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1. 发明申请

WO2012142529A2 CLONAL STRAINS OF ATTENUATED VACCINIA VIRUSES AND METHODS OF USE THEREOF 审中-公开
标题翻译：衰老疫苗病毒的克隆菌株及其使用方法
公开(公告)号：WO2012142529A2
公开(公告)日：2012-10-18
申请号：PCT/US2012/033684
申请日：2012-04-13
申请人： GENELUX CORPORATION , SZALAY, Aladar, A. , CHEN, Nanhai, George , YU, Yong, A. , ZHANG, Qian
发明人： SZALAY, Aladar, A. , CHEN, Nanhai, George , YU, Yong, A. , ZHANG, Qian
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/768 , C07K16/22 , C07K2317/622 , C12N2710/24121 , C12N2710/24132 , C12N2710/24143
摘要： Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations, Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
摘要翻译：提供了痘苗病毒的克隆菌株。还提供了鉴定和分离来自病毒制剂的减毒和溶瘤克隆菌株的方法，还提供了克隆菌株的修饰重组形式。克隆菌株和病毒制剂可用于诊断和治疗方法，特别是用于治疗和诊断或监测治疗增殖性疾病，包括肿瘤性疾病，例如但不限于实体瘤和血癌。

2. 发明申请

WO2011120333A1 TRANSMITTING AND/OR RECEIVING DATA IN SIDE CHANNEL 审中-公开
标题翻译：发送和/或接收边界信息中的数据
公开(公告)号：WO2011120333A1
公开(公告)日：2011-10-06
申请号：PCT/CN2011/000543
申请日：2011-03-30
申请人： THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY , WU, Kaishun , ZHANG, Qian , NI, Lionel
发明人： WU, Kaishun , ZHANG, Qian , NI, Lionel
IPC分类号： H04W4/20 , H01Q5/00
CPC分类号： H04B14/026 , H04B14/02 , H04J3/1676
摘要： Systems, methods, and apparatus are described that employ specially designed interference patterns to build an in-band side channel without degrading the effective throughput of the main channel. A first device (100) includes a control component (130) that generates control information and an interference component (140) that transmits the control information (450) through emission of patterned interference data concurrently while other users are transmitting other data (420). A second device (300) receives the patterned interference data and the other data via a single antenna (350) and decodes the patterned interference data to extract the control data (450). The first device (100) transmits the other data (420) on a side channel (440) that resides in the same spectrum as the main channel (410) in which the other data (420) is emitted. The first device (100) encodes the interference patterns such that the control data (450) can be safely transmitted and extracted without effecting other data transmission. In one aspect, devices (100, 200, 300) can employ a dynamic cooperation multi-access channel (DC-MAC) protocol (1510) to schedule transmission of the other data (420) on the main channel (410), and to employ the side channel (440) for control and coordination.
摘要翻译：描述了使用专门设计的干扰模式来构建带内侧信道而不降低主信道的有效吞吐量的系统，方法和装置。第一设备（100）包括产生控制信息的控制组件（130）和通过在其他用户正在发送其他数据的同时发射图案化干扰数据来发送控制信息（450）的干扰组件（140）（420）。第二设备（300）经由单个天线（350）接收图案化的干扰数据和其它数据，并解码图案化的干扰数据以提取控制数据（450）。第一设备（100）在与发送其他数据（420）的主信道（410）在同一频谱中的侧信道（440）上发送其他数据（420）。第一设备（100）对干扰图案进行编码，使得可以安全地传输和提取控制数据（450）而不影响其他数据传输。在一个方面，设备（100,200,300）可以采用动态协作多接入信道（DC-MAC）协议（1510）来调度主信道（410）上的其他数据（420）的传输，并且使用侧信道（440）进行控制和协调。

3. 发明申请

WO2011018258A3 COSMETIC COMPOSITIONS WITH GOLD PARTICLES AND ALKYL ACID MONOETHANOLAMIDES 审中-公开
标题翻译：具有金颗粒和烷基酸单硬脂酸酯的化妆品组合物
公开(公告)号：WO2011018258A3
公开(公告)日：2011-04-07
申请号：PCT/EP2010058587
申请日：2010-06-17
申请人： UNILEVER PLC , UNILEVER NV , UNILEVER HINDUSTAN , ANG ENDANG SARASWATI ANGKA , WU JI WEI , ZHANG QIAN
发明人： ANG ENDANG SARASWATI ANGKA , WU JI WEI , ZHANG QIAN
IPC分类号： A61K8/19 , A61K8/42 , A61Q1/00 , A61Q1/02
CPC分类号： A61K8/19 , A61K8/42 , A61K2800/412 , A61Q1/02
摘要： A cosmetic composition is provided which includes from 0.00001 to 0.05% of gold particles, from 0.05 to 10% by weight of an alkanolamide having a formula RCONHCH2CH2OH wherein the R radical ranges from C1 to C3, and a cosmetically acceptable carrier. Relatively small amounts of gold particles can achieve soft focus effects by the presence of a benefit enhancing agent such as a low molecular weight alkanolamide.
摘要翻译：提供了一种化妆品组合物，其包含0.00001至0.05％的金颗粒，0.05至10重量％的具有式RCONHCH2CH2OH的链烷醇酰胺，其中R基团的范围为C1至C3，以及化妆品可接受的载体。相对少量的金颗粒可以通过存在有益增强剂如低分子量链烷醇酰胺来实现软焦点效应。

4. 发明申请

WO2008156655A9 MICROORGANISMS FOR IMAGING AND/OR TREATMENT OF TUMORS 审中-公开
标题翻译：用于成像和/或治疗肿瘤的微生物
公开(公告)号：WO2008156655A9
公开(公告)日：2009-03-19
申请号：PCT/US2008007377
申请日：2008-06-13
申请人： GENELUX CORP , SLOAN KETTERING INST CANCER , FONG YUMAN , CHEN NANHAI , ZHANG QIAN , YU YONG A , SZALAY ALADAR A
发明人： FONG YUMAN , CHEN NANHAI , ZHANG QIAN , YU YONG A , SZALAY ALADAR A
IPC分类号： C07K14/00
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译：提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。提供含有病毒的疫苗。病毒也可用于诊断方法，如肿瘤的检测和成像。病毒也可以用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。

5. 发明申请

WO2008156655A2 MICROORGANISMS FOR IMAGING AND/OR TREATMENT OF TUMORS 审中-公开
标题翻译：用于成像和/或治疗肿瘤的微生物
公开(公告)号：WO2008156655A2
公开(公告)日：2008-12-24
申请号：PCT/US2008007377
申请日：2008-06-13
申请人： GENELUX CORP , SLOAN KETTERING INST CANCER , FONG YUMAN , CHEN NANHAI , ZHANG QIAN , YU YONG A , SZALAY ALADAR A
发明人： FONG YUMAN , CHEN NANHAI , ZHANG QIAN , YU YONG A , SZALAY ALADAR A
IPC分类号： C07K14/00
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译：提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。提供含有病毒的疫苗。病毒也可用于诊断方法，如肿瘤的检测和成像。病毒也可以用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。

6. 发明申请

WO2008012622A3 AZABENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR 审中-公开
标题翻译：作为谷氨酸受体的MGLUR2亚型的电位的AZABENZIMIDAZOLYL化合物
公开(公告)号：WO2008012622A3
公开(公告)日：2008-04-03
申请号：PCT/IB2007002030
申请日：2007-07-13
申请人： PFIZER PROD INC , EFREMOV IVAN VIKTOROVICH , ROGERS BRUCE NELSEN , DUPLANTIER ALLEN JACOB , ZHANG LEI , ZHANG QIAN , MAKLAD NOHA SEROUR
发明人： EFREMOV IVAN VIKTOROVICH , ROGERS BRUCE NELSEN , DUPLANTIER ALLEN JACOB , ZHANG LEI , ZHANG QIAN , MAKLAD NOHA SEROUR
IPC分类号： C07D471/04 , A61K31/4523 , A61P25/00 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中化合物具有如说明书中定义的式（I）的结构。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

7. 发明申请

WO2007051081B1 METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS 审中-公开
标题翻译：制备CC-1065类似物的方法和化合物
公开(公告)号：WO2007051081B1
公开(公告)日：2007-07-19
申请号：PCT/US2006060050
申请日：2006-10-18
申请人： MEDAREX INC , GANGWAR SANJEEV , ZHANG QIAN
发明人： GANGWAR SANJEEV , ZHANG QIAN
IPC分类号： C07D209/60 , C07D403/12
CPC分类号： C07D209/60 , C07D403/12 , Y02P20/55
摘要： A method of forming a CBI CC- 1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.
摘要翻译：形成CBI CC-1065类似物的方法利用NH 2作为原料，其中R 3为H或烷基且R 6为H，取代或未取代的低级烷基，氰基或烷氧基。中间体（I）被使用并被要求保护。

8. 发明申请

WO2007051081A8 METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS 审中-公开
公开(公告)号：WO2007051081A8
公开(公告)日：2007-05-03
申请号：PCT/US2006/060050
申请日：2006-10-18
申请人： MEDAREX, INC. , GANGWAR, Sanjeev , ZHANG, Qian
发明人： GANGWAR, Sanjeev , ZHANG, Qian
IPC分类号： C07D209/60 , C07D403/12
摘要： A method of forming a CBI CC- 1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.

9. 发明申请

WO2007051081A1 METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS 审中-公开
标题翻译：制备CC-1065模拟物的方法和化合物
公开(公告)号：WO2007051081A1
公开(公告)日：2007-05-03
申请号：PCT/US2006060050
申请日：2006-10-18
申请人： MEDAREX INC , GANGWAR SANJEEV , ZHANG QIAN
发明人： GANGWAR SANJEEV , ZHANG QIAN
IPC分类号： C07D209/60 , C07D403/12
CPC分类号： C07D209/60 , C07D403/12 , Y02P20/55
摘要： A method of forming a CBI CC- 1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.
摘要翻译：形成CBI CC-1065类似物的方法利用NH 2作为起始原料，其中R3是H或烷基，R6是H，取代或未取代的低级烷基，氰基或烷氧基。中间体（I）被使用并被要求保护。

10. 发明申请

WO2005047458A3 MODIFIED RECOMBINANT VACCINA VIRUSES AND OTHER MICROORGANISMS, USES THEREOF 审中-公开
公开(公告)号：WO2005047458A3
公开(公告)日：2005-05-26
申请号：PCT/US2004/019866
申请日：2004-06-18
申请人： GENELUX CORPORATION , SZALAY, Aladar, A. , TIMIRYASOVA, Tatyana , YU, Yong, A. , ZHANG, Qian
发明人： SZALAY, Aladar, A. , TIMIRYASOVA, Tatyana , YU, Yong, A. , ZHANG, Qian
IPC分类号： C12N7/04
摘要： Recombinant vaccinia viruses useful as tumor-specific delivery vehicle for cancer gene therapy and vaccination Therapeutic methods and microorganisms therefore are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisme. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating tissues, particularly tumors, to produce selected proteins and other products.. Methods for making tumor specific antibodies and also methods of making gene products encoded by the microorganism as well as antibodies reactive therewith are provided.

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