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1. 发明申请

WO2008075171A1 A METHOD BASED ON A BREATH TEST FOR THE DETECTION OF PATHOGEN MICROORGANISMS 审中-公开
标题翻译：一种用于检测病原微生物的呼吸试验方法
公开(公告)号：WO2008075171A1
公开(公告)日：2008-06-26
申请号：PCT/IB2007/003923
申请日：2007-12-14
申请人： CAMPUZANO MAYA, Germán, Antonio
发明人： CAMPUZANO MAYA, Germán, Antonio
IPC分类号： G01N33/497 , G01N33/60 , G01N33/62 , C12Q1/58
CPC分类号： G01N33/497 , A61K51/1206
摘要： The present invention provides a method based on urea breath tests for the detection and diagnostic of Helicobacter pylori in the gastroduodenal track, and a kit to carry out said method. The method comprises collecting a first basal breath sample from an individual or patient; giving to said individual a labeled carbon urea solution; in an immediate following novel and independent step, giving an adequate amount of water to the individual to clean his oral cavity from any residual urea; and after a time of not less than 5 minutes, collecting a second breath sample.
摘要翻译：本发明提供了一种基于用于胃十二指肠轨道中的幽门螺杆菌的检测和诊断的尿素呼吸试验的方法，以及用于实施所述方法的试剂盒。该方法包括从个体或患者收集第一基础呼吸样品; 向所述个体给予标记的碳尿素溶液; 在立即进行的新颖独立的步骤中，给予个人足够的水以清洁他的口腔免于任何残留的尿素; 并经过不少于5分钟的时间，收集第二次呼吸样本。

2. 发明申请

WO2004002308A3 MANAGEMENT OF GASTRO-INTESTINAL DISORDERS 审中-公开
标题翻译：胃肠功能障碍的治疗
公开(公告)号：WO2004002308A3
公开(公告)日：2005-09-29
申请号：PCT/IL0300178
申请日：2003-03-06
申请人： ORIDION BREATHID LTD , BEN-OREN ILAN , DAICH JULIAN , CARLEBACH EPHRAIM , YARIV GEORGE
发明人： BEN-OREN ILAN , DAICH JULIAN , CARLEBACH EPHRAIM , YARIV GEORGE
IPC分类号： A23L33/00 , A61B5/083 , A61K49/00 , A61K51/12 , G01N33/497
CPC分类号： A61B5/42 , A23L33/30 , A61B5/083 , A61B5/411 , A61K49/0004 , A61K51/1206 , G01N33/497

3. 发明申请

WO2004002308A2 MANAGEMENT OF GASTRO-INTESTINAL DISORDERS 审中-公开
标题翻译：胃肠疾病的管理
公开(公告)号：WO2004002308A2
公开(公告)日：2004-01-08
申请号：PCT/IL2003/000178
申请日：2003-03-06
申请人： ORIDION BREATHID LTD. , BEN-OREN, Ilan , DAICH, Julian , CARLEBACH, Ephraim , YARIV, George
发明人： BEN-OREN, Ilan , DAICH, Julian , CARLEBACH, Ephraim , YARIV, George
IPC分类号： A61B5/083
CPC分类号： A61B5/42 , A23L33/30 , A61B5/083 , A61B5/411 , A61K49/0004 , A61K51/1206 , G01N33/497

4. 发明申请

WO2002074348A1 DRY POWDER COMPOSITIONS COMPRISING LABELLED PARTICLES FOR INHALATION 审中-公开
标题翻译：干粉组合物包含用于吸入的标签颗粒
公开(公告)号：WO2002074348A1
公开(公告)日：2002-09-26
申请号：PCT/GB2002/001148
申请日：2002-03-13
申请人： PHARMACEUTICAL PROFILES , PITCAIRN, Gary, Roy
发明人： PITCAIRN, Gary, Roy
IPC分类号： A61K51/12
CPC分类号： A61K9/0075 , A61K9/0043 , A61K31/13 , A61K31/155 , A61K31/341 , A61K31/352 , A61K31/4741 , A61K31/58 , A61K31/635 , A61K31/7036 , A61K33/18 , A61K33/24 , A61K45/06 , A61K47/6923 , A61K51/0497 , A61K51/1206 , A61K51/1244 , B82Y5/00
摘要： A dry powder composition is described. In one embodiment, the composition comprises smaller label particles attached to larger particles. In another embodiment, the composition comprises label particles comprising a core of a gamma emitting radionuclide and a shell of a non-radioactive material that are attached to a second particulate material. A method for preparing the compositions as well as their use in the evaluation of drug distribution following inhalation of the compositions into the respiratory tract is also described.
摘要翻译：描述干粉组合物。在一个实施方案中，组合物包含连接到较大颗粒的较小标签颗粒。在另一个实施方案中，组合物包含标记颗粒，其包含连接到第二颗粒材料的发射放射性核素的芯和非放射性材料的壳。还描述了制备组合物的方法及其在吸入组合物进入呼吸道时评估药物分布中的用途。

5. 发明申请

WO00000636A3 IN VIVO DETERMINATION OF METABOLIC FUNCTION FOR USE IN THERAPY MANAGEMENT 审中-公开
标题翻译：体内确定用于治疗的药物代谢功能
公开(公告)号：WO00000636A3
公开(公告)日：2000-04-27
申请号：PCT/US1999/014725
申请日：1999-06-29
IPC分类号： C12Q1/26 , A61K49/00 , A61K51/12 , A61K101/00 , C12Q1/28 , C12Q1/34 , C12Q1/37 , C12Q1/44 , C12Q1/48 , C12Q1/52 , C12Q1/527 , A61K51/04
CPC分类号： A61K51/1206
摘要： It is an object of the present invention to provide in vivo analytical methods that allow for diagnosis and management of therapy for diseases involving discrete biochemical pathways. In the method of the invention, a labelled tracer probe, a specifically designed substrate of a "gateway" enzyme, an enzyme marking a regulatory point in a discrete biochemical pathway, is administered to a subject; a labelled product of the action of the enzyme is measured; and the appearance and concentration of the product are related to the disease condition of interest. Determination of the rate of substrate-product conversion of the gateway enzyme allows for the analysis to be made. The method involves administering a defined amount of a labelled "metaprobe" substrate of the gateway enzyme to a subject, at a site that provides access to a desired pool of the gateway enzyme in the subject, and measuring the amount of the chosen labelled product. The presence and amount of the chosen labelled product in, e.g., the breath, definitely indicates that the labelled metaprobe has been metabolized by the specific enzyme in the specific biochemical pathway under consideration, and from the calculated rate of substrate-product conversion by the gateway enzyme, the desired diagnostic determination may be made. Likewise, if a specific therapeutic treatment for a disease is underway with a patient, this method allows for a minimally invasive assessment of the effectiveness of the treatment, with minimal discomfort to the patient.
摘要翻译：本发明涉及用于诊断和管理涉及离散的生物化学途径的疾病的治疗的体内测定技术。为了所描述的方法的目的，将标记的指示剂探针施用于患者，特别指定的“传代点”酶的底物，其标记离散的生物化学途径上的调节点; 然后测量标记有酶作用的产物; 最后，在产品的外观和浓度以及所考虑的疾病之间建立联系。确定上述酶特异性的底物产物转化率可以进行分析。该方法包括向受试者施用一个限定在所述衬底“métasonde”标记与所讨论的酶的量，在一个位点，其允许访问一个组中所述对象的这种酶，并测定产物量标记如此选择。此产物的存在和量，例如，在呼吸，表示肯定地标记métasonde通过在特定的生化路径中的特定的酶而言，由此转化产物的底物的确定保险代谢通过上述酶可以建立所需的诊断。类似地，如果患者正在进行治疗性治疗，则该方法允许在微创基础上且对患者造成最小不便的情况下评估治疗的有效性。

6. 发明申请

WO99056790A2 <13>C GLUCOSE BREATH TEST FOR THE DIAGNOSIS OF DIABETIC INDICATIONS AND MONITORING GLYCEMIC CONTROL 审中-公开
标题翻译： <13> C用于糖尿病指征诊断和监测糖化控制的葡萄糖肠道试验
公开(公告)号：WO99056790A2
公开(公告)日：1999-11-11
申请号：PCT/IB1999/000933
申请日：1999-05-06
IPC分类号： G01N33/497 , A61B5/00 , A61B5/08 , A61B5/083 , A61K49/00 , A61K51/00 , A61K51/12 , G01N33/66
CPC分类号： A61K51/1206 , A61B5/0813 , A61B5/0836 , A61B5/14532 , G01N33/497 , Y10T436/104998 , Y10T436/13 , Y10T436/24 , Y10T436/25875
摘要： A breath test and kit for performing the breath test are described for the diagnosis of diabetic indications and monitoring of glycemic control. The breath test utilizes the measurement of expired C-labeled CO2 following the ingestion of a C-enriched glucose source.
摘要翻译：描述了用于进行呼吸试验的呼吸试验和试剂盒，用于诊断糖尿病适应症和监测血糖控制。呼吸试验利用摄入富含13 C的葡萄糖源后测量过期的13 C标记的CO2。

7. 发明申请

WO1998009658A1 MEASUREMENT OF LIQUID PHASE GASTRIC EMPTYING 审中-公开
标题翻译：液相气相色谱法测定
公开(公告)号：WO1998009658A1
公开(公告)日：1998-03-12
申请号：PCT/US1997014592
申请日：1997-08-19
申请人： MERETEK DIAGNOSTICS
发明人： MERETEK DIAGNOSTICS , KLEIN, Peter, D.
IPC分类号： A61K51/00
CPC分类号： A61K51/1206
摘要： A drink adapted to be consumed by a patient to enable measurement of gastric emptying of the liquid phase, is a fruit juice having mixed and suspended therein a quantity of Spirulina platensis alga grown in a CO2 atmosphere. These single cell organisms pass from the stomach into the small intestine where they are digested, absorbed and oxidized to produce a detectible rise in the level of CO2 in the patient's breath which is sampled and the measured valves plotted to enable determination of gastric emptying rate abnormalities.
摘要翻译：适于被患者消耗以使得能够测量液相的胃排空的饮料是在<13> CO2气氛中生长的一定数量的螺旋藻的混合和悬浮液的果汁。这些单细胞生物从胃进入小肠，在那里它们被消化，吸收和氧化，以产生患者呼吸中<13> CO 2水平的可检测到的上升，其被抽样，并且测量的阀被绘制以使得能够测定胃排空率异常。

8. 发明申请

WO1997027804A1 VENTILATION IMAGING USING A FINE PARTICLE AEROSOL GENERATOR 审中-公开
标题翻译：使用细颗粒气溶胶发生器的通风成像
公开(公告)号：WO1997027804A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001888
申请日：1997-02-04
申请人： ARADIGM CORPORATION
发明人： ARADIGM CORPORATION , RUBSAMEN, Reid, M. , FARR, Stephen, J. , SILVERSTEIN, Fred
IPC分类号： A61B06/00
CPC分类号： A61K51/1206 , A61B5/0813 , A61B6/4258 , A61K2123/00
摘要： A method of diagnosing a patient is carried out by delivering an aerosolized dose of a radioactive formulation to a patient and making a ventilation image of radioactive material deposited in the lung. Devices and methodology for creating aerosols are provided wich allow for efficient and repeatable delivery of radio-aerosols to the lungs of a patient. The device is loaded with a container (1) of a radioactive formulation (5). Actuation of the device forces the radioactive formulation (5) through a porous membrane (3) of the container which membrane has pores having a diameter in the range of about 0.25 microns to 6.0 microns. The container includes radioactive shielding (84) in the form of a lead coating and/or a lead surrounding packet. The porous membrane (3) is positioned in alignment with a surface of a channel (6) through which a patient inhales air.
摘要翻译：通过将放射性制剂的雾化剂量递送到患者并且放置在肺中的放射性物质的通风图像来进行诊断患者的方法。提供了用于产生气溶胶的装置和方法，其允许将放射性气溶胶有效且可重复地递送到患者的肺部。该装置装载有放射性制剂（5）的容器（1）。该装置的致动迫使放射性制剂（5）通过容器的多孔膜（3），该膜具有直径在约0.25微米至6.0微米范围内的孔。容器包括铅涂层形式的放射性屏蔽（84）和/或引线周围的包装。多孔膜（3）被定位成与患者吸入空气的通道（6）的表面对准。

9. 发明申请

WO9427653A3 SYSTEMS FOR THE INTRAPULMONARY DELIVERY OF AEROSOLIZED AQUEOUS FORMULATIONS 审中-公开
标题翻译：气溶胶配方的输送系统
公开(公告)号：WO9427653A3
公开(公告)日：1995-02-09
申请号：PCT/US9405825
申请日：1994-05-20
申请人： MIRIS MEDICAL CORP
发明人： LLOYD LESTER JOHN , LLOYD PETER M , RUBSAMEN REID M , SCHUSTER JEFFREY ARTHUR
IPC分类号： B65D81/24 , A61J1/03 , A61J1/14 , A61J3/00 , A61J7/04 , A61K51/12 , A61M11/00 , A61M13/00 , A61M15/00 , A61M16/00 , B65D81/32 , B65D83/00 , A61M
CPC分类号： A61K51/1206 , A61J1/035 , A61J7/0418 , A61M11/002 , A61M15/00 , A61M15/001 , A61M15/0031 , A61M15/0043 , A61M15/0051 , A61M15/0055 , A61M15/008 , A61M15/0085 , A61M2016/0021 , A61M2016/0039 , A61M2205/8206 , A61M2230/40 , B65D81/32 , A61M2230/005
摘要： A disposable package, tape, and cassette are provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. In one embodiment formulation is packaged in individual dosage unit containers which containers are preferably interconnected. The package is designed to be integrated into a cassette which can be loaded into a dispersing device capable of individually opening dosage unit containers and aerosolizing the contents through a porous membrane, into a mouth piece on the cassette, for delivery to a patient. In addition to an alongside of each porous membrane, the package may include one or more openings through which air is forced in order to aid in avoiding the accumulation of aerolized particles. The package may be configured so that the formulation is held in a container not positioned directly vertical to and below the porous membrane, thus making it necessary to channel formulation horizontally to the porous membrane and making it possible to include a vibrating mechanism directly below a chamber covered by the porous membrane. Release of aerosolized drug is breath actuated based on simultaneous measurements of inspiratory flow and volume so as to provide for repeatable dosing of drug to the patient. 00000
摘要翻译：提供了一次性包装，胶带和盒，其使得可以将含有药物活性药物的水性制剂（直径小于0.25微米的溶液或分散体）的液体可流动制剂保持并分散。在一个实施方案中，将制剂包装在单独的剂量单位容器中，这些容器优选地互连。包装被设计成集成到盒子中，该盒子可以装载到能够单独打开剂量单位容器并通过多孔膜将内容物雾化到分离盒中的口件中的分散装置中，用于递送给患者。除了每个多孔膜的旁边，包装可以包括一个或多个开口，通过该开口迫使空气，以帮助避免气溶胶颗粒的积聚。包装可以被配置成使得制剂保持在不直接垂直于多孔膜的下方的容器中，因此使得必须水平地配制到多孔膜上，并且使得可以在腔室的正下方包括振动机构被多孔膜覆盖。基于吸气流量和体积的同时测量，气雾化药物的释放是呼吸启动的，以便向患者提供药物的可重复剂量。 00000

10. 发明申请

WO2011033118A1 PREPARATION AND USE OF 68GA-COMPRISING PARTICLES FOR LUNG VENTILATION/PERFUSION AND PET IMAGING AND QUANTIFICATION 审中-公开
标题翻译：用于肺通气/灌注和PET成像和定量的68GA包裹颗粒的制备和使用
公开(公告)号：WO2011033118A1
公开(公告)日：2011-03-24
申请号：PCT/EP2010/063860
申请日：2010-09-21
申请人： GE HEALTHCARE LIMITED , HAMMERSMITH IMANET LIMITED , LANGSTROM, Bengt , SANDBERG, Hans-Olof , VELIKYAN, Irina
发明人： LANGSTROM, Bengt , SANDBERG, Hans-Olof , VELIKYAN, Irina
IPC分类号： A61K51/12
CPC分类号： A61K51/1206
摘要： The invention provides a preparation of a ventilation/perfusion imaging agent comprising positron emitting 68 Ga, produced, from a 68 Ge/ 68 Ga generator. The agent provides high quality images and quantification that make PET examinations available to improve the management of patients under critical conditions such as pulmonary embolism. Assessment of the ventilation distribution is part of the evaluation of lung function prior to lung resection and is also part of the diagnosis of pulmonary emboli.
摘要翻译：本发明提供了一种通气/灌注显像剂的制备方法，其包括从68Ge / 68Ga发生器产生的正电子发射68Ga。该药物提供高质量的图像和定量，使得PET检查可用于改善在诸如肺栓塞的关键条件下的患者的管理。通气分布的评估是肺切除术前肺功能评估的一部分，也是肺栓塞诊断的一部分。

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