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21. 发明申请

WO2012006210A3 ANALYTE TEST STRIP AND ANALYTE METER DEVICE 审中-公开
标题翻译：分析测试条和分析仪器设备
公开(公告)号：WO2012006210A3
公开(公告)日：2014-03-20
申请号：PCT/US2011042572
申请日：2011-06-30
申请人： AGAMATRIX INC , IYENGAR SRIDHAR , HARDING IAN , BOITEAU CHARLES , BUTTERS COLIN
发明人： IYENGAR SRIDHAR , HARDING IAN , BOITEAU CHARLES , BUTTERS COLIN
IPC分类号： G01N21/25 , G01N27/327
CPC分类号： G01N27/327 , G01J1/42 , G01N21/255 , G01N21/7703 , G01N21/8483 , G01N27/3272 , G01N27/3273 , G01N33/48707 , G01N33/48771 , G01N2201/08
摘要： A test strip with an incorporated optical waveguide and deflectors punched through the optical waveguide allows light to exit through a layer of the test strip and be detected by a photo detector. Using light and a photodetector, these uniquely coded strips are identified. The waveguide can be constructed by sandwiching two layers of the test strip around a light transmissible layer. This configuration allows light to be transmitted through the test strip and out the other end, as well as allowing some light to escape the deflector. This light is detected by a photodetector mounted in the analyte test meter. The deflectors may be placed in patterns such that detection of this light indicates certain characteristics of the strip, such as non-counterfeit, regional identification, type of analyte tested, and coding information.
摘要翻译：具有结合的光波导的测试条和穿过光波导穿过的偏转器允许光通过测试条的层离开并由光电检测器检测。使用光和光电检测器，识别这些唯一编码的条带。波导可以通过将两条测试条夹在透光层周围来构造。这种配置允许光线通过测试条传输，并将光线从另一端传输，并允许一些光线从偏转器中逸出。该光被安装在分析物测试仪中的光检测器检测。偏转器可以被放置成图案，使得该光的检测指示条带的某些特性，例如非假冒，区域识别，被测试分析物的类型和编码信息。

22. 发明申请

WO2005116622B1 CONNECTOR CONFIGURATION FOR ELECTROCHEMICAL CELLS AND METERS FOR USE IN COMBINATION THEREWITH 审中-公开
标题翻译：电化学电池用连接器配置及其组合使用
公开(公告)号：WO2005116622B1
公开(公告)日：2006-02-16
申请号：PCT/IB2005051660
申请日：2005-05-21
申请人： AGAMATRIX INC , HARDING IAN
发明人： HARDING IAN
IPC分类号： C12Q1/00 , G01N27/26 , G01N27/30 , G01N33/487
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/30 , G01N27/3272 , Y10T29/49002 , Y10T29/49114 , Y10T29/49117 , Y10T156/1052 , Y10T156/1062 , Y10T156/1074
摘要： A substantially planar electrochemical test strip for determination of the presence and/or quantity of an analyte in a sample is provided that has a first electrode, a first connector including two contact pads, and a first conductive lead extending between the first electrode and the first connector to establish a path for conduction of an electrical signal between the first electrode and the first connector; a second electrode, a second connector including one or more contact pads, and a second conductive lead extending between the second electrode and the second connector to establish a path for conduction of an electrical signal between the second electrode and the second connector, and a sample chamber for receiving a sample. The first and second electrode are disposed to contact a sample within the sample chamber such that an electrochemical signal is generated. The contact pad or pads of the second connector are between the contact pads of the first connector when viewed in the plane of the test strip. A meter having contacts for use with the electrochemical test strip, and a combination of a meter and an electrochemical test strip are also provided.
摘要翻译：提供了用于确定样品中分析物的存在和/或数量的基本上平面的电化学测试条，其具有第一电极，包括两个接触焊盘的第一连接器和在第一电极和第一电极之间延伸的第一导电引线连接器以建立用于在第一电极和第一连接器之间传导电信号的路径; 第二电极，包括一个或多个接触焊盘的第二连接器和在第二电极和第二连接器之间延伸的第二导电引线，以建立用于在第二电极和第二连接器之间传导电信号的路径，以及样品用于接收样品的室。第一和第二电极设置成与样品室内的样品接触，从而产生电化学信号。当在测试条的平面中观察时，第二连接器的接触焊盘或焊盘位于第一连接器的接触焊盘之间。还提供了具有用于电化学测试条的触点的仪表以及仪表和电化学测试条的组合。

23. 发明申请

WO2005028629A3 WHOLE GENOME EXPRESSION ANALYSIS SYSTEM 审中-公开
标题翻译：全基因表达分析系统
公开(公告)号：WO2005028629A3
公开(公告)日：2006-06-08
申请号：PCT/US2004030520
申请日：2004-09-17
申请人： APPLERA CORP , HARDING IAN , SANDELL DON , BODNER KEVIN , PATEL JAYNISH , WOUDENBERG TIMOTHY , OLDHAM MARK , KAO H PIN , LIM GARY , BODEAU JOHN , BAHATT DAR , ERMAKOV SERGEY , FAWCETT ADRIAN
发明人： HARDING IAN , SANDELL DON , BODNER KEVIN , PATEL JAYNISH , WOUDENBERG TIMOTHY , OLDHAM MARK , KAO H PIN , LIM GARY , BODEAU JOHN , BAHATT DAR , ERMAKOV SERGEY , FAWCETT ADRIAN
IPC分类号： C12Q1/68 , C12M1/00 , C12M3/00 , C12N20060101 , C12P19/34 , G01N20060101
CPC分类号： B01L3/50851 , B01L3/50853 , B01L3/50857 , B01L2200/0642 , B01L2300/044 , B01L2300/0819 , B01L2300/0829 , B01L2400/0409 , B01L2400/0487 , C12Q1/6837
摘要： The present invention provides methods for simultaneously determining the genetic expression profile an individual member of a species relative to a standard genome for said species, comprising distributing a sample comprising substantially all the genetic material of said member into an array of reaction chambers on a substrate, wherein each chamber has a volume of less than about 1 microliter, and each chamber comprises (1) a primer for a polynucleotide target within said standard genome, and (2) a probe associated with said primer which emits a concentration dependent signal if the primer binds with said target, and the array comprises at least one chamber comprising a primer for each of the polynucleotide target within said standard genome; performing an amplification reaction on the distributed sample in the array so as to increase the concentration of polynucleotides in each of the chambers in which the polynucleotide binds to a primer; and identifying which of the reaction chambers contains a polynucleotide that has been bound to a primer, by detecting the presence of the probe associated with the primer. In one embodiment, the organism is human, and the array comprises primers for 30,000 genomic polynucleotides. In one embodiment, the amplification is PCR.
摘要翻译：本发明提供了用于同时确定物种的单个成员相对于所述物种的标准基因组的遗传表达谱的方法，包括将包含所述成员的基本上所有遗传物质的样品分布在基底上的反应室阵列中，其中每个室具有小于约1微升的体积，并且每个室包含（1）用于所述标准基因组内的多核苷酸靶的引物，和（2）与所述引物相关的探针，如果引物与所述靶结合，并且所述阵列包含至少一个室，其包含用于所述标准基因组内的多核苷酸靶的每一个的引物; 对阵列中的分布样品进行扩增反应，以增加其中多核苷酸与引物结合的每个室中的多核苷酸的浓度; 并且通过检测与引物相关的探针的存在，鉴定哪个反应室含有已结合引物的多核苷酸。在一个实施方案中，生物是人，并且阵列包含30,000个基因组多核苷酸的引物。在一个实施方案中，扩增是PCR。

24. 发明申请

WO2005028110B1 MICROPLATES USEFUL FOR CONDUCTING THERMOCYCLED NUCLEOTIDE AMPLIFICATION 审中-公开
标题翻译：用于诱导热包核素扩增的微孔
公开(公告)号：WO2005028110B1
公开(公告)日：2005-10-06
申请号：PCT/US2004030788
申请日：2004-09-17
申请人： APPLERA CORP , LI ROBIN , AMIN YUSUF , CARRILLO ALBERT , REEVE VINCENT , HARDING IAN , FAWCETT ADRIAN , KAO H PIN , LU MIKE , LIM GARY
发明人： LI ROBIN , AMIN YUSUF , CARRILLO ALBERT , REEVE VINCENT , HARDING IAN , FAWCETT ADRIAN , KAO H PIN , LU MIKE , LIM GARY
IPC分类号： B01L20060101 , B01L3/00 , B01L7/00 , C12M1/34 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1072 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/0689 , B01L2300/021 , B01L2300/041 , B01L2300/0829 , B01L2300/12 , B01L2300/1805
摘要： A reaction plate (22) comprises a plurality of reaction cells (34), wherein the plate (22) comprises a thermal conductive material, each of the wells (34) has an open top and a closed bottom, and a distance between the wells is less than 0.5 mm. Other embodiments include an alignment feature (31, 190, 192) which may be, but not limited to, a bar code (192), an alignment pin (31), an alignment slot or a keyed corner (31). In various embodiments, the plate has about 6,144 wells at a pitch of about 1.125 mm. In some embodiments, each well has a volume of less than 600 nanoliters. Some embodiments include a cover (24) for the reaction plate.
摘要翻译：反应板（22）包括多个反应池（34），其中板（22）包括导热材料，每个井（34）具有敞开的顶部和封闭的底部，并且井之间的距离小于0.5mm。其他实施例包括可以但不限于条形码（192），对准销（31），对准槽或键角（31）的对准特征（31,190,192）。在各种实施例中，板具有约6,144个孔，间距约为1.125mm。在一些实施方案中，每个孔的体积小于600纳升。一些实施例包括用于反应板的盖（24）。

25. 发明申请

WO2005028109A2 MICROPLATES USEFUL FOR CONDUCTING THERMOCYCLED NUCLEOTIDE AMPLIFICATION 审中-公开
标题翻译：用于诱导热包核素扩增的微孔
公开(公告)号：WO2005028109A2
公开(公告)日：2005-03-31
申请号：PCT/US2004030489
申请日：2004-09-17
申请人： APPLERA CORP , HARDING IAN
发明人： HARDING IAN
IPC分类号： B01L20060101 , B01L3/00 , B01L7/00 , C12M1/34 , C12P19/34 , C12Q1/68 , B01L
CPC分类号： C12N15/1072 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/0689 , B01L2300/021 , B01L2300/041 , B01L2300/0829 , B01L2300/12 , B01L2300/1805
摘要： An inverted microplate having a plurality of reaction wells and a transparent cover. The plate comprising a solution in a well, a surface of the cover in contact with the solution and the head space of the well a distance from the cover. In another embodiment, the reaction plate is made from a material that has a thermal conductive property. In another embodiment, a well of a microplate, the well comprising a closed top and an open bottom, a cover, a solution in the well and the solution touching the surface of the cover. Other embodiments include a multi-well microtiter plate comprising a plurality of reaction wells and a transparent cover, the plate comprising a solution in a well, the solution held to the surface of the cover by a force.
摘要翻译：具有多个反应孔和透明盖的倒置微孔板。该板包括井中的溶液，与溶液接触的盖的表面和与盖的距离的阱的顶部空间。在另一个实施例中，反应板由具有导热性能的材料制成。在另一个实施例中，微板的孔，阱包括封闭的顶部和敞开的底部，盖子，井中的溶液和接触盖子表面的溶液。其他实施方案包括多孔微量滴定板，其包含多个反应孔和透明盖，该板包括在井中的溶液，该溶液通过力保持在盖的表面上。

26. 发明申请

WO2005028110A2 MICROPLATES USEFUL FOR CONDUCTING THERMOCYCLED NUCLEOTIDE AMPLIFICATION 审中-公开
标题翻译：用于诱导热包核素扩增的微孔
公开(公告)号：WO2005028110A2
公开(公告)日：2005-03-31
申请号：PCT/US2004030788
申请日：2004-09-17
申请人： APPLERA CORP , LI ROBIN , AMIN YUSUF , CARRILLO ALBERT , REEVE VINCENT , HARDING IAN , FAWCETT ADRIAN , KAO H PIN , LU MIKE , LIM GARY
发明人： LI ROBIN , AMIN YUSUF , CARRILLO ALBERT , REEVE VINCENT , HARDING IAN , FAWCETT ADRIAN , KAO H PIN , LU MIKE , LIM GARY
IPC分类号： B01L20060101 , B01L3/00 , B01L7/00 , C12M1/34 , C12P19/34 , C12Q1/68 , B01L
CPC分类号： C12N15/1072 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/0689 , B01L2300/021 , B01L2300/041 , B01L2300/0829 , B01L2300/12 , B01L2300/1805
摘要： A reaction plate comprises a plurality of reaction cells, wherein the plate comprises a thermal conductive material, each of the wells has an open top and a closed bottom, and a distance between the wells is less than 0.5 mm. Other embodiments include an alignment feature which may be, but not limited to, a bar code, an alignment pin, an alignment slot or a keyed corner. In various embodiments, the plate has about 6,144 wells at a pitch of about 1.125 mm. In some embodiments, each well has a volume of less than 600 nanoliters. Some embodiments include a cover for the reaction plate.
摘要翻译：反应板包括多个反应池，其中板包括导热材料，每个孔具有开口顶部和封闭的底部，并且孔之间的距离小于0.5mm。其它实施例包括对准特征，其可以是但不限于条形码，对准销，对准槽或带键角。在各种实施例中，板具有约6,144个孔，间距约为1.125mm。在一些实施方案中，每个孔的体积小于600纳升。一些实施例包括用于反应板的盖。

27. 发明申请

WO2005028109B1 MICROPLATES USEFUL FOR CONDUCTING THERMOCYCLED NUCLEOTIDE AMPLIFICATION 审中-公开
标题翻译：用于传导热核苷酸扩增的微孔板
公开(公告)号：WO2005028109B1
公开(公告)日：2005-09-01
申请号：PCT/US2004030489
申请日：2004-09-17
申请人： APPLERA CORP , HARDING IAN
发明人： HARDING IAN
IPC分类号： B01L20060101 , B01L3/00 , B01L7/00 , C12M1/34 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1072 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/0689 , B01L2300/021 , B01L2300/041 , B01L2300/0829 , B01L2300/12 , B01L2300/1805
摘要： An inverted microplate (22') having a plurality of reaction wells (34') and a transparent cover (24). The plate (22') comprising a solution (38) in a well (34'), a surface of the cover (24) in contact with the solution (38) and the head space of the well (34') a distance from the cover (24). In another embodiment, the reaction plate (22') is made from a material that has a thermal conductive property. In another embodiment, a well (34') of a microplate (34'), the well (34') comprising a closed top and an open bottom, a cover (24), a solution (38) in the well (34') and the solution (38) touching the surface of the cover (24). Other embodiments include a multi-well microtiter plate (22') comprising a plurality of reaction wells (34') and a transparent cover (24), the plate (22') comprising a solution (38) in a well (34'), the solution (38) held to the surface of the cover (24) by a force.
摘要翻译：一个具有多个反应孔（34'）和透明盖（24）的倒置微孔板（22'）。板（22'）包括在井（34'）中的溶液（38），与溶液（38）接触的盖（24）的表面以及井（34'）的顶部空间距离盖（24）。在另一个实施例中，反应板（22'）由具有导热性的材料制成。在另一个实施方案中，微孔板（34'）的井（34'），井（34'）包括封闭的顶部和敞开的底部，盖子（24），井中的溶液（38））和溶液（38）接触盖（24）的表面。其他实施方案包括包含多个反应孔（34'）和透明盖（24）的多孔微量滴定板（22'），所述板（22'）在孔（34'）中包含溶液（38），溶液（38）通过力保持在盖（24）的表面上。

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