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21. 发明申请

WO2005115469A2 ESTROGEN MODULATION OF IFN-GAMMA-MEDIATED CONDITIONS AND DISEASES 审中-公开
标题翻译： IFN-GAMMA介导的病症和疾病的雌激素调节
公开(公告)号：WO2005115469A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/018161
申请日：2005-05-24
申请人： CEDARS-SINAI MEDICAL CENTER , GONSKY, Rivkah , TARGAN, Stephan, R.
发明人： GONSKY, Rivkah , TARGAN, Stephan, R.
IPC分类号： A61K45/00
CPC分类号： A61K31/56 , A61K35/26 , Y02A50/481
摘要： Particular aspects provide methods for: modulating IFN-γ-mediated conditions and diseases ( e.g. inflammation, HIV/AIDS, etc). Additionally provided are methods for: reducing IFN-γ expression or secretion in cultured mammalian cells, comprising culturing in the presence of at least one agent selected from the group consisting of estrogen, estriol, estrone and a SERM; for ex-vivo therapy for an IFN-γ-mediated condition or disease, comprising culturing isolated lymphoid cells in the presence of at least one of the above agents; for treating an IFN-γ-mediated condition or disease in a mammal, comprising administering to a subject at least one at least one of the above agents; for treating an IFN-γ-mediated condition or disorder in a gender-dependent manner; for conferring estrogen-responsive expression using a recombinant SNP IFN-γ-179G/T promoter; and for gene therapy using same. Preferably, mammalian cells are human, selected from T cells, PBL, LPMC, and combinations thereof. In particular aspects, the cells are female.
摘要翻译：具体方面提供了用于调节IFN-γ介导的病症和疾病（例如炎症，HIV / AIDS等）的方法。另外提供了用于：减少培养的哺乳动物细胞中的IFN-γ表达或分泌的方法，包括在至少一种选自雌激素，雌三醇，雌酮和SERM的药剂的存在下培养; 用于IFN-γ介导的病症或疾病的离体治疗，包括在至少一种上述试剂存在下培养分离的淋巴样细胞; 用于治疗哺乳动物中的IFN-γ介导的病症或疾病，包括向受试者施用至少一种上述药物中的至少一种; 用于以性别依赖的方式治疗IFN-γ介导的病症或障碍; 用于使用重组SNP IFN-γ-179G / T启动子赋予雌激素反应性表达; 并使用相同的基因治疗。优选地，哺乳动物细胞是人，选自T细胞，PBL，LPMC及其组合。在特定方面，细胞是雌性的。

22. 发明申请

WO2022140283A1 TL1A THERAPY COMPOSITIONS AND METHODS OF TREATMENT THEREWITH 审中-公开
公开(公告)号：WO2022140283A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064406
申请日：2021-12-20
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： MCGOVERN, Dermot, P. , BILSBOROUGH, Janine , TARGAN, Stephan, R. , POTDAR, Alka
IPC分类号： C07K14/525 , C12Q1/6883 , A61P1/00
摘要： Disclosed herein are methods, kits and compositions for treating an inflammatory disease or condition, or fibrosis in a subject that has been determined to have increased fold-change in Tumor necrosis factor (TNF)-like cytokine 1A (TL1A) expression based, at least partially, on a presence of a combination of genotypes detected in a sample obtained from the subject. In some embodiments, the combination of genotypes is significantly associated with the increased fold-change in TL1A, and in some cases, may also be predictive of severe forms of the inflammatory disease or condition. In some embodiments, the inflammatory disease or condition is an inflammatory bowel disease, such as Crohn's disease or ulcerative colitis.

23. 发明申请

WO1997039147A1 METHODS OF IDENTIFYING AND DIAGNOSING INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：识别和诊断炎症性皮肤病的方法
公开(公告)号：WO1997039147A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006039
申请日：1997-04-11
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , PLEVY, Scott, E. , YANG, Huiying , TARGAN, Stephan, R. , ROTTER, Jerome, I.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides methods of identifying, diagnosing and screening for inflammatory bowel disease, particularly Crohn's Disease (CD) comprising identifying alleles and polymorphisms associated with a biological response related to an inflammatory bowel disease. The invention further provides for a method of determining whether a therapy which decreases the levels of TNF- alpha would be effective in treating an inflammatory bowel disease. The invention also provides for an assay system for screening for susceptibility to inflammatory bowel disease.
摘要翻译：本发明提供鉴定，诊断和筛选炎症性肠病，特别是克罗恩氏病（CD）的方法，其包括鉴定与与炎性肠病相关的生物反应相关的等位基因和多态性。本发明进一步提供了确定降低TNF-α水平对治疗炎性肠病有效的疗法的方法。本发明还提供了用于筛选对炎症性肠病易感性的测定系统。

24. 发明申请

WO1996012189A2 METHODS OF SCREENING FOR ULCERATIVE COLITIS AND CROHN'S DISEASE BY DETECTING VH3-15 AUTOANTIBODY AND pANCA 审中-公开
标题翻译：通过检测VH3-15自身抗体和pANCA检测血清COLITIS和CROHN病变的方法
公开(公告)号：WO1996012189A2
公开(公告)日：1996-04-25
申请号：PCT/US1995013422
申请日：1995-10-05
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BRAUN, Jonathan , TARGAN, Stephan, R.
IPC分类号： G01N33/564
CPC分类号： C07K16/4258 , G01N33/56922 , G01N33/56972 , G01N33/686 , Y10S435/961 , Y10S435/965 , Y10S435/975
摘要： The present invention provides novel methods of screening for ulcerative colitis and Crohn's disease which include the detection of two disparate autoantibodies: pANCA and VH3-15 autoantibody. The present invention also provides kits for screening ulcerative colitis and Crohn's disease.
摘要翻译：本发明提供筛选溃疡性结肠炎和克罗恩病的新方法，其包括检测两种不同的自身抗体：pANCA和VH3-15自身抗体。本发明还提供了用于筛选溃疡性结肠炎和克罗恩病的试剂盒。

25. 发明申请

WO1998037415A1 ULCERATIVE COLITIS pANCA SECRETORY VESICLE ANTIGEN AND METHODS OF USING SAME 审中-公开
标题翻译：维生素BANA秘密VESICLE抗原及其使用方法
公开(公告)号：WO1998037415A1
公开(公告)日：1998-08-27
申请号：PCT/US1997013059
申请日：1997-08-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER , BRAUN, Jonathan , GORDON, Lynn, K. , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： G01N33/53
CPC分类号： C07K14/4713 , A61K38/00 , C07K16/18 , G01N33/564 , G01N33/6893
摘要： The present invention provides a substantially pure UC pANCA secretory vesicle antigen, including a protein immunoreactive with NANUC-1 and NANUC-2 and having the characteristic of being selectively expressed in secretory vesicle membrane. Pharmaceutical compositions containing the substantially pure UC pANCA secretory vesicle antigen and a pharmaceutical carrier also are provided. The invention further provides a tolerogenic composition containing the substantially pure UC pANCA secretory vesicle antigen, or tolerogenic fragment thereof, combined with a tolerogizing molecule. In addition, there are provided methods of diagnosing ulcerative colitis in a patient and methods of determining susceptibility to ulcerative colitis in an individual using the substantially pure UC pANCA secretory vesicle antigen. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC and methods of preventing ulcerative colitis in an individual by administering the substantially pure UC pANCA secretory vesicle antigen, or tolerogenic fragment thereof.
摘要翻译：本发明提供了基本上纯的UC pANCA分泌囊泡抗原，其包括与NANUC-1和NANUC-2免疫反应的蛋白质，并且具有在分泌囊泡膜中选择性表达的特征。还提供了含有基本上纯的UC pANCA分泌囊泡抗原和药物载体的药物组合物。本发明进一步提供含有基本上纯的UC pANCA分泌囊泡抗原或其耐受性片段与耐受性分子组合的耐受性组合物。此外，提供了诊断患者溃疡性结肠炎的方法以及使用基本上纯的UC pANCA分泌囊泡抗原确定个体中溃疡性结肠炎易感性的方法。本发明还提供了在具有UC的pANCA阳性患者中诱导耐受性的方法以及通过施用基本上纯的UC pANCA分泌囊泡抗原或其耐受性片段来预防个体的溃疡性结肠炎的方法。

26. 发明申请

WO2014186665A3 DISTINCT EFFECTS OF IFN-GAMMA AND IL-17 ON TL1A MODULATED INFLAMMATION AND FIBROSIS 审中-公开
公开(公告)号：WO2014186665A3
公开(公告)日：2014-11-20
申请号：PCT/US2014/038333
申请日：2014-05-16
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： SHIH, David, Q. , TARGAN, Stephan, R. , BILSBOROUGH, Janine
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
摘要： Described herein are methods and compositions related to Inflammatory Bowel Disease. Specifically TL1A drives regional intestinal inflammation and fibrosis and is differentially modulated by IFN gamma and IL-17a. In one embodiment, the present invention is a method of diagnosing a condition in a subject by determining the presence or absence of IFN gamma and/or IL-17 and diagnosing the subject.

27. 发明申请

WO1997038713A1 DIAGNOSIS, PREVENTION AND TREATMENT OF ULCERATIVE COLITIS, AND CLINICAL SUBTYPES THEREOF, USING HISTONE H1 审中-公开
标题翻译：诊断，预防和治疗精神分裂症及其临床亚型，使用HISTONE H1
公开(公告)号：WO1997038713A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006987
申请日：1997-04-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER , BRAUN, Jonathan , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： A61K39/00
CPC分类号： G01N33/564 , A61K39/0008
摘要： The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment thereof, under conditions suitable to form a complex of human histone H1, or pANCA-reactive fragment thereof, and antibody to human histone H1; and detecting the presence or absence of the complex, where the presence of the complex indicates that the individual has UC. The invention also provides related methods of diagnosing a perinuclear anti-neutrophil cytoplasmic antibody positive (pANCA-positive) clinical subtype of UC in a patient with UC. In addition, the invention further provides methods of determining susceptibility to UC in an individual. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC by administering an effective dose of histone H1, or tolerogenic fragment thereof, to the pANCA-positive patient with UC. Compositions of histone H1, or fragment thereof, combined with a tolerogizing molecule also are provided.
摘要翻译：本发明提供一种通过从个体获得样品来诊断疑似患有炎症性肠病的受试者的溃疡性结肠炎（UC）的方法; 在适于形成人组蛋白H1或其pANCA反应性片段的复合物和人组蛋白H1的抗体的条件下，将样品与人组蛋白H1或其pANCA反应性片段接触; 并检测复合物的存在或不存在，其中复合物的存在表明个体具有UC。本发明还提供了在UC患者中诊断UC的核周抗中性粒细胞胞质抗体阳性（pANCA阳性）临床亚型的相关方法。此外，本发明还提供了确定个体对UC的易感性的方法。本发明进一步提供了通过向具有UC的pANCA阳性患者施用有效剂量的组蛋白H1或其耐受性片段来诱导具有UC的pANCA阳性患者的耐受性的方法。还提供组蛋白H1或其片段的组合物与耐受性分子组合。

28. 发明申请

WO1997038642A1 METHODS OF DETERMINING THE RISK OF POUCHITIS DEVELOPMENT 审中-公开
标题翻译：确定发展风险的方法
公开(公告)号：WO1997038642A1
公开(公告)日：1997-10-23
申请号：PCT/US1997005583
申请日：1997-04-03
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , TARGAN, Stephan, R. , FLESCHNER, Phillip , PLEVY, Scott, E.
IPC分类号： A61B19/00
CPC分类号： G01N33/6893 , G01N33/56972 , G01N2800/065
摘要： The present invention provides a method of determining a risk of pouchitis development following a surgical procedure whereby colon is removed and an internal pouch is created in a patient with UC by determining a first pANCA titer, where the first pANCA titer is determined following the surgical procedure; determining a second pANCA titer at a later time; and comparing the first pANCA titer and the second pANCA titer, where a significantly elevated second pANCA titer indicates an increased risk of pouchitis development. In addition, the invention provides a method of determining a risk of pouchitis development following a surgical procedure whereby colon is removed and an internal pouch is created in a patient with UC by determining a first pANCA titer, where the first pANCA titer is determined prior to the surgical procedure; determining a second pANCA titer following said surgical procedure; and comparing the first pANCA titer and the second pANCA titer, where a significantly elevated second pANCA titer indicates an increased risk of pouchitis development.
摘要翻译：本发明提供一种在外科手术之后确定囊泡炎发展的风险的方法，其中结肠被移除，并且通过确定第一pANCA滴度在患有UC的患者中产生内部小袋，其中在手术过程之后确定第一pANCA滴度 ; 在稍后时间确定第二个pANCA滴度; 并比较第一个pANCA滴度和第二个pANCA滴度，其中明显升高的第二个pANCA滴度表明发生囊泡炎的风险增加。另外，本发明提供了一种确定外科手术后肠粘膜炎发展风险的方法，其中结肠被移除并且通过确定第一pANCA滴度来确定第一pANCA滴度，在患有UC的患者中产生内部小袋，其中第一pANCA滴度在外科手术; 在所述外科手术之后确定第二pANCA滴度; 并比较第一个pANCA滴度和第二个pANCA滴度，其中明显升高的第二个pANCA滴度表明发生囊泡炎的风险增加。

29. 发明申请

WO1995031575A1 METHODS OF SCREENING FOR CROHN'S DISEASE USING TNF MICROSATELLITE ALLELES 审中-公开
标题翻译：使用TNF微阵列蛋白筛选克隆病的方法
公开(公告)号：WO1995031575A1
公开(公告)日：1995-11-23
申请号：PCT/US1995006107
申请日：1995-05-17
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , PLEVY, Scott, E. , ROTTER, Jerome, I. , TARGAN, Stephan, R. , TOYODA, Hiroo , YANG, Huiying
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presence or absence of nucleic acid of a subject encoding TNF microsatellite alleles associated with Crohn's disease, wherein the presence of nucleic acid encoding three or more of the alleles is indicative of Crohn's disease. Kits useful for screening for Crohn's disease are also provided which comprise nucleic acid encoding TNF microsatellite alleles associated with Crohn's disease.
摘要翻译：已经发现了某些肿瘤坏死因子微卫星等位基因与克罗恩病之间的关联。根据本发明，提供了用于筛选克罗恩病的方法，包括检测编码与克罗恩病相关的TNF微卫星等位基因的受试者的核酸的存在或不存在，其中编码三个或更多个等位基因的核酸的存在表明克罗恩病。还提供了用于筛选克罗恩病的试剂盒，其包含编码与克罗恩病相关的TNF微卫星等位基因的核酸。

30. 发明申请

WO1995021941A1 METHODS OF DIAGNOSING ULCERATIVE COLITIS AND CROHN'S DISEASE 审中-公开
标题翻译：诊断精神分裂症和冠状动脉疾病的方法
公开(公告)号：WO1995021941A1
公开(公告)日：1995-08-17
申请号：PCT/US1995001434
申请日：1995-02-06
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： CEDARS-SINAI MEDICAL CENTER , BEAUDET, Arthur, L. , ROTTER, Jerome, I. , TARGAN, Stephan, R. , YANG, Huiying , VORA, Devendra
IPC分类号： C12Q01/68
CPC分类号： C07K16/2821 , C07K14/70525 , C12Q1/6883 , C12Q2600/156
摘要： A novel association between inflamatory bowel disease (IBD) and a polymorphism at amino acid residue 241 or intracellular adhesion molecule-1 ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive with ICAM-1 encoded by R241 allele and kits which exploit the inventive methods.
摘要翻译：已经发现了炎症性肠病（IBD）与氨基酸残基241或细胞内粘附分子-1 ICAM-1的多态性之间的新型关联。根据本发明，提供了筛选IBD的方法，用于治疗IBD的方法，与由R241等位基因编码的ICAM-1特异性反应的抗体以及利用本发明方法的试剂盒。

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