺; D是直接键，取代或未取代的C1至C4烷基，取代或未取代的C3至C7环烷基，环烷基烷基或4至6元环胺; B和E独立地为N或CH，条件是两者都不是CH;

32. 发明申请

WO2008019061A2 ANTI-IL-6 MONOCLONAL ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗IL-6单克隆抗体及其用途
公开(公告)号：WO2008019061A2
公开(公告)日：2008-02-14
申请号：PCT/US2007/017337
申请日：2007-08-03
申请人： VACCINEX, INC. , SMITH, Ernest, S. , WANG, Wei
发明人： SMITH, Ernest, S. , WANG, Wei
CPC分类号： C07K16/248 , C07K2317/56 , C07K2317/565 , C07K2317/73
摘要： The present invention provides novel monoclonal antibodies that bind specifically to IL- 6. The antibodies of the invention comprise a variable heavy chain (VH) region selected from any of the VH regions disclosed herein as well as amino acid variants thereof, and/or a variable light chain (VL) region selected from any of the VL regions disclosed herein as well as amino acid variants thereof. The invention also provides methods of treating diseases and disorders associated with IL-6 expression and/or activity.
摘要翻译：本发明提供了与IL-6特异性结合的新型单克隆抗体。本发明的抗体包含选自本文公开的任何VH区的可变重链（VH）区及其氨基酸变体，和/或选自本文公开的任何VL区的可变轻链（VL）区以及其氨基酸变体。本发明还提供了治疗与IL-6表达和/或活性相关的疾病和病症的方法。

33. 发明申请

WO2007044998A1 RETROCYCLINS: ANTIVIRAL AND ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译： RETROCYCLINS：抗病毒和抗微生物肽
公开(公告)号：WO2007044998A1
公开(公告)日：2007-04-19
申请号：PCT/US2006/040733
申请日：2006-10-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LEHRER, Robert I. , WARING, Alan J. , BRADLEY, Kenneth A. , WANG, Wei
发明人： LEHRER, Robert I. , WARING, Alan J. , BRADLEY, Kenneth A. , WANG, Wei
IPC分类号： A61K38/00
CPC分类号： A61K38/12
摘要： Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from an infection by a vancomycin resistant enterococcus.
摘要翻译：逆转录肽是针对细菌和病毒的有效活性的小抗微生物剂。肽是非溶血性的，并且表现出最小的体外细胞毒性。将包含逆转录酶作为活性剂的药物组合物治疗性地施用于患有万古霉素耐药性肠球菌感染的患者。

34. 发明申请

WO2006135771A2 COMPREHENSIVE SYSTEM FOR PRODUCT MANAGEMENT 审中-公开
标题翻译：产品管理综合体系
公开(公告)号：WO2006135771A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022528
申请日：2006-06-09
申请人： WHIRLPOOL CORPORATION , MCCOY, Richard A. , EBROM, Matthew P. , GLOTZBACH, Patrick J. , GLOTZBACH, Mark E. , PAUSTIAN, Michelle A. , NIBBELINK, Matthew , MORRELL, Michael A. , JENKINS, Anthony E. , LIETO, Gregory S. , WANG, Wei , KREFMAN, Stephen D.
发明人： MCCOY, Richard A. , EBROM, Matthew P. , GLOTZBACH, Patrick J. , GLOTZBACH, Mark E. , PAUSTIAN, Michelle A. , NIBBELINK, Matthew , MORRELL, Michael A. , JENKINS, Anthony E. , LIETO, Gregory S. , WANG, Wei , KREFMAN, Stephen D.
IPC分类号： A01N25/02
CPC分类号： H04L12/2814 , A47L15/0063 , D06F33/02 , D06F39/005 , G04G7/02 , G04R20/26 , G06F9/54 , G06F11/3495 , G06Q10/06 , H04L12/2803 , H04L12/2807 , H04L12/2818 , H04L12/282 , H04L12/2823 , H04L12/2825 , H04L12/2827 , H04L12/2832 , H04L63/105 , H04L67/12 , H04L69/26 , H04L2012/285 , H05B6/688 , Y02B40/143 , Y02D10/34
摘要： A comprehensive product management system for a product is provided. The system (10) includes discrete processes for planning (1000), engineering (2000), testing (3000), producing (4000), selling (6000), using (8000), and servicing (10000) a product comprising one or more components. It also includes a comprehensive relational database (30) containing information about the product, performance, sales, consumers, and markets, and system tools (20) for operating on the discrete processes.
摘要翻译：提供产品综合产品管理系统。系统（10）包括用于规划（1000），工程（2000），测试（3000），生产（4000），销售（6000），使用（8000）和维修（10000）包括一个或多个组件。它还包括一个综合关系数据库（30），其中包含有关产品，性能，销售，消费者和市场的信息，以及用于在离散流程上运行的系统工具（20）。

35. 发明申请

WO2006028639A1 MEDICINAL AEROSOL FORMULATION RECEPTACLE CONTAINING A MEDICINAL AEROSOL FORMULATION HAVING A LASER WELED METAL FOIL AND A METHOD OF PRODUCTION THEREOF 审中-公开
标题翻译：含有激光焊接金属箔的医药气溶胶制剂的药用气溶胶制剂及其生产方法
公开(公告)号：WO2006028639A1
公开(公告)日：2006-03-16
申请号：PCT/US2005/028440
申请日：2005-08-11
申请人： 3M INNOVATIVE PROPERTIES COMPANY , WANG, Wei , LI, Lin , STEWART, Robert , HODSON, Peter, D.
发明人： WANG, Wei , LI, Lin , STEWART, Robert , HODSON, Peter, D.
IPC分类号： B23K26/28 , A61M15/00 , B05B7/14 , B65D75/28 , B65D83/14
CPC分类号： B23K26/28 , A61M15/0028 , A61M15/0033
摘要： The present application discloses a hermetically sealed metal receptacle con-taining a medicinal aerosol formulation, preferably a pressurized medicinal aerosol formulation, or a liquefied aerosol propellant, wherein at least a portion of the receptacle comprises metal foil (1) having a thickness of from 25µm to 250µm which is laser welded to form a hermetic seal. The present application describes also a method of manufacturing such a hermetically sealed metal receptacle.
摘要翻译：本申请公开了一种密封的金属容器，其容纳药用气溶胶制剂，优选加压药用气溶胶制剂或液化气溶胶推进剂，其中容器的至少一部分包括厚度为25μm的金属箔（1）到250μm，其被激光焊接以形成气密密封。本申请还描述了制造这种密封金属容器的方法。

36. 发明申请

WO2006007586A1 ORGANOCATALYSTS AND METHODS OF USE IN CHEMICAL SYNTHESIS 审中-公开
标题翻译：化学合成中的有机物和使用方法
公开(公告)号：WO2006007586A1
公开(公告)日：2006-01-19
申请号：PCT/US2005/023691
申请日：2005-06-30
申请人： SCIENCE & TECHNOLOGY CORPORATION @ UNM , WANG, Wei , WANG, Jian , LI, Hao
发明人： WANG, Wei , WANG, Jian , LI, Hao
IPC分类号： C07D211/08
CPC分类号： C07D207/09 , C07B2200/07 , C07C45/511 , C07C45/54 , C07C45/72 , C07C45/74 , C07C47/56 , C07C49/203 , C07C49/21 , C07C49/235 , C07C49/647 , C07C49/653 , C07C49/683 , C07C49/697 , C07C49/753 , C07C49/86 , C07C67/343 , C07C201/12 , C07C205/44 , C07C205/45 , C07C213/02 , C07C215/42 , C07C227/32 , C07C239/20 , C07C253/30 , C07C319/14 , C07C391/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D309/30 , C07D317/72 , C07D333/22 , C07C49/258 , C07C49/245 , C07C69/76 , C07C323/22 , C07C255/56 , C07C229/22 , C07C229/28 , C07C229/30 , C07C229/36
摘要： The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use. These compounds have the structure of the Formulas (I) and (II). Where X is independently selected from CH 2 , N-R a , O, S or C=O; Y is CH 2 , N-R a , O, S or C=O, with the proviso that at least one of X or Y is CH 2 , and preferably both of X and Y are CH 2 ; R a is H, an optionally substituted C 1 -C 12 alkyl, preferably an optionally substituted C 1 -C 6 alkyl including a C 3 -C 6 cyclic alkyl group, or an optionally substituted aryl group, preferably an optionally substituted phenyl group; R b is H, an optionally substituted C 1 -C 12 alkyl, preferably an optionally substituted C 1 -C 6 acyclic or a a C 3 -C 6 cyclic alkyl group, CHO, N(Me)O, CO(S)R a or the group of Formula (III). Where R c and R d are each independently H, F, C1, an optionally substituted C 1- C 20 alkyl, preferably an optionally substituted C 1 -C 12 alkyl, more preferably a C 1 -C 6 alkyl, and an optionally substituted aryl group, or together R c and R d form an optionally substituted carbocyclic or optionally substituted heterocyclic ring; R 1 is OH, OR, NR'R", NHC(=O)R, NHSO 2 R; R 2 is H, F, C1, an optionally substituted C 1- C 20 alkyl, preferably an optionally substituted C 1 C 6 alkyl, an optionally substituted aryl group or a =O group (which establishes a carbonyl group with the carbon to which =O is attached; R 3 is H, OH, F, C1, Br, I, Cl, an optionally substituted C 1 -C 20 alkyl, alkenyl or alkynyl ("hydrocarbyl") group, preferably an optionally substituted C 1 -C 6 alkyl, or an optionally substituted aryl, such that the carbon to which R 3 is attached has an R or S configuration; R is H, an optionally substituted C 1 -C 20 alkyl, preferably an optionally substituted C 1 -C 6 alkyl, or an optionally substituted aryl group, R' and R" are each independently H, an optionally substituted C 1 -C 20 alkyl group, preferably an optionally substituted C 1 -C 6 alkyl, or an optionally substituted aryl group; or together R' and R" form an optionally substituted heterocyclic, preferably a 4 to 7 membered optionally substituted heterocyclic group or an optionally substituted heteroaryl ring with the nitrogen to which R' and R" are attached; and wherein said compound is free from a metal catalyst.
摘要翻译：本发明通常涉及促进立体选择性反应的有机催化剂及其合成和使用方法的组合物。特别地，本发明涉及促进立体选择性反应的无金属有机催化剂及其合成和使用方法。这些化合物具有式（I）和（II）的结构。其中X独立地选自CH 2，N-R a，O，S或C = O; Y是CH 2，NR a，O，S或C = O，条件是X或Y中的至少一个是CH 2 2 >，并且优选X和Y两者都是CH 2 2; R a是H，任选取代的C 1 -C 12烷基，优选任选取代的C 1 -C 12 - 包括C 3 -C 6环烷基的C 6 -C 6烷基或任选取代的芳基，优选任选取代的苯基; R b是H，任选取代的C 1 -C 12烷基，优选任选取代的C 1 -C 12烷基， C 6不饱和环或C 3 -C 6环烷基，CHO，N（Me）O，CO（S）R SUP > III或式（III）的基团。其中R 0和R d各自独立地为H，F，C 1，任选取代的C 1 -C 20 >烷基，优选任选取代的C 1 -C 12烷基，更优选C 1 -C 12烷基，更优选C 1 -C 12 - 烷基和任选取代的芳基，或一起R和C和R d形成任选取代的碳环或任选取代的杂环; R 1是OH，OR，NR'R“，NHC（= O）R，NHSO 2 R; R 2是H，F ，C 1，任选取代的C 1 -C 20烷基，优选任选取代的C 1 -C 6烷基，任选取代的芳基或= O基团（其中与O连接的碳上形成羰基; R 3是H，OH，F，Cl，Br，I，Cl ，任选取代的C 1 -C 20烷基，烯基或炔基（“烃基”）基团，优选任选取代的C 1 -C C 6 -C 6烷基或任选取代的芳基，使得R 3连接的碳具有R或S构型; R是H，任选取代的C

37. 发明申请

WO2005113608A1 METHOD OF COVALENTLY LINKING HYALURONAN AND CHITOSAN 审中-公开
标题翻译：共价连接HYALURONONAN和CHITOSAN的方法
公开(公告)号：WO2005113608A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/017498
申请日：2005-05-19
申请人： MENTOR CORPORATION , WANG, Wei
发明人： WANG, Wei
IPC分类号： C08B37/08
CPC分类号： C08B37/003 , A61K8/735 , A61K8/736 , A61K9/0019 , A61K47/36 , A61K2800/57 , A61L27/20 , A61L2400/06 , A61Q19/00 , C08B37/0072 , C08J3/246 , C08J2305/08 , C08L5/08 , C08L2666/26
摘要： A method of covalently linking hyaluronan and chitosan, the method comprising mixing a solution of hyaluronan and chitosan at a pH of at least 7.2 in the presence of a water soluble carbodiimide is described. Also described are products of this method, as well as uses for the products.
摘要翻译：描述了共价连接透明质酸和壳聚糖的方法，所述方法包括在水溶性碳二亚胺的存在下，在至少7.2的pH下混合透明质酸溶液和壳聚糖溶液。还描述了该方法的产品，以及产品的用途。

38. 发明申请

WO2003099192A3 BIS-AROMATIC ALKANOLS 审中-公开
公开(公告)号：WO2003099192A3
公开(公告)日：2003-12-04
申请号：PCT/EP2003/005510
申请日：2003-05-26
申请人： NOVARTIS AG , NOVARTIS Pharma GmbH , IRM LLC , FAN, Yi , GAO, Wenqi , GRAY, Nathanael, S. , HINTERDING, Klaus , LEFEBVRE, Sophie , MI, Yuan , NUSSBAUMER, Peter , PAN, Shifeng , WANG, Wei , ZECRI, Frédéric , PEREZ, Lawrence, Blas , LA MONTAGNE, Kenneth, Richard , ETTMAYER, Peter
发明人： FAN, Yi , GAO, Wenqi , GRAY, Nathanael, S. , HINTERDING, Klaus , LEFEBVRE, Sophie , MI, Yuan , NUSSBAUMER, Peter , PAN, Shifeng , WANG, Wei , ZECRI, Frédéric , PEREZ, Lawrence, Blas , LA MONTAGNE, Kenneth, Richard , ETTMAYER, Peter
IPC分类号： A61K31/133
摘要： The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them.

39. 发明申请

WO2023029030A1 SYSTEMS AND METHODS OF SEMANTIC TAGGING 审中-公开
公开(公告)号：WO2023029030A1
公开(公告)日：2023-03-09
申请号：PCT/CN2021/116652
申请日：2021-09-06
申请人： JOHNSON CONTROLS TYCO IP HOLDINGS LLP , WANG, Wei
发明人： WANG, Wei
IPC分类号： G06F9/44 , G06F16/36
摘要： A method of retrieving data using metadata tags including identifying, by a processing circuit from a data structure, a digital representation of a device deployed within a space, tagging, by the processing circuit, a data point associated with the digital representation of the device with a semantic description having a tag schema, receiving, by the processing circuit, a query including a partial string referencing the tag schema, identifying, by the processing circuit, the semantic description from a plurality of semantic descriptions based on the partial string of the query and the tag schema, retrieving, by the processing circuit, one or more tagged data points by querying the data structure using the semantic description, and automatically performing an operation using the one or more tagged data points.

40. 发明申请

WO2021102123A1 METHOD AND APPARATUS FOR THREE-DIMENSIONAL (3D)-TREE CODING FOR NEURAL NETWORK MODEL COMPRESSION 审中-公开
公开(公告)号：WO2021102123A1
公开(公告)日：2021-05-27
申请号：PCT/US2020/061255
申请日：2020-11-19
申请人： TENCENT AMERICA LLC , WANG, Wei , JIANG, Wei , LIU, Shan
发明人： WANG, Wei , JIANG, Wei , LIU, Shan
IPC分类号： G06K9/36 , G06N3/08
摘要： A method of three-dimensional (3D)-Tree coding for neural network model compression, is performed by at least one processor, and includes reshaping a four-dimensional (4D) parameter tensor of a neural network into a 3D parameter tensor of the neural network, the 3D parameter tensor comprising a convolution kernel size, an input feature size, and an output feature size, partitioning the 3D parameter tensor along a plane that is formed by the input feature size and the output feature size into 3D coding tree units (CTU3Ds), partitioning each of the CTU3Ds into a plurality of 3D coding units (CU3Ds) recursively until a predetermined depth, using a quad-tree, constructing a 3D tree for each of the plurality of CU3Ds, and entropy encoding each of a plurality of values of a plurality of nodes of the 3D tree

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