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31. 发明申请

WO2003040147A1 AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：用于治疗疾病的亚甲基替代替代化合物
公开(公告)号：WO2003040147A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/033618
申请日：2002-11-06
申请人： PHARMACIA & UPJOHN COMPANY , PIOTROWSKI, David, W. , MYERS, Jason, K. , ROGERS, Bruce, N. , JACOBSEN, E., Jon , BODNAR, Alice, L. , GROPPI, Vincent, E., Jr. , WALKER, Daniel, P. , ACKER, Brad, A.
发明人： PIOTROWSKI, David, W. , MYERS, Jason, K. , ROGERS, Bruce, N. , JACOBSEN, E., Jon , BODNAR, Alice, L. , GROPPI, Vincent, E., Jr. , WALKER, Daniel, P. , ACKER, Brad, A.
IPC分类号： C07D487/08
CPC分类号： C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/08 , C07D487/08
摘要： The invention provides compounds of Formula (I): Azabicyclo-N(R 1 )-C(=X)-W These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula (I) are useful in pharmaceuticals in which α7 is known to be involved.
摘要翻译：本发明提供式（I）化合物：氮杂双环-N（R 1）-C（= X）-W。这些化合物可以是药物盐或组合物，外消旋混合物或其纯对映体的形式。式（I）的化合物可用于已知其中涉及α7的药物。

32. 发明申请

WO2007135529A3 AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS 审中-公开
公开(公告)号：WO2007135529A3
公开(公告)日：2007-11-29
申请号：PCT/IB2007/001293
申请日：2007-05-11
申请人： PFIZER PRODUCTS INC. , BERKE, Helen , DUPLANTIER, Allen, Jacob , EFREMOV, Ivan Viktorovich , MCHARDY, Stanton, Furst , QIAN, Weimin , ROGERS, Bruce, Nelson , ZHAN, Lei , ZHANG, Qian
发明人： BERKE, Helen , DUPLANTIER, Allen, Jacob , EFREMOV, Ivan Viktorovich , MCHARDY, Stanton, Furst , QIAN, Weimin , ROGERS, Bruce, Nelson , ZHAN, Lei , ZHANG, Qian
IPC分类号： C07D471/04 , C07D471/14 , C07D471/18 , A61K31/437 , A61K31/4745 , A61P25/00
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R 17 , R 2 , X 4 , X 9 , X 5 , X 6 , R 8 , X 2 , Y 1 and n are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

33. 发明申请

WO2007135529A2 AZABENZIMIDAZOLYL COMPOUNDS 审中-公开
标题翻译： AZABENZIMIDAZOLYL化合物
公开(公告)号：WO2007135529A2
公开(公告)日：2007-11-29
申请号：PCT/IB2007001293
申请日：2007-05-11
申请人： PFIZER PROD INC , BERKE HELEN , DUPLANTIER ALLEN JACOB , EFREMOV IVAN VIKTOROVICH , MCHARDY STANTON FURST , QIAN WEIMIN , ROGERS BRUCE NELSON , ZHAN LEI , ZHANG QIAN
发明人： BERKE HELEN , DUPLANTIER ALLEN JACOB , EFREMOV IVAN VIKTOROVICH , MCHARDY STANTON FURST , QIAN WEIMIN , ROGERS BRUCE NELSON , ZHAN LEI , ZHANG QIAN
CPC分类号： C07D471/04 , C07D471/14 , C07D471/18
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R 17 , R 2 , X 4 , X 9 , X 5 , X 6 , R 8 , X 2 , Y 1 and n are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式（I）的结构：或其药学上可接受的盐，其中R 17，R 2，，X 4，X 9，X 5，X 6，R 8，，X 2，Y 1和n如本发明的详细描述中所定义。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

34. 发明申请

WO2007135527A3 BENZIMIDAZOLYL COMPOUNDS 审中-公开
公开(公告)号：WO2007135527A3
公开(公告)日：2007-11-29
申请号：PCT/IB2007/001290
申请日：2007-05-14
申请人： PFIZER PRODUCTS INC. , BERKE, Helen , DUPLANTIER, Allen, Jacob , EFREMOV, Ivan , MCHARDY, Stanton, Furst , ROGERS, Bruce, Nelsen , QIAN, Weimin , ZHANG, Lei , ZHANG, Qian
发明人： BERKE, Helen , DUPLANTIER, Allen, Jacob , EFREMOV, Ivan , MCHARDY, Stanton, Furst , ROGERS, Bruce, Nelsen , QIAN, Weimin , ZHANG, Lei , ZHANG, Qian
IPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D417/06 , A61K31/4184 , A61K31/4745 , A61P25/00 , A61P9/00
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of formula (I): or pharmaceutically acceptable salts thereof. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

35. 发明申请

WO2006051413A8 AZABENOXAZOLES FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS病症的AZABENOXAZOLES
公开(公告)号：WO2006051413A8
公开(公告)日：2007-06-07
申请号：PCT/IB2005003427
申请日：2005-11-04
申请人： PFIZER , DUPLANTIER ALLEN JACOB , O'DONNELL CHRISTOPHER JOHN , ROGERS BRUCE NELSEN , ZHANG LEI
发明人： DUPLANTIER ALLEN JACOB , O'DONNELL CHRISTOPHER JOHN , ROGERS BRUCE NELSEN , ZHANG LEI
IPC分类号： C07D471/08 , A61K31/551 , A61P25/00 , C07D519/00
CPC分类号： C07D471/08
摘要： The present invention relates to a7 nicotinic receptor agonists of formula I as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an a7 nicotinic receptor agonist of formula I. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant a7 nicotinic receptor agonist of formula (I).
摘要翻译：本发明涉及本文所述的式I的烟碱型受体激动剂和通过向哺乳动物施用a7烟碱样受体来治疗哺乳动物（包括人）中的中枢神经系统（CNS）和其它疾病的疾病的方法其还涉及含有药学上可接受的载体和式（I）的CNS渗透剂α7烟碱受体激动剂的药物组合物。

36. 发明申请

WO2005084343A3 METHOD OF CHARGING A BATTERY 审中-公开
标题翻译：充电方法
公开(公告)号：WO2005084343A3
公开(公告)日：2007-04-19
申请号：PCT/US2005006781
申请日：2005-03-02
申请人： GALAXY POWER INC , ARNOLD EDWARD H , ROGERS BRUCE J
发明人： ARNOLD EDWARD H , ROGERS BRUCE J
IPC分类号： H02J7/00
CPC分类号： H02J7/0077
摘要： A method of charging a battery having an internal resistance and an external resistance connected to the battery includes applying electrical energy to the battery. The method also includes adjusting, at a plurality of predetermined intervals, the electrical energy applied to the battery based on at least one of the internal resistance of the battery and the external resistance connected to the battery.
摘要翻译：对具有连接到电池的内部电阻和外部电阻的电池进行充电的方法包括向电池施加电能。该方法还包括基于电池的内部电阻和连接到电池的外部电阻中的至少一个，以多个预定间隔调整施加到电池的电能。

37. 发明申请

WO2006051410A1 AZABENZOXAZOLES FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS病症的AZABENZOXAZOLES
公开(公告)号：WO2006051410A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003394
申请日：2005-11-04
申请人： PFIZER INC. , BELYANKIN, Andrei, V. , DUPLANTIER, Allen, Jacob , ZHANG, Lei , O'DONNELL, Christopher, John , ROGERS, Bruce, Nelsen , VINCENT, Lawrence, Albert , SVIRIDOV, Sergey, I.
发明人： BELYANKIN, Andrei, V. , DUPLANTIER, Allen, Jacob , ZHANG, Lei , O'DONNELL, Christopher, John , ROGERS, Bruce, Nelsen , VINCENT, Lawrence, Albert , SVIRIDOV, Sergey, I.
IPC分类号： C07D519/00 , A61K31/4995 , A61P3/04 , A61P9/10 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/16 , A61P25/18 , A61P25/28 , A61P35/00
CPC分类号： C07D519/00
摘要： The present invention relates to a7 nicotinic receptor agonists of formula (la) or (lb) as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an a7 nicotinic receptor agonist of formula (la) or (lb). It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant a7nicotinic receptor agonist of formula (la) or (lb).
摘要翻译：本发明涉及本文所述的式（Ia）或（Ib）的烟碱型受体激动剂，以及涉及通过施用以下方法治疗哺乳动物（包括人）的中枢神经系统（CNS）和其它疾病的疾病的方法哺乳动物是式（Ia）或（1b）的a7烟碱受体激动剂。它还涉及含有药学上可接受的载体和式（Ia）或（Ib）的CNS-渗透剂a7烟酰受体激动剂的药物组合物。

38. 发明申请

WO2004066778A2 HAIR HOLDING DEVICE WITH ELASTIC CLOSURE OPERATION 审中-公开
标题翻译：具有弹性封闭操作的头发保持装置
公开(公告)号：WO2004066778A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/001763
申请日：2004-01-23
申请人： ROGERS, Bruce, A.
发明人： ROGERS, Bruce, A.
IPC分类号： A45D
CPC分类号： A45D8/22
摘要： Novel hair holding devices having first and second pivotally connected body members including hair gripping portions, and methods for improving existing such hair holding devices, in which the improvement involves providing the first and second body members with at least one elastomeric member for biasing the first and second body members into a closed position and for conforming to gathered strands of a user's hair when the hair gripping portions come into contact with gathered strands of a user's hair.
摘要翻译：具有包括头发夹持部分的第一和第二枢转连接的身体构件的新型头发保持装置以及用于改进现有这种头发夹持装置的方法，其中改进包括为第一和第二主体构件提供至少一个弹性构件，用于偏置第一和第二身体构件进入关闭位置并且当头发夹持部分与使用者头发的聚集的股线接触时，用于与使用者的头发的聚集的股线一致。

39. 发明申请

WO2004066777A2 ADJUSTABLE HAIR HOLDING DEVICE 审中-公开
标题翻译：可调节头发保持装置
公开(公告)号：WO2004066777A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/001761
申请日：2004-01-23
申请人： ROGERS, Bruce, A. , LIVINGSTON, David
发明人： ROGERS, Bruce, A. , LIVINGSTON, David
IPC分类号： A45D
CPC分类号： A45D8/22
摘要： A hair holding device including hingedly connected first and second body members each including hair gripping portions adapted to be squeezed by a user whereby the hair gripping portions come into contact with gathered strands of a user's hair. The device further includes a friction-type adjustment mechanism coaxially arranged with respect to the hinge for causing the hair gripping portions to remain at a point at which the hair gripping portions are squeezed together by a user. Optionally, the device may include squeezable release handles or other release mechanism, as well as a torsion spring for biasing the hair gripping portions into either an open or a closed position.
摘要翻译：一种头发保持装置，包括铰接地连接的第一和第二主体部件，每个主体部件包括适于被使用者挤压的头发夹持部分，由此毛发夹持部分与用户头发的聚集的股线接触。该装置还包括相对于铰链同轴布置的摩擦式调节机构，用于使头发夹持部分保持在使用者将头发夹持部分挤压在一起的点处。可选地，该装置可以包括可挤压释放手柄或其它释放机构，以及用于将头发夹持部分偏压到打开或关闭位置的扭转弹簧。

40. 发明申请

WO2004039815A3 COMPOUNDS HAVING BOTH ALPHA7 NACHR AGONIST AND ANTAGONIST ACTIVITY FOR TREATMENT OF CNS DISEASES 审中-公开
标题翻译：具有两种ALPHA7 NACHR激动剂的化合物和用于治疗CNS疾病的拮抗剂活性
公开(公告)号：WO2004039815A3
公开(公告)日：2004-07-22
申请号：PCT/IB0304681
申请日：2003-10-20
申请人： UPJOHN CO , WONG ERIK HO FONG , CORTES-BURGOS LUZ AMPARO , ROGERS BRUCE NELSEN , PIOTROWSKI DAVID WALTER , WALKER DANIEL PATRICK , JACOBSEN ERIC JON , WISHKA DONN GREGORY , ACKER BRAD ALAN
发明人： WONG ERIK HO FONG , CORTES-BURGOS LUZ AMPARO , ROGERS BRUCE NELSEN , PIOTROWSKI DAVID WALTER , WALKER DANIEL PATRICK , JACOBSEN ERIC JON , WISHKA DONN GREGORY , ACKER BRAD ALAN
IPC分类号： C07D453/02 , C07D487/08 , C07D519/00 , A61K31/439
CPC分类号： C07D487/08 , C07D453/02 , Y02P20/55
摘要： The invention discloses compounds that are selective alpha7 nAChR agonists and 5-HT3 antagonists. The compounds are useful for treating many CNS diseases. The compounds have the following Formula (I): Azabicyclo-N(H)-C(=O)-W wherein Azabicyclo is Formula (2) each R1 is independently H, alkyl, or substituted alkyl; R2 is H, alkyl, or substituted alkyl; k is 1 or 2, provided that one R2 is other than H when k is 2; R3 is H, alkyl, or an amino protecting group; W is Formula (3); W is CH or N; W is O, N(R4), N(C(O)R4), or S; W is O, N(R4), N(C(O)R4), or S; R is H, F, Cl, Br, I, alkyl, substituted alkyl, or alkynyl; Alkyl is both straight- and branched-chain moieties having from 1-6 carbon atoms.
摘要翻译：本发明公开了选择性α7nAChR激动剂和5-HT3拮抗剂的化合物。该化合物可用于治疗许多CNS疾病。化合物具有下式（I）：氮杂双环-N（H）-C（= O）-W 0，其中，氮杂双环是式（2），每个R 1独立地是H，烷基或取代的烷基; R2是H，烷基或取代的烷基; k为1或2，条件是当k为2时，一个R2不为H; R3是H，烷基或氨基保护基; W 0是式（3）; W是CH或N; W 1是O，N（R 4），N（C（O）R 4）或S; W 2是O，N（R 4），N（C（O）R 4）或S; R是H，F，Cl，Br，I，烷基，取代的烷基或炔基; 烷基是具有1-6个碳原子的直链和支链部分。

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