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21. 发明申请

WO2003071928A2 METHOD AND APPARATUS FOR DETERMINING CEREBRAL OXYGEN SATURATION 审中-公开
标题翻译：确定脑氧饱和度的方法和设备
公开(公告)号：WO2003071928A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/005868
申请日：2003-02-27
申请人： NEUROPHYSICS CORPORATION , STODDART, Hugh, F. , STODDART, Hugh, A. , SEFRANEK, Thomas, Christopher, John , OLDEN, Timothy , MARTIN, Dale
发明人： STODDART, Hugh, F. , STODDART, Hugh, A. , SEFRANEK, Thomas, Christopher, John , OLDEN, Timothy , MARTIN, Dale
IPC分类号： A61B
CPC分类号： G01N21/49 , A61B5/14553 , A61B5/1464 , A61B2562/0242 , G01N21/4795 , G01N2021/3144
摘要： A new and improved method and apparatus for determining cerebral oxygenation. In one basic aspect, a new processing methodology for oxygenation determination, in particular cerebral oxygenation, is provided based on the apprehension and discovery that time-based photon quantity determinations of the wavelength-specific light leaving the head of the patient may be significantly improved, and simplified, by determining the quantity of returning photons in at least one set of two different but closely spaced points in time following the instant of injection, and then taking the ratio of the determinations in each set, to thereby cancel and remove several important sources of error.
摘要翻译：一种用于确定脑氧合的新的和改进的方法和装置。在一个基本方面，基于对于离开患者头部的波长特异性光的基于时间的光子量确定可能被显着改善的理解和发现，提供了用于氧合确定，尤其是脑氧合的新处理方法，并且通过确定在注射瞬间之后的至少一组两个不同但紧密间隔的时间点中的返回光子的量并且然后获取每组中的确定的比率来简化，从而消除和去除若干重要来源的错误。

22. 发明申请

WO2003055382A2 VERFAHREN UND VORRICHTUNG ZUR BESTIMMUNG EINES LICHTTRANSPORTPARAMETERS UND EINES ANALYTEN IN EINER BIOLOGISCHEN MATRIX 审中-公开
标题翻译：方法和一种用于确定光传输和参数分析物在生物MATRIX
公开(公告)号：WO2003055382A2
公开(公告)日：2003-07-10
申请号：PCT/EP2002/013884
申请日：2002-12-07
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMAN-LA ROCHE AG , KRAEMER, Uwe , HEIN, Heinz-Michael , HERMANN, Marcus
发明人： KRAEMER, Uwe , HEIN, Heinz-Michael , HERMANN, Marcus
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： Verfahren zur selektiven Bestimmung des Streuindex µ s in einer streuenden biologischen Matrix, insbesondere zum Zwecke der nichtinvasiven Bestimmung der Konzentration von Glucose in der Haut, mit Hilfe von Detektionsmessungen, bei denen jeweils Licht als Primärlicht (9) in die biologische Matrix (5) eingestrahlt wird und ein Intensitätsmesswert von an einem Detektionsort (33-40), der sich bei den Detektionsmessungen in unterschiedlichen Messabständen (ρ) von dem jeweiligen Einstrahlungsort (10) befindet, austretendem Sekundärlicht (12) gemessen wird. Um die Qualität und Selektivität der Bestimmung von µ s zu verbessern, wird das Primärlicht mittels eines Kontaktierenden Lichtleitelementes schräg unter einem Winkel zwischen 5° und 85° eingestrahlt, wobei bei mindestens zwei Detektionsmessungen der Messabstand (ρ) zwischen dem jeweiligen Einstrahlungsort (10) und dem jeweiligen Detektionsort (33-40) höchstens der fünffachen mittleren freien Weglänge des in der biologischen Matrix propagierenden Lichts entspricht.
摘要翻译：对于散射指数万分之一的在散射生物基质的选择性测定用于非侵入性测定葡萄糖在皮肤的浓度的目的，在每个光的方法，特别是，具有检测测量值的帮助下，照射作为一次光（9）在生物基质（5）和的强度测量值在在各个照射点（10）的不同的测量距离（RHO）在检测测量延伸，离开第二光的检测部位（33-40）（12）被测量。为了提高百万分之一的确定的质量和选择性，所述初级光通过以5°和85°之间的角度倾斜的导光元件接触的手段照射，与所述各照射部位（10）之间的测量距离（RHO）的至少两个检测测量和各个检测（33-40）是至多等于在生物基质中的传播光的五倍的平均自由程。

23. 发明申请

WO2003041582A1 生体成分濃度の測定方法及びその装置审中-公开
标题翻译：测量生物组分浓度的方法及其设备
公开(公告)号：WO2003041582A1
公开(公告)日：2003-05-22
申请号：PCT/JP2002/011871
申请日：2002-11-14
申请人：松下電工株式会社 , 丸尾勝彦 , 鶴来充啓
发明人：丸尾勝彦 , 鶴来充啓
IPC分类号： A61B5/145
CPC分类号： A61B5/1495 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/7264 , A61B2562/0242
摘要： A biological component concentration (for example, glucose concentration) of a subject is measured by irradiating the skin of the subject with light having a wavelength of near−infrared spectrum, taking out the near−infrared spectrum reflected from the skin of the subject and substituting the near−infrared spectral data for values in a definite calibration formula. A plural number of different calibration formulae respectively corresponding to different groups classified on the basis of skin thickness parameters showing skin thickness of species to which subjects belong are prepared. Then the skin thickness parameter of the subject is determined by a non−invasive method and the group to which the subject belongs is distinguished based on the skin thickness parameter. Next, a calibration formula agreeing with the thus distinguished group is taken so that the biological component concentration of the subject is calculated.
摘要翻译：通过用具有近红外光谱波长的光照射受试者的皮肤来测量受试者的生物成分浓度（例如葡萄糖浓度），取出从受试者的皮肤反射的近红外光谱并代替用于确定校准公式中的值的近红外光谱数据。分别对应于根据显示受试者属于物种的皮肤厚度的皮肤厚度参数分类的不同组的多个不同校准公式。然后通过非侵入性方法确定受试者的皮肤厚度参数，并且基于皮肤厚度参数区分受试者所属的组。接下来，采用与这样辨别的组一致的校准公式，以便计算受试者的生物成分浓度。

24. 发明申请

WO2002083003A1 TISSUE STRUCTURE IDENTIFICATION IN ADVANCE OF INSTRUMENT 审中-公开
标题翻译：仪器结构组织结构鉴定
公开(公告)号：WO2002083003A1
公开(公告)日：2002-10-24
申请号：PCT/US2002/011436
申请日：2002-04-11
申请人： CLARKE, Dana, S.
发明人： CLARKE, Dana, S.
IPC分类号： A61B6/00
CPC分类号： A61B17/3211 , A61B5/0066 , A61B5/0084 , A61B5/6848 , A61B5/6849 , A61B17/34 , A61B90/37 , A61B2017/00061 , A61B2090/061 , A61B2090/062 , A61B2090/306 , A61B2090/3614 , A61B2562/0242 , G01N21/8507
摘要： A method and apparatus for identifying tissue structures in advance of a mechanical medical instrument during a medical procedure. A mechanical tissue penetrating medical instrument (22) has a distal end for penetrating tissue in a penetrating direction. An optical wavefront analysis system (32-50) provides light to illuminate tissue ahead of the medical instrument and receives light returned by tissue ahead of the medical instrument. An optical fiber (30) is coupled at a proximal end to the wavefront analysis system and attached at a distal end to the medical instrument proximate the distal end of the medical instrument. The distal end of the fiber has an illumination pattern directed substantially in the penetrating direction for illuminating the tissue ahead of the medical instrument and receiving light returned therefrom. The wavefront analysis system provides information about the distance from the distal end of the medical instrument to tissue features ahead of the medical instrument.
摘要翻译：一种用于在医疗过程期间识别机械医疗器械之前的组织结构的方法和装置。机械组织穿透医疗器械（22）具有用于沿穿透方向穿透组织的远端。光学波前分析系统（32-50）提供光以照亮医疗器械前方的组织，并接收医疗器械前方的组织返回的光。光纤（30）在近端处耦合到波前分析系统，并且在远端附近附接到靠近医疗器械的远端的医疗器械。纤维的远端具有基本上沿着穿透方向指向的照明图案，用于照亮医疗器械前方的组织并且接收从其返回的光。波前分析系统提供关于从医疗器械的远端到医疗器械前方的组织特征的距离的信息。

25. 发明申请

WO2002060320A1 METHOD FOR THE NON-INVASIVE DETERMINATION OF AN ANALYTE IN A SELECTED VOLUME OF TISSUE 审中-公开
标题翻译：非选择性地确定选定体积组织中分析物的方法
公开(公告)号：WO2002060320A1
公开(公告)日：2002-08-08
申请号：PCT/US2001/050717
申请日：2001-10-18
申请人： ABBOTT LABORATORIES
发明人： KHALIL, Omar, S. , YEH, Shu-jen , HANNA, Charles, F. , KANTOR, Stanislaw
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/0059 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1491 , A61B5/6824 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/4795
摘要： A method for the determination of concentrations of analytes, e. g., glucose, and other metabolites in human tissue, wherein the temperature of a defined cutaneous volume of tissue is controlled. The method involves calculating the concentration of an analyte in the tissue by taking into consideration the values of optical parameters of a sample of tissue measured in the defined cutaneous volume of the tissue at various temperatures. The selection of the defined volume is a function of the sampling distance along the surface of the tissue, the wavelength of light used to illuminate the tissue, and the temperature in the defined volume of tissue, which is a function of the temperature at the surface of the tissue. In an embodiment of the method of this invention, the temperature of the defined cutaneous volume of the tissue is varied within a defined physiological range to change the depth of penetration of light into the tissue, thereby achieving a depth profile for the optical signal. The method of this invention utilizes changes in temperature and selection of wavelengths to define cutaneous volumes below the surface of the tissue, in which volumes the concentration of an analyte can be determined.
摘要翻译：一种测定分析物浓度的方法，例如葡萄糖和人体组织中的其它代谢物，其中控制组织的限定皮肤体积的温度。该方法包括通过考虑在各种温度下在组织的定义的皮肤体积中测量的组织样品的光学参数的值来计算组织中分析物的浓度。定义体积的选择是沿着组织表面的采样距离，用于照亮组织的光的波长和组织的限定体积中的温度的函数，其是表面温度的函数的组织。在本发明方法的一个实施方案中，组织的限定的皮肤体积的温度在规定的生理范围内变化，以改变光进入组织的深度，从而实现光信号的深度分布。本发明的方法利用温度的变化和波长的选择来限定组织表面以下的皮肤体积，其中可以确定分析物的浓度。

26. 发明申请

WO02057758A1 ANALYSIS OF A COMPOSITION 审中-公开
标题翻译：组合物的分析
公开(公告)号：WO02057758A1
公开(公告)日：2002-07-25
申请号：PCT/IB2002/000111
申请日：2002-01-16
IPC分类号： A61B5/00 , A61B5/145 , A61B5/15 , A61B10/00 , G01N21/65 , G02B21/00
CPC分类号： G01N21/65 , A61B5/0068 , A61B5/0075 , A61B5/489 , A61B5/6824 , A61B5/7207 , A61B2562/0242 , G01N2021/656 , G02B21/0024 , G02B21/008
摘要： An analysis apparatus, in particular a spectroscopic analysis apparatus, comprises an excitation system (exs) for emitting an excitation beam (exb) to excite a target region during an excitation period. A monitoring system (lso) is provided for emitting a monitoring beam (irb) to image the target region during a monitoring period. The monitoring period and the excitation period being substantially overlap, so that monitoring the target region is maintained during excitation. The analysis apparatus is provided with a tracking system (osc, dcu) to control the excitation system to direct the excitation beam onto the target region.
摘要翻译：分析装置，特别是光谱分析装置，包括用于在激发期间发射激发光束（exb）以激发目标区域的激励系统（exs）。提供监测系统（lso），用于在监测期间发射监测光束（irb）以对目标区域成像。监视周期和激励周期基本上重叠，从而在激励期间维持目标区域的监视。分析装置设有跟踪系统（osc，dcu），以控制激励系统将激发光束引导到目标区域上。

27. 发明申请

WO0224048A2 APPARATUS AND METHOD FOR MONITORING TISSUE VITALITY PARAMETERS 审中-公开
标题翻译：用于监测组织活力参数的装置和方法
公开(公告)号：WO0224048A2
公开(公告)日：2002-03-28
申请号：PCT/IL0100906
申请日：2001-09-25
申请人： VITAL MEDICAL LTD , PEWZNER ELIAHU , MAYEVSKY AVRAHAM
发明人： PEWZNER ELIAHU , MAYEVSKY AVRAHAM
IPC分类号： A61B5/00 , A61B5/026 , A61B
CPC分类号： A61B5/14546 , A61B5/0261 , A61B5/14553 , A61B2562/0242
摘要： Apparatus for monitoring a plurality of tissue viability parameters of a tissue layer element, in which two different illumination sources are used via a common illumination element in contact with the tissue. One illumination source is used for monitoring blood flow rate and optionally flavoprotein concentration, and collection fibers are provided to receive the appropriate radiation from the tissue. The other illuminating radiation is used for monitoring any one of and preferably all of NADH, blood volume and blood oxygenation state of the tissue element, and collection fibers are provided to receive the appropriate radiation from the tissue. In one embodiment, the wavelengths of the two illumination sources are similar, and common collection fibers for the two illuminating radiations are used. In another embodiment, the respective collection fibers are distanced from the illumination point at different distances correlated to the ratio of the first and second illuminating wavelengths.
摘要翻译：用于监测组织层元件的多个组织层存活性参数的设备，其中两个不同的照明源经由与组织接触的共同照明元件被使用。一个照明源用于监测血流速度和任选的黄素蛋白浓度，并且提供收集纤维以从组织接收适当的辐射。其他照射辐射用于监测组织元件的NADH，血容量和血液氧合状态中的任何一个，优选全部，并且提供收集纤维以从组织接收适当的辐射。在一个实施例中，两个照射源的波长相似，并且使用两个照射射线的公共收集光纤。在另一个实施例中，各个收集光纤在与第一和第二照射波长的比率相关的不同距离处与照射点间隔开。

28. 发明申请

WO0139665A3 METHOD AND APPARATUS FOR NONINVASIVE ASSESSMENT OF SKIN CONDITION AND DIAGNOSIS OF SKIN ABNORMALITIES 审中-公开
标题翻译：非皮肤评估皮肤异常和皮肤异常诊断的方法和装置
公开(公告)号：WO0139665A3
公开(公告)日：2001-12-13
申请号：PCT/US0032682
申请日：2000-11-30
申请人： LIGHTOUCH MEDICAL INC
发明人： CHAIKEN JOSEPH , PETERSON CHARLES M , PETERSON KAREN P
IPC分类号： A61B5/00 , A61B5/103 , G01N21/65
CPC分类号： A61B5/444 , A61B5/0059 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0091 , A61B5/442 , A61B5/7239 , A61B2562/0242 , G01N21/65
摘要： Disclosed is a method for obtaining feedback to drive a servo system for aligning and maintaining alignment in optical systems that bring light to an in vivo skin sample, for adjusting the focus of the optical system, and for adjusting the net depth of focus of the optical system within the in vivo system under characterization. The invention additionally provides a method for obtaining feedback to drive a servo system for aligning and maintaining alignment in optical systems that collect light from an in vivo skin sample, and for adjusting the focus of the optical system. These methods comprise adjusting the angle of incidence of electromagnetic radiation and/or providing a shielding lens to block scattered incident light, or otherwise limiting the field of view of the Raman scattered radiation collection system to exclude optical surfaces of the excitation delivery portion of the optical system. Also provided is a method for identifying spectroscopic depth markers in tissues. In one embodiment, the method comprises discriminating between Raman signals originating on outer portions of skin from signals originating from substances deeper within the skin or other tissues. In another embodiment, the invention provides a method for detecting skin abnormalities and for assessing the aging of skin and related tissues. The method comprises characterizing the content of the skin using Raman spectroscopy. In one embodiment, the collagen, elastin, and or keratin content of the skin is characterized.
摘要翻译：公开了一种用于获得反馈的方法，用于驱动伺服系统以对准和维持光学系统中的对准，其将光引入体内皮肤样本，用于调节光学系统的焦点，并且用于调整光学系统在体内<！ - SIPO - >系统中的净深度在表征下。本发明另外提供了一种用于获得反馈的方法，用于驱动用于对准和维持在收集来自体内皮肤样品的光的光学系统中的对准并用于调整光学系统的焦点的伺服系统。这些方法包括调整电磁辐射的入射角和/或提供屏蔽透镜以阻挡散射的入射光，或以其它方式限制拉曼散射辐射收集系统的视野，以排除光学的激发传递部分的光学表面系统。还提供了一种用于在组织中鉴定光谱深度标记的方法。在一个实施方案中，该方法包括从源于皮肤或其他组织内的物质的信号中识别源于皮肤的外部部分的拉曼信号。在另一个实施方案中，本发明提供了一种用于检测皮肤异常和评估皮肤和相关组织的老化的方法。该方法包括使用拉曼光谱学表征皮肤的内容。在一个实施方案中，表征皮肤的胶原蛋白，弹性蛋白和角蛋白含量。

29. 发明申请

WO01087151A2 METHOD AND DEVICE FOR THE NONINVASIVE DETERMINATION OF HEMOGLOBIN AND HEMATOCRIT 审中-公开
标题翻译： HEMOGLOBIN和HEMATOCRIT的非活性测定方法和装置
公开(公告)号：WO01087151A2
公开(公告)日：2001-11-22
申请号：PCT/US2001/014542
申请日：2001-05-07
IPC分类号： G01N21/01 , A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/17 , G01N21/47 , H01L29/04
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/1491 , A61B5/6824 , A61B2562/0233 , A61B2562/0242 , A61B2562/043
摘要： A method for the determination of hemoglobin and hematocrit by means of an apparatus that is capable of controlling the temperature of a defined subcutaneous volume of human skin. The method involves a calculation of hemoglobin concentration and hematocrit value that takes into consideration the values of optical parameters of the sample at various pre-set temperatures. The apparatus and method employ steady state optical measurements of samples, such as, for example, human tissue, by means of a reflectance tissue photometer and localized control of the temperature of the sample. According to the method of this invention, an optical signal from a defined subcutaneous volume of human skin is measured as the temperature of this volume is controlled. The method and apparatus of this invention allow determination of hemoglobin concentration and hematocrit value non-invasively in a population of subjects having different skin colors by means of steady state reflectance measurements. The method of this invention for determination of hemoglobin concentration and hematocrit value is useful for monitoring patients, testing at the point of care, and screening for anemia. In contrast to other attempts in the prior art that rely on signals of cardiac pulses, the method of this invention has the advantage for the determination of analytes in weak cardiac pulse situations, such as, for example, in elderly patients.
摘要翻译：用于通过能够控制人皮肤的规定的皮下体积的温度的装置来测定血红蛋白和血细胞比容的方法。该方法涉及在各种预设温度下考虑样品的光学参数的值的血红蛋白浓度和血细胞比容值的计算。该装置和方法利用反射组织光度计对样品（例如人体组织）进行稳态光学测量，并对样品的温度进行局部控制。根据本发明的方法，当控制该体积的温度时，测量来自人体皮肤的确定的皮下体积的光学信号。本发明的方法和装置允许通过稳态反射测量在具有不同皮肤颜色的受试者群体中非侵入性地测定血红蛋白浓度和血细胞比容值。用于测定血红蛋白浓度和血细胞比容值的本发明的方法对于监测患者，在护理点进行测试和筛查贫血是有用的。与依靠心脏脉冲信号的现有技术中的其他尝试相反，本发明的方法具有测定弱心脏脉搏情况下的分析物的优点，例如老年患者。

30. 发明申请

WO01003571A1 METHOD OF MEASURING CONCENTRATION OF LUMINESCENT MATERIALS IN TURBID MEDIA 审中-公开
标题翻译：测量流体介质中的发光材料浓度的方法
公开(公告)号：WO01003571A1
公开(公告)日：2001-01-18
申请号：PCT/CA2000/000823
申请日：2000-07-13
IPC分类号： A61B5/00
CPC分类号： A61B5/14556 , A61B5/0071 , A61B5/0084 , A61B5/1459 , A61B2562/0242
摘要： The present invention provides a method for measurement of concentration of fluorophores in turbid media. The method uses a fluorescence plus reflectance technique to measure quantitatively the iin vivo concentration of a fluorescent drug independent of the tissue optical properties. The method involves using the reflectance measurement as a means of correcting for tissue scattering and absorption in the fluorescence measurement. Light directed to the tissue by means of an optical fiber to excite the fluorophores. Fluorescence from the fluorophores is measured by another fiber at a distance (D1) from the source in the turbid medium, while the excitation light is simultaneously collected at a distance (D2) from the source. The ratio fluorescence/reflectance will be approximately constant for a fixed concentration of the fluorophore and a judicious choice of D1 and D2, regardless of the optical properties of the tissue. The ratio of fluorescence to reflectance on a tissue sample is compared to a calibration curve for a range of fluorophore concentrations, in order to estimate the in vivo concentration in the turbid medium.
摘要翻译：本发明提供了一种测量浑浊介质中荧光团浓度的方法。该方法使用荧光加反射技术定量地测量荧光药物的体内浓度，而与组织光学性质无关。该方法包括使用反射测量作为校正荧光测量中的组织散射和吸收的手段。光通过光纤导向组织以激发荧光团。来自荧光团的荧光是通过另一纤维在与混浊介质中的源距离（D1）测量的，而激发光同时来自与源距离（D2）收集。对于固定浓度的荧光团，荧光/反射率的比率将近似恒定，并且D1和D2的明智选择，而不管组织的光学性质如何。将组织样品上的荧光与反射率的比率与荧光团浓度范围的校准曲线进行比较，以估计混浊介质中的体内浓度。

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