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1. 发明申请

WO1996016063A1 MORPHINE AND CODEINE DERIVATIVES FOR USE IN THERAPY 审中-公开
标题翻译：用于治疗的吗啡和代谢衍生物
公开(公告)号：WO1996016063A1
公开(公告)日：1996-05-30
申请号：PCT/GB1995002712
申请日：1995-11-20
申请人： BRITISH TECHNOLOGY GROUP LIMITED , MARPLES, Brian, Arthur , TRAYNOR, John, Richard
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： C07D489/02
CPC分类号： C07D489/02
摘要： A compound of formula (I) wherein R1 = H (morphine analogue), CH3 (codeine analogue), R2 = H, alkyl group of 1 to 4 carbon atoms, allyl, cyclopropylmethyl, R3 = a group (A), -O-CH2-R4 (ether), -O-COCH = CHR4 (cinnamate), R4 = (B), wherein X1, X2, X3, X4 and X5 which may be the same or different are separately selected from H, alkyl of 1 to 4 carbon atoms, NH2, NO2, alkoxy group of 1 to 4 carbon atoms, hydroxy, halogen, N-alkyl, group of 1 to 4 carbon atoms, morpholine, or a group COR5 wherein R5 is H, OH, O-alkyl where alkyl is from 1 to 4 carbon atoms, or one of X1 and X2, X2 and X3, X3 and X4 or X4 and X5 together with an alkylene group optionally interrupted by O, S or N of up to 5 atoms in length complete a ring and a pharmaceutically acceptable salt thereof for use in therapy.
摘要翻译：式（I）的化合物，其中R1 = H（吗啡类似物），CH3（可待因类似物），R 2 = H，1至4个碳原子的烷基，烯丙基，环丙基甲基，R 3 = A（A） CH2-R4（醚），-O-COCH = CHR4（肉桂酸酯），R4 =（B），其中X1，X2，X3，X4和X5可以相同或不同，分别选自H， 4个碳原子，NH 2，NO 2，1至4个碳原子的烷氧基，羟基，卤素，N-烷基，1至4个碳原子，吗啉或基团COR 5，其中R 5是H，OH，O-烷基烷基是1至4个碳原子，或者X 1和X 2，X 2和X 3，X 3和X 4或X 4和X 5中的一个与任选被长达5个原子的O，S或N间隔的亚烷基一起形成环及其药学上可接受的盐用于治疗。

2. 发明申请

WO1998019175A1 MAGNETIC RESONANCE APPARATUS HAVING REDUCED "e;DEAD TIME"e; 审中-公开
标题翻译：具有减少“死亡时间”的磁共振装置
公开(公告)号：WO1998019175A1
公开(公告)日：1998-05-07
申请号：PCT/GB1997002936
申请日：1997-10-24
申请人： BRITISH TECHNOLOGY GROUP LIMITED , LURIE, David, John , ALECCI, Marcello , BRIVATI, John, Anthony , TESTA, Luca , PLACIDI, Giuseppe , SOTGIU, Antonello
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： G01R33/32
CPC分类号： G01R33/3628
摘要： The invention concerns an improved magnetic resonance apparatus and method for substantially reducing the dead time of the apparatus, in order to recover as much of the submicrosecond FID signals as quickly as possible. A double-channel, out-of-phase signal combination is employed. Two RF receiving coils are arranged with identical ringing characteristics, preferably mutually perpendicular to one another. The RF signal received by one coil is phase shifted by 180 DEG , amplified, and combined with the amplified RF signal received by the other coil. The ringing components cancel, whilst the FID components in phase quadrature do not. The transmitter/receiver apparatus may be of duplex or crossed coil configuration. In the latter case, one of the receiver coils may be oriented parallel to the main field so that it receives no FID signal and operates only to reduce the dead time. The invention is particularly well suited for imagers and spectrometers using pulsed electron paramagnetic resonance (EPR), for the detection of free radicals in biological systems, or for pulsed nuclear magnetic resonance (NMR), where relaxation times are of the order of 100ns to 10 mu s.
摘要翻译：本发明涉及一种改进的磁共振装置和方法，用于大大减少装置的死区时间，以尽可能快地恢复尽可能多的亚微米FID信号。采用双通道异相信号组合。两个RF接收线圈被布置成具有相同的振铃特性，优选彼此相互垂直。由一个线圈接收的RF信号相移180°，放大，并与由另一个线圈接收的放大的RF信号组合。振铃分量取消，而相位正交的FID分量不能。发射机/接收机设备可以是双工或交叉线圈配置。在后一种情况下，接收器线圈中的一个可以平行于主场定向，使得其不接收FID信号并且仅操作以减少死区时间。本发明特别适用于使用脉冲电子顺磁共振（EPR），用于检测生物系统中的自由基或用于脉冲核磁共振（NMR）的成像器和光谱仪，其中弛豫时间为100ns至10 亩。

3. 发明申请

WO1998018387A1 INSTRUMENT HAVING ENHANCED ULTRASOUND VISIBILITY 审中-公开
标题翻译：具有增强超声可见性的仪器
公开(公告)号：WO1998018387A1
公开(公告)日：1998-05-07
申请号：PCT/GB1997002935
申请日：1997-10-24
申请人： BRITISH TECHNOLOGY GROUP LIMITED , JOSEPH, Anton, Emmanuel, Arulraj
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： A61B08/00
CPC分类号： A61B8/481 , A61B2090/3925 , A61K49/223
摘要： An instrument (10) for ultrasonic imaging comprises a probe (12) for insertion into a material (62) containing a liquid. The probe (12) has a coating comprising a carrier material (30) and a quantity of reactive material (32) which, upon contacting a reactant produce a quantity of bubbles (62) adjacent the coating for reflecting ultrasonic energy. In one application the probe (12) comprises a biopsy needle and the coating is positioned towards a sharp distal end thereof (14a) thereby to facilitate the guiding and positioning thereof. Alternatively, the coating can be provided along the entire length of the instrument (10) or at descrete portions along its length.
摘要翻译：用于超声波成像的仪器（10）包括用于插入到含有液体的材料（62）中的探针（12）。探针（12）具有包括载体材料（30）和一定量的反应性材料（32）的涂层，其在反应物接触时产生邻近涂层的反射超声波能量的气泡（62）。在一个应用中，探针（12）包括活检针，并且涂层朝向其尖端远端（14a）定位，从而便于其引导和定位。或者，可以沿着仪器（10）的整个长度或沿其长度的分支部分提供涂层。

4. 发明申请

WO1998017973A1 A SOLID-STATE, MULTI-AXIS GYROSCOPE 审中-公开
标题翻译：一个固态，多轴陀螺仪
公开(公告)号：WO1998017973A1
公开(公告)日：1998-04-30
申请号：PCT/GB1997002713
申请日：1997-10-02
申请人： BRITISH TECHNOLOGY GROUP LIMITED , COOPER, George
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： G01C19/56
CPC分类号： G01C19/5684
摘要： A gyroscope (36) includes a gyro body-portion (48, 50, 52 or 54) which is driven into vibratory primary oscillation P and, if turned about on axis X, Y or Z experiences a Coriolis force induced vibration. Matching the primary oscillation mode and the secondary modes allow one to accurately detect motion about one, two or three axis.
摘要翻译：陀螺仪（36）包括被驱动进入振动一次振荡P的陀螺仪本体部分（48,50,52或54），并且如果在X轴上转动，则Y或Z经受科里奥利力感应振动。匹配主振荡模式和次模式可以准确地检测一个，两个或三个轴的运动。

5. 发明申请

WO1998004355A1 APPARATUS AND METHOD FOR TESTING PARTICLES USING DIELECTROPHORESIS 审中-公开
标题翻译：使用电子显微镜测试颗粒的装置和方法
公开(公告)号：WO1998004355A1
公开(公告)日：1998-02-05
申请号：PCT/GB1997002011
申请日：1997-07-28
申请人： BRITISH TECHNOLOGY GROUP LIMITED , PETHIG, Ronald , MARKX, Gerardus, Hendricus
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： B03C05/00
CPC分类号： B03C5/005
摘要： The behaviour of particles is tested by placing a suspension of the particles in a chamber in which an electrode array is arranged to generate a spectrum of different frequency dielectrophoretic fields. The behaviour of the particles at the different frequencies can be studied in a convenient and rapid manner. The apparatus and method can be used for a variety of purposes, including characterising the properties of specified particle types, or analysing the particle population in a fluid. It is also possible to expose the particles to different fluid parameters to extend the test spectrum in other senses.
摘要翻译：通过将颗粒的悬浮液放置在其中设置电极阵列以产生不同频率介电泳场的光谱的室中来测试颗粒的行为。可以以方便快速的方式研究不同频率下颗粒的行为。该装置和方法可以用于各种目的，包括表征特定颗粒类型的性质，或分析流体中的颗粒群。也可以将颗粒暴露于不同的流体参数，以便在其他感官中扩展测试光谱。

6. 发明申请

WO1997009632A1 METHODS OF ACHIEVING PHASE CONTRAST IN MAGNETIC RESONANCE IMAGING AND A RELATED APPARATUS 审中-公开
标题翻译：在磁共振成像中实现相位对比的方法及相关设备
公开(公告)号：WO1997009632A1
公开(公告)日：1997-03-13
申请号：PCT/GB1996002172
申请日：1996-09-04
申请人： BRITISH TECHNOLOGY GROUP LIMITED , REDPATH, Thomas, William, Tennant , MCKIDDIE, Fergus, Iain , DYMOND, Rosemary, Carmen
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： G01R33/563
CPC分类号： G01R33/565 , G01R33/56509 , G01R33/56563
摘要： The invention relates to a method of obtaining phase information in magnetic resonance imaging (MRI) and employing this information to produce an enhanced image. In the past, magnetic resonance imagers have obtained data which contains phase as well as magnitude information. Often the phase information has been discarded in order to avoid image artefacts, which are usually attributable to motion. The present invention employs a technique in which this phase information is used in order to improve image quality, in an analogous method to that used in optical microscopy.
摘要翻译：本发明涉及一种在磁共振成像（MRI）中获得相位信息并采用该信息产生增强图像的方法。在过去，磁共振成像器已经获得了包含相位和幅度信息的数据。通常相位信息被丢弃以避免图像伪影，这通常归因于运动。本发明采用一种技术，其中使用该相位信息以便以与用于光学显微镜的方法类似的方式来提高图像质量。

7. 发明申请

WO1997007412A1 MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：磁共振成像
公开(公告)号：WO1997007412A1
公开(公告)日：1997-02-27
申请号：PCT/GB1996001901
申请日：1996-08-05
申请人： BRITISH TECHNOLOGY GROUP LIMITED , LURIE, David, John , McCALLUM, Stephen, John , HUTCHISON, James, McDonald, Strachan , ALECCI, Marcello
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： G01R33/34
CPC分类号： G01R33/34076 , G01R33/3642 , G01R33/3678 , G01R33/385
摘要： In a magnetic resonance apparatus for providing an image of a sample a birdcage resonator (12) is provided with its axis parallel to the magnetic field of the apparatus. A radio-frequency source (36) is connected to the resonator (12) so as to generate a magnetic field by a first resonance mode of the resonator and a detector (44, 46) is connected to the resonator (12) so as to detect any signal received by the resonator in its second, orthogonal mode.
摘要翻译：在用于提供样本的图像的磁共振装置中，鸟笼式共振器（12）的轴线平行于装置的磁场。射频源（36）连接到谐振器（12），以通过谐振器的第一谐振模式产生磁场，并且检测器（44,46）连接到谐振器（12），以便在其第二正交模式中检测由谐振器接收的任何信号。

8. 发明申请

WO1996037056A1 OPTICAL COMMUNICATION SYSTEMS MINIMIZING DISPERSION 审中-公开
标题翻译：光通信系统最小化分散
公开(公告)号：WO1996037056A1
公开(公告)日：1996-11-21
申请号：PCT/GB1996001172
申请日：1996-05-16
申请人： BRITISH TECHNOLOGY GROUP LIMITED , DORAN, Nicholas, John , KEAN, Peter, Neil , KNOX, Finlay, MacDonald
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： H04B10/18
CPC分类号： H04B10/2513
摘要： A return-to-zero pulse optical communication system includes fast saturable absorber means (F1, DSF) to provide substantially zero average dispersion in a single amplifier span (SIF, DSF) to reduce the effect of timing jitter and provide considerably enhanced propagation distances.
摘要翻译：归零脉冲光通信系统包括快速可饱和吸收装置（F1，DSF），以在单个放大器跨度（SIF，DSF）中提供基本为零的平均色散，以减少定时抖动的影响并提供显着增强的传播距离。

9. 发明申请

WO1996026453A2 METHOD OF AND APPARATUS FOR NUCLEAR QUADRUPOLE RESONANCE TESTING A SAMPLE, AND PULSE SEQUENCE FOR EXCITING NUCLEAR QUADRUPOLE RESONANCE 审中-公开
标题翻译：用于核子四元共振测试样品的方法和装置以及用于提高核四次谐振的脉冲序列
公开(公告)号：WO1996026453A2
公开(公告)日：1996-08-29
申请号：PCT/GB1996000422
申请日：1996-02-23
申请人： BRITISH TECHNOLOGY GROUP LIMITED , SMITH, John, Alec, Sydney , PEIRSON, Neil, Francis
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： G01R33/44
CPC分类号： G01R33/441
摘要： A method of nuclear quadrupole resonance testing a sample comprising a first type substance containing quadrupolar nuclei and a second type substance which may give rise to spurious signals which interfere with response signals from the quadrupolar nuclei, comprises applying a pulse sequence to the sample to excite nuclear quadrupole resonance, the pulse sequence comprising at least one pair of pulses; detecting response signals; and comparing, for the or each such pair, the respective response signals following the two member pulses of the pair; the pulse sequence being such that the respective spurious signals following the two member pulses can be at least partially cancelled by the comparison without the corresponding true quadrupole resonance signals being completely cancelled; and for the or each such pair, the two member pulses being of like phase.
摘要翻译：核四极共振测试包含含有四极核的第一类物质的样品和可能产生干扰来自四极核的响应信号的寄生信号的第二类物质的方法包括向样品施加脉冲序列以激发核四极共振，所述脉冲序列包括至少一对脉冲; 检测响应信号; 并且对于所述对或每个这样的对，比较所述对中的两个成员脉冲之后的各个响应信号; 脉冲序列使得可以通过比较至少部分地抵消跟随两个成员脉冲的相应杂散信号，而没有相应的真实四极谐振信号被完全消除; 并且对于这些或每个这样的对，两个成员脉冲具有相同的相位。

10. 发明申请

WO1996025440A1 POLYMERIC COMPOUNDS 审中-公开
标题翻译：聚合化合物
公开(公告)号：WO1996025440A1
公开(公告)日：1996-08-22
申请号：PCT/GB1996000356
申请日：1996-02-16
申请人： BRITISH TECHNOLOGY GROUP LIMITED , HIDER, Robert, Charles , GOODWIN, Brian, Leonard
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： C08F08/30
CPC分类号： C08F8/30 , C08F212/08 , C08F212/36 , C08F212/14 , C08F8/44 , C08F8/32
摘要： A polystyrene polymer crosslinked by 1.5 % to 8 % with divinylbenzene based on the total weight of the polymer and having a minimum weight average molecular weight of 10000 wherein 50 to 100 % of the aromatic groups of the polystyrene are substituted by at least one -(R n group wherein R represents a straight or branched chain alkylene or cycloalkylene group of 1 to 6 carbon atoms and n is 0 or 1 and NHR represents a guanidino group of formula -NH-C(=NH)NH2 or a biguanidino group of formula -NH-C(=NH)-NH-C(=NH)-NH2 for use in therapy.
摘要翻译：基于聚合物的总重量与二乙烯基苯交联1.5％至8％的聚苯乙烯聚合物，其最小重均分子量为10000，其中聚苯乙烯的50-100％芳族基团被至少一个 - （其中R 1表示1〜6个碳原子的直链或支链亚烷基或亚环烷基，n为0或1，NHR 2表示胍基，式-NH-C（= NH）NH 2或式-NH-C（= NH）-NH-C（= NH）-NH 2）的双胍基可用于治疗。

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