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21. 发明申请

WO1995007287A1 2' OR 3'-DEOXY AND 2'-DIDEOXY-'beta'-L-PENTAFURANONUCLEOSIDE COMPOUNDS, METHOD OF PREPARATION AND APPLICATION IN THERARY, ESPECIALLY AS ANTI-VIRAL AGENTS 审中-公开
标题翻译： 2'或3'-脱氧和2'-二脱氧-β-L-蓬特壬烷砜化合物，其制备方法及其应用，特别是作为抗病毒剂
公开(公告)号：WO1995007287A1
公开(公告)日：1995-03-16
申请号：PCT/FR1994001066
申请日：1994-09-09
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , GOSSELIN, Gilles , IMBACH, Jean-Louis , AUBERTIN, Anne-Marie , SOMMADOSSI, Jean-Pierre , SCHINAZI, Raymond, F.
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： C07H19/04
CPC分类号： C07D473/00 , C07D405/04 , C07H19/04
摘要： Method for the stereospecific preparation of 2' or 3' deoxy and 2', 3'-dideoxy- beta -L-pentafuanonucleoside compounds. 2' or 3' deoxy and 2', 3'-dideoxy- beta -L-pentofuranonucleoside compounds are also described. Finally, the invention concerns the use of these compounds, and particularly 2', 3' dideoxy- beta -L-5-fluorocytidine, as drugs, and especially as anti-viral agents.
摘要翻译： 2'或3'脱氧和2'，3'-二脱氧-β-L-戊酮核苷化合物的立体特异性制备方法。还描述了2'或3'脱氧和2'，3'-二脱氧-β-L-呋喃核糖核苷化合物。最后，本发明涉及这些化合物，特别是2'，3'-二脱氧-β-1-L-5-氟胞嘧啶作为药物，特别是作为抗病毒剂的用途。

22. 发明申请

WO1998029452A1 ANTIBODIES SPECIFICALLY RECOGNISING A NITROSYLATED PROTEIN, METHOD OF PREPARATION, THERAPEUTIC AND DIAGNOSTIC USE 审中-公开
标题翻译：抗体特异性识别硝酸纤维蛋白，制备方法，治疗和诊断用途
公开(公告)号：WO1998029452A1
公开(公告)日：1998-07-09
申请号：PCT/FR1997002412
申请日：1997-12-23
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CHAGNAUD, Jean-Luc , GEFFARD, Michel , VEYRET, Bernard , VINCENDEAU, Philippe
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K38/00 , G01N33/6893
摘要： The invention concerns a purified antibody specifically recognising a nitrosylated protein and more particularly a NO carrier such as albumin. These antibodies may be polyclonal-or monoclonal. The invention also concerns immunogens for preparing said antibodies and the pharmaceutical compositions containing them. The invention further concerns a method using said antibodies for detecting in vitro nitrosylated proteins in a biological sample.
摘要翻译：本发明涉及一种特异性识别亚硝基化蛋白质的纯化抗体，更具体地说是NO载体如白蛋白。这些抗体可以是多克隆的或单克隆的。本发明还涉及用于制备所述抗体的免疫原和含有它们的药物组合物。本发明还涉及使用所述抗体检测生物样品中的体外亚硝基化蛋白质的方法。

23. 发明申请

WO1998013383A1 ADENOVIRAL VECTORS FOR MUTANTS OF HUMAN INTERLEUKIN 6 (HIL-6) WITH HIL-6 ANTAGONIST ACTIVITY, PHARMACEUTICAL COMPOSITIONS THEREWITH AND THEIR USES 审中-公开
标题翻译：具有HIL-6拮抗剂活性的人类白细胞介素6（HIL-6）的突变体载体及其用途的药物组合物
公开(公告)号：WO1998013383A1
公开(公告)日：1998-04-02
申请号：PCT/IT1997000231
申请日：1997-09-24
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CILIBERTO, Gennaro , SAGGIO, Isabella , SAVINO, Rocco , PERRICAUDET, Michel
发明人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： C07K14/54
CPC分类号： A61K38/204 , C07K14/5412 , C12N2799/022
摘要： The subject matter of the present invention are recombinant defective adenoviruses comprising a heterologous DNA sequence coding for a mutein having the activity of human Interleukin 6 (hIL-6) antagonists or superantagonist. Moreover, the invention refers to therapeutical uses thereof, in particular for preparing pharmaceutical compositions for treating and/or preventing pathologies caused by hIL-6 overproduction. The subject matter of the present invention are recombinant defective adenoviruses comprising a heterologous DNA sequence coding for a mutein having the activity of human Interleukin 6 (hIL-6) antagonists or superantagonist. Moreover, the invention refers to therapeutical uses thereof, in particular for preparing pharmaceutical compositions for treating and/or preventing pathologies caused by hIL-6 overproduction.
摘要翻译：本发明的主题是重组缺陷型腺病毒，其包含编码具有人白细胞介素6（hIL-6）拮抗剂或超吸附剂活性的突变蛋白的异源DNA序列。此外，本发明涉及其治疗用途，特别是用于制备用于治疗和/或预防由hIL-6过量产生引起的病理学的药物组合物。本发明的主题是重组缺陷型腺病毒，其包含编码具有人白细胞介素6（hIL-6）拮抗剂或超吸附剂活性的突变蛋白的异源DNA序列。此外，本发明涉及其治疗用途，特别是用于制备用于治疗和/或预防由hIL-6过量产生引起的病理学的药物组合物。

24. 发明申请

WO1998002244A1 METHOD OF METATHESIS OF ALCANES AND CATALYST 审中-公开
标题翻译：甲烷和催化剂组成的方法
公开(公告)号：WO1998002244A1
公开(公告)日：1998-01-22
申请号：PCT/FR1997001266
申请日：1997-07-10
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , VIDAL, Véronique , THEOLIER, Albert , THIVOLLE-CAZAT, Jean , BASSET, Jean-Marie
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： B01J31/12
CPC分类号： B01J37/0203 , B01J31/121 , C07C6/10 , C07C2521/04 , C07C2521/08 , C07C2521/12 , C07C2523/20 , C07C2529/06 , C07C2531/12 , C07C2531/36
摘要： The method for the metathesis of original linear or branched alkanes consists in reacting this or these original alkane(s) on a catalyst comprising a support formed by a solid oxide on which are grafted and dispersed metal atoms in hydride form, these metal atoms having high degrees of unsaturation. It concerns in particular the hydride of metals of groups 5 and 6 of the periodic system of elements and more particularly tantalum, tungsten and chromium.
摘要翻译：原始直链或支链烷烃的复分解方法在于使这种或这些原始烷烃反应在催化剂上，该催化剂包含由固体氧化物形成的载体，其上接枝并分散有氢化物形式的金属原子，这些金属原子具有高的不饱和度。它特别涉及元素周期性系统的组5和6的金属的氢化物，更特别地涉及钽，钨和铬。

25. 发明申请

WO1997021349A1 METHOD FOR DESTROYING TERMITARIA 审中-公开
标题翻译：破坏限制的方法
公开(公告)号：WO1997021349A1
公开(公告)日：1997-06-19
申请号：PCT/FR1996001954
申请日：1996-12-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CENTRE TECHNIQUE DU BOIS ET DE L'AMEUBLEMENT , CLEMENT, Jean-Luc , VAUCHOT, Blandine , SERMENT, Marie-Madeleine
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CENTRE TECHNIQUE DU BOIS ET DE L'AMEUBLEMENT
IPC分类号： A01N47/34
CPC分类号： A01N25/006 , A01N47/34 , A01N2300/00
摘要： A method for destroying termitaria, wherein a bait consisting of a carrier containing Flufenoxuron or active derivatives thereof is placed adjacent to a termitarium to destroy workers, nymphs, larvae and soldiers, whether or not they have come into direct contact with the bait. Said carrier comprises a termite-ingestible material and the Flufenoxuron is at a concentration of 10-1000 ppm on the carrier.
摘要翻译：一种破坏毒蛾的方法，其中将由含有氟虫脲TM或其活性衍生物的载体组成的诱饵放置在白placed附近以破坏工人，若虫，幼虫和士兵，无论它们是否与诱饵直接接触。所述载体包含白蚁可摄取材料，并且Flufenoxuron TM在载体上的浓度为10-1000ppm。

26. 发明申请

WO1997018317A1 DODECAHEDRAL ADENOVIRAL PROTEIN COMPLEX, COMPOSITION CONTAINING SAME AND USES THEREOF 审中-公开
标题翻译：十二烷酸腺嘌呤复合物，包含其的组合物及其用途
公开(公告)号：WO1997018317A1
公开(公告)日：1997-05-22
申请号：PCT/FR1996001790
申请日：1996-11-13
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CHROBOCZEK, Jadwiga , FENDER, Pascal
发明人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： C12N15/85
CPC分类号： C07K14/005 , A61K48/00 , C12N2710/10222 , C12N2710/14143
摘要： A native or recombinant adenoviral protein complex, a pharmaceutical composition containing said protein complex, and the uses thereof for treating and preventing human and animal diseases, are disclosed. Said adenoviral protein complex consists of either 12 pentons each including at least one fibre and a penton base but no other element from an adenovirus genome, said fibre(s) and said penton base being derived from one or more adenoviruses, said pentons being bound by the penton bases and forming a proteolytic enzyme-stable dodecahedral structure, said complex having a molecular weight between 4.8 x 10 and 6.6 x 10 , and such complexes being known as dodecahedron-penton complexes; or 12 penton bases but no other element from an adenovirus genome, said penton bases being derived from one or more adenoviruses and forming a proteolytic enzyme-stable dodecahedral structure, said complex having a molecular weight between 3.2 x 10 and 4 x 10 , and such complexes being known as dodecahedron-base complexes.
摘要翻译：公开了天然或重组腺病毒蛋白复合物，含有所述蛋白质复合物的药物组合物及其用于治疗和预防人和动物疾病的用途。所述腺病毒蛋白复合物由12个多核苷酸组成，每个包含至少一个纤维和五邻体碱基，但没有来自腺病毒基因组的其它元件，所述纤维和所述五邻体衍生自一种或多种腺病毒，所述五氧化物被五羟基碱基并形成蛋白水解酶稳定的十二面体结构，所述络合物的分子量为4.8×10 6至6.6×10 6，这些络合物称为十二面体 - 五邻体络合物; 或12个五邻体碱基，但没有来自腺病毒基因组的其它元件，所述五邻体衍生自一种或多种腺病毒并形成蛋白水解酶稳定的十二面体结构，所述复合物的分子量为3.2×10 6至4×10 这种络合物被称为十二面体碱基络合物。

27. 发明申请

WO1997005911A1 BIOMATERIAL COMPOSITION AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：生物组合物及其制备方法
公开(公告)号：WO1997005911A1
公开(公告)日：1997-02-20
申请号：PCT/FR1996001196
申请日：1996-07-29
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , DACULSI, Guy , WEISS, Pierre , DUPRAZ, Anne , LAPKOWSKI, Mieczyslam
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： A61L27/00
CPC分类号： A61L27/50 , A61L27/46 , A61F2/28 , C08L5/14 , C08L3/02 , C08L1/28
摘要： A biomaterial composition for the resorption/substitution of organic supporting tissues, including 20-75 wt.% of an inorganic phase consisting of particles that include either hydroxyapatite (A) optionally mixed with tricalcium phosphate beta (B), or calcium-titanium-phosphate (Ca(Ti)4 (PO4)6) (C), and 80-25 wt.% of a liquid phase including an aqueous solution of a water-soluble biocompatible polymer that is cross-linkable by means of the pH of the medium. Said composition is sterilisable, injectable and curable in biological media to form a biomaterial for replacing supporting tissues.
摘要翻译：用于吸收/取代有机支持组织的生物材料组合物，包括20-75重量％的无机相组成的无机相，其包括任选与磷酸三钙β（B）或磷酸钙 - 磷酸钙混合的羟基磷灰石（A）（Ca（Ti）4（PO 4）6）（C）和80-25重量％的液相，其包含通过介质的pH可交联的水溶性生物相容性聚合物的水溶液。所述组合物在生物培养基中是可灭菌的，可注射的和可固化的，以形成用于替代支持组织的生物材料。

28. 发明申请

WO1996030961A1 MICROWAVE SIGNAL SWITCH 审中-公开
标题翻译：微波信号开关
公开(公告)号：WO1996030961A1
公开(公告)日：1996-10-03
申请号：PCT/FR1996000471
申请日：1996-03-28
申请人： RADIALL , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CELLARD, Jérôme , EUDELINE, Vincent , BODIN, Camille , BOYER, Lionel , HOUZE, Frédéric , NOEL, Sophie
发明人： RADIALL , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： H01P01/12
CPC分类号： H01H1/06 , H01P1/12
摘要： A microwave signal switch with a metal housing containing an electrically conductive part and two electrically conductive pads each having a contact surface for contacting a facing surface on said part, said electrically conductive part being movable from a closed position in which it engages and electrically interconnects the contact surfaces of both pads, and an open position in which it is spaced apart from said contact surfaces. At least one of the contact surfaces (5) and/or the surface (9) of said electrically conductive part (3) are provided with projections (6) comprising, in a cross-sectional plane perpendicular to the contact surface, an acute-angled cross-section with a vertex angle ( THETA ) of less than 110 DEG and a radius of curvature of less than 0.05 mm.
摘要翻译：一种具有金属壳体的微波信号开关，其包含导电部分和两个导电焊盘，每个导电焊盘具有用于接触所述部件上的相对表面的接触表面，所述导电部件可从关闭位置移动，在该位置，所述导电部件接合并电连接两个焊盘的接触表面以及与所述接触表面间隔开的打开位置。所述导电部分（3）的接触表面（5）和/或表面（9）中的至少一个设置有突起（6），所述突起（6）在与接触表面垂直的横截面中包括锐角 - 具有小于110°的顶角（THETA）和曲率半径小于0.05mm的倾斜横截面。

29. 发明申请

WO1996030527A1 MUTATED PROTEINS CODED BY A LENTIVIRUS MUTATED ENV GENE, PEPTIDE FRAGMENTS AND EXPRESSION VECTORS 审中-公开
标题翻译：乳酸脱氢酶基因编码的突变蛋白，肽片段和表达载体
公开(公告)号：WO1996030527A1
公开(公告)日：1996-10-03
申请号：PCT/FR1996000449
申请日：1996-03-26
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , PANCINO, Gianfranco , SONIGO, Pierre
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： C12N15/63
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/15022 , C12N2740/15043 , C12N2740/16122
摘要： Mutated proteins coded by a mutated env gene of a lentivirus, particularly FIV, HIV or CAEV, peptide fragments contained in said mutated proteins and expression vectors expressing said mutated proteins as well as the applications thereof are described. The peptide fragments are contained in the principal immunodominant domain (PID) of the transmembrane protein (TM) of lentiviruses and particularly of feline immunodeficiency virus (FIV), human immunodeficiency virus (HIV-1 and HIV-2), arthritis virus and caprine encephalitis virus (CAEV), and are capable of modifying the immunogenic properties of the PID domain and of the Env protein of the lentiviruses containing them. Such fragments have one of the following sequences: SEQ ID N DEG 1: CNQNQWLCK, SEQ ID N DEG 2: CNQNQFLCK, SEQ ID N DEG 3: CNQNQLWCK, SEQ ID N DEG 4: CNQNQPFCK, SEQ ID N DEG 5: CEHQHFFCK, SEQ ID N DEG 6: CSMGTFFCK, SEQ ID N DEG 7: CLTDSFFCK, SEQ ID N DEG 8: CELKNFFCK, SEQ ID N DEG 9: CRPAAFFCK, SEQ ID N DEG 10: ELGCGSKLICKIP, SEQ ID N DEG 11: IWGCNQNQFFCTTAVPWN, SEQ ID N DEG 12: IWGVAFRQVCTTAVPW.
摘要翻译：描述了由慢病毒，特别是FIV，HIV或CAEV的突变env基因编码的突变蛋白，所述突变蛋白中包含的肽片段和表达所述突变蛋白的表达载体及其应用。肽片段包含在慢病毒，特别是猫免疫缺陷病毒（FIV），人类免疫缺陷病毒（HIV-1和HIV-2），关节炎病毒和山羊脑炎的跨膜蛋白（TM）的主要免疫显性域（PID）病毒（CAEV），并且能够修饰含有它们的慢病毒的PID结构域和Env蛋白的免疫原性。这样的片段具有以下序列之一：SEQ ID NO：CNQNQWLCK，SEQ ID NO：CNQNQFLCK，SEQ ID NO：3：CNQNQLWCK，SEQ ID NO：4：CNQNQPFCK，SEQ ID NO：5：CEHQHFFCK，SEQ ID NO： ID N DEG 6：CSMGTFFCK，SEQ ID NO：7：CLTDSFFCK，SEQ ID NO：8：CELKNFFCK，SEQ ID NO：9：CRPAAFFCK，SEQ ID NO：10：ELGCGSKLICKIP，SEQ ID NO：11：IWGCNQNQFFCTTAVPWN，SEQ ID N DEG 12：IWGVAFRQVCTTAVPW。

30. 发明申请

WO1996017172A1 INTEGRATED ELECTRICAL DISCHARGE MICROACTUATOR AND MICROSYSTEM COMPRISING SAME 审中-公开
标题翻译：集成放电微电脑和包含相同的微型体
公开(公告)号：WO1996017172A1
公开(公告)日：1996-06-06
申请号：PCT/FR1995001525
申请日：1995-11-20
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ESTEVE, Daniel , BAYLE, Pierre , CAEN, Robert
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： F04B43/04
CPC分类号： F04F99/00 , F04B17/00 , F04B19/24 , F04B43/043 , F04F1/16 , F15B15/10 , H01J17/00
摘要： An integrated microactuator including a gas-containing cavity (4) within at least one layer (1, 2, 3) of photolithographically machinable material, electrodes (13, 15, 16) for generating an electric field inside the cavity (4) that can cause an electrical discharge in the gas, and an actuation device (7) sensitive to the gas pressure and/or velocity in the cavity (4), said actuation device (7) being connected to the cavity (4) in such a way that it is controlled by changes in the gas pressure and/or velocity resulting from the electrical discharges caused by the electrodes (13, 15, 16). An integrated microsystem including said microactuator is also disclosed.
摘要翻译：一种集成微致动器，其包括在光刻机加工材料的至少一个层（1,2,3）内的含气体腔（4），用于在空腔（4）内产生电场的电极（13,15,16）导致气体中的放电，以及对空腔（4）中的气体压力和/或速度敏感的致动装置（7），所述致动装置（7）以这样的方式连接到空腔（4），使得它由由电极（13,15,16）引起的放电产生的气体压力和/或速度的变化来控制。还公开了包括所述微致动器的集成微系统。

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