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21. 发明申请

WO2006020958B1 ORGANOGENESIS FROM DISSOCIATED CELLS 审中-公开
标题翻译：来自不同细胞的成骨细胞
公开(公告)号：WO2006020958B1
公开(公告)日：2006-07-27
申请号：PCT/US2005028933
申请日：2005-08-15
申请人： ADERANS RES INST INC , ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
发明人： ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
IPC分类号： A61K8/98 , A61K35/36 , A61Q7/00 , C12N5/071
CPC分类号： A61K35/36 , A61K8/02 , A61K8/985 , A61K35/12 , A61Q7/00 , C12N5/0627
摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate "infundibular cysts". From the "infundibular cysts" hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the "infundibular cysts" by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
摘要翻译：公开了一种用于从解离的上皮和间充质细胞中快速和可重复地产生毛囊的方法测定法。该方法既用于测量细胞的致毛体（即毛发生长诱导）性质和用于研究解离的细胞用于组装器官的机制。在这种方法中，从新生小鼠皮肤分离的解离的细胞被注射到成年小鼠的截肢皮肤中，形成毛囊。该过程涉及上皮细胞的聚集以形成通过凋亡而雕刻以产生“漏斗状囊肿”的簇。从“漏斗状囊肿”毛发细胞形式，然后是滤泡芽，然后是不对称生长的分离成循环成熟的皮脂状结构的栓。使用各种技术，通过穿刺，刺穿或刮伤皮肤暴露“漏斗状囊肿”，并且在使用产生流出毛囊的伤口敷料材料覆盖暴露的囊肿的方法中。

22. 发明申请

WO2004004665A2 SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译：用作抗糖尿病药和抗衰老药的取代的杂环衍生物和方法
公开(公告)号：WO2004004665A2
公开(公告)日：2004-01-15
申请号：PCT/US0322149
申请日：2003-07-02
申请人： SQUIBB BRISTOL MYERS CO , CHENG PETER T W , CHEN SEAN , DEVASTHALE PRATIK , DING CHARLES Z , HERPIN TIMOTHY F , WU SHUNG , ZHANG HAO , WANG WEI , YE XIANG-YANG
发明人： CHENG PETER T W , CHEN SEAN , DEVASTHALE PRATIK , DING CHARLES Z , HERPIN TIMOTHY F , WU SHUNG , ZHANG HAO , WANG WEI , YE XIANG-YANG
IPC分类号： A61K31/155 , A61K31/216 , A61K31/22 , A61K31/365 , A61K31/366 , A61K31/397 , A61K31/401 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/616 , A61K31/64 , A61K38/28 , A61K45/00 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/10 , A61P17/06 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/14 , C07D413/12 , C07D413/14 , A61K
CPC分类号： C07D413/12 , C07D413/14
摘要： Formula, wherein Z is (CH2)q or C=O; Z is (CH2)p or C=O; D is -CH= or C=O or (CH2)m where m is 0, 1, 2 or 3; n = 0, 1 or 2; p = 1 or 2; q = 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x , where x is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x -O-(CH2)x - where x is 0 to 5 and x is 0 to 5, provided that at least one of x and x is other than 0; B is a bond or is (CH2)x where x is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C. R is H or alkyl; R is H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; R , R and R may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; and R , E, Z and Y are as defined herein.
摘要翻译：式，其中Z 1是（CH 2）q或C = O; Z 2是（CH 2）p或C = O; D是-CH =或C = O或（CH 2）m，其中m是0,1,2或3; n = 0,1或2; p = 1或2; q = 0,1或2; Q是C或N; A是（CH 2）x，其中x是1至5，或A是（CH 2）x 1，其中x 1是1至5且链中任何位置嵌入烯基键或炔基键，或A是 - （CH 2）x 2 -O-（CH 2）x 3 - 其中x 2为0至5且x 3为0至5，条件是x 2和x中的至少一个 <3>不是0; B是键或是（CH 2）x 4，其中x 4是1至5; X是CH或N; X2是C，N，O或S; X3是C，N，O或S; X4是C，N，O或S; X5是C，N，O或S; X6是C，N，O或S; 条件是X2，X3，X4，X5和X6中的至少一个是N; 并且X 2，X 3，X 4，X 5和X 6中的至少一个是C.R 1是H或烷基; R 2是H，烷基，烷氧基，卤素，氨基，取代的氨基或氰基; R 2a，R 2b和R 2c可以相同或不同，并且选自H，烷基，烷氧基，卤素，氨基，取代的氨基或氰基; 并且R 3，E，Z和Y如本文所定义。

23. 发明申请

WO0200243A3 STABILIZED INTERLEUKIN 2 审中-公开
标题翻译：稳定的白蛋白2
公开(公告)号：WO0200243A3
公开(公告)日：2003-10-02
申请号：PCT/US0120675
申请日：2001-06-27
申请人： BAYER AG , WANG WEI , NAYAR RAJIV , SHEARER MICHAEL A
发明人： WANG WEI , NAYAR RAJIV , SHEARER MICHAEL A
IPC分类号： A61K9/19 , A61K38/00 , A61K38/20 , A61K47/04 , A61K47/18 , A61K47/22 , A61K47/26 , A61P35/00 , A61P43/00
CPC分类号： A61K38/2013
摘要： A stable pharmaceutical preparation comprising Human interleukin-2 or a variant thereof and a stabilizing amount of histidine. A preferred formulation includes glycine and sucrose and a variant of IL-2 having a single mutation, N88R. The preferred formulation is in lyophilized form which, on reconstitution with an aqueous diluent, results in a solution having a pH ranging from about 5.0 to 6.5.
摘要翻译：一种稳定的药物制剂，其包含人白细胞介素-2或其变体和稳定量的组氨酸。优选的制剂包括甘氨酸和蔗糖以及具有单一突变的N88R的IL-2的变体。优选的制剂是冻干形式，其在与水性稀释剂重建时产生pH范围为约5.0至6.5的溶液。

24. 发明申请

WO2012091827A3 GRAPHENE/LIFEPO4 CATHODE WITH ENHANCED STABILITY 审中-公开
标题翻译：具有增强稳定性的GRAPHENE / LIFEPO4阴茎
公开(公告)号：WO2012091827A3
公开(公告)日：2014-04-10
申请号：PCT/US2011062016
申请日：2011-11-23
申请人： BATTELLE MEMORIAL INSTITUTE , CHOI DAIWON , LIU JUN , YANG ZHENGUO , WANG WEI , GRAFF GORDON L
发明人： CHOI DAIWON , LIU JUN , YANG ZHENGUO , WANG WEI , GRAFF GORDON L
IPC分类号： H01M10/052 , H01M10/0563
CPC分类号： H01M4/5825 , B82Y30/00 , H01M4/583
摘要： A lithium ion battery having an anode, an electrolyte, and a cathode comprising nano-structured carbon in electrical communication with LiFePO4. The cathode of the lithium ion battery of the present invention has sufficient structural stability to maintain at least 90-99 percent of the specific capacity of the cathode over 500 charge/discharge cycles.
摘要翻译：一种具有阳极，电解质和阴极的锂离子电池，其包含与LiFePO 4电连通的纳米结构碳。本发明的锂离子电池的阴极具有足够的结构稳定性，以在500次充电/放电循环中保持阴极的比容量的至少90-99％。

25. 发明申请

WO2013192277A3 CONSTRUCTS AND METHODS INVOLVING GENES ENCODING GLUTAMATE RECEPTOR POLYPEPTIDES 审中-公开
标题翻译：涉及编码谷氨酸受体多肽的基因的构建和方法
公开(公告)号：WO2013192277A3
公开(公告)日：2014-03-27
申请号：PCT/US2013046488
申请日：2013-06-19
申请人： PIONEER HI BRED INT , BEIJING KAITUO DNA BIOTECH RES CT CO LTD , GAO YANG , LIU JINGMEI , LIU JUNHUA , LOUSSAERT DALE , LU GUIHUA , SIVASANKAR SHOBA , WANG CHANGGUI , WANG WEI , WANG XIPING , XIA MIAN , YU KUN
发明人： GAO YANG , LIU JINGMEI , LIU JUNHUA , LOUSSAERT DALE , LU GUIHUA , SIVASANKAR SHOBA , WANG CHANGGUI , WANG WEI , WANG XIPING , XIA MIAN , YU KUN
IPC分类号： C12N15/82 , C07H21/04 , C12N15/87
CPC分类号： C07K14/415 , C07K14/70571 , C12N15/8273
摘要： The invention discloses isolated polynucleotides and polypeptides, and recombinant DNA constructs useful for conferring drought tolerance and/or improved nitrogen use efficiency; compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode glutamate receptor polypeptides.
摘要翻译：本发明公开了分离的多核苷酸和多肽，以及可用于赋予耐旱性和/或提高的氮利用效率的重组DNA构建体; 包含这些重组DNA构建体的组合物（例如植物或种子）和利用这些重组DNA构建体的方法。重组DNA构建体包含可操作地连接到在植物中有功能的启动子的多核苷酸，其中所述多核苷酸编码谷氨酸受体多肽。

26. 发明申请

WO2012159001A3 NANOMATERIALS FOR SODIUM-ION BATTERIES 审中-公开
标题翻译：钠离子电池的纳米材料
公开(公告)号：WO2012159001A3
公开(公告)日：2013-04-11
申请号：PCT/US2012038505
申请日：2012-05-18
申请人： BATTELLE MEMORIAL INSTITUTE , LIU JUN , CAO YULIANG , XIAO LIFEN , YANG ZHENGUO , WANG WEI , CHOI DAIWON , NIE ZIMIN
发明人： LIU JUN , CAO YULIANG , XIAO LIFEN , YANG ZHENGUO , WANG WEI , CHOI DAIWON , NIE ZIMIN
IPC分类号： H01M4/505 , H01M4/131 , H01M10/054
CPC分类号： H01M4/505 , H01M4/131 , H01M4/50 , H01M10/054 , H01M14/00 , Y02E60/122 , Y10T428/298
摘要： A crystalline nanowire and method of making a crystalline nanowire are disclosed. The method includes dissolving a first nitrate salt and a second nitrate salt in an acrylic acid aqueous solution. An initiator is added to the solution, which is then heated to form polyacrylatyes. The polyacrylates are dried and calcined. The nanowires show high reversible capacity, enhanced cycleability, and promising rate capability for a battery or capacitor.
摘要翻译：公开了晶体纳米线和制造结晶纳米线的方法。该方法包括将第一硝酸盐和第二硝酸盐溶解在丙烯酸水溶液中。向溶液中加入引发剂，然后将其加热形成聚丙烯酰胺。将聚丙烯酸酯干燥并煅烧。纳米线显示出高可逆容量，增强的循环性，以及电池或电容器的有前途的速率能力。

27. 发明申请

WO2012061578A3 SPERM MOTILITY ANALYZER AND RELATED METHODS 审中-公开
标题翻译： SPERM MOTILITY分析仪及相关方法
公开(公告)号：WO2012061578A3
公开(公告)日：2012-06-28
申请号：PCT/US2011059112
申请日：2011-11-03
申请人： UNIV NORTH CAROLINA , GOODSON SUMMER , ZHANG ZHAOJUN , TSURUTA JAMES , WANG WEI , O'BRIEN DEBORAH
发明人： GOODSON SUMMER , ZHANG ZHAOJUN , TSURUTA JAMES , WANG WEI , O'BRIEN DEBORAH
IPC分类号： G01N33/487 , C12M1/00 , G01N21/85
CPC分类号： G01N33/5091
摘要： Method and systems of classifying sperm motility include detecting one or more movement parameters of a plurality of sperm in a sample using a computer-assisted sperm analysis device. The movement parameters of individual ones of the plurality of sperm are classified into one of at least four classifications.
摘要翻译：分类精子活力的方法和系统包括使用计算机辅助精子分析装置检测样品中多个精子的一个或多个运动参数。将多个精子中的各个精子的运动参数分类为至少四个分类中的一个。

28. 发明申请

WO2011103002A3 GOLD COLORED METALLIC PIGMENTS THAT INCLUDE MANGANESE OXIDE NANOPARTICLES LAYERS 审中-公开
标题翻译：黄金色金属色素，包括锰氧化物纳米颗粒层
公开(公告)号：WO2011103002A3
公开(公告)日：2011-12-29
申请号：PCT/US2011024170
申请日：2011-02-09
申请人： SILBERLINE MFG CO INC , WANG WEI , LIN HAI HUI , LIKIBI PARFAIT JEAN MARIE
发明人： WANG WEI , LIN HAI HUI , LIKIBI PARFAIT JEAN MARIE
IPC分类号： C09C1/62 , C09C3/10
CPC分类号： C09C1/0015 , B82Y30/00 , C01P2002/85 , C01P2004/03 , C01P2004/04 , C01P2004/64 , C01P2006/62 , C01P2006/63 , C01P2006/64 , C08K3/08 , C08K3/22 , C08K3/34 , C08K3/38 , C08K3/40 , C08K9/02 , C08K9/04 , C09C2200/1058 , C09C2200/407 , C09C2200/505 , C09D7/62 , C09D7/70 , C09D11/037 , C09D17/004
摘要： A gold color metallic pigment with coating of manganese oxide nanoparticles and a method to produce the gold color pigment are described. The disclosed coated pigment includes a platelet shaped substrate, a passivation layer applied to the substrate with surface anchoring groups and a manganese oxide nanoparticles layer. The coated pigment further includes an encapsulation layer or a surface property modification layer. The disclosed method provides pigments that exhibit brilliant gold color and a highly desirable appearance of real gold without the environmental issues causing by heavy metals.
摘要翻译：描述了具有氧化锰纳米颗粒涂层的金色金属颜料和制备金色颜料的方法。所公开的涂覆颜料包括片状基材，用表面锚定基团施加到基材上的钝化层和氧化锰纳米颗粒层。涂层颜料还包括封装层或表面性质改性层。所公开的方法提供了颜料，其显示出明亮的金色和真正金色的非常理想的外观，而没有由重金属引起的环境问题。

29. 发明申请

WO2011011105A3 TRACEABLE RETINOID ACID FOR IMAGING, DISEASE PREVENTION AND THERAPY 审中-公开
标题翻译：用于成像，疾病预防和治疗的可追踪的抗感染药
公开(公告)号：WO2011011105A3
公开(公告)日：2011-03-17
申请号：PCT/US2010033918
申请日：2010-05-06
申请人： BAYLOR COLLEGE MEDICINE , KE SHI , WANG WEI , MAWAD MICHEL
发明人： KE SHI , WANG WEI , MAWAD MICHEL
IPC分类号： A61K49/00 , C07D403/06
CPC分类号： A61K49/0052 , A61K49/0032 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/574 , G01N33/582 , G01N2800/56
摘要： The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.
摘要翻译：本发明提供了基于类视黄酸衍生物的结构的非放射性近红外光学成像剂。已经通过共焦显微镜在细胞水平上评估了非放射性近红外光学成像剂，并且在使用各种异种移植模型的整个动物体内进行了体内评估。该药物在人类癌细胞和多种异种移植物模型中的特异性摄取表明，非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于早期癌症研究和诊断。此外，本发明提供了非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于体内药物再分布的可视化，其可用于确定最佳生物剂量。最终，可视化数据可用作分析工具，以减少任何全身毒性。

30. 发明申请

WO2010093926A3 COMPOSITE MATERIALS FORMED WITH ANCHORED NANOSTRUCTURES 审中-公开
标题翻译：形成具有锚定纳米结构的复合材料
公开(公告)号：WO2010093926A3
公开(公告)日：2010-12-02
申请号：PCT/US2010024107
申请日：2010-02-12
申请人： BABCOCK & WILCOX TECH SERV Y12 , UT BATTELLE LLC , SEALS ROLAND D , MENCHHOFER PAUL A , HOWE JANE Y , WANG WEI
发明人： SEALS ROLAND D , MENCHHOFER PAUL A , HOWE JANE Y , WANG WEI
IPC分类号： B82B3/00 , B82B1/00
CPC分类号： B01J23/74 , B01J23/745 , B01J35/0013 , B01J35/006 , B01J37/0207 , B01J37/0217 , B01J37/0221 , B01J37/033 , B01J37/18 , B22F1/025 , C22C29/08 , Y10S977/742 , Y10S977/773 , Y10S977/843
摘要： A method of forming nano-structure composite materials that have a binder material and a nanostructure fiber material is described. A precursor material may be formed using a mixture of at least one metal powder and anchored nanostructure materials. The metal powder mixture may be (a) Ni powder and (b) NiAl powder. The anchored nanostructure materials may comprise (i) NiAl powder as a support material and (ii) carbon nanotubes attached to nanoparticles adjacent to a surface of the support material. The process of forming nano-structure composite materials typically involves sintering the mixture under vacuum in a die. When Ni and NiAl are used in the metal powder mixture M3AI may form as the binder material after sintering. The mixture is sintered until it consolidates to form the nano-structure composite material.
摘要翻译：描述了形成具有粘合剂材料和纳米结构纤维材料的纳米结构复合材料的方法。前体材料可以使用至少一种金属粉末和锚定纳米结构材料的混合物形成。金属粉末混合物可以是（a）Ni粉末和（b）NiAl粉末。锚定的纳米结构材料可以包含（i）作为载体材料的NiAl粉末和（ii）附着到与载体材料的表面相邻的纳米颗粒上的碳纳米管。形成纳米结构复合材料的过程通常涉及在模具中在真空下烧结混合物。当在金属粉末混合物中使用Ni和NiAl时，在烧结之后可以形成M3Al作为粘合剂材料。将混合物烧结直至其固结形成纳米结构复合材料。

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