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    • 32. 发明申请
    • APPARATUS AND METHOD FOR MANIPULATING PARTICLES IN A LIQUID MEDIUM BY ULTRASONIC WAVES
    • 通过超声波处理液体介质中的颗粒的装置和方法
    • WO1997043026A1
    • 1997-11-20
    • PCT/GB1997001239
    • 1997-05-08
    • BRITISH TECHNOLOGY GROUP LIMITEDSCHRAM, Cornelius, John
    • BRITISH TECHNOLOGY GROUP LIMITED
    • B01D21/00
    • B01D21/283B01D43/00B01J19/10
    • The invention relates to an apparatus and a method for munipulating particles in a liquid medium by ultrasonic waves. A vessel is provided for receiving the particle-carrying liquid, as well as means, such as an ultrasonic transducer for generating an ultrasonic standing wave in the vessel such that particles are attracted to nodal fronts of the standing wave. The standing wave is intermittently suppressed, whilst the particle-carrying liquid is oscillated relative to the transducer. If the oscillation and the intermittency are carried out in synchronisation, the particles can be shepherded from one nodal front to another in a prescribed direction to concentrate them for separation from the liquid medium. The invention has application to separation or concentration of inorganic or organic particulate matter in laboratory or industrial processes.
    • 本发明涉及一种通过超声波在液体介质中调节颗粒的装置和方法。 提供容器用于接收载运液体,以及诸如用于在容器中产生超声波驻波的超声波换能器的装置,使得颗粒被吸引到驻波的节点。 驻波被间歇地抑制,而颗粒携带液体相对于换能器振荡。 如果振荡和间歇性同步进行,则颗粒可以从规定的方向从一个节点前面传播到另一个节点,以将它们集中以与液体介质分离。 本发明适用于实验室或工业过程中无机或有机颗粒物质的分离或浓缩。
    • 33. 发明申请
    • DEVICE AND METHOD FOR TRANSCUTANEOUS SURGERY
    • 用于手术治疗的装置和方法
    • WO1997010021A1
    • 1997-03-20
    • PCT/GB1996002263
    • 1996-09-12
    • BRITISH TECHNOLOGY GROUP LIMITEDBYRNE, Phillip, OwenELLIOTT, Thomas, Stuart, Jackson
    • BRITISH TECHNOLOGY GROUP LIMITED
    • A61M25/01
    • A61M25/0111A61B90/40
    • This invention relates to a device and method for use in transcutaneous surgical procedures, such as transcutaneous catheterisation and surgical biopsy. To provide that the operative parts of instrumentation to be introduced into the patient's body are shielded from contact with the patient's skin, and thereby to inhibit transfer of microorganisms from the skin into the body, there is provided a transcutaneous indwelling shield device for insertion into a skin aperture, comprising a transcutaneous distal portion providing an instrument access port, connecting to a proximal portion of shallow dished form of substantially greater dimension than said access port, the proximal portion tapering inwardly to said distal portion to readily guide the distal tip of the instrument to said access port. The distal portion serves as a wound retractor, and to this end at least the distal portion may be of resilient form to be resiliently deformed from a first, relatively open, configuration to a second, relatively closed, configuration. The invention has particular application in the field of central venous catheterisation.
    • 本发明涉及用于经皮手术的装置和方法,例如经皮导管插入术和外科活检。 为了提供要引入患者体内的仪器的操作部分被屏蔽以免与患者的皮肤接触,从而阻止微生物从皮肤转移到体内,提供了一种用于插入到皮肤中的经皮留置屏蔽装置 皮肤孔,包括提供仪器进入口的经皮远端部分,其连接到具有比所述进入口大得多的尺寸的浅盘形形状的近端部分,所述近端部分向内渐缩到所述远端部分,以容易地引导所述器械的远端 到所述访问端口。 远侧部分用作缠绕的牵开器,并且为此,至少远端部分可以是弹性形式,以从第一相对开放的构造弹性变形到第二相对封闭的构型。 本发明在中心静脉导管插入术中具有特殊的应用。
    • 34. 发明申请
    • METHOD AND APPARATUS FOR USE IN IMAGING A BODY
    • 用于成像身体的方法和装置
    • WO1997000642A1
    • 1997-01-09
    • PCT/GB1996001499
    • 1996-06-21
    • BRITISH TECHNOLOGY GROUP LIMITEDBOONE, Kevin, GrahamHOLDER, David, Simon
    • BRITISH TECHNOLOGY GROUP LIMITED
    • A61B05/05
    • A61B5/0536A61B5/0042
    • The present invention relates to imaging, and more particularly to a method and apparatus for use in imaging a body by means of the technique of electrical impedance tomography (EIT). A plurality of electrodes (E, to E16) are provided in electrical contact with the body (10) around the periphery of the body. A first electrical input signal is applied to at least one of the electrodes over a first time period (T1), and a second electrical input signal, which is preferably in inverted form of the first, is then applied to the at least one of the electrodes over a subsequent, second time period (T2). The resulting electrical output signal is measured at one or more of the remaining electrodes over the first and second time periods and the difference between the measured signal obtained during the first time period and that obtained during the second time period is calculated to provide a difference signal. The difference signal can be stored and used for image reconstruction. The invention has particular application in imaging neurological function within the body, where the impedance changes associated with neuronal depolarisations are very small and the resulting electrical signals measured at the body periphery are even smaller. By use of this technique electrical signals corresponding to the dynamic components of impedance change can be reinforced whilst those corresponding to other unwanted components can be cancelled.
    • 本发明涉及成像,更具体地涉及一种通过电阻抗层析成像(EIT)技术用于成像身体的方法和装置。 多个电极(E,至E16)设置成与身体(10)电连接在身体周围。 第一电输入信号在第一时间段(T1)中被施加到至少一个电极,然后将优选地以第一时间的反向形式的第二电输入信号施加到第一时间段 电极在随后的第二时间段(T2)中。 所得到的电输出信号在第一和第二时间段的一个或多个剩余电极处测量,并且计算在第一时间段期间获得的测量信号与在第二时间段期间获得的测量信号之间的差,以提供差分信号 。 差分信号可以存储并用于图像重建。 本发明在体内成像神经功能方面具有特别的应用,其中与神经元去极化相关的阻抗变化非常小,并且在体周边测量的所得电信号甚至更小。 通过使用这种技术,可以加强对应于阻抗变化的动态分量的电信号,而可以取消对应于其它不需要的部件的电信号。
    • 35. 发明申请
    • ANTIBIOTICS
    • 抗生素
    • WO1996035701A1
    • 1996-11-14
    • PCT/GB1996001144
    • 1996-05-10
    • BRITISH TECHNOLOGY GROUP LIMITEDBOROWSKI, EdwardGRZYBOWSKA, JolantaSOWINSKI, PawelGUMIENIAK, JerzyCZERWINSKI, Andrzej
    • BRITISH TECHNOLOGY GROUP LIMITED
    • C07H17/08
    • C07H17/08
    • The invention relates to N-alkyl-N-glycosyl derivatives of alkyl esters of antifungal antibiotics of polyene macrolide group of general formula (1a), wherein M represents polyene macrolide antibiotics residues, R represents a variable part of sugar residue, and each of R and R represents a C1-4 alkyl group; their salts of general formula (2a), wherein R, R , R and M are as herein defined and A represents an anion of organic or inorganic acid. Compounds of formula (1b) and (2b) wherein the N-alkyl and alkyl ester groups are represented by methyl are of particular interest. The invention relates also to processes for preparation of the compounds, to compositions containing these compounds and to their use in therapy and the treatment of external and internal fungal infections in humans and animals.
    • 本发明涉及通式(1a)的多烯大环内酯类抗真菌抗生素的烷基酯的N-烷基-N-糖基衍生物,其中M表示多烯大环内酯类抗生素残基,R表示糖残基的可变部分,R表示R 1和R 2代表C 1-4烷基; 其通式(2a)的盐,其中R,R 1,R 2和M如本文所定义,A表示有机酸或无机酸的阴离子。 特别令人感兴趣的是其中N-烷基和烷基酯基由甲基表示的式(1b)和(2b)的化合物。 本发明还涉及制备化合物的方法,含有这些化合物的组合物及其在治疗和治疗人和动物中的外部和内部真菌感染中的用途。
    • 36. 发明申请
    • USE OF XANTHINE OXIDASE INHIBITORS AS ANTI-ISCHAEMIC AGENTS
    • 使用XANTHINE氧化酶抑制剂作为抗药剂
    • WO1996017610A1
    • 1996-06-13
    • PCT/GB1995002890
    • 1995-12-08
    • BRITISH TECHNOLOGY GROUP LIMITEDSINGH, SurinderLEWIS, Anthony, Edward
    • BRITISH TECHNOLOGY GROUP LIMITED
    • A61K31/505
    • C07D471/04A61K31/505A61K31/52A61K31/522C07D473/04C07D473/30C07D475/02C07D487/04
    • The use of a compound of formula (I), in which R1 and R2 which may be the same or different are N or CH, X1 and X2 which may be the same or different are hydrogen, hydroxy, or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclyl group and Z1 and Z2 which may be the same or different are hydrogen, hydroxy, keto (=O), or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclyl group or one of Z1 and X1 and Z2 and X2 form a second bond of a double bond at the 1,6 or 2,3 positions with the proviso that at least one of the groupings R1Z1X1R2Z2X2 and R1X1Z2 form a hydroxamate moiety (-N(OH)C(=O)- in which R1 and/or R2 is N, Z1 and/or Z2 is =O and X1 and/or X2 is OH or R1 is N, Z2 is =O and X1 is OH and B is a 5- or 6-membered ring of formula (II) or (III), in which R4, R5, R6, R7, R8, R9 and R10 which may be the same or different are CH or N with the proviso that ring B cannot contain more than 3 ring members which are nitrogen and the ring B may optionally be substituted by one or more of hydroxy, keto (=O), and an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclyl group or a salt thereof formed with a physiologically acceptable organic or inorganic acid, for the manufacture of a medicament for use as an anti-ischaemic agent.
    • 式(I)化合物或其可以相同或不同的R 1和R 2可以相同或不同的式(I)化合物是氢,羟基或任选取代的烷基,烯基 ,炔基,环烷基,芳基或杂环基,Z 1和Z 2可以相同或不同,是氢,羟基,酮基(= O)或任选取代的烷基,烯基,炔基,环烷基,芳基或杂环基或 Z1和X1和Z2和X2在1,6或2,3位上形成双键的第二个键,条件是R1Z1X1R2Z2X2和R1X1Z2中的至少一个形成氧肟基部分(-N(OH)C( = O) - 其中R 1和/或R 2为N,Z 1和/或Z 2为= O且X 1和/或X 2为OH或R 1为N,Z 2为= O且X 1为OH且B为5-或 式(II)或(III)的6-元环,其中可以相同或不同的R 4,R 5,R 6,R 7,R 8,R 9和R 10是CH或N,条件是环B不能含有 3个环状构件,为氮和th e环B可任选地被羟基,酮基(= O)和与生理上可接受的有机或无机酸形成的任选取代的烷基,烯基,炔基,环烷基,芳基或杂环基或其盐中的一个或多个取代, 用于制造用作抗缺血剂的药物。
    • 37. 发明申请
    • MORPHINE AND CODEINE DERIVATIVES FOR USE IN THERAPY
    • 用于治疗的吗啡和代谢衍生物
    • WO1996016063A1
    • 1996-05-30
    • PCT/GB1995002712
    • 1995-11-20
    • BRITISH TECHNOLOGY GROUP LIMITEDMARPLES, Brian, ArthurTRAYNOR, John, Richard
    • BRITISH TECHNOLOGY GROUP LIMITED
    • C07D489/02
    • C07D489/02
    • A compound of formula (I) wherein R1 = H (morphine analogue), CH3 (codeine analogue), R2 = H, alkyl group of 1 to 4 carbon atoms, allyl, cyclopropylmethyl, R3 = a group (A), -O-CH2-R4 (ether), -O-COCH = CHR4 (cinnamate), R4 = (B), wherein X1, X2, X3, X4 and X5 which may be the same or different are separately selected from H, alkyl of 1 to 4 carbon atoms, NH2, NO2, alkoxy group of 1 to 4 carbon atoms, hydroxy, halogen, N-alkyl, group of 1 to 4 carbon atoms, morpholine, or a group COR5 wherein R5 is H, OH, O-alkyl where alkyl is from 1 to 4 carbon atoms, or one of X1 and X2, X2 and X3, X3 and X4 or X4 and X5 together with an alkylene group optionally interrupted by O, S or N of up to 5 atoms in length complete a ring and a pharmaceutically acceptable salt thereof for use in therapy.
    • 式(I)的化合物,其中R1 = H(吗啡类似物),CH3(可待因类似物),R 2 = H,1至4个碳原子的烷基,烯丙基,环丙基甲基,R 3 = A(A) CH2-R4(醚),-O-COCH = CHR4(肉桂酸酯),R4 =(B),其中X1,X2,X3,X4和X5可以相同或不同,分别选自H, 4个碳原子,NH 2,NO 2,1至4个碳原子的烷氧基,羟基,卤素,N-烷基,1至4个碳原子,吗啉或基团COR 5,其中R 5是H,OH,O-烷基 烷基是1至4个碳原子,或者X 1和X 2,X 2和X 3,X 3和X 4或X 4和X 5中的一个与任选被长达5个原子的O,S或N间隔的亚烷基一起形成环 及其药学上可接受的盐用于治疗。
    • 39. 发明申请
    • PROSTHETIC KNEE JOINT DEVICE
    • PROSTHETIC KNEE JOINT设备
    • WO1996008215A1
    • 1996-03-21
    • PCT/GB1995002180
    • 1995-09-14
    • BRITISH TECHNOLOGY GROUP LIMITEDGOODFELLOW, John, WilliamO'CONNOR, John, Joseph
    • BRITISH TECHNOLOGY GROUP LIMITED
    • A61F02/38
    • A61F2/3868
    • The invention concerns prosthetic knee joint devices, in particular of the meniscal type having femoral, tibial and meniscal components co-operable to allow congruence of the interfacing articulation surfaces while allowing close simulation of the natural joint in flexion-extension. The device features meniscal and tibial components each of one-piece bicompartmental construction having a pair of mutually spaced portions respectively defining condylar articulation surfaces, such portions being joined by way of an intercondylar portion, and the tibial and meniscal intercondylar portions being interengageable by means of complementary elements of a rib-and-groove joint arranged substantially in the antero-posterior direction, both the rib and the groove having curved side faces to allow limited long axis rotation between the components, and the groove being open at at least one end. With appropriate dimensioning, the device allows movement of the meniscal component in the antero-posterior direction, limited movement in the medio-lateral direction and limited long-axis rotation. It also provides in a simple and effective manner a securement against tibio-meniscal dislocation.
    • 本发明涉及假膝关节装置,特别是具有股骨,胫骨和半月板部件的半月板类型,其可共同操作以允许接合关节表面的一致,同时允许在屈曲伸展中的天然关节的紧密模拟。 该装置具有半月板和胫骨部件,每个部件具有一对相互间隔开的部分,分别限定髁关节表面,这些部分通过髁间部分连接,并且胫骨和半月板间髁部分可通过 基本上沿前后方向布置的肋 - 槽接头的互补元件,肋和槽具有弯曲的侧面,以允许部件之间的有限的长轴旋转,并且凹槽在至少一端是敞开的。 通过适当的尺寸,该装置允许半月板部件在前后方向上移动,中内侧方向上的有限运动和有限的长轴旋转。 它还以简单有效的方式提供了针对胫骨 - 半月板脱位的固定。
    • 40. 发明申请
    • PESTICIDAL FLUOROOLEFINS
    • 杀虫剂氟化物
    • WO1995029887A1
    • 1995-11-09
    • PCT/GB1995000954
    • 1995-04-26
    • BRITISH TECHNOLOGY GROUP LIMITEDKHAMBAY, Bhupinder, Pall, SinghLIU, Mu-Guang
    • BRITISH TECHNOLOGY GROUP LIMITED
    • C07C43/29
    • C07C43/29A01N31/14
    • A pesticidal compound of formula (I) in which R is hydrogen and R represents a cyclopropyl group or R and R each represents an alkyl group, which alkyl groups may be the same or different; ArA represents an optionally substituted phenyl or naphthyl group; ArB represents a phenoxy, phenyl, benzyl or benzoyl-substituted phenyl groups which is optionally further substituted; the configuration of the groups ArA-CR R and -CH2ArB about the double bond being mutually trans . Preferably ArA is a substituted phenyl group; more preferably being substituted at the 4-(para) position by halogen, alkoxy or haloalkyl. Further provided is a process for the preparation of a pesticidal compound of formula (I) in which a compound comprising a moiety (a) and a compound comprising the moiety ArB- are reacted together forming a link -CH=C(F)CH2- between (a) and Arb in the compound of formula (I).
    • 式(I)的杀虫化合物,其中R 1是氢,R 2表示环丙基或R 1和R 2各自表示烷基,该烷基可以相同或不同 ; ArA表示任选取代的苯基或萘基; ArB表示任选进一步取代的苯氧基,苯基,苄基或苯甲酰基取代的苯基; ArA-CR 1 R 2基团和-CH 2 ArB基团的构型相互相反。 ArA优选为取代的苯基; 更优选在4-(对位)位被卤素,烷氧基或卤代烷基取代。 还提供了制备式(I)的杀虫化合物的方法,其中包含部分(a)的化合物和包含部分ArB-的化合物一起反应,形成连接-CH = C(F)CH 2 - 在式(I)化合物中的(a)和Arb之间。