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21. 发明申请

WO1996038188A1 INHIBITION OF VASCULAR OCCLUSION FOLLOWING VASCULAR INTERVENTION 审中-公开
标题翻译：血管闭塞后血管闭塞的抑制作用
公开(公告)号：WO1996038188A1
公开(公告)日：1996-12-05
申请号：PCT/US1996006707
申请日：1996-05-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , EDELMAN, Elazer , NATHAN, Aruna , NUGENT, Matthew, A.
IPC分类号： A61L27/00
CPC分类号： C12N5/069 , A61K35/12 , A61L27/507 , A61L31/005 , C12N2533/54
摘要： Compositions and methods are described for treating hyperplasia of vascular smooth muscle cells and restenosis of blood vessels or accelerated arteriopathy following vascular injury or disease. Endothelial cells are cultured in a biocompatible polymeric matrix which is then implanted or wrapped around the exterior of a blood vessel. The engrafted matrix-associated endothelial cells inhibit progression or promote regression of intimal hyperplasia or smooth muscle cell proliferation in the vicinity of the blood vessel's inner surface and decreases the incidence of restenosis often associated with vascular hyperplasia.
摘要翻译：描述了用于治疗血管平滑肌细胞增生和血管再狭窄或血管损伤或疾病后加速的动脉病变的组合物和方法。内皮细胞在生物相容的聚合物基质中培养，然后将其植入或缠绕在血管的外部。移植的基质相关的内皮细胞抑制血管内表面附近的内膜增生或平滑肌细胞增殖的退化或减少与血管增生通常相关的再狭窄的发生。

22. 发明申请

WO1996034263A1 POWER ABSORBING DYNAMOMETER 审中-公开
标题翻译：功率吸收测差仪
公开(公告)号：WO1996034263A1
公开(公告)日：1996-10-31
申请号：PCT/US1996005117
申请日：1996-04-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SMITH, Joseph, L., Jr. , OGNIBENE, Edward, J.
IPC分类号： G01L03/20
CPC分类号： G01L3/20
摘要： A power absorbing dynamometer includes a stator having an inside stator surface and a rotor having an inside rotor surface. The rotor is rotatable by a mechanical power source. The inside rotor and stator surfaces generally face and oppose each other. Together, the rotor and stator define a passage bounded substantially by the inside surfaces thereof. The passage preferably is a torus-shaped passage within the dynamometer. Liquid is introduced into the passage via a port of the dynamometer. The dynamometer also includes means for developing and maintaining within the passage a unique liquid flow which is a substantially helical recirculating flow of the liquid on the inside rotor and stator surfaces as the rotor is rotated by the mechanical power source. The liquid is thereby heated or vaporized as the rotor is rotated by the mechanical power source, and power absorbed from the mechanical power source is related to a rate at which the liquid is heated or vaporized. The power absorbing dynamometer preferably causes at least some of the liquid in the passage to boil and vaporize due substantially only to friction associated with the substantially helical recirculating flow of the liquid on the inside rotor and stator surfaces. The power absorbed from the mechanical power source is related to the rate at which the liquid vaporizes. The vaporized liquid preferably collects in the center of the passage where it can be easily vented.
摘要翻译：功率吸收测力计包括具有内部定子表面的定子和具有内部转子表面的转子。转子可通过机械动力源旋转。内转子和定子表面通常面对并相互对置。转子和定子一起限定了基本上由其内表面限定的通道。通道优选地是在测力计内的环形通道。液体通过测力计的端口引入通道。测力计还包括用于在通道内显影和保持独特的液体流动的装置，该液体流是当机械动力源转动转子时内部转子和定子表面上的液体的基本上螺旋状的循环流动。由于当机械动力源转动转子时液体被加热或汽化，并且从机械动力源吸收的功率与液体被加热或蒸发的速率有关。功率吸收测力计优选地使得通道中的至少一些液体基本上仅与内转子和定子表面上的液体的基本螺旋状的再循环流动相关的摩擦而沸腾和汽化。从机械动力源吸收的功率与液体蒸发的速率有关。蒸发的液体优选地聚集在通道的中心，其中可以容易地排出。

23. 发明申请

WO1996033474A2 ELIMINATING BLOCK ARTIFACTS FROM A COMPRESSED IMAGE BY EXTRAPOLATION 审中-公开
标题翻译：从压缩图像中通过提取消除块状物质
公开(公告)号：WO1996033474A2
公开(公告)日：1996-10-24
申请号：PCT/US1996005023
申请日：1996-04-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WILLIAMS, John, R. , AMARATUNGA, Kevin
IPC分类号： G06T09/00
CPC分类号： H04N19/527 , H04N19/63 , H04N19/86
摘要： A method and apparatus to eliminate artifacts in data processing and compression systems.
摘要翻译：消除数据处理和压缩系统中的伪影的方法和装置。

24. 发明申请

WO1996027657A1 CELL GROWTH SUBSTRATES WITH TETHERED CELL GROWTH EFFECTOR MOLECULES 审中-公开
标题翻译：细胞生长基质与细胞生长效应分子
公开(公告)号：WO1996027657A1
公开(公告)日：1996-09-12
申请号：PCT/US1996002851
申请日：1996-02-29
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CIMA, Linda, G. , MERRILL, Edward, W. , KUHL, Philip, R.
IPC分类号： C12N05/00
CPC分类号： A61K35/407 , A61K38/1808 , C07K17/08 , C07K17/10 , C07K17/12 , C07K17/14 , C12M35/08 , C12N5/0068 , C12N2533/30 , Y10S530/812 , Y10S530/815 , Y10S530/816 , A61K2300/00
摘要： Disclosed are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and extracellular matrix molecules, are flexibly tethered to a solid substrate. The compositions can be used either in vitro or in vivo to grow cells and tissues. By tethering the growth factors, they will not diffuse away from the desired location. By making the attachment flexible, the growth effector molecules can more naturally bind to cell surface receptors. A significant feature of these compositions and methods is that they enhance the biological response to the growth factors. The new method also offers other advantages over the traditional methods, in which growth factors are delivered in soluble form: (1) the growth factor is localized to a desired target cell population; (2) significantly less growth factor is needed to exert a biologic response. This method can be used as a means of enhancing the therapeutic use of growth factors in vivo and of creating surfaces which will enhance in vitro growth of difficult-to-grow cells such as liver cells.
摘要翻译：公开了具有束缚生长效应分子的组合物，以及使用这些组合物生长细胞和组织的方法。生长因子分子，包括生长因子和细胞外基质分子，灵活地束缚于固体底物。组合物可以在体外或体内用于生长细胞和组织。通过束缚生长因子，它们不会扩散到所需的位置。通过使附着变得柔性，生长效应分子可以更天然地结合细胞表面受体。这些组合物和方法的显着特征是它们增强了对生长因子的生物反应。新方法还具有优于传统方法的其他优点，其中生长因子以可溶形式递送：（1）生长因子定位于期望的靶细胞群; （2）需要显着较少的生长因子来施加生物反应。该方法可用作增强体内生长因子的治疗用途并产生表面的手段，其将增强难以生长的细胞如肝细胞的体外生长。

25. 发明申请

WO1996025946A1 HOMOLOGY OF INTERLEUKIN-1'beta'-CONVERTASE WITH C. ELEGANS CED-3 AND INHIBITION OF CELL DEATH 审中-公开
标题翻译：具有C.ELEGANS CED-3的白细胞介素-1β-转移酶与细胞死亡抑制的同源性
公开(公告)号：WO1996025946A1
公开(公告)日：1996-08-29
申请号：PCT/US1996002473
申请日：1996-02-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HORVITZ, H., Robert , YUAN, Junying , SHAHAM, Shai
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： A61K38/55
CPC分类号： C12N9/641 , A61K38/55 , C07K14/43581 , C07K14/4747 , C07K2319/00 , C12N9/6475 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158
摘要： Described herein is the discovery that human interleukin-1 beta convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3 protein may be a cysteine protease like ICE and that ICE may be a human equivalent of the nematode cell death gene. Another mammalian protein, the murine NEDD-2 protein, was also found to be similar to Ced-3. The NEDD-2 gene is implicated in the development of the murine central nervous system. On the basis of these findings, novel drugs for enhancing or inhibiting the activity of ICE, ced-3, or related genes are provided. Such drugs may be useful for treating inflammatory diseases and/or diseases characterized by cell deaths, as well as cancers, autoimmune disorders, infections, and hair growth and hair loss. Furthermore, such drugs may be useful for controlling pests, parasites and genetically engineered organisms. Furthermore, novel inhibitors of the activity of ced-3, ICE and related genes are described which comprise portions of the genes or their encoded products.
摘要翻译：这里描述的发现是人白介素-1β转化酶（ICE）在结构上类似于由线虫类细胞死亡基因ced-3编码的蛋白质。两种蛋白质的比较和突变分析结合以前的观察结果表明，Ced-3蛋白可能是像ICE这样的半胱氨酸蛋白酶，并且ICE可能是人类等效于线虫细胞死亡基因。还发现另一种哺乳动物蛋白，鼠类NEDD-2蛋白质与Ced-3相似。 NEDD-2基因涉及鼠中枢神经系统的发展。在这些发现的基础上，提供了用于增强或抑制ICE，ced-3或相关基因活性的新型药物。这些药物可用于治疗以细胞死亡为特征的炎性疾病和/或疾病，以及癌症，自身免疫性疾病，感染和毛发生长和脱发。此外，这些药物可用于控制害虫，寄生虫和遗传工程生物体。此外，描述了包含部分基因或其编码产物的ced-3，ICE和相关基因的活性的新型抑制剂。

26. 发明申请

WO1996020951A1 CHIMERIC DNA-BINDING PROTEINS 审中-公开
标题翻译： CHIMERIC DNA结合蛋白
公开(公告)号：WO1996020951A1
公开(公告)日：1996-07-11
申请号：PCT/US1995016982
申请日：1995-12-29
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , POMERANTZ, Joel, L. , SHARP, Phillip, A. , PABO, Carl, O.
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： C07K14/00
CPC分类号： C07K14/4702 , A01K2217/05 , C07K2319/00 , C12N9/22 , C12N15/1055
摘要： Chimeric proteins containing composite DNA-binding regions are disclosed together with DNA constructs encoding them, compositions containing them and applications in which they are useful.
摘要翻译：含有复合DNA结合区的嵌合蛋白与编码它们的DNA构建体，含有它们的组合物和它们有用的应用一起被公开。

27. 发明申请

WO1996018411A1 LOCALIZED DELIVERY OF FACTORS ENHANCING SURVIVAL OF TRANSPLANTED CELLS 审中-公开
标题翻译：局部递送因子增强移植细胞存活
公开(公告)号：WO1996018411A1
公开(公告)日：1996-06-20
申请号：PCT/US1995016356
申请日：1995-12-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CHILDREN'S MEDICAL CENTER CORPORATION
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CHILDREN'S MEDICAL CENTER CORPORATION , MOONEY, David, J. , LANGER, Robert, S. , VACANTI, Joseph, P.
IPC分类号： A61K38/18
CPC分类号： A61K9/0024 , A61K35/407 , A61K38/1808 , C12N5/0075 , C12N5/067 , C12N2501/11 , C12N2531/00 , C12N2533/40
摘要： Growth factors and/or angiogenic factors are administered in combination with dissociated cells to be transplanted, preferably in microspheres with the cells on or in a polymeric matrix, to enhance survival and profileration of the transplanted cells. Examples demonstrate that epidermal growth factor (EGF) was incorporated into microspheres fabricated from a copolymer of lactic and glycolic acid using a double emulsion technique, the incorporated EGF was steadily released over one month in vitro, and it remained biologically active, as determined by its ability to stimulate DNA synthesis, division, and long-term survival of cultured hepatocytes. EGF-containing microspheres were mixed with a suspension of hepatocytes, seeded onto porous sponges, and implanted into the mesentery of two groups of Lewis rats, to demonstrate efficacy in vivo. Two weeks after implantation in PCS animals, devices which included EGF-containing microspheres showed a two-fold increase in the number of engrafted hepatocytes, as compared to implants which received blank microspheres.
摘要翻译：生长因子和/或血管生成因子与待移植的解离的细胞组合施用，优选在具有在聚合物基质上或聚合物基质中的细胞的微球体中，以增强移植细胞的存活和分化。实施例表明，使用双乳液技术将表皮生长因子（EGF）掺入由乳酸和乙醇酸共聚物制成的微球体中，结合的EGF在体外稳定释放一个月，并且其保持生物活性，如刺激培养肝细胞的DNA合成，分裂和长期存活的能力。将含EGF的微球与肝细胞悬浮液混合，接种到多孔海绵上，并植入两组Lewis大鼠的肠系膜，以体现体内效力。植入PCS动物后两周，与含有空白微球的植入物相比，包含含EGF的微球的装置显示出移植肝细胞数量增加了两倍。

28. 发明申请

WO1996013942A1 ILLUMINATION SYSTEM FOR DISPLAYS PANELS 审中-公开
标题翻译：显示面板照明系统
公开(公告)号：WO1996013942A1
公开(公告)日：1996-05-09
申请号：PCT/US1995013769
申请日：1995-10-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SWANSON, Gary, J.
IPC分类号： H04N09/31
CPC分类号： H01L28/60 , G02B5/02 , G02B5/18 , G02B27/0994 , G02F1/133504 , G02F1/133621 , H01L28/55 , H01L28/75 , H04N5/74 , H04N5/7441 , H04N9/3108 , H04N9/315 , Y10S359/90
摘要： Binary optics are used in an illumination system for a color projection display. In one embodiment a broad spectrum light source illuminates a multilevel optical phase element which disperses the broad spectrum light from the light source by diffraction. A display having a number of pixel elements, each capable of transmitting a predetermined spectral region, is positioned within the near field region of the multilevel optical phase element so as to receive the light dispersed by the multilevel phase element.
摘要翻译：二元光学器件用于彩色投影显示器的照明系统。在一个实施例中，广谱光源照亮通过衍射分散来自光源的广谱光的多电平光学相位元件。具有能够发送预定光谱区域的多个像素元件的显示器位于多级光学相位元件的近场区域内，以接收由多级相位元件分散的光。

29. 发明申请

WO1996013806A1 METHOD AND APPARATUS FOR GENERATING A SYNTHETIC IMAGE BY THE FUSION OF SIGNALS REPRESENTATIVE OF DIFFERENT VIEWS OF THE SAME SCENE 审中-公开
标题翻译：通过融合相同场景的不同视图的信号来产生合成图像的方法和装置
公开(公告)号：WO1996013806A1
公开(公告)日：1996-05-09
申请号：PCT/US1995014063
申请日：1995-10-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WAXMAN, Allen, M. , FAY, David, A. , GOVE, Alan, N. , SEIBERT, Michael, C. , RACAMATO, Joseph, P.
IPC分类号： G06T05/20
CPC分类号： H04N5/332 , G06T5/20 , G06T5/50 , H04N5/33
摘要： A method and system for processing two input digital image signals, each being representative of a different two dimensional view of the same scene, to produce three processed image signals. A center-surround shunt processor transforms each input image signal to produce a respective processed image signal. Another center-surround shunt processor produces the third processed image signal from the first two processed image signals. In the latter processor, one of the first two processed image signals is selected as a center image and the other is selected as a surround image. The processor performs a computation associated with each pixel in the center image with data selected from the center image to form a central element for the computation and data selected from the surround image to form a surround element for the computation. The result of each computation is a pixel of the third processed image signal. The three processed image signals may be applied to the respective RGB inputs of an RGB display device.
摘要翻译：一种用于处理两个输入数字图像信号的方法和系统，每个输入数字图像信号代表相同场景的不同二维视图，以产生三个处理的图像信号。中心环绕分路器转换每个输入图像信号以产生相应的处理后的图像信号。另一个中心环绕分流处理器从前两个处理的图像信号产生第三处理图像信号。在后一处理器中，前两个处理后的图像信号中的一个被选择为中心图像，另一个被选择为环绕图像。处理器使用从中心图像中选择的数据来执行与中心图像中的每个像素相关联的计算，以形成用于计算的中心元件和从环绕图像中选择的数据，以形成用于计算的环绕元件。每次计算的结果是第三处理图像信号的像素。三个处理的图像信号可以被施加到RGB显示装置的各个RGB输入。

30. 发明申请

WO1996013395A1 BALL JOINT 审中-公开
标题翻译：球联
公开(公告)号：WO1996013395A1
公开(公告)日：1996-05-09
申请号：PCT/US1994012262
申请日：1994-10-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WEST, Mark, T.
IPC分类号： B60B33/08
CPC分类号： B25J5/005 , B60B33/08 , B62D11/00 , B62D55/08 , B62D55/28 , Y10T16/1887
摘要： A ball joint assembly comprising a base member (60), a spherical member (20), a ring of at least three rolling members (40) mounted around the spherical member (30) such that a point on a rolling surface of each of the least three rolling members (40) contacts a point on a first great circle (50) on the surface of the spherical member, the ring of rollers being freely rotatable around the axis of the first great circle, at least two capture rolling members (40), one capture rolling member being mounted such that a rolling surface of the one capture rolling member is in contact with a point on the surface of the spherical member (20) above the plane of the first great circle and another capture rolling member being mounted such that a rolling surface of the other roller member is in contact with a point below the plane of the first great circle.
摘要翻译：一种球接头组件，包括基部构件（60），球形构件（20），安装在球形构件（30）周围的至少三个滚动构件（40）的环，使得每个的滚动表面上的点至少三个滚动构件（40）接触球形构件表面上的第一大圆（50）上的点，所述滚子环可围绕第一大圆的轴线自由旋转，至少两个捕获滚动构件（40 ），一个捕获滚动部件安装成使得一个捕获滚动部件的滚动表面与第一大圆的平面上方的球形部件（20）的表面上的点接触，另一个捕获滚动部件被安装使得另一个辊构件的滚动表面与第一大圆的平面下方的点接触。

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