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21. 发明申请

WO02083926A3 METHODS OF DIAGNOSING AND TREATING SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO) AND SIBO-RELATED CONDITIONS 审中-公开
标题翻译：诊断和治疗小肠细菌生长（SIBO）和SIBO相关病症的方法
公开(公告)号：WO02083926A3
公开(公告)日：2003-05-15
申请号：PCT/US0212034
申请日：2002-04-16
申请人： CEDARS SINAI MEDICAL CENTER
发明人： LIN HENRY C , PIMENTEL MARK
IPC分类号： G01N27/62 , A01N31/00 , A23L33/00 , A61K9/08 , A61K9/10 , A61K9/14 , A61K9/22 , A61K9/28 , A61K9/48 , A61K9/50 , A61K31/201 , A61K31/353 , A61K31/4045 , A61K31/496 , A61K33/18 , A61K33/24 , A61K33/40 , A61K35/22 , A61K35/23 , A61K38/00 , A61K38/17 , A61K38/22 , A61K45/06 , A61K49/00 , A61K51/12 , A61P1/02 , A61P1/04 , A61P3/00 , A61P19/08 , A61P21/00 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , G01N30/62 , G01N30/86 , G01N30/88 , G01N30/90 , G01N33/497 , G01N33/50 , G01N33/68 , A61K9/00
CPC分类号： A61K38/54 , A23L33/40 , A23V2002/00 , A61B5/0836 , A61B5/412 , A61B5/415 , A61B5/418 , A61K9/0053 , A61K9/0087 , A61K31/135 , A61K31/138 , A61K31/198 , A61K31/201 , A61K31/353 , A61K31/4045 , A61K31/4164 , A61K31/4184 , A61K31/424 , A61K31/43 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K36/534 , A61K38/1796 , A61K38/22 , A61K38/225 , A61K38/2271 , A61K45/06 , A61K49/0004 , A61K51/1206 , G01N33/497 , G01N33/6893 , G01N2033/4977 , G01N2333/70571 , G01N2800/06 , Y10S426/80 , Y10S426/801 , Y10T436/145555 , Y10T436/147777 , Y10T436/18 , Y10T436/214 , Y10T436/22 , A61K2300/00
摘要： Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.
摘要翻译：公开了一种在人类受试者中治疗小肠细菌过度生长（SIBO）或SIBO引起的病症的方法。 SIBO引起的病症包括肠易激综合征，纤维肌痛，慢性盆腔疼痛综合征，慢性疲劳综合征，抑郁症，受损的记忆力，记忆障碍，口臭，耳鸣，糖渴求，自闭症，注意力缺陷/多动障碍，药物敏感性，自身免疫性疾病，和克罗恩病。还公开了筛选人受试者中SIBO异常可能存在的方法和在人受试者中检测SIBO的方法。还公开了确定已经检测到小肠细菌过度生长（SIBO）的人受试者中SIBO或SIBO引起的病症的相对严重性的方法。

22. 发明申请

WO2003017818A2 MANAGEMENT OF GASTRO-INTESTINAL DISORDERS 审中-公开
标题翻译：胃肠道疾病的管理
公开(公告)号：WO2003017818A2
公开(公告)日：2003-03-06
申请号：PCT/IL2002/000702
申请日：2002-08-22
申请人： ORIDION BREATHID LTD. , BEN-OREN, Ilan , DAICH, Julian , CARLEBACH, Ephraim , YARIV, George
发明人： BEN-OREN, Ilan , DAICH, Julian , CARLEBACH, Ephraim , YARIV, George
IPC分类号： A61B
CPC分类号： A61K51/1206 , A23L33/30 , A61B5/083 , A61K49/0004 , G01N33/497
摘要： Methods of determining gastro-intestinal conditions by performing a succession of breath tests or others tests, particularly for determining the gastic emptying or gastric accomodation condition of a subject. Methods of performing successive gastric emptying tests with different test meals are also presented, enabling the gastric accommodation to be determined. The effects of different test meals on the results is presented. Novel substrates for use in such tests are suggested, including the use of micro-encapsulation. Breath tests for the detection of bacterial overgrowth, lactose intolerance and combinations thereof are presented.
摘要翻译：通过进行一系列呼吸试验或其他测试来确定胃肠道状况的方法，特别是用于确定受试者的胃排空或胃胃适应状况。还提出了用不同试验餐进行连续胃排空试验的方法，使胃适应性得以确定。介绍了不同试餐对结果的影响。提出了用于这种测试的新型底物，包括使用微胶囊。提出了用于检测细菌过度生长，乳糖不耐症及其组合的呼吸试验。

23. 发明申请

WO02087630A2 A METHOD FOR THE DETERMINATION OF GASTRIC AND OESOPHAGEAL TUMOURS 审中-公开
标题翻译：一种确定胃肠道肿瘤的方法
公开(公告)号：WO02087630A2
公开(公告)日：2002-11-07
申请号：PCT/EP0204242
申请日：2002-04-17
申请人： EUROSPITAL S P A , DI LEO ALFREDO , LINSALATA MICHELLE , RUSSO FRANCESCO
发明人： DI LEO ALFREDO , LINSALATA MICHELLE , RUSSO FRANCESCO
IPC分类号： A61K51/12 , A61K51/00
CPC分类号： A61K51/1206
摘要： A method for the diagnosis of gastric and oesophageal tumors in human patients which comprises 1) administration of C ornithine or a metabolically active precursor thereof, and 2) quantitation of the 13CO2 in the breath.
摘要翻译：一种用于诊断人类和胃食管肿瘤的方法，其包括：1）施用13 C鸟氨酸或其代谢活性前体，和2）定量呼吸中的13CO2。

24. 发明申请

WO01087353A1 PREPARATIONS FOR DIAGNOSING INFECTION WITH HELICOBACTER PYLORI 审中-公开
标题翻译：用 HELICOBACTER PYLORI诊断感染的准备

公开(公告)号：WO01087353A1

公开(公告)日：2001-11-22

申请号：PCT/JP2001/004122

申请日：2001-05-17

IPC分类号： A61K9/30 , A61K49/18 , A61K51/12 , A61K51/04 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38

CPC分类号： A61K51/1206 , A61K49/1815

摘要： Preparations by which infection with H. pylori can be quickly detected while eliminating the effects of urease-producing bacteria occurring in organs other than the gastrointestinal tract (i.e., oral cavity, throat, etc.) without any fear of the detection of false positive. Namely, preparations for detecting infection with H. pylori by the urea expiration test wherein a core composition, which contains at least a C isotope-labeled urea, a filler and a lubricant at a definite ratio, is surface-coated with from 0.1 to 10% by weight, per 100% by weight of the core composition, of a coating.

摘要翻译： H感染的准备。可以快速检测幽门螺杆菌，同时消除在胃肠道以外的器官（即口腔，咽喉等）中发生的产生尿素酶的细菌的作用，而不用担心检测到假阳性。即用H检测感染的制剂。通过尿素呼气试验，其中含有至少一种C同位素标记的尿素，一种填充剂和一定比例的润滑剂的核心组合物以0.1-10重量％的比例被表面涂覆， 100重量％的芯组合物，涂层。

25. 发明申请

WO1998029728A1 BREATH TEST FOR DETECTION OF DRUG METABOLISM 审中-公开
标题翻译：用于检测药物代谢的呼吸试验
公开(公告)号：WO1998029728A1
公开(公告)日：1998-07-09
申请号：PCT/IL1997000445
申请日：1997-12-31
申请人： ORIDION MEDICAL, LTD. , KATZMAN, Daniel, E.
发明人： ORIDION MEDICAL, LTD.
IPC分类号： G01N01/22
CPC分类号： A61K51/1206 , A61K47/6949 , B82Y5/00 , Y10S436/90 , Y10T436/13 , Y10T436/204998 , Y10T436/24 , Y10T436/25875
摘要： A breath test for determining the rate of metabolism of a drug is described. First, a safe and effective amount of the drug, preferably appropriately labelled and most preferably isotopically-labelled, is administered to a subject. After a suitable time period, the exhaled breath of the subject is analyzed to determine the concentration of a metabolite. The concentration of the metabolite is then used to determine the rate of metabolism of the drug. A breath test kit is also described. Such a breath test kit would include an item or items necessary for performing at least one of the methods of determining the rate of metabolism of a drug in a subject. For example, such a breath test kit could include an isotopically-labelled drug to be administrated to the subject.
摘要翻译：描述了用于确定药物代谢速率的呼气试验。首先，对受试者施用安全有效量的药物，优选适当标记，最优选同位素标记。在合适的时间段后，分析受试者的呼出气体以确定代谢物的浓度。然后使用代谢物的浓度来确定药物的代谢速率。还描述了呼吸测试试剂盒。这样的呼吸测试试剂盒将包括执行测定受试者中药物的代谢速率的方法中至少一种方法所必需的物品或物品。例如，这种呼吸测试试剂盒可以包括要给受试者施用的同位素标记的药物。

26. 发明申请

WO1998006442A1 ISOTOPIC UREA TABLETS 审中-公开
标题翻译：同位素尿素片
公开(公告)号：WO1998006442A1
公开(公告)日：1998-02-19
申请号：PCT/JP1997002809
申请日：1997-08-12
申请人： KYOWA HAKKO KOGYO CO., LTD. , HAYAKAWA, Eiji , MIURA, Shigemitsu , ITO, Kunio , SAKATO, Kuniaki
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： A61K49/00
CPC分类号： A61K51/1206 , A61K31/17 , A61K51/1258
摘要： Tablets comprising isotopic urea and an inorganic compound. Tableting a mixture of the urea with one or more inorganic compounds (additives) can inhibit the adhesion due to cohesiveness of urea and can give tablets having a practical disintegration time and sufficiently high hardness. The tablets are useful for the diagnosis of infections with urease-producing microorganisms containing isotopic urea, particularly the one with Helicobacter pylori.
摘要翻译：包含同位素尿素和无机化合物的片剂。将尿素与一种或多种无机化合物（添加剂）的混合物压制可以抑制由于尿素的内聚力引起的粘附，并且可以产生具有实际崩解时间和足够高硬度的片剂。片剂可用于诊断含有尿素酶的微生物的含有同位素尿素的感染，特别是具有幽门螺杆菌的微生物。

27. 发明申请

WO1994027653A2 SYSTEMS FOR THE INTRAPULMONARY DELIVERY OF AEROSOLIZED AQUEOUS FORMULATIONS 审中-公开
标题翻译：气溶胶配方的输送系统
公开(公告)号：WO1994027653A2
公开(公告)日：1994-12-08
申请号：PCT/US1994005825
申请日：1994-05-20
申请人： MIRIS MEDICAL CORPORATION
发明人： MIRIS MEDICAL CORPORATION , LLOYD, Lester, John , LLOYD, Peter, M. , RUBSAMEN, Reid, M. , SCHUSTER, Jeffrey, Arthur
IPC分类号： A61M00/00
CPC分类号： A61K51/1206 , A61J1/035 , A61J7/0418 , A61M11/002 , A61M15/00 , A61M15/001 , A61M15/0031 , A61M15/0043 , A61M15/0051 , A61M15/0055 , A61M15/008 , A61M15/0085 , A61M2016/0021 , A61M2016/0039 , A61M2205/8206 , A61M2230/40 , B65D81/32 , A61M2230/005
摘要： A disposable package, tape, and cassette are provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. In one embodiment formulation is packaged in individual dosage unit containers which containers are preferably interconnected. The package is designed to be integrated into a cassette which can be loaded into a dispersing device capable of individually opening dosage unit containers and aerosolizing the contents through a porous membrane, into a mouth piece on the cassette, for delivery to a patient. In addition to an alongside of each porous membrane, the package may include one or more openings through which air is forced in order to aid in avoiding the accumulation of aerolized particles. The package may be configured so that the formulation is held in a container not positioned directly vertical to and below the porous membrane, thus making it necessary to channel formulation horizontally to the porous membrane and making it possible to include a vibrating mechanism directly below a chamber covered by the porous membrane. Release of aerosolized drug is breath actuated based on simultaneous measurements of inspiratory flow and volume so as to provide for repeatable dosing of drug to the patient.
摘要翻译：提供了一次性包装，胶带和盒，其使得可以将含有药物活性药物的水性制剂（直径小于0.25微米的溶液或分散体）的液体可流动制剂保持并分散。在一个实施方案中，将制剂包装在单独的剂量单位容器中，这些容器优选地互连。包装被设计成集成到盒子中，该盒子可以装载到能够单独打开剂量单位容器并通过多孔膜将内容物雾化到分离盒中的口件中的分散装置中，用于递送给患者。除了每个多孔膜的旁边，包装可以包括一个或多个开口，通过该开口迫使空气，以帮助避免气溶胶颗粒的积聚。包装可以被配置成使得制剂保持在不直接垂直于多孔膜的下方的容器中，因此使得必须水平地配制到多孔膜上，并且使得可以在腔室的正下方包括振动机构被多孔膜覆盖。基于吸气流量和体积的同时测量，气雾化药物的释放是呼吸启动的，以便向患者提供药物的可重复剂量。

28. 发明申请

WO1991019978A1 USING 5,10,15,20-TETRAKIS(4-CARBOXYPHENYL)PORPHINE FOR DETECTING AND TREATING LUNG CANCERS 审中-公开
标题翻译：使用5,10,15,20-TETRAKIS（4-羧基苯基）哌啶来检测和治疗肺癌
公开(公告)号：WO1991019978A1
公开(公告)日：1991-12-26
申请号：PCT/US1991004267
申请日：1991-06-14
申请人： ST. MARY'S HOSPITAL AND MEDICAL CENTER, INC. , UNITED STATES DEPARTMENT OF ENERGY
发明人： ST. MARY'S HOSPITAL AND MEDICAL CENTER, INC. , UNITED STATES DEPARTMENT OF ENERGY , COLE, Dean, A. , MOODY, David, C., III , ELLINWOOD, L., Edward , KLEIN, M., Gerard
IPC分类号： G01N33/48
CPC分类号： A61K51/0485 , A61K49/00 , A61K49/0036 , A61K51/1206 , A61K2121/00 , A61K2123/00 , G01N33/57423 , Y10S435/968 , Y10S436/80 , Y10S436/805
摘要： Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass.
摘要翻译：使用四芳基卟啉，特别是5,10,15,20-四（4-羧基苯基）卟吩作为肺癌的荧光示踪剂的方法，作为与67A的复合物作为放射性示踪剂。后一种复合物还提供了用于选择性破坏肺恶性肿瘤的β辐射的来源以及用于通过单光子发射计算机断层扫描的图像分析其图像分析的γ辐射，作为体内实例。如果只有放射性示踪剂的特征是有意义的话，铜64可以代替67。铜的较轻同位素是正电子发射体，正电子发射断层扫描技术可用于定位恶性组织质量。

29. 发明申请

WO1991019977A1 USING 5,10,15,20-TETRAKIS(r-CARBOXYPHENYL)PORPHINE FOR DETECTING AND TREATING LUNG CANCER 审中-公开
标题翻译：使用5,10,15,20-TETRAKIS（γ-羧基苯基）吗啡来检测和治疗肺癌
公开(公告)号：WO1991019977A1
公开(公告)日：1991-12-26
申请号：PCT/US1991004132
申请日：1991-06-17
申请人： UNITED STATES DEPARTMENT OF ENERGY
发明人： UNITED STATES DEPARTMENT OF ENERGY , COLE, Dean, A. , MOODY, David, C., III , ELLINWOOD, L., Edward , KLEIN, M., Gerard
IPC分类号： G01N33/48
CPC分类号： A61K51/0485 , A61K49/00 , A61K49/0036 , A61K51/1206 , A61K2121/00 , A61K2123/00 , G01N33/57423 , Y10S435/968 , Y10S436/80 , Y10S436/805
摘要： Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass.
摘要翻译：使用四芳基卟啉，特别是5,10,15,20-四（4-羧基苯基）卟吩作为肺癌的荧光示踪剂的方法，作为与67A的复合物作为放射性示踪剂。后一种复合物还提供了用于选择性破坏肺恶性肿瘤的β辐射的来源以及用于通过单光子发射计算机断层扫描的图像分析其图像分析的γ辐射，作为体内实例。如果只有放射性示踪剂的特征是有意义的话，铜64可以代替67。铜的较轻同位素是正电子发射体，正电子发射断层扫描技术可用于定位恶性组织质量。

30. 发明申请

WO1991018105A1 LABELED COMPOUNDS FOR USE IN A DIAGNOSTIC BREATH TEST 审中-公开
标题翻译：用于诊断性呼吸试验的标签化合物
公开(公告)号：WO1991018105A1
公开(公告)日：1991-11-28
申请号：PCT/US1991003335
申请日：1991-05-13
申请人： MARTEK CORPORATION
发明人： MARTEK CORPORATION , KYLE, David, John
IPC分类号： C12P07/62
CPC分类号： A61K51/1206 , A61K2123/00 , C11B1/00 , C12N1/06 , C12P7/6463 , C12P7/6472 , G01N33/497 , Y10S435/946
摘要： Disclosed is a process for the production of compounds labeled with stable isotopes of carbon. Such compounds are useful in diagnostic breath tests. The process involves the cultivation of microorganisms capable of producing such compounds in appropriately controlled environments such as bioreactors, feeding such microorganisms labeled carbon substrates, inducing the microorganisms to produce the labeled compounds and recovering the compounds therefrom. Also, encompassed by the present invention are perlabeled compounds useful in diagnostic breath tests.

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