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31. 发明申请

WO2014033540A3 PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF 审中-公开
公开(公告)号：WO2014033540A3
公开(公告)日：2014-03-06
申请号：PCT/IB2013/002349
申请日：2013-08-28
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , DOSCHAK, Michael , YANG, Yang , BHANDARI, Krishna, Hari
发明人： DOSCHAK, Michael , YANG, Yang , BHANDARI, Krishna, Hari
IPC分类号： C07K14/65 , A61K38/28 , A61P19/08 , C07K14/62 , C07K14/635 , C07K17/08
摘要： Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate de novo bone turnover and stimulate bone fracture repair.

32. 发明申请

WO2013166581A1 SOLID GEL AMPLIFICATION METHOD AND APPARATUS FOR PLATFORM MOLECULAR DIAGNOSTICS 审中-公开
标题翻译：固体凝胶扩增方法和平台分子诊断装置
公开(公告)号：WO2013166581A1
公开(公告)日：2013-11-14
申请号：PCT/CA2013/000162
申请日：2013-02-25
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , MANAGE, Dammika
发明人： MANAGE, Dammika
IPC分类号： C12M1/34 , C12Q1/68 , C40B60/12 , C12M1/38 , C12M1/40 , C12P19/34
CPC分类号： C12Q1/686 , B01L3/502707 , B01L3/50851 , B01L7/52 , B01L9/065 , B01L2200/0673 , B01L2200/0689 , B01L2300/069 , B01L2300/0816 , B01L2300/0838 , B01L2300/12 , C12M21/18 , C12M23/16 , C12M23/20 , C12M43/00 , C12P19/34
摘要： The present invention provides for a novel system and method for amplification and detection of nucleic acids within a miniaturized device wherein sample administration occurs via capillary forces through a channel created by drying a hydrogel containing all components needed for a cell-free, enzymatic, nucleic-acid amplification system other than the template nucleic acid or precursor thereto, and wherein an aqueous sample is provided to the desiccated hydrogel, and the hydrogel is rehydrated, through capillary forces.
摘要翻译：本发明提供了一种用于在小型化装置内扩增和检测核酸的新型系统和方法，其中通过毛细管力通过干燥含有无细胞，酶促，核酸的所有组分的水凝胶产生的通道进行样品施用，除了模板核酸或其前体之外的酸扩增系统，并且其中将水性样品提供给干燥的水凝胶，并且水凝胶通过毛细管力再水合。

33. 发明申请

WO2013044352A1 METHOD OF FABRICATING NANO-TIPS WITH CONTROLLED PROFILE 审中-公开
标题翻译：用控制型材制作纳米薄膜的方法
公开(公告)号：WO2013044352A1
公开(公告)日：2013-04-04
申请号：PCT/CA2012/000878
申请日：2012-09-26
申请人： NATIONAL RESEARCH COUNCIL OF CANADA , THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
发明人： PITTERS, Jason, L. , URBAN, Radovan , WOLKOW, Robert, A.
IPC分类号： B82B3/00 , B82Y15/00 , G01Q70/16 , G01Q80/00 , H01J37/26
CPC分类号： B44C1/227 , B82Y10/00 , B82Y35/00 , G01Q70/16 , H01J2237/2818 , H01J2237/3174 , H01J2237/31749 , Y10S977/888
摘要： A nanotip, is fabricated by modifying a precursor nanotip having an apex and a shank by applying an electric field in the presence of a reactive gas to perform field-assisted etching wherein atoms are preferentially removed from the shank by chemical interaction with the reactive gas, and controlling the reactive gas pressure and/or tip voltage to vary the electric field so as to promote field evaporation of apex atoms during fabrication of the nanotip and thereby control the overall profile of the resulting nanotip. The method permits shaping of the overall tip profile.
摘要翻译：通过在存在反应性气体的情况下施加电场来修饰具有顶点和柄的前体纳米尖端来制造纳米尖端，以进行场辅助蚀刻，其中通过与反应性气体的化学相互作用优先从柄脱除原子，以及控制反应性气体压力和/或尖端电压以改变电场，以便在纳米尖端的制造期间促进顶点原子的场蒸发，从而控制所得到的纳米尖端的整体轮廓。该方法允许对整个末端轮廓进行成形。

34. 发明申请

WO2013023296A1 METHOD OF DIAGNOSING BACTERIAL INFECTIONS USING BACTERIAL GLYCOPROTEINS 审中-公开
标题翻译：使用细菌糖蛋白诊断细菌感染的方法
公开(公告)号：WO2013023296A1
公开(公告)日：2013-02-21
申请号：PCT/CA2012/050549
申请日：2012-08-13
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS-INSTITUTO TECNOLOGICO DE CHASCOMUS CONSEJO DE INVESTIGACIONES CIENTIFICAS Y TECNICAS, UNIVERSIDAD NACIONAL DE SAN MARTIN , FELDMAN, Mario , IWASHKIW, Jeremy , UGALDE, Juan Esteban , CIOCCHINI, Andrés Eduardo , COMERCI, Diego José
发明人： FELDMAN, Mario , IWASHKIW, Jeremy , UGALDE, Juan Esteban , CIOCCHINI, Andrés Eduardo , COMERCI, Diego José
IPC分类号： G01N33/564
CPC分类号： G01N33/56916 , C07K14/205 , G01N33/56911 , G01N2333/23 , G01N2333/245 , G01N2400/00 , Y02A50/52
摘要： The present application provides a method of diagnosing bacterial infections using engineered glycoproteins in an immunoassay. The engineered bacterial glycoproteins used in the immunoassay comprise a bacterial antigen covalently attached to a protein via polysaccharyltransferase (PTase)-mediated glycosylation, wherein the bacterial antigen is selected based on the bacterial infection of interest. Antibodies in a bodily fluid of subjects infected with a bacteria will bind to the engineered glycoprotein, and the resulting binding complexes are detected or quantitated.
摘要翻译：本申请提供了在免疫测定中使用工程糖蛋白诊断细菌感染的方法。在免疫测定中使用的工程化细菌糖蛋白包括通过多糖转移酶（PTase）介导的糖基化共价连接到蛋白质的细菌抗原，其中基于感兴趣的细菌感染选择细菌抗原。感染细菌的受试者的体液中的抗体将与工程化糖蛋白结合，并且检测或定量得到的结合复合物。

35. 发明申请

WO2012139220A1 PRODUCTION OF TECHNETIUM FROM A MOLYBDENUM METAL TARGET 审中-公开
标题翻译：从金属金属目标生产技术
公开(公告)号：WO2012139220A1
公开(公告)日：2012-10-18
申请号：PCT/CA2012/050230
申请日：2012-04-10
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , WILSON, John , GAGNON, Katherine , MCQUARRIE, Stephen
发明人： WILSON, John , GAGNON, Katherine , MCQUARRIE, Stephen
IPC分类号： G21G1/00 , H05H6/00
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0042 , H05H6/00
摘要： Recycling of isotopically enriched molybdenum metal targets that are suitable for the large scale cyclotron production of 99m Tc or 94m Tc includes the charged particle irradiation of an enriched molybdenum metal target to produce a technetium isotope, separation of the technetium isotope following irradiation of the molybdenum, re-claiming the molybdenum metal and reformation of the molybdenum target for a further irradiation step. This process may then be repeated. Separation of the technetium isotope preferably is achieved by oxidative dissolution of the molybdenum thereby removing it from a target support plate, and forming molybdate and pertechnetate. The technetium isotope is isolated by various means, such as the ABEC process. To reuse the molybdenum, additional steps of isolating the molybdate and reducing it back to molybdenum metal are required. The recovered molybdenum metal may then be reformed as a target for example by pressing or pressing and sintering, followed by bonding to a target support plate.
摘要翻译：适用于大规模回旋加速器生产99mTc或94mTc的同位素富集的钼金属靶的回收包括富集的钼金属靶的带电粒子照射以产生锝同位素，在钼照射之后分离锝同位素，要求钼金属和钼靶的再形成用于进一步的照射步骤。然后可以重复该过程。锝同位素的分离优选通过钼的氧化溶解实现，从而将其从靶支撑板除去，并形成钼酸盐和高锝酸盐。锝同位素通过各种方法分离，如ABEC过程。为了重新使用钼，需要额外的步骤来分离钼酸盐并将其还原成钼金属。回收的钼金属可以例如通过压制或压制和烧结作为目标进行重整，接着与目标支撑板结合。

36. 发明申请

WO2012116447A1 USE OF BACTERIAL ENDOTOXINS AND LIPOTEICHOIC ACIDS TO IMPROVE POSTPARTAL HEALTH AND PRODUCTIVITY OF DAIRY COWS AND THEIR NEWBORNS 审中-公开
标题翻译：使用细菌内毒素和LIPOTEICHOIC酸提高乳制品的营养健康和生产力及其新生儿
公开(公告)号：WO2012116447A1
公开(公告)日：2012-09-07
申请号：PCT/CA2012/050120
申请日：2012-02-29
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , AMETAJ, Burim N.
发明人： AMETAJ, Burim N.
IPC分类号： A61K31/739 , A61K31/7032 , A61K35/74 , A61P3/00 , A61P31/04 , C07H15/06 , C08B37/00 , C08L5/00
CPC分类号： A61K39/0258 , A61K31/715 , A61K31/739 , A61K38/164 , A61K39/07 , A61K2039/552 , A61K2039/70 , A61K2300/00
摘要： A combination of a bacterial endotoxin, in particular a lipopolysaccharide, and a lipoteichoic acid for treating or preventing a metabolic disorder or bacterial infection, or for improving milk energy efficiency in a subject. The combination may be administered separately, simultaneously or sequentially to a subject.
摘要翻译：细菌内毒素，特别是脂多糖和用于治疗或预防代谢紊乱或细菌感染的脂磷壁酸或用于改善受试者的乳能量效率的组合。组合可以单独地，同时地或顺序施用于受试者。

37. 发明申请

WO2012106799A1 PIEZORESISTIVE LOAD SENSOR 审中-公开
标题翻译： PIEZORESISTIVE负载传感器
公开(公告)号：WO2012106799A1
公开(公告)日：2012-08-16
申请号：PCT/CA2012/000096
申请日：2012-02-07
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , BENFIELD, David , MOUSSA, Walied Ahmed Mohamed
发明人： BENFIELD, David , MOUSSA, Walied Ahmed Mohamed
IPC分类号： G01L5/16 , G01L1/18
CPC分类号： G01L5/162 , G01L1/18
摘要： A three-axis load sensor utilizing four piezoresistive devices on a flexible silicon membrane is provided. The load sensor further includes a mesa disposed on the membrane substantially equidistant from the piezoresistive devices. A six-axis load cell is provided by placing a plurality of load sensors disposed on a substrate, the substrate configured to attach to an object wherein forces applied to the object can be measured and/or determined. The load sensors can be manufactured using bulk microfabrication techniques on a single crystal silicon wafer, and can detect normal and shear loading applied to the membrane.
摘要翻译：提供了一种在柔性硅膜上利用四个压阻器件的三轴负载传感器。负载传感器还包括设置在基本上等距离压阻器件的膜上的台面。通过放置布置在基板上的多个负载传感器来提供六轴称重传感器，所述基板被构造成附接到物体，其中可以测量和/或确定施加到物体的力。负载传感器可以使用单晶硅晶片上的大量微加工技术制造，并且可以检测施加到膜上的正常和剪切负载。

38. 发明申请

WO2012097451A1 LEUKOCYTE ACTIVATION AND METHODS OF USE THEREOF 审中-公开
标题翻译：低密度脂蛋白激活及其使用方法
公开(公告)号：WO2012097451A1
公开(公告)日：2012-07-26
申请号：PCT/CA2012/000068
申请日：2012-01-23
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , GOMEZ-LOPEZ, Nardhy , OLSON, David
发明人： GOMEZ-LOPEZ, Nardhy , OLSON, David
IPC分类号： C12Q1/02 , C12Q1/68 , G01N33/48 , G01N33/53 , G01N33/68
CPC分类号： G01N33/5047 , C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2800/368
摘要： Described herein are compositions, methods and/or kits for determining the likelihood of a pregnant subject delivering at term, or developing a disorder associated with pregnancy. These compositions, methods and/or kits feature the measurement of the chemotactic activity of peripheral leukocytes, the measurement of ccl2 mRNA expression or the measurement of Fp or Otr protein expression.
摘要翻译：本文描述了用于确定怀孕受试者在术中递送或发展与怀孕相关的障碍的可能性的组合物，方法和/或试剂盒。这些组合物，方法和/或试剂盒测量外周白细胞的趋化活性，测量ccl2 mRNA表达或测量Fp或Otr蛋白表达。

39. 发明申请

WO2012009798A1 MOLECULAR DIAGNOSIS OF ANTIBODY MEDIATED REJECTION 审中-公开
标题翻译：抗体介导的抗体的分子诊断
公开(公告)号：WO2012009798A1
公开(公告)日：2012-01-26
申请号：PCT/CA2011/000839
申请日：2011-07-21
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , HALLORAN, Philip F.
发明人： HALLORAN, Philip F.
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/48 , G01N33/68
CPC分类号： G01N33/6893 , G01N2800/245
摘要： This document relates to methods and materials involved in assessing antibody mediated rejection of tissues (e.g., transplanted organs) in mammals.
摘要翻译：本文件涉及参与评估哺乳动物中抗体介导的组织（例如移植器官）排斥的方法和材料。

40. 发明申请

WO2012000102A1 APPARATUS AND METHOD FOR MICROSCOPE-BASED LABEL-FREE MICROFLUTDIC CYTOMETRY 审中-公开
标题翻译：用于基于微阵列的无标签MICROFLUTDIC CYTOMETRY的装置和方法
公开(公告)号：WO2012000102A1
公开(公告)日：2012-01-05
申请号：PCT/CA2011/000775
申请日：2011-06-30
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , TSUI, Ying, Yin , SU, Xuantao
发明人： TSUI, Ying, Yin , SU, Xuantao
IPC分类号： G01N15/14
CPC分类号： G01N15/1484 , G01N15/1468 , G01N15/1475
摘要： An apparatus and method is provided for a microscope-based label-free microfluidic cytometry device. The device was developed to obtain two dimensional scattered light patterns from single cells or particles passing through a channel in a microfluidic chip without having a label attached to the cells or particles, where analysis of the scattered light pattern can determine information such as cell or particle size, orientation and inner nanostructure. The device can obtain light scattering patterns from the smallest mature human blood cells (platelets) and large cells (CFU-GM and cord blood CD34+ cells).
摘要翻译：提供了一种用于基于显微镜的无标记微流体细胞计数装置的装置和方法。该装置被开发以从单个细胞或通过微流控芯片中的通道的颗粒获得二维散射光图案，而不附加到细胞或颗粒的标记，其中散射光图案的分析可以确定诸如细胞或颗粒的信息尺寸，取向和内部纳米结构。该装置可以从最小的成熟人血细胞（血小板）和大细胞（CFU-GM和脐带血CD34 +细胞）获得光散射图。

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