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    • 28. 发明申请
    • AZABICYCLO[3.2.1]OCTANE DERIVATIVES
    • AZABICYCLO [3.2.1] OCTANE DERIVATIVES
    • WO2009056520A1
    • 2009-05-07
    • PCT/EP2008/064529
    • 2008-10-27
    • GLAXO GROUP LIMITEDANDREOTTI, DanielePROFETA, Roberto
    • ANDREOTTI, DanielePROFETA, Roberto
    • C07D221/22
    • C07D221/22
    • The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein R 1 is hydrogen or C 1-4 alkyl; R 2 is a group A or W, wherein A is formula (IA) wherein p is 0, 1, 2, 3, 4 or 5 and R 5 is halogen, cyano or C 1-4 alkyl, each of them being the same or different; and W is an α or β naphthyl group, optionally substituted by 1 or 2 groups R 5 , each of them being the same or different; R 3 is a group (P) wherein R 6 is selected from the group consisting of hydrogen, C 1-4 alkyl, haloC 1-4 alkyl, C 3-6 cycloalkyl and C 3-6 cycloalkylC 1-3 alkyl, and n is 1 or 2; R4 is hydrogen, linear or branched C 1-4 alkyl, hydroxyl or C 1-4 alkoxy; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as serotonin (5-HT), dopamine (DA) and norepinephrine (NE), re-uptake inhibitors.
    • 本发明涉及新的式(I)化合物或其药学上可接受的盐,溶剂合物或前药,其中R 1是氢或C 1-4烷基; R2是A或W基团,其中A是式(IA),其中p是0,1,2,3,4或5,R 5是卤素,氰基或C 1-4烷基,它们各自相同或不同; 并且W是一个或者萘基,任选地被1或2个基团R 5取代,它们各自相同或不同; R3是一个基团(P),其中R6选自氢,C1-4烷基,卤代C 1-4烷基,C 3-6环烷基和C 3-6环烷基C 1-3烷基,n是1或2; R4是氢,直链或支链C 1-4烷基,羟基或C 1-4烷氧基; 再摄入抑制剂,作为5-羟色胺(5-HT),多巴胺(DA)和去甲肾上腺素(NE),再摄取抑制剂,它们的制备方法,这些方法中使用的中间体,含有它们的药物组合物及其在治疗中的应用。