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1. 发明申请

WO2007105053A3 TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR 审中-公开
标题翻译： H-3受体的四氢萘酮拮抗剂
公开(公告)号：WO2007105053A3
公开(公告)日：2007-12-06
申请号：PCT/IB2007000536
申请日：2007-03-01
申请人： PFIZER PROD INC , MCHARDY STANTON FURST , PARIKH VINOD DIPAK
发明人： MCHARDY STANTON FURST , PARIKH VINOD DIPAK
IPC分类号： C07D401/08 , A61K31/40 , A61K31/4025 , A61K31/4427 , A61P11/00 , C07D207/06 , C07D403/08 , C07D405/08 , C07D409/08 , C07D413/08
CPC分类号： C07D207/06 , C07D401/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
摘要： This invention is directed to a compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula (I) a process of preparation of a compound of formula (I), a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit hyperactivity disorder (ADHD), psychotic disorders, cognitive disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy- induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the Gl tract, hyper and hypo motility and acidic secretion of the gastro- intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above.
摘要翻译：本发明涉及如本文所定义的式（I）化合物或其药学上可接受的盐; 含有式（I）化合物的药物组合物，制备式（I）化合物的方法，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向哺乳动物需要这种治疗的如上所述的式（I）化合物，以及治疗选自抑郁症，心境障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷多动障碍（ADHD），精神障碍，认知障碍，睡眠障碍，肥胖症，头晕，癫痫，晕动病，呼吸系统疾病，变态反应，过敏引起的气道反应，变应性鼻炎，鼻充血，过敏性充血，充血，低血压，心血管疾病，胃肠道的过度和低运动性以及酸性分泌的方法，所述方法包括向哺乳动物给药需要这种治疗的患者需要如上所述的式（I）化合物。

2. 发明申请

WO2004089908A2 3-AZABICYCLO[3.2.1]OCTANE DERIVATIVES 审中-公开
标题翻译： 3-氮杂环庚三烯并[3.2.1]辛烷衍生物
公开(公告)号：WO2004089908A2
公开(公告)日：2004-10-21
申请号：PCT/IB2004/001189
申请日：2004-04-02
申请人： PFIZER PRODUCTS INC. , COE, Jotham, Wadsworth , MCHARDY, Stanton, Furst , BASHORE, Crystal, Gayle
发明人： COE, Jotham, Wadsworth , MCHARDY, Stanton, Furst , BASHORE, Crystal, Gayle
IPC分类号： C07D221/00
CPC分类号： C07D401/06 , C07D221/24 , C07D405/06 , C07D409/06 , C07D417/06
摘要： The subject invention relates to 3-azabicyclo[3.2.1]octane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject invention also particularly relates to using such derivatives to treat certain disorders and conditions, for example irritable bowel syndrome, drug addiction, depression, anxiety, schizophrenia and eating disorders, among others.
摘要翻译：本发明涉及3-氮杂双环[3.2.1]辛烷衍生物，包含此类衍生物的药物组合物以及使用这些衍生物治疗由阿片受体介导的疾病状态，病症和病症的方法。本发明还特别涉及使用这样的衍生物治疗某些病症和病症，例如肠易激综合征，药物成瘾，抑郁症，焦虑症，精神分裂症和进食障碍等。

3. 发明申请

WO2005018670A1 PHARMACEUTICAL COMPOSITION COMPRISING AN ALPHA2DELTA LIGAND AND AN OPIOID RECEPTOR ANTAGONIST FOR THE PREVENTION AND TREATMENT OF ADDICTION IN A MAMMAL 审中-公开
标题翻译：包含ALPHA2DELTA配偶和用于预防和治疗哺乳动物的阿片受体拮抗剂的药物组合物
公开(公告)号：WO2005018670A1
公开(公告)日：2005-03-03
申请号：PCT/IB2004/002602
申请日：2004-08-09
申请人： PFIZER PRODUCTS INC. , COE, Jotham, Wadsworth , IREDALE, Philip, Andrew , MCHARDY, Stanton, Furst , MCLEAN, Stafford
发明人： COE, Jotham, Wadsworth , IREDALE, Philip, Andrew , MCHARDY, Stanton, Furst , MCLEAN, Stafford
IPC分类号： A61K45/00
CPC分类号： A61K45/06 , A61K31/18 , A61K31/197 , A61K31/33 , A61K31/407 , A61K31/4745 , A61K2300/00
摘要： Pharmaceutical compositions are disclosed for the treatment of alcohol or cocaine dependence or addiction, tobacco dependence or addiction, reduction of alcohol withdrawal symptoms or aiding in the cessation or lessening of alcohol use or substance abuse or other behavioral dependencies including gambling. The pharmaceutical compositions are comprised of a therapeutically effective combination of an opioid receptor antagonist and an alpha2delta ligand and a pharmaceutically acceptable carrier. The use of these compounds is also disclosed.
摘要翻译：公开了药物组合物用于治疗酒精或可卡因依赖或成瘾，烟草依赖或成瘾，减少酒精戒断症状或帮助停止或减轻酒精使用或药物滥用或其他行为依赖性，包括赌博。药物组合物由阿片受体拮抗剂和α2delta配体和药学上可接受的载体的治疗有效组合组成。还公开了这些化合物的用途。

4. 发明申请

WO2004089908A3 3-AZABICYCLO[3.2.1]OCTANE DERIVATIVES 审中-公开
标题翻译： 3-AZABICYCLO [3.2.1] OCTANE DERIVATIVES
公开(公告)号：WO2004089908A3
公开(公告)日：2004-12-23
申请号：PCT/IB2004001189
申请日：2004-04-02
申请人： PFIZER PROD INC , COE JOTHAM WADSWORTH , MCHARDY STANTON FURST , BASHORE CRYSTAL GAYLE
发明人： COE JOTHAM WADSWORTH , MCHARDY STANTON FURST , BASHORE CRYSTAL GAYLE
IPC分类号： A61K31/46 , A61K31/55 , A61P25/04 , A61P25/32 , C07D221/24 , C07D401/06 , C07D405/06 , C07D409/06 , C07D417/06 , A61K31/439
CPC分类号： C07D401/06 , C07D221/24 , C07D405/06 , C07D409/06 , C07D417/06
摘要： The subject invention relates to 3-azabicyclo[3.2.1]octane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject invention also particularly relates to using such derivatives to treat certain disorders and conditions, for example irritable bowel syndrome, drug addiction, depression, anxiety, schizophrenia and eating disorders, among others.
摘要翻译：本发明涉及3-氮杂双环[3.2.1]辛烷衍生物，包含这些衍生物的药物组合物和使用这些衍生物治疗由阿片受体介导的疾病状态，病症和病状的方法。本发明还特别涉及使用这样的衍生物来治疗某些疾病和病症，例如肠易激综合征，药物成瘾，抑郁，焦虑，精神分裂症和进食障碍等。

5. 发明申请

WO2003035622A1 3-AZABICYCLO (3.1.0) HEXANE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 3-AZABICYCLO（3.1.0）作为阿片受体拮抗剂的HEXANE衍生物
公开(公告)号：WO2003035622A1
公开(公告)日：2003-05-01
申请号：PCT/IB2002/003668
申请日：2002-09-09
申请人： PFIZER PRODUCTS INC. , MCHARDY, Stanton, Furst , LIRAS, Spiros , HECK, Steven, Donald
发明人： MCHARDY, Stanton, Furst , LIRAS, Spiros , HECK, Steven, Donald
IPC分类号： C07D209/52
CPC分类号： C07D403/12 , C07D209/52 , C07D303/04
摘要： The subject invention provides a compound of the formula (I), wherein X, Q, n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined. Compounds of formula (I) have activity as opioid receptor antagonists. The subject invention furthermore provides for pharmaceutical compositions and therapeutic methods comprising compounds of formula (I).
摘要翻译：本发明提供式（I）化合物，其中X，Q，n，R 1，R 2，R 3，R 4，R 5，R 6， R 7，R 8，R 9和R 10如上所定义。式（I）化合物具有作为阿片受体拮抗剂的活性。本发明还提供包含式（I）化合物的药物组合物和治疗方法。

6. 发明申请

WO2007135529A3 AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS 审中-公开
公开(公告)号：WO2007135529A3
公开(公告)日：2007-11-29
申请号：PCT/IB2007/001293
申请日：2007-05-11
申请人： PFIZER PRODUCTS INC. , BERKE, Helen , DUPLANTIER, Allen, Jacob , EFREMOV, Ivan Viktorovich , MCHARDY, Stanton, Furst , QIAN, Weimin , ROGERS, Bruce, Nelson , ZHAN, Lei , ZHANG, Qian
发明人： BERKE, Helen , DUPLANTIER, Allen, Jacob , EFREMOV, Ivan Viktorovich , MCHARDY, Stanton, Furst , QIAN, Weimin , ROGERS, Bruce, Nelson , ZHAN, Lei , ZHANG, Qian
IPC分类号： C07D471/04 , C07D471/14 , C07D471/18 , A61K31/437 , A61K31/4745 , A61P25/00
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R 17 , R 2 , X 4 , X 9 , X 5 , X 6 , R 8 , X 2 , Y 1 and n are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

7. 发明申请

WO2007135529A2 AZABENZIMIDAZOLYL COMPOUNDS 审中-公开
标题翻译： AZABENZIMIDAZOLYL化合物
公开(公告)号：WO2007135529A2
公开(公告)日：2007-11-29
申请号：PCT/IB2007001293
申请日：2007-05-11
申请人： PFIZER PROD INC , BERKE HELEN , DUPLANTIER ALLEN JACOB , EFREMOV IVAN VIKTOROVICH , MCHARDY STANTON FURST , QIAN WEIMIN , ROGERS BRUCE NELSON , ZHAN LEI , ZHANG QIAN
发明人： BERKE HELEN , DUPLANTIER ALLEN JACOB , EFREMOV IVAN VIKTOROVICH , MCHARDY STANTON FURST , QIAN WEIMIN , ROGERS BRUCE NELSON , ZHAN LEI , ZHANG QIAN
CPC分类号： C07D471/04 , C07D471/14 , C07D471/18
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R 17 , R 2 , X 4 , X 9 , X 5 , X 6 , R 8 , X 2 , Y 1 and n are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式（I）的结构：或其药学上可接受的盐，其中R 17，R 2，，X 4，X 9，X 5，X 6，R 8，，X 2，Y 1和n如本发明的详细描述中所定义。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

8. 发明申请

WO2007135527A3 BENZIMIDAZOLYL COMPOUNDS 审中-公开
公开(公告)号：WO2007135527A3
公开(公告)日：2007-11-29
申请号：PCT/IB2007/001290
申请日：2007-05-14
申请人： PFIZER PRODUCTS INC. , BERKE, Helen , DUPLANTIER, Allen, Jacob , EFREMOV, Ivan , MCHARDY, Stanton, Furst , ROGERS, Bruce, Nelsen , QIAN, Weimin , ZHANG, Lei , ZHANG, Qian
发明人： BERKE, Helen , DUPLANTIER, Allen, Jacob , EFREMOV, Ivan , MCHARDY, Stanton, Furst , ROGERS, Bruce, Nelsen , QIAN, Weimin , ZHANG, Lei , ZHANG, Qian
IPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D417/06 , A61K31/4184 , A61K31/4745 , A61P25/00 , A61P9/00
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of formula (I): or pharmaceutically acceptable salts thereof. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

9. 发明申请

WO2007105053A2 TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR 审中-公开
标题翻译： H-3受体的四肽拮抗剂
公开(公告)号：WO2007105053A2
公开(公告)日：2007-09-20
申请号：PCT/IB2007/000536
申请日：2007-03-01
申请人： PFIZER PRODUCTS INC. , MCHARDY, Stanton, Furst , PARIKH, Vinod, Dipak
发明人： MCHARDY, Stanton, Furst , PARIKH, Vinod, Dipak
IPC分类号： C07D401/08 , C07D403/08 , C07D207/06 , C07D405/08 , C07D409/08 , C07D413/08 , A61K31/4427 , A61K31/40 , A61K31/4025 , A61P11/00
CPC分类号： C07D207/06 , C07D401/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
摘要： This invention is directed to a compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula (I) a process of preparation of a compound of formula (I), a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit hyperactivity disorder (ADHD), psychotic disorders, cognitive disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy- induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the Gl tract, hyper and hypo motility and acidic secretion of the gastro- intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above.
摘要翻译：本发明涉及如本文定义的式（I）化合物或其药学上可接受的盐; 含有式（I）化合物的药物组合物制备式（I）化合物的方法，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括对哺乳动物施用需要这样的治疗时，如上所述的式（I）化合物和治疗选自以下的病症或病症的方法：抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默病，注意力缺陷多动障碍（ADHD），精神障碍，认知障碍，睡眠障碍，肥胖症，眩晕，癫痫，运动病，呼吸系统疾病，过敏，过敏引起的气道反应，过敏性鼻炎，鼻塞，过敏性充血，充血，低血压，心血管疾病的GI道，胃肠道的超低运动性和酸性分泌，所述方法包括给予mam 需要这种治疗的男性，如上所述的式（I）化合物。

10. 发明申请

WO2004089909A1 2-AZABICYCLO[3.3.1]NONANE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 2-亚苄基胆碱[3.3.1]作为阿片受体拮抗剂的非衍生物
公开(公告)号：WO2004089909A1
公开(公告)日：2004-10-21
申请号：PCT/IB2004/001237
申请日：2004-04-02
申请人： PFIZER PRODUCTS INC. , COE, Jotham, Wadsworth , MCHARDY, Stanton, Furst
发明人： COE, Jotham, Wadsworth , MCHARDY, Stanton, Furst
IPC分类号： C07D221/22
CPC分类号： C07D221/22
摘要： The subject invention relates to 2-azabicyclo[3.3.1 ]nonane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject invention also particularly relates to using such derivatives to treat certain disorders and conditions, for example irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia and eating disorders, among others, as are more fully described herein. Formula (I):
摘要翻译：本发明涉及2-氮杂二环[3.3.1]壬烷衍生物，包含这些衍生物的药物组合物和使用这些衍生物的方法来治疗由阿片受体介导的疾病状态，病症和病况。本发明还特别涉及如本文更充分描述的那样使用这些衍生物来治疗某些疾病和病症，例如肠易激综合征，药物成瘾，包括酒精成瘾，抑郁，焦虑，精神分裂症和进食障碍等。式（I）：

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