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21. 发明申请

WO2020242751A1 HYBRID LIGAND AND LIQUID CHROMATOGRAPHY STATIONARY PHASE INCLUDING HYBRID LIGAND 审中-公开
公开(公告)号：WO2020242751A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/032349
申请日：2020-05-11
申请人： RESTEK CORPORATION
发明人： LU, Xiaoning , BARTLETT, Charles Vernon , FLANNERY, Connor , GREEN, Ahren Iver , REID, Terrence Scott
IPC分类号： B01J20/32 , B01J20/289 , B01D15/30 , B01D15/36 , B01D15/38
摘要： A composition includes a hybrid ligand. The hybrid ligand includes an amine group, an amide group or a sulfonamide group, and hydroxyl groups. A first method includes providing a solution containing a first polar analyte and a second polar analyte, applying the solution to a stationary phase including an immobilized hybrid ligand, applying an elution solvent to the stationary phase such that the first polar analyte and the second polar analyte pass through the stationary phase with different elution times, and collecting the first polar analyte at a first elution time and collecting the second polar analyte at a second elution time after the first elution time. A device of a packed column, a cartridge, a tube, a well plate, a membrane, or a planar thin-layer chromatography plate includes a solid support and a hybrid ligand coupled to the solid support. A second method forms an immobilized hybrid ligand.

22. 发明申请

WO2019018366A1 METHOD OF CHEMICALLY MODIFYING PLASTIC SURFACES 审中-公开
公开(公告)号：WO2019018366A1
公开(公告)日：2019-01-24
申请号：PCT/US2018/042444
申请日：2018-07-17
申请人： OMNIOME, INC.
发明人： DAMBACHER, Corey M.
IPC分类号： B01J20/28 , B01D15/02 , B01J20/289 , B01J20/32
摘要： Disclosed herein are finished products, methods, compositions and kits for derivatizing plastic ( e.g. , "polymer") surfaces in a manner that renders the surfaces appropriate for various downstream applications. For example, flow cells incorporating modified plastic surfaces provide greatly enhanced stability for retention of attached chemical species such as polypeptides and nucleic acids.

23. 发明申请

WO2018065269A1 NOVEL CHROMATOGRAPHY MEDIA 审中-公开
标题翻译：新型色谱介质
公开(公告)号：WO2018065269A1
公开(公告)日：2018-04-12
申请号：PCT/EP2017/074459
申请日：2017-09-27
申请人： GE HEALTHCARE BIOPROCESS R&D AB
发明人： BERGH, Ann, Catharina , AHMAD, Tania , ALGOTSSON, Mattias , GRANER, Therese
IPC分类号： B01J20/289 , B01J20/32 , B01D15/38
摘要： The present invention relates to a novel chromatography media, more closely a novel IMAC (Immobilized Metal Affinity Chromatography) media. The novel chromatography media comprises a pentaligand and provides high dynamic binding capacity as well as high purity of the sample proteins purified on the media of the invention.
摘要翻译：本发明涉及新型色谱介质，更接近新型IMAC（固定化金属亲和色谱）介质。新颖的色谱介质包含三配体，并提供高的动态结合能力以及在本发明的培养基上纯化的样品蛋白的高纯度。

24. 发明申请

WO2017174422A1 CHROMATOGRAPHY MATRIX 审中-公开
标题翻译：色谱矩阵
公开(公告)号：WO2017174422A1
公开(公告)日：2017-10-12
申请号：PCT/EP2017/057482
申请日：2017-03-30
申请人： GE HEALTHCARE BIOPROCESS R&D AB
发明人： MALOISEL, Jean-Luc , SÖDERMAN, Tobias, E. , LIND, Ola , EKLIND, Ida
IPC分类号： B01J20/32 , B01J20/286 , B01D15/38 , B01J20/26 , B01J20/289
摘要： The invention discloses a separation matrix for purification of biomacromolecules, comprising a plurality of particles (1) having a core region (2) and a shell region (3), wherein: a) said shell region is accessible to a target biomacromolecule; b) said core region is less accessible to the target biomacromolecule than the shell region; and c) the core region comprises a grafted polymer comprising residues of at least one polymerizable monomer.
摘要翻译：本发明公开了用于纯化生物大分子的分离基质，其包含多个具有核心区（2）和壳区（3）的颗粒（1），其中：a）所述壳区为可达到目标生物大分子; b）所述核心区比目标生物大分子难以接近壳区; 和c）核心区域包含含有至少一种可聚合单体的残基的接枝聚合物。

25. 发明申请

WO2017155848A1 POROUS MATERIALS WITH CONTROLLED POROSITY; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS 审中-公开
标题翻译：控制孔隙度的多孔材料; 其制备方法; 及其用于色谱分离的用途
公开(公告)号：WO2017155848A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/020859
申请日：2017-03-06
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： WALSH, Daniel, P. , WYNDHAM, Kevin, Daniel , FAIRCHILD, Jacob, Nathan , LAWRENCE, Nicole, L.
IPC分类号： B01J20/283 , B01J20/288 , B01J20/22 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01J20/28 , B01J20/289 , B01J20/32 , B01D15/34 , B01D15/38
摘要： The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The chromatograpich materials of the invention have controlled porosity and comprise a chromatographic core material and one or more layers of chromatographic surface material which each independently provide an average pore diameter, an average pore volume, or a specific surface area such that the combined layers form a chromatographic material having a predetermined or desired pattern of porosity from the core material to the outermost surfece. The materials are useful for HPLC separations, normal-phase selarations, reversed -phase separations, chiral separations, HILIC separations, SFC separations, affinity separations, perfusive separations, partially perfusive separations, and SEC separations.
摘要翻译：本发明提供了新的色谱材料，例如用于色谱分离，其制备方法和含有色谱材料的分离装置。本发明的色谱图材料具有可控孔隙率，并包含色谱芯材和一层或多层色谱表面材料，其各自独立地提供平均孔径，平均孔体积或比表面积，使得组合层形成色谱材料具有从核心材料到最外面表面的预定或期望孔隙度图案。该材料适用于HPLC分离，正相分离，反相分离，手性分离，HILIC分离，SFC分离，亲和分离，灌注分离，部分灌注分离和SEC分离。

26. 发明申请

WO2014020152A1 LIGANDS FOR APHERESIS AND IMMUNOABSORPTION 审中-公开
标题翻译：用于饲养和免疫的配体
公开(公告)号：WO2014020152A1
公开(公告)日：2014-02-06
申请号：PCT/EP2013/066280
申请日：2013-08-02
申请人： GRAFFINITY PHARMACEUTICALS GMBH
发明人： BITTERMANN, Holger , ARNOLD, Marc , NEUMANN, Thomas
IPC分类号： C07K1/22 , B01D15/38 , B01J20/289
CPC分类号： B01D15/3809 , B01J20/267 , B01J20/289 , B01J20/3204 , B01J20/3208 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3255 , C07K1/22
摘要： The present invention relates to a method for separating one or more proteins from plasma by immunoadsorption IA, comprising • contacting the plasma with a ligand-substituted matrix; and • removing the plasma from the ligand-substituted matrix; • wherein the ligand-substituted matrix comprises a support material and at least one ligand covalently bonded to the support material.
摘要翻译：本发明涉及通过免疫吸附IA从血浆中分离一种或多种蛋白质的方法，其包括。使等离子体与配体取代的基质接触; 和。从配体取代的基质中除去等离子体; 。其中所述配体取代的基质包含载体材料和共价键合到所述载体材料的至少一种配体。

27. 发明申请

WO2013130388A1 SURFACE FUNCTIONALIZATION OF CARBON NANOTUBES VIA OXIDATION FOR SUBSEQUENT COATING 审中-公开
标题翻译：碳纳米管通过氧化后续涂层的表面官能化
公开(公告)号：WO2013130388A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/027609
申请日：2013-02-25
申请人： BRIGHAM YOUNG UNIVERSITY
发明人： JENSEN, David, Scott
IPC分类号： G01N30/93 , C01B31/02 , B01J20/286 , B01J20/32 , B01J20/289
CPC分类号： B05D5/00 , B01J20/286 , B01J20/289 , B01J20/324 , B01J20/3259 , B01J20/3295 , G01N30/93
摘要： In an embodiment, a method for manufacturing a chromatography apparatus such as a thin layer chromatography ("TLC") plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), oxidizing the elongated nanostructures to form a surface enriched in oxygen moieties, and at least partially coating the oxidized elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to a base or acid. The stationary phase may further be treated with a silane (e.g., an amino silane) to improve the performance of the chromatography apparatus. Embodiments for TLC plates and related methods are also disclosed.
摘要翻译：在一个实施方式中，公开了薄层色谱（“TLC”）板等色谱装置的制造方法。该方法包括形成细长的纳米结构层（例如，碳纳米管），氧化细长纳米结构以形成富含氧部分的表面，并且用涂层至少部分地涂覆氧化的细长纳米结构。涂层包括用于色谱法的固定相和/或固定相的前体。固定相可以通过暴露于碱或酸而被羟基官能化。进一步用硅烷（例如氨基硅烷）处理固定相以改进色谱装置的性能。还公开了TLC板的实施例和相关方法。

28. 发明申请

WO2009014481A1 SEPARATION MATRIX 审中-公开
标题翻译：分离矩阵
公开(公告)号：WO2009014481A1
公开(公告)日：2009-01-29
申请号：PCT/SE2008/000461
申请日：2008-07-22
申请人： GE HEALTHCARE BIO-SCIENCES AB , AXÉN, Andreas , BERGSTRÖM, Jan , GLAD, Gunnar , JOHANSSON, Bo-Lennart , NORRMAN, Nils
发明人： AXÉN, Andreas , BERGSTRÖM, Jan , GLAD, Gunnar , JOHANSSON, Bo-Lennart , NORRMAN, Nils
IPC分类号： B01J20/289
CPC分类号： B01J20/289 , B01D15/362 , B01D15/363 , B01J20/3274 , B01J20/328
摘要： The present invention relates to a separation matrix, which comprises a support; extenders coupled to an outer part of said support; and ligands coupled to said extenders, wherein the part of the support to which the extenders are coupled constitutes less than 50% of the volume of the separation matrix. The invention also embraces a method of preparing such a separation matrix, as well as a process wherein the separation media is used.
摘要翻译：本发明涉及一种分离基质，其包括载体; 联接到所述支撑件的外部的延伸器; 和与所述增量剂偶联的配体，其中与所述增量剂偶联的载体的部分构成小于分离基质体积的50％。本发明还包括制备这种分离基质的方法，以及其中使用分离介质的方法。

29. 发明申请

WO2009008802A1 METHOD FOR PREPARATION OF A BIOMOLECULE ADSORBENT 审中-公开
标题翻译：生物分子吸附剂的制备方法
公开(公告)号：WO2009008802A1
公开(公告)日：2009-01-15
申请号：PCT/SE2008/000436
申请日：2008-07-07
申请人： GE HEALTHCARE BIO-SCIENCES AB , ANDERSSON, Lars, C. , AREFALK, Anna , LIND, Ola , NORÉN, Björn
发明人： ANDERSSON, Lars, C. , AREFALK, Anna , LIND, Ola , NORÉN, Björn
IPC分类号： B01D15/38 , B01J20/289 , C07K1/22
CPC分类号： B01J20/3242 , B01D15/3828 , B01J20/289 , B01J20/3219 , B01J20/3251 , B01J20/3265
摘要： The present invention is relates to method for production of a biomolecule adsorbent with a pentadentate ligand with very strong chelating properties, and to methods for use thereof for, for example, protein purification, detection or binding.
摘要翻译：本发明涉及生产具有非常强螯合性的五齿配体的生物分子吸附剂的方法及其用于例如蛋白质纯化，检测或结合的方法。

30. 发明申请

WO2006083022A1 PACKING MATERIAL FOR ION CHROMATOGRAPHY 审中-公开
标题翻译：包装材料用于离子色谱
公开(公告)号：WO2006083022A1
公开(公告)日：2006-08-10
申请号：PCT/JP2006/302285
申请日：2006-02-03
申请人： SHOWA DENKO K.K. , KONDO, Hideyuki , OKADA, Yoshiji
发明人： KONDO, Hideyuki , OKADA, Yoshiji
IPC分类号： B01J41/20 , B01D15/36 , B01J20/289 , G01N30/96
CPC分类号： B01D15/363 , B01J20/289 , B01J41/20 , B01J2220/54 , G01N30/96
摘要： The present invention relates to a packing material for ion chromatography, wherein a quaternary ammonium base represented by the following formula (1) is bonded to the substrate directly or through a spacer: wherein R 1 represents a group having at least one olefinic double bond or conjugated double bond, each R 2 and R 3 independently represents an organic residue which may be the same with or different from R 1 ; and separating equipment for chemical substances and a separating method using the packing material. The packing material for ion chromatography, separating equipment for chemical substances and a separating method using the packing material of the present invention, enable to sufficiently separate seven standard inorganic anions and three halogen oxide anions in either of the conductometric detection or ultraviolet detection by postcolumn derivatization while preventing increase in the pressure and imposing no limitations on the measurement temperature or flow rate of mobile phase.
摘要翻译：本发明涉及一种用于离子色谱的包装材料，其中由下式（1）表示的季铵碱基直接或通过间隔基键合到基材上：其中R 1表示具有至少一个烯属双键或共轭双键，每个R 2和R 3独立地表示可以与R 1相同或不同的有机残基 ; 化学物质分离设备和使用包装材料的分离方法。用于离子色谱的包装材料，用于化学物质的分离设备和使用本发明的包装材料的分离方法使得能够通过后柱衍生化在电导检测或紫外检测中充分分离七种标准无机阴离子和三种卤素氧化物阴离子同时防止压力增加，并且不限制流动相的测量温度或流速。

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