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1. 发明申请

WO2006020958A3 ORGANOGENESIS FROM DISSOCIATED CELLS 审中-公开
标题翻译：离散细胞中的有机体
公开(公告)号：WO2006020958A3
公开(公告)日：2006-06-01
申请号：PCT/US2005028933
申请日：2005-08-15
申请人： ADERANS RES INST INC , ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
发明人： ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
IPC分类号： A61K8/98 , A61K35/36 , A61Q7/00 , C12N5/071
CPC分类号： A61K35/36 , A61K8/02 , A61K8/985 , A61K35/12 , A61Q7/00 , C12N5/0627
摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate "infundibular cysts". From the "infundibular cysts" hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the "infundibular cysts" by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
摘要翻译：公开了用于从解离的上皮细胞和间充质细胞快速且可重复产生毛囊的方法测定法。该方法既可用作测量细胞毛发生成（即毛发生长诱导）特性的工具，也可用于研究分离细胞用于组装器官的机制。在本申请的方法中，将从新生小鼠皮肤分离的分离的细胞注射到成年小鼠躯干皮肤中，形成毛囊。该过程涉及上皮细胞的聚集以形成簇，其通过细胞凋亡雕刻以产生“漏斗状囊肿”。从“漏斗状囊肿”形成毛发，然后形成毛囊芽，然后栓不对称生长以分化为成熟的毛囊皮脂结构。使用各种技术，通过穿刺，刺穿或刮擦皮肤暴露“漏斗囊肿”，并且在一种方法中，用产生毛囊的创伤敷料材料覆盖暴露的囊肿。

2. 发明申请

WO2006020958B1 ORGANOGENESIS FROM DISSOCIATED CELLS 审中-公开
标题翻译：来自不同细胞的成骨细胞
公开(公告)号：WO2006020958B1
公开(公告)日：2006-07-27
申请号：PCT/US2005028933
申请日：2005-08-15
申请人： ADERANS RES INST INC , ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
发明人： ZHENG YING , DU XIAOBING , WANG WEI , BOUCHER MARYLENE , PARIMOO SATISH , STENN KURT STRICKER
IPC分类号： A61K8/98 , A61K35/36 , A61Q7/00 , C12N5/071
CPC分类号： A61K35/36 , A61K8/02 , A61K8/985 , A61K35/12 , A61Q7/00 , C12N5/0627
摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate "infundibular cysts". From the "infundibular cysts" hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the "infundibular cysts" by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
摘要翻译：公开了一种用于从解离的上皮和间充质细胞中快速和可重复地产生毛囊的方法测定法。该方法既用于测量细胞的致毛体（即毛发生长诱导）性质和用于研究解离的细胞用于组装器官的机制。在这种方法中，从新生小鼠皮肤分离的解离的细胞被注射到成年小鼠的截肢皮肤中，形成毛囊。该过程涉及上皮细胞的聚集以形成通过凋亡而雕刻以产生“漏斗状囊肿”的簇。从“漏斗状囊肿”毛发细胞形式，然后是滤泡芽，然后是不对称生长的分离成循环成熟的皮脂状结构的栓。使用各种技术，通过穿刺，刺穿或刮伤皮肤暴露“漏斗状囊肿”，并且在使用产生流出毛囊的伤口敷料材料覆盖暴露的囊肿的方法中。

3. 发明申请

WO2009086000A2 BIOMARKERS FOR TRICHOGENICITY 审中-公开
标题翻译：生物标志物的生物多样性
公开(公告)号：WO2009086000A2
公开(公告)日：2009-07-09
申请号：PCT/US2008087513
申请日：2008-12-18
申请人： ADERANS RES INST INC , STENN KURT , PARIMOO SATISH , YANG HONGHUA , HOMAN YING , CHEN WEI , ZHENG YING
发明人： STENN KURT , PARIMOO SATISH , YANG HONGHUA , HOMAN YING , CHEN WEI , ZHENG YING
IPC分类号： A61K48/00 , C12N15/11 , C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6881 , C12Q2600/178 , G01N33/6881 , G01N33/6893 , G01N2500/10
摘要： Biomarkers for identifying trichogenic cells have been identified. The biomarkers include microRNA as wells as mRNA and proteins. Certain biomarkers are upregulated in trichogenic cells compared to non-trichogenic cells; whereas, other biomarkers are down-regulated in trichogenic cells compared to non-trichogenic cells. The cells can be dermal cells, epidermal cells, or a combination thereof. Preferably the cells are mammalian, more preferably the cells are human. One embodiment provides a method for selecting trichogenic cells by assaying the cells for expression of one or more biomarkers for trichogenicity, and selecting the cells having increased expression of the one or more biomarkers relative to a control, wherein increased expression of the a biomarker in the cells is indicative of trichogenicity. Preferably, the one or more biomarkers are selected from the group consisting of hsa-miR-200c, hsa-miR-205, hsa-miR-200a*, hsa-miR- 200a, hsa-miR-141, hsa-miR-182, DEPDC1, hFLEG1, ESM1, TOME-1, THBD and combinations thereof.
摘要翻译：已鉴定出用于鉴定发生细胞的生物标志物。生物标志物包括微RNA作为mRNA和蛋白质的孔。与非致毛细胞相比，某些生物标志物在致毛细胞中上调; 而与非致毛细胞相比，其它生物标志物在发育细胞中下调。细胞可以是真皮细胞，表皮细胞或其组合。优选地，细胞是哺乳动物，更优选细胞是人。一个实施方案提供了通过测定细胞用于表达一种或多种针刺性生物标志物并选择相对于对照而增加一种或多种生物标志物表达的细胞来选择发生细胞的方法，其中所述生物标志物在细胞表示毛发性。优选地，一种或多种生物标志物选自hsa-miR-200c，hsa-miR-205，hsa-miR-200a *，hsa-miR-200a，hsa-miR-141，hsa-miR-182 ，DEPDC1，hFLEG1，ESM1，TOME-1，THBD及其组合。

4. 发明申请

WO2013066481A3 COSMETIC USE OF N-HETEROARYLBISAMIDE ANALOGS AND RELATED COMPOUNDS 审中-公开
标题翻译： N-异辛二酰胺类似物及其相关化合物的化学应用
公开(公告)号：WO2013066481A3
公开(公告)日：2014-05-08
申请号：PCT/US2012052040
申请日：2012-08-23
申请人： AVON PROD INC , PARIMOO SATISH , ILAYA NANCY T , LYGA JOHN W
发明人： PARIMOO SATISH , ILAYA NANCY T , LYGA JOHN W
IPC分类号： A61K31/16 , A01N37/18 , A01N43/56 , A61K31/415
CPC分类号： A61K8/494 , A61K8/49 , A61K9/0014 , A61K31/415 , A61K2800/10 , A61Q19/007 , A61Q19/08
摘要： Cosmetic and dermatological compositions comprising N-heteroarylbisamide analogs and methods of using such compositions to impart anti-aging benefits to the skin and/or improve skin conditions resulting from reduced collagen and hyaluronic acid production are disclosed. The N-heteroarylbisamides are believed to stimulate collagen and hyaluronic acid production and restore or maintain homeostasis for these compounds.
摘要翻译：公开了包含N-杂芳基双酰胺类似物的化妆品和皮肤病学组合物以及使用这些组合物赋予皮肤抗老化益处和/或改善由胶原蛋白和透明质酸产生减少引起的皮肤病症的方法。据信N-杂芳基双酰胺刺激胶原蛋白和透明质酸的产生并恢复或维持这些化合物的体内平衡。

5. 发明申请

WO2013039597A3 METHOD FOR ENHANCING THE GROWTH AND FULLNESS OF HAIR 审中-公开
标题翻译：增加头发充实的方法
公开(公告)号：WO2013039597A3
公开(公告)日：2014-05-08
申请号：PCT/US2012045344
申请日：2012-07-03
申请人： AVON PROD INC , DUGGAN MICHELE C , PARIMOO SATISH , HWANG CHENG S
发明人： DUGGAN MICHELE C , PARIMOO SATISH , HWANG CHENG S
IPC分类号： A61K8/97 , A61Q7/00
CPC分类号： A61K8/49 , A61K8/342 , A61K8/97 , A61K31/045 , A61K31/426 , A61K36/185 , A61K38/06 , A61K45/06 , A61Q7/00 , A61K2300/00
摘要： New fibroblast growth factor receptor 1 (FGFR1) inhibitors have been identified which are useful for promoting the retention and/or growth of keratin fibers, such as hair of the scalp, hair of the face (moustache, beard, etc.), eyebrows, eyelashes, and the like. The FGFR1 inhibitors may be formulated in effective amounts in a variety of cosmetic and personal care products.
摘要翻译：已经鉴定了新的成纤维细胞生长因子受体1（FGFR1）抑制剂，其可用于促进角蛋白纤维的保留和/或生长，例如头皮毛发，面部毛发（胡子，胡须等），眉毛，睫毛等。 FGFR1抑制剂可以有效量配制在各种化妆品和个人护理产品中。

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