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31. 发明申请

WO1996014305A1 BENZISOXAZOLE DERIVATIVES AND PESTICIDAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：苯并噻唑衍生物和含有它们的杀虫剂组合物
公开(公告)号：WO1996014305A1
公开(公告)日：1996-05-17
申请号：PCT/EP1995004154
申请日：1995-10-23
申请人： CIBA-GEIGY AG , FAROOQ, Saleem , TRAH, Stephan , ZURFLÜH, René
发明人： CIBA-GEIGY AG
IPC分类号： C07D261/20
CPC分类号： C07D261/20 , A01N43/80
摘要： Compounds of formula (I), wherein X, Z, W, R2, R3, R4, R5 and n are as defined in claim 1, and possible E/Z isomers thereof, can be used as agrochemical agents, in particular as fungicides and insecticides/acaricides, and can be prepared in per se known manner.
摘要翻译：式（I）化合物，其中X，Z，W，R 2，R 3，R 4，R 5和n如权利要求1中所定义，并且其可能的E / Z异构体可用作农药，特别是作为杀真菌剂，杀虫剂/杀螨剂，并且可以以本身已知的方式制备。

32. 发明申请

WO1996011574A1 HERBICIDAL COMPOSITIONS 审中-公开
标题翻译：除草剂组合物
公开(公告)号：WO1996011574A1
公开(公告)日：1996-04-25
申请号：PCT/EP1995003935
申请日：1995-10-05
申请人： CIBA-GEIGY AG , GLOCK, Jutta , HUDETZ, Manfred , KERBER, Elmar
发明人： CIBA-GEIGY AG
IPC分类号： A01N43/90
CPC分类号： A01N43/56 , A01N43/90 , A01N43/42 , A01N25/32 , A01N2300/00
摘要： Selective herbicidal compositions for controlling grasses and weeds in crops of cultivated plants, comprising: a) a herbicidally effective amount of a compound of formula (I), wherein R1 is the (i), (ii) or (iii) group; the substituents R4 are each independently of one another halogen, nitro, cyano, C1-C4alkyl, C1-C4haloalkyl, C1-C10alkoxy, C1-C4haloalkoxy, C3-C6alkenyloxy, C1-C4alkoxy-C2-C4alkoxy, C3-C6alkynyloxy, C1-C4alkylcarbonyl, C1-C4alkoxycarbonyl, C1-C4alkylthio, C1-C4alkylsulfinyl, C1-C4alkylsulfonyl, amino, C1-C4alkylamino or di-C1-C4alkylamino; R5 is the (iv) or (v) group; n is 0, 1, 2, 3 or 4; m is 0 or 1, the sum of m and n being 0, 1, 2, 3 or 4; q is 0, 1, 2 or 3; X1 is oxygen, sulfur, -CH2- or -N(R7)-; the substituents R6 are each independently of one another C1-C4alkyl, halogen, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, nitro, cyano, C1-C4alkoxycarbonyl, amino, C1-C4alkylamino or di-C1-C4alkylamino; R7 is hydrogen, C1-C4alkyl, formyl or C1-C4alkylcarbonyl; A and B are each independently of one another hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl or cycloalkyl, or substituted or unsubstituted aryl; or A and B, taken together, form the divalent radical of a saturated or unsaturated and unsubstituted or substituted mono-, bi-, tri- or polycyclic system; G is hydrogen or a group -CO-R18 (a), (b), -SO2-R20 (c), (d), (e) or X (f); L and M are each independently of the other oxygen or sulfur; R18 is halogen-substituted alkyl, alkenyl, alkoxyalkyl, alkylthioalkyl, polyalkoxyalkyl or cycloalkyl, which may contain hetero atoms; unsubstituted or substituted phenyl, unsubstituted or substituted phenylalkyl, substituted heteroaryl, substituted phenoxyalkyl, or substituted heteroaryloxyalkyl; R19 is halogen-substituted alkyl, alkenyl, alkoxyalkyl or polyalkoxyalkyl, or unsubstituted or substituted phenyl or benzyl; R20, R21 and R22 are each independently of one another unsubstituted or halogen-substituted alkyl, alkoxy, alkylamino, dialkylamino, alkylthio, alkenylthio, alkynylthio or cycloalkylthio, or unsubstituted or substituted phenyl, phenoxy or phenylthio; R23 and R24 are each independently of the other hydrogen, unsubstituted or halogen-substituted alkyl, alkenyl, alkoxy or alkoxyalkyl, unsubstituted or substituted phenyl or benzyl; or R23 and R24, taken together, form an alkenyl radical, which may contain oxygen as hetero atom; and X is a metal ion equivalent or an ammonium ion; as well as salts and diastereoisomers of the compounds of formula (I); and b) to antagonise the herbicide, an antidotally effective amount of either a quinoline derivative of formula (IIa), wherein R10 is hydrogen, C1-C8alkyl, or C1-C8alkyl which is substituted by C1-C6alkoxy or C3-C6alkenyloxy; and X2 is hydrogen or chloro; of a 1-phenylazole-3-carboxylic acid derivative of formula (IIb), wherein E is nitrogen or methine; R11 is -CCl3 or unsubstituted or halogen-substituted phenyl; R12 and R13 are each independently of the other hydrogen or halogen; and R14 is C1-C4alkyl, are particularly suitable for controlling weeds in crops of cultivated plants, in particular maize and cereals.
摘要翻译：选择性除草组合物，用于控制栽培植物作物中的草和杂草，包括：a）除草有效量的式（I）化合物，其中R1是（i），（ii）或（iii）基团; 取代基R 4各自独立地为卤素，硝基，氰基，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 10烷氧基，C 1 -C 4卤代烷氧基，C 3 -C 6烯氧基，C 1 -C 4烷氧基-C 2 -C 4烷氧基，C 3 -C 6炔氧基，C 1 -C 4烷基羰基 C1-C4烷氧基羰基，C1-C4烷硫基，C1-C4烷基亚磺酰基，C1-C4烷基磺酰基，氨基，C1-C4烷基氨基或二C1-C4烷基氨基; R5是（iv）或（v）组; n为0,1,2,3或4; m为0或1，m和n的和为0,1,2,3或4; q为0,1,2或3; X1是氧，硫，-CH2-或-N（R7） - ; 取代基R6各自独立地为C1-C4烷基，卤素，C1-C4卤代烷基，C1-C4烷氧基，C1-C4卤代烷氧基，硝基，氰基，C1-C4烷氧基羰基，氨基，C1-C4烷基氨基或二C1-C4烷基氨基; R 7是氢，C 1 -C 4烷基，甲酰基或C 1 -C 4烷基羰基; A和B各自独立地为氢，烷基，烯基，炔基，烷氧基烷基，烷硫基烷基或环烷基，或取代或未取代的芳基; 或A和B一起形成饱和或不饱和和未取代或取代的单，双，三或多环体系的二价基团; G是氢或-CO-R18（a），（b），-SO2-R20（c），（d），（e）或X（f） L和M各自独立地为其它氧或硫; R18是可以含有杂原子的卤素取代的烷基，烯基，烷氧基烷基，烷硫基烷基，聚烷氧基烷基或环烷基; 未取代或取代的苯基，未取代或取代的苯基烷基，取代的杂芳基，取代的苯氧基烷基或取代的杂芳基烷基; R19是卤素取代的烷基，烯基，烷氧基烷基或聚烷氧基烷基，或未取代或取代的苯基或苄基; R20，R21和R22各自独立地为未取代的或卤素取代的烷基，烷氧基，烷基氨基，二烷基氨基，烷硫基，烯硫基，炔硫基或环烷硫基，或未取代或取代的苯基，苯氧基或苯硫基; R 23和R 24各自独立地为氢，未取代或卤素取代的烷基，烯基，烷氧基或烷氧基烷基，未取代或取代的苯基或苄基; 或R 23和R 24一起形成可以含有氧作为杂原子的烯基; X为金属离子当量或铵离子; 以及式（I）化合物的盐和非对映异构体; 和b）拮抗除草剂，一种解药有效量的式（IIa）的喹啉衍生物，其中R 10是氢，C 1 -C 8烷基或被C 1 -C 6烷氧基或C 3 -C 6烯氧基取代的C 1 -C 8烷基; X2是氢或氯; 的式（IIb）的1-苯基唑-3-羧酸衍生物，其中E是氮或次甲基; R 11是-CCl 3或未取代的或卤素取代的苯基; R 12和R 13各自独立地为氢或卤素; 和R14是C1-C4烷基，特别适用于控制栽培植物，特别是玉米和谷类作物的杂草。

33. 发明申请

WO1996008146A3 HERBICIDAL SYNERGISTIC COMPOSITION AND METHOD OF WEED CONTROL 审中-公开
公开(公告)号：WO1996008146A3
公开(公告)日：1996-03-21
申请号：PCT/EP1995003365
申请日：1995-08-25
申请人： CIBA-GEIGY AG , HUDETZ, Manfred , HOFER, Urs
发明人： CIBA-GEIGY AG
IPC分类号： A01N47/36

34. 发明申请

WO1996007666A1 MONONUCLEOTIDE AND DINUCLEOTIDE ANALOGUES AND INTERMEDIATES THEREFOR 审中-公开
标题翻译：单核苷酸和胆固醇类似物及其中间体
公开(公告)号：WO1996007666A1
公开(公告)日：1996-03-14
申请号：PCT/GB1995001986
申请日：1995-08-21
申请人： CIBA-GEIGY AG , IRVING, Edward , BAXTER, Anthony, David , COLLINGWOOD, Stephen, Paul , TAYLOR, Roger, John
发明人： CIBA-GEIGY AG
IPC分类号： C07H19/04
CPC分类号： C07H23/00 , C07H19/06 , C07H21/00 , C07H21/04 , Y02P20/55
摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof, where R is hydrogen, R a or a group of formula (II), R a b or a protecting group Q, R b is C1-C20 alkyl, C2-C20 alkenyl, C3-C10 cycloalkyl, C6-C15 aryl, C7-C16 aralkyl or a 5- or 6- membered heterocyclic group attached by a carbon atom in the heterocyclic group to the indicated phosphorus atom, R is hydrogen, R a or -OR , provided that when R is hydrogen, R is R a or -OR , R a is a C1-C20 aliphatic group, a C3-C10 cycloaliphatic group, a C6-C15 aromatic group, a C7-C16 araliphatic group, or a 5- or 6- membered heterocyclic group attached by a carbon atom in the heterocyclic group to the indicated phosphorus atom, R is hydrogen, halogen, hydroxy, R , -OR , OSO2R , OCOR or tri(C1-C15 hydrocarbyl) silyloxy, R is R a or together with R denotes a valence bond, R a is hydrogen, halogen or R , R is hydrogen, halogen, hydroxy, R , -OR , -OCOR , OSO2R , or tri(C1-C15 hydrocarbyl) silyloxy, R is hydrogen, halogen or R , or together with R denotes a valence bond, R is hydrogen, or an atom or group capable of terminating a replicating strand of a nucleic acid or of inhibiting viral DNA synthesis, other than a group connected to the indicated furanose ring through an oxygen atom, or together with R denotes a valence bond, R is R a, or together with R denotes a valence bond, R a is hydrogen, halogen, hydroxy, R , -OR , -OCOR , -OSO2R or tri(C1-C15 hydrocarbyl) silyloxy, R is a monovalent nucleoside base radical, R is hydrogen or R a, R a is R , -COR , -SO2R or tri(C1-C15 hydrocarbyl)silyl, R is hydrogen, halogen, hydroxy, R , -OR , -OCOR , -OSO2R or Z, R is hydrogen, halogen or R . R is hydrogen or R a, R a is halogen, hydroxy, R , -OR , -OCOR , -OSO2R or tri(C1-C15 hydrocarbyl)silyloxy, R is a monovalent nucleoside base radical, R is hydrogen or R a, R a is a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C15 aromatic group or a C7 to C16 araliphatic group, R , R , R , R , R , R , R , R and R are independently a C1 to C10 aliphatic group, a C3 to C10 cycloaliphatic group, a C6 to C15 aromatic group or a C7 to C30 araliphatic group, and Z is substituted or unsubstituted C6 to C10 aryloxythiocarbonyloxy.
摘要翻译：式（I）化合物或其药学上可接受的盐，其中R 1是氢，R 1a或式（II）的基团，R 1'> a <= R 1> b或保护基Q，R 1b是C 1 -C 20烷基，C 2 -C 20烯基，C 3 -C 10环烷基，C 6 -C 15芳基，C 7 -C 16芳烷基或被碳原子连接的5-或6-元杂环基在指定的磷原子的杂环基中，R 2是氢，R 2 a或-OR 15，条件是当R 1是氢时，R 2是R 2 a或 -OR 15，R 2a是C 1 -C 20脂族基团，C 3 -C 10脂环族基团，C 6 -C 15芳族基团，C 7 -C 16芳脂族基团或5-或6-元杂环基团通过杂环基中的碳原子与指定的磷原子连接，R 3是氢，卤素，羟基，R 16，-OR 16，OSO 2 R 16，OCOR 16或三（C 1 -C 6） -C 15烃基）甲硅烷氧基，R 4是R 4 a或与R 6一起代表价键，R 4是氢，卤素或R 17，R 5是氢，卤素，羟基，R 18，-OR 18，-OCOR 18 ，OSO 2 R 18或三（C 1 -C 15烃基）甲硅烷氧基，R 6是氢，卤素或R 19，或与R 4一起代表价键，R 7是氢，或可以终止核酸的复制链或抑制病毒DNA合成的原子或基团，除了通过氧原子与所示的呋喃糖环连接的基团，或与R 8一起，表示价键， R 8是R 8，或与R 7一起代表价键，R 8 a是氢，卤素，羟基，R 20，-OR 20，-OCOR 20， -OSO 2 R 20或三（C 1 -C 15烃基）甲硅烷氧基，R 9是一价核苷碱基，R 10是氢或R 10a，R 10a是R 21， -COR 21，-SO 2 R 21或三（C 1 -C 15烃基）甲硅烷基，R 11是氢，卤素，羟基，R 22，-OR 22，-OCOR 22， OSO 2 R 22或Z，R 12是氢，卤素或R 23。 R 13是氢或R 13 a，R 13是卤素，羟基，R 24，-OR 24，-OCOR 24，-OSO 2 R 24或三（C1- C 15烃基）甲硅烷氧基，R 14是单价核苷碱基，R 15是氢或R 15 a，R 15是C 1至C 10脂族基团，C 3至C 8脂环族基团， C 6至C 15芳族基团或C 7至C 16芳脂基基团，R 16，R 17，R 18，R 19，R 20，R 21，R 22， 23>和R 24独立地为C 1至C 10脂族基团，C 3至C 10脂环族基团，C 6至C 15芳族基团或C 7至C 30芳脂族基团，Z为取代或未取代的C 6至C 10芳氧基硫代羰基氧基。

35. 发明申请

WO1996007424A1 USE OF INSULIN-LIKE GROWTH FACTORS (I) AND (II) FOR INHIBITION OF INFLAMMATORY RESPONSE 审中-公开
标题翻译：胰岛素样生长因子（I）和（II）的使用用于抑制炎症反应
公开(公告)号：WO1996007424A1
公开(公告)日：1996-03-14
申请号：PCT/EP1995003393
申请日：1995-08-29
申请人： CIBA-GEIGY AG , HALLORAN, Philip, Francis
发明人： CIBA-GEIGY AG
IPC分类号： A61K38/30
CPC分类号： C07K14/65 , A61K38/00 , F04B39/0016 , F04B39/1073 , Y10T137/7892
摘要： The present invention relates to methods for using IGF as inhibitors of inflammatory response, ischemic injury, and organ rejection.
摘要翻译：本发明涉及使用IGF作为炎性反应，缺血性损伤和器官排斥抑制剂的方法。

36. 发明申请

WO1996005247A1 STABILISED PVDC-CONTAINING PVC 审中-公开
标题翻译：稳定的含PVDC的PVC
公开(公告)号：WO1996005247A1
公开(公告)日：1996-02-22
申请号：PCT/EP1995003110
申请日：1995-08-04
申请人： CIBA-GEIGY AG , HERBST, Heinz , HOFFMANN, Kurt , PFAENDNER, Rudolf
发明人： CIBA-GEIGY AG
IPC分类号： C08K03/22
CPC分类号： C08K3/22 , C08K3/26 , C08L27/06 , C08L27/08 , C08L2205/02 , C08L2666/04
摘要： The invention relates to stabilised PVDC-containing PVC, preferably a PVC recyclate, comprising as polymer at least 50 % by weight of polyvinyl chloride (PVC) and 0.05-50 % by weight of PVDC and additionally comprising at least one inorganic compound of the series of the metal oxides, metal hydroxides or metal carbonates.
摘要翻译：本发明涉及含稳定化的含PVDC的PVC，优选PVC再循环，其包含聚合物至少50重量％的聚氯乙烯（PVC）和0.05-50重量％的PVDC，另外包含至少一种该系列的无机化合物的金属氧化物，金属氢氧化物或金属碳酸盐。

37. 发明申请

WO1996003432A1 NOVEL PROCESS FOR THE PRODUCTION OF BIOLOGICALLY ACTIVE DIMERIC PROTEIN 审中-公开
标题翻译：生物活性二聚体蛋白生产的新方法
公开(公告)号：WO1996003432A1
公开(公告)日：1996-02-08
申请号：PCT/EP1995002718
申请日：1995-07-12
申请人： CIBA-GEIGY AG , CERLETTI, Nico
发明人： CIBA-GEIGY AG
IPC分类号： C07K14/495
CPC分类号： C07K1/1133 , A61K38/00 , C07K14/495
摘要： The present invention relates to a folding process for the preparation of biologically active, dimeric TGF- beta (transforming Growth Factor type beta )-like protein.
摘要翻译：本发明涉及用于制备生物活性的二聚体TGF-β（转化生长因子型β）样蛋白质的折叠方法。

38. 发明申请

WO1996003425A1 PROCESS FOR FOLDING OF PROTEINS LIKE RECOMBINANT HIRUDIN OR EPIDERMAL GROWTH FACTOR 审中-公开
标题翻译：蛋白质折叠类似重组生长因子或细胞生长因子的过程
公开(公告)号：WO1996003425A1
公开(公告)日：1996-02-08
申请号：PCT/EP1995002720
申请日：1995-07-12
申请人： CIBA-GEIGY AG , CHANG, Jui, Yoa
发明人： CIBA-GEIGY AG
IPC分类号： C07K01/113
CPC分类号： C07K14/485 , A61K38/00 , C07K1/1136 , C07K14/815
摘要： The invention relates to a process for the preparation of a biologically active and correctly folded protein in the presence of a denaturing agent like urea or guanidine hydrochloride and the separation of the correctly folded protein therefrom directly. This process can be applied, for example, in the renaturation of recombinant proteins like hirudin or epidermal growth factor.
摘要翻译：本发明涉及在变性剂如尿素或盐酸胍存在下制备生物活性和正确折叠的蛋白质的方法，并直接分离正确折叠的蛋白质。该方法可以用于例如重组蛋白质如水蛭素或表皮生长因子的复性。

39. 发明申请

WO1996003040A1 PROCESS FOR THE PREPARATION OF SPHERICAL MICROPARTICLES CONTAINING BIOLOGICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：制备含有生物活性化合物的球形微生物的方法
公开(公告)号：WO1996003040A1
公开(公告)日：1996-02-08
申请号：PCT/EP1995002727
申请日：1995-07-12
申请人： CIBA-GEIGY AG , NASTKE, Rudolf , NEUENSCHWANDER, Ernst
发明人： CIBA-GEIGY AG
IPC分类号： A01N25/28
CPC分类号： A01N25/28
摘要： The invention relates to a process for encapsulating biologically active compounds in the form of substantially spherical microparticles, comprising the steps of a) preparing an aqueous solution of surfactants, catalysts and monomers or prepolymers which are suitable for forming a crosslinked polycondensate, b) forming an emulsion of the substantially water-insoluble biologically active compound or mixture thereof in the solution a) by adding said solution under high shear force, and c) forming a solid capsule wall around the biologically active compound or mixture thereof by heating the reaction mixture to a temperature at which the crosslinking reaction takes place, which process comprises fusing the biologically active compound or mixture thereof and adding the melt to the aqueous reaction mixture at a temperature which is higher than the temperature of the reaction mixture. The invention further relates to the use of the microparticles for the preparation of a composition for controlling plant pests, weeds or animal parasites, as well as to aqueous spray mixtures, water-dispersible granulates or water-dilutable powders containing the claimed microparticles.
摘要翻译：本发明涉及以基本上为球形的微粒形式包封生物活性化合物的方法，其包括以下步骤：a）制备适于形成交联缩聚物的表面活性剂，催化剂和单体或预聚物的水溶液，b）形成基本上不溶于水的生物活性化合物或其混合物在溶液中的乳液a）通过在高剪切力下加入所述溶液，和c）在生物活性化合物或其混合物周围形成固体胶囊壁，将反应混合物加热至交联反应发生的温度，该方法包括熔融生物活性化合物或其混合物，并在高于反应混合物温度的温度下将熔体加入到水性反应混合物中。本发明还涉及微粒用于制备用于防治植物害虫，杂草或动物寄生虫的组合物以及含有所要求保护的微粒的水性喷雾混合物，水分散性颗粒或水可稀释粉末的用途。

40. 发明申请

WO1996002638A1 GRANULAR FORMULATION CONTAINING MICROORGANISMS, A PROCESS FOR THE PREPARATION AND THE USE THEREOF 审中-公开
标题翻译：含有微生物的颗粒配方，其制备方法及其用途
公开(公告)号：WO1996002638A1
公开(公告)日：1996-02-01
申请号：PCT/EP1995002571
申请日：1995-07-03
申请人： CIBA-GEIGY AG , ENZMANN, Margarete , BAETTIG, William
发明人： CIBA-GEIGY AG
IPC分类号： C12N11/02
CPC分类号： C12N11/02 , C12N9/54 , C12N9/58 , C12N15/80 , C12P21/06
摘要： The invention relates to a) a film-forming, water-soluble and essentially uncrosslinked polymer, and the granular formulation contains not less than 0.5 % by weight of water, based on said formulation, or b) a film-forming, structurally crosslinked polysaccharide which contains carboxyl or sulfate groups and is swellable in water in the presence of potassium ions, and the granular formulation contains not less than 0.5 % by weight of water, based on said formulation. The invention further relates to a process for the preparation of said granular formulation and to the use thereof for protecting plants from attack by disease or damage by insects.
摘要翻译：本发明涉及a）成膜，水溶性和基本上未交联的聚合物，并且所述颗粒制剂基于所述制剂含有不小于0.5重量％的水，或b）成膜，结构交联的多糖其含有羧基或硫酸根基团，并且在钾离子存在下在水中可溶胀，并且基于所述制剂，所述颗粒制剂含有不小于0.5重量％的水。本发明还涉及制备所述颗粒制剂的方法及其用于保护植物免受疾病或昆虫损害的侵害。

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