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21. 发明申请

WO2009082286A1 IMPLANTABLE ANALYTE RF SPECTROSCOPY MEASURING SYSTEM 审中-公开
标题翻译：可伸缩分析仪射频光谱测量系统
公开(公告)号：WO2009082286A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001157
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils , ERIKSSON, Tom
发明人： ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils , ERIKSSON, Tom
IPC分类号： G01N33/483 , A61B5/145 , A61N1/372 , G01N22/00
CPC分类号： A61B5/05 , A61B5/14546 , A61B5/7253 , A61N1/36557 , A61N1/3702 , A61N1/37252
摘要： An analyte measuring system (1) comprises and implantable medical device (100; 400) having a RF signal source (120; 420) arranged for generating a RF signal and a transmitting antenna (300) for transmitting the RF signal into a surrounding tissue (10) in a subject body (5). The system (1) has a receiving RF antenna (310) for receiving the RF signal from the tissue (10) and a signal processor (130; 530) arranged for generating an estimate of a concentration of an analyte in the tissue (10) based on a spectrum analysis of the received RF signal.
摘要翻译：分析物测量系统（1）包括具有设置用于产生RF信号的RF信号源（120; 420）和用于将RF信号传输到周围组织的发射天线（300）的可植入医疗设备（100; 400） 10）在主体（5）中。系统（1）具有用于接收来自组织（10）的RF信号的接收RF天线（310）和布置成用于产生组织（10）中分析物浓度的估计的信号处理器（130; 530）基于所接收的RF信号的频谱分析。

22. 发明申请

WO2009082285A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2009082285A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001156
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils
发明人： ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils
IPC分类号： A61B5/053 , A61N1/365
CPC分类号： A61B5/053 , A61B5/14546 , A61N1/36557
摘要： An analyte measuring system (1) comprises and implantable medical device (100) having a signal source (120) arranged for generating a current signal and electrodes (202, 204; 212, 214) for applying the current signal to a surrounding tissue (10) in a subject body (5). The device (100) measures a resulting voltage signal with the electrodes (202, 204; 212, 214) and calculates an impedance signal therefrom. The system (1) comprises a signal processor (150; 550) arranged for generating an estimate of a concentration of an analyte in the tissue (10) based on a spectrum analysis of the determined impedance signal.
摘要翻译：分析物测量系统（1）包括可植入医疗设备（100），其具有布置成产生电流信号的信号源（120）和用于将电流信号施加到周围组织（10,20）的电极（202,204; 212,214））在主体（5）中。装置（100）利用电极（202,204; 212,214）测量得到的电压信号，并从其计算阻抗信号。系统（1）包括信号处理器（150; 550），信号处理器被设置用于基于所确定的阻抗信号的频谱分析来生成组织（10）中的分析物的浓度的估计。

23. 发明申请

WO2006065184A1 IMPLANTABLE HEART STIMULATOR AND METHOD AT AN IMPLANTABLE HEART STIMULATOR 审中-公开
标题翻译：可植入心脏刺激器和可植入心脏刺激器的方法
公开(公告)号：WO2006065184A1
公开(公告)日：2006-06-22
申请号：PCT/SE2004/001924
申请日：2004-12-17
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , HOLMSTRÖM, Nils
发明人： BJÖRLING, Anders , HOLMSTRÖM, Nils
IPC分类号： A61N1/37 , A61N1/18
CPC分类号： A61N1/3712
摘要： An implantable heart stimulator for delivering stimulation pulses of varying amplitudes. Threshold searches are performed at selectable time intervals, which threshold searches determine a threshold value required for effectuating capture. The amplitudes of the stimulation pulses are set to a value exceeding the determined threshold value by a safety margin, which safety margin is selected as a function of said selected time intervals.
摘要翻译：一种植入式心脏刺激器，用于传递不同幅度的刺激脉冲。阈值搜索以可选择的时间间隔执行，阈值搜索确定实现捕获所需的阈值。刺激脉冲的幅度被设置为超过所确定的阈值的值，该安全裕度选择作为所选择的时间间隔的函数的安全裕度。

24. 发明申请

WO2007086782A1 ANODAL CAPTURE 审中-公开
标题翻译：阳极捕获
公开(公告)号：WO2007086782A1
公开(公告)日：2007-08-02
申请号：PCT/SE2006/000119
申请日：2006-01-26
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BJÖRLING, Anders
发明人： HOLMSTRÖM, Nils , BJÖRLING, Anders
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3684
摘要： Implantable heart stimulating device comprising a left ventricular (LV) coronary sinus (CS) electrode lead at least provided with a tip electrode, a right ventricular (RV) electrode lead at least provided with a ring electrode, a pulse generating means connected to said leads and adapted to apply a stimulation pulse between said tip electrode and ring electrode, wherein the tip electrode being the cathode. The device comprises a monitoring means adapted to monitor for and detect anodal capture at said right ventricular ring electrode subsequent to a stimulation. If anodal capture at said right ventricular ring electrode is detected one of the following is performed. Either a threshold search is performed by varying the pulse width and/or pulse amplitude in order to identify stimulation pulse characteristics that avoid anodal capture at the ring electrode, or at least one further electrode is arranged to function as indifferent electrode together with the ring electrode, also in order to avoid anodal capture at the ring electrode.
摘要翻译：可植入心脏刺激装置，其包括至少设置有尖端电极的左心室（LV）冠状窦（CS）电极引线，至少设置有环形电极的右心室（RV））电极引线，连接到所述引线的脉冲发生装置并且适于在所述尖端电极和环形电极之间施加刺激脉冲，其中所述尖端电极为阴极。该装置包括适于在刺激之后监测并检测所述右心室环电极处的阳极捕获的监测装置。如果检测到所述右心室环电极处的阳极捕获，则执行以下之一。通过改变脉冲宽度和/或脉冲幅度来执行阈值搜索，以便识别避免在环形电极处的阳极捕获的刺激脉冲特性，或者至少一个另外的电极被布置成与环电极一起用作无关电极，也是为了避免在环形电极处的阳极捕获。

25. 发明申请

WO2007053064A1 AN IMPLANTABLE HEART STIMULATING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏刺激装置，系统和方法
公开(公告)号：WO2007053064A1
公开(公告)日：2007-05-10
申请号：PCT/SE2005/001629
申请日：2005-10-31
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , HOLMSTRÖM, Nils , JÄRVERUD, Karin
发明人： BJÖRLING, Anders , HOLMSTRÖM, Nils , JÄRVERUD, Karin
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3712
摘要： The invention concerns an implantable bi- ventricular heart stimulating device (10) including a control circuit (14) comprising a first atrial sensing and/or pacing circuit (25, 27) and ventricular sensing (35, 45) and pacing (37, 47) circuits for a first (IV) and a second (2V) ventricle. The device (10) is arranged to normally operate with a time VV between a pacing pulse delivered, or inhibited, by a first ventricular pacing circuit (37) and a pacing pulse delivered, or inhibited, by a second ventricular pacing circuit (47). The device (10) is arranged to determine a particular time VV cts that is to be used instead of VV during a capture threshold search. The invention also concerns a system including such a device (10) and a method of, in a human or animal being, performing a capture threshold search.
摘要翻译：本发明涉及一种可植入的双心室心脏刺激装置（10），其包括包括第一心房感测和/或起搏电路（25,27）和心室感测（35,45）和起搏（37,47）的控制电路（14））电路用于第一（IV）和第二（2V）心室。设备（10）被布置成通过由第一心室起搏电路（37）递送或抑制的起搏脉冲与由第二心室起搏电路（47）输送或抑制的起搏脉冲之间的时间VV进行正常操作，。设备（10）被布置成在捕获阈值搜索期间确定要用于代替VV的特定时间V V C c C s。本发明还涉及一种包括这样的装置（10）的系统以及在人或动物中执行捕获阈值搜索的方法。

26. 发明申请

WO2006093442A1 BIVENTRICULAR HEART STIMULATOR AND METHOD OF CONTROLLING A BIVENTRICULAR HEART STIMULATOR 审中-公开
标题翻译：双向心脏刺激器和控制双向心脏刺激器的方法
公开(公告)号：WO2006093442A1
公开(公告)日：2006-09-08
申请号：PCT/SE2005/000313
申请日：2005-03-03
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , HOLMSTRÖM, Nils
发明人： BJÖRLING, Anders , HOLMSTRÖM, Nils
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： A biventricular heart stimulator and a method for controlling such a biventricular heart stimulator. Successive stimulation pulses are delivered to the ventricles of a human heart such that stimulation pulses in a single heart beat cycle is first delivered to the first ventricle and then to the second ventricle. Capture or loss of capture in response to stimulation pulses delivered to one ventricle is detected. As a result of a detected loss of capture, preventive measures are taken for prevention of loss of capture in the other ventricle.
摘要翻译：双心室心脏刺激器和控制这种双心室心脏刺激器的方法。连续的刺激脉冲被输送到人心脏的心室，使得单个心搏周期中的刺激脉冲首先被递送到第一心室，然后传送到第二脑室。检测到响应于输送到一个脑室的刺激脉冲的捕获或丢失。由于检测到的捕获损失，采取预防措施来防止在另一个心室中的捕获损失。

27. 发明申请

WO2012163414A1 DYNAMIC CARDIAC RESYNCHRONIZATION THERAPY BY TRACKING INTER -ATRIAL CONDUCTION DELAYS 审中-公开
标题翻译：通过跟踪直接导联延迟进行动态心脏再生治疗
公开(公告)号：WO2012163414A1
公开(公告)日：2012-12-06
申请号：PCT/EP2011/058982
申请日：2011-05-31
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
发明人： HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： The present invention relates generally to implantable medical devices and more particularly to systems and methods for stimulating a heart of a patient. A first ventricle is activated by delivering stimulation to at least one stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the first ventricle is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation is computed. Thereafter, the other ventricle is stimulated by delivering stimulation to at least one stimulation site. A point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the other ventricle is then estimated and a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation is computed. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.
摘要翻译：本发明一般涉及可植入医疗装置，更具体地涉及用于刺激患者心脏的系统和方法。通过向至少一个刺激部位递送刺激来激活第一脑室，估计到达在第一脑室刺激产生的至少一个去极化波的AV节点的时间点，并且基本对应于计算使用去极化波的到达的估计时间点和用于递送刺激的时间点的至少一个去极化波从第一脑室的刺激部位行进到AV节点所需的时间间隔。此后，通过将刺激递送至至少一个刺激部位刺激另一个心室。然后估计到达AV节点对于在另一个心室中的刺激产生的至少一个去极化波的时间点，并且基本对应于至少一个去极化波从刺激行进所需的时间的第二激活时间间隔计算使用去极化波的估计到达和输送刺激的时间点在AV节点的另一脑室中的位置。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗，其中如果激活时间差指示第一激活时间间隔长于第二心室第二激活时间间隔，则第一心室在另一心室激活之前起搏如果所述激活时间差指示所述第二激活时间间隔长于所述第一激活时间间隔，则所述激活时间间隔和所述另一个心室在所述第一心室激活之前起步。

28. 发明申请

WO2011040840A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MULTISITE MEASUREMENT OF INTRACARDIAC IMPEDANCE 审中-公开
标题翻译：可植入医疗装置和方法用于多药耐药的测量
公开(公告)号：WO2011040840A1
公开(公告)日：2011-04-07
申请号：PCT/SE2009/000428
申请日：2009-09-29
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BJÖRLING, Anders
发明人： HOLMSTRÖM, Nils , BJÖRLING, Anders
IPC分类号： A61B5/053 , A61N1/368
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/686 , A61N1/3627 , A61N1/3702 , A61N1/3956
摘要： The present invention generally relates to an implantable medical device and method for detecting and monitoring cardiac status of a patient using simultaneous multisite measurements of the intracardiac impedance and in particular to ischemia detection using the simultaneous multisite measurements. The device comprises an impedance measuring unit being connectable to a plurality of electrode configurations including a current generating device adapted to generate a current and apply the current between two electrodes of a current injecting electrode configuration of the electrode configurations and a voltage sensing device including a plurality of voltage sensing circuits arranged in parallel. Each voltage sensing circuit being connectable to a specific voltage sensing electrode configuration of the electrode configurations and being arranged to sense a voltage over the voltage sensing electrode configuration resulting from the applied current, wherein the voltage sensing circuits are capable of sensing the resulting voltages simultaneously. The device further comprises an impedance calculating module adapted to calculate a plurality of impedance values, each impedance value being based on the applied current and a resulting voltage.
摘要翻译：本发明总体上涉及一种可植入医疗装置和方法，用于使用同时进行心脏内阻抗的多站点测量来检测和监测患者的心脏状态，特别是使用同时多站点测量的缺血检测。该装置包括阻抗测量单元，其可连接到多个电极配置，包括适于产生电流的电流产生装置，并施加电极配置的电流注入电极配置的两个电极之间的电流;以及电压感测装置，包括多个的电压感测电路并联布置。每个电压感测电路可连接到电极配置的特定电压感测电极配置，并且布置成感测由所施加的电流产生的电压感测电极配置上的电压，其中电压感测电路能够同时感测所得到的电压。该装置还包括适于计算多个阻抗值的阻抗计算模块，每个阻抗值基于所施加的电流和所得到的电压。

29. 发明申请

WO2005028030A1 HEART STIMULATION DEVICE 审中-公开
标题翻译：心脏刺激装置
公开(公告)号：WO2005028030A1
公开(公告)日：2005-03-31
申请号：PCT/SE2003/001494
申请日：2003-09-25
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BJÖRLING, Anders , HOLMSTRÖM, Nils , LAGERCRANTZ, Per
发明人： HEDBERG, Sven-Erik , BJÖRLING, Anders , HOLMSTRÖM, Nils , LAGERCRANTZ, Per
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/368 , A61N1/3684
摘要： A biventricular stimulation device comprises a pulse generator for delivering stimulation pulses at least to the ventricles of a patient's heart. An evoked response detector has first and second, independent ventricular sensing channels for ventricular evoked response detection in the ventricles. The pulse generator is controlled to deliver stimulation pulses (106) to the second ventricle (RV) with a VV time delay after stimulation pulse delivery (104) to the first stimulated ventricle (LV) which is shorter than an evoked response detection time window (106) following the delivery of the stimulation pulse (104) to the first ventricle. The evoked response detector is arranged to close the evoked response detection time window (106) or discard detections therein in response to the emission of a stimulation pulse (107) to the second ventricle (RV) during the evoked response detection time window (106) of the first stimulated ventricle (LV).
摘要翻译：双心室刺激装置包括用于至少向患者心脏的心室输送刺激脉冲的脉冲发生器。诱发反应检测器具有第一和第二独立心室感知通道，用于心室中的心室诱发反应检测。脉冲发生器被控制以在刺激脉冲传送（104）之后的VV时间延迟到第一激励心室（LV）处将刺激脉冲（106）传递到第二心室（RV），所述第一受激心室（LV）比诱发的响应检测时间窗 106）在将刺激脉冲（104）递送到第一脑室之后。诱发响应检测器被安排为在诱发响应检测时间窗口（106）期间响应于向第二心室（RV）发射刺激脉冲（107）而关闭诱发响应检测时间窗口（106）或丢弃其中的检测，的第一个刺激心室（LV）。

30. 发明申请

WO2007064260A1 IMPLANTABLE MEDICAL DEVICE WITH THERAPY CONTROL 审中-公开
标题翻译：具有治疗控制的可植入医疗装置
公开(公告)号：WO2007064260A1
公开(公告)日：2007-06-07
申请号：PCT/SE2005/001807
申请日：2005-11-30
申请人： ST. JUDE MAEDICAL AB , HOLMSTRÖM, Nils , NOREN, Kjell
发明人： HOLMSTRÖM, Nils , NOREN, Kjell
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36514 , A61B7/04 , A61N1/3627 , A61N1/36578 , A61N1/3684
摘要： The present invention relates to a method for operating an implantable medical device to obtain substantially synchronized closure of the mitral and tricuspid valves based on sensed heart sounds comprising sensing an acoustic energy; producing signals indicative of heart sounds of the heart of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles; calculating a pulse width of such a signal; and iteratively controlling a delivery of the ventricular pacing pulses based on calculated pulse widths of successive heart sound signals to identify an RV interval or W interval that causes a substantially synchronized closure of the mitral and tricuspid valve. Furthermore, the invention relates to a medical device for optimizing an RV interval or W interval based on sensed heart sounds and a computer readable medium comprising instructions for bringing a computer to perform the method.
摘要翻译：本发明涉及一种用于操作可植入医疗装置的方法，以基于感测到的心音来获得二尖瓣和三尖瓣的基本上同步的闭合，包括感测声能; 在连续心脏周期期间产生指示心脏周期的预定周期的患者心脏的心脏声音的信号; 计算这种信号的脉冲宽度; 并且基于所计算的连续心脏声音信号的脉冲宽度迭代地控制心室起搏脉冲的递送，以识别导致二尖瓣和三尖瓣的基本上同步闭合的RV间隔或W间隔。此外，本发明涉及一种用于基于感测到的心脏声音优化RV间隔或W间隔的医疗装置以及包括用于使计算机执行该方法的指令的计算机可读介质。

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