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21. 发明申请

WO2004085433A3 POSITIVE ALLOSTERIC MODULATORS OF THE NICOTINIC ACETYLCHOLINE RECEPTOR 审中-公开
标题翻译：烟碱型乙酰胆碱受体阳性调节因子
公开(公告)号：WO2004085433A3
公开(公告)日：2004-12-16
申请号：PCT/IB2004000838
申请日：2004-03-15
申请人： UPJOHN CO , ROGERS BRUCE NELSEN , PIOTROWSKI DAVID WALTER , MARGOLIS BRANDON JEROME , MYERS JASON KENNETH , GROPPI VINCENT EDWARD JR , RUDMANN DANIEL GREGORY
发明人： ROGERS BRUCE NELSEN , PIOTROWSKI DAVID WALTER , MARGOLIS BRANDON JEROME , MYERS JASON KENNETH , GROPPI VINCENT EDWARD JR , RUDMANN DANIEL GREGORY
IPC分类号： C07D413/12 , C07D417/12 , G01N33/68 , G01N33/94 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4439
CPC分类号： C07D417/12 , C07D413/12 , G01N33/6893 , G01N33/944
摘要： The invention provides compounds of Formula (I). These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which alpha7 nAChR is known to be involved.
摘要翻译：本发明提供了式（I）的化合物。这些化合物可以是药物盐或组合物的形式，可以是纯对映体形式或外消旋混合物，并且可用于用于治疗已知α7nAChR参与的疾病或病症的药物。

22. 发明申请

WO1992015186A1 MODULAR STACKABLE INTERLOCKING STORAGE CABINET FOR ELECTRONIC COMPONENTS 审中-公开
标题翻译：用于电子元件的模块化堆叠式互锁储物柜
公开(公告)号：WO1992015186A1
公开(公告)日：1992-09-03
申请号：PCT/US1991005482
申请日：1991-07-31
申请人： LEONARD, Steven, S. , SORENSON, Bradford, T. , ROGERS, Bruce
发明人： LEONARD, Steven, S.
IPC分类号： H05K07/00
CPC分类号： H05K7/18 , H05K7/1435 , Y10S206/816
摘要： A modular storage cabinet (100) for electronic components which includes at least one base (1) having front back and opposite sidewalls. Each base sidewall includes a coacting top (12) and botto fastener (14). A plurality of stackable side bars (2) wherein each side bar includes an elongated wall portion having interior (7) and exterior faces (5) and coacting top (12) and bottom (14) fastening means on each wall portion. The bottom fastening means is adapted to engage with the top fastening means of a base or side bar for stackably supporting the side bar in registered relation thereon and the top fastening means being engageable with a bottom fastening means of a base (1) or side bar (2) for stackably supporting the last mentioned base (1) or side bar (2) thereon. Any selected number of side bars (2) may be stacked on each of opposite sidewalls of a base (1) for defining the spacing between adjacent stacked bases (1).
摘要翻译：一种用于电子部件的模块化存储柜（100），其包括至少一个具有前后壁和相对侧壁的基座（1）。每个基座侧壁包括共同作用顶部（12）和机器人紧固件（14）。多个可堆叠侧杆（2），其中每个侧杆包括在每个壁部分上具有内部（7）和外表面（5）以及共面顶部（12）和底部（14）紧固装置的细长壁部分。底部紧固装置适于与基座或侧杆的顶部紧固装置接合，用于可堆叠地支撑侧杆，并且顶部紧固装置可与基部（1）或侧杆的底部紧固装置接合（2），用于堆叠地支撑最后提到的底座（1）或侧杆（2）。任何选定数量的侧杆（2）可以堆叠在基座（1）的每个相对侧壁上，用于限定相邻堆叠基座（1）之间的间隔。

23. 发明申请

WO2008012623A1 BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR 审中-公开
标题翻译：作为谷氨酸受体MGLUR2亚型的潜在剂的苯并咪唑化合物
公开(公告)号：WO2008012623A1
公开(公告)日：2008-01-31
申请号：PCT/IB2007/002032
申请日：2007-07-12
申请人： PFIZER PRODUCTS INC. , EFREMOV, Ivan Viktorovich , ROGERS, Bruce Nelsen , DUPLANTIER, Allen, Jacob , ZHANG, Lei , ZHANG, Qian , MAKLAD, Noha Serour , EVRARD, Edelweiss Virginie , BRODNEY, Michael, A.
发明人： EFREMOV, Ivan Viktorovich , ROGERS, Bruce Nelsen , DUPLANTIER, Allen, Jacob , ZHANG, Lei , ZHANG, Qian , MAKLAD, Noha Serour , EVRARD, Edelweiss Virginie , BRODNEY, Michael, A.
IPC分类号： C07D401/06 , C07D405/14 , C07D413/14 , C07D471/10 , C07D491/052 , C07D491/107 , A61K31/4375 , A61K31/438 , A61K31/454 , A61P25/00
CPC分类号： C07D401/06 , C07D405/14 , C07D413/14 , C07D471/10 , C07D491/052 , C07D491/107
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有如说明书中定义的式（I）的结构。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

24. 发明申请

WO2006051407A1 AZABENZOXAZOLES FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS病症的AZABENZOXAZOLES
公开(公告)号：WO2006051407A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003389
申请日：2005-11-03
申请人： PFIZER PRODUCTS INC. , ROGERS, Bruce, Nelsen , DUPLANTIER, Allen, Jacob , O'DONNELL, Christopher, John , ZHANG, Lei
发明人： ROGERS, Bruce, Nelsen , DUPLANTIER, Allen, Jacob , O'DONNELL, Christopher, John , ZHANG, Lei
IPC分类号： C07D519/00 , A61K31/551 , A61P25/18
CPC分类号： C07D519/00
摘要： The present invention relates to α7 nicotinic receptor agonists of formula I as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an α7 nicotinic receptor agonist of formula I as shown herein. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist of formula I.
摘要翻译：本发明涉及本文所述的式I的烟碱型受体激动剂和通过向哺乳动物施用a7烟碱样受体来治疗哺乳动物（包括人）中的中枢神经系统（CNS）和其它疾病的疾病的方法如本文所示的式I的激动剂。它还涉及含有药学上可接受的载体和式I的CNS渗透剂a7烟碱受体激动剂的药物组合物。

25. 发明申请

WO2005084343A2 METHOD OF CHARGING A BATTERY 审中-公开
标题翻译：充电方法
公开(公告)号：WO2005084343A2
公开(公告)日：2005-09-15
申请号：PCT/US2005/006781
申请日：2005-03-02
申请人： GALAXY POWER, INC. , ARNOLD, Edward, H. , ROGERS, Bruce, J.
发明人： ARNOLD, Edward, H. , ROGERS, Bruce, J.
IPC分类号： H02J7/00
CPC分类号： H02J7/0077
摘要： A method of charging a battery having an internal resistance and an external resistance connected to the battery includes applying electrical energy to the battery. The method also includes adjusting, at a plurality of predetermined intervals, the electrical energy applied to the battery based on at least one of the internal resistance of the battery and the external resistance connected to the battery.
摘要翻译：对具有与电池连接的内部电阻和外部电阻的电池进行充电的方法包括向电池施加电能。该方法还包括基于电池的内部电阻和连接到电池的外部电阻中的至少一个，以多个预定间隔调整施加到电池的电能。

26. 发明申请

WO2004071233A3 HAIR HOLDING DEVICE WITH CONCEALED SPRING 审中-公开
标题翻译：头发保持装置与隐形弹簧
公开(公告)号：WO2004071233A3
公开(公告)日：2005-06-23
申请号：PCT/US2004002916
申请日：2004-02-02
申请人： ROGERS BRUCE A
发明人： ROGERS BRUCE A , LIVINGSTON DAVID
IPC分类号： A45D8/20
CPC分类号： A45D8/20
摘要： A hair holding device and spring concealment mechanism including a pair of opposed, hingedly connected body members adapted to pivot about a hinge axis between closed and open positions. A torsion biasing spring biases the device into a predetermined position. The spring is concealed in multiple casings, which are unattached to either body member of the hair holding device. The casings do not bear any torque exerted by the spring and do not encase the entireties of the spring's first and second projecting arms. Consequently, they can be made relatively thin-walled and compact to closely conform to the size and shape of the coil portion of the spring. The thin walls and small diameter of the spring casings minimize the extent to which the casings protrude from the hair holding device, thereby improving its aesthetic appeal.
摘要翻译：一种头发夹持装置和弹簧隐蔽机构，包括一对相对的，铰接连接的本体构件，适于在闭合位置和打开位置之间围绕铰链轴线枢转。扭转偏压弹簧将装置偏压到预定位置。弹簧被隐藏在多个壳体中，这些壳体与头发夹持装置的任何一个主体部件无关。壳体不承受弹簧施加的任何扭矩，并且不包围弹簧的第一和第二突出臂的整体。因此，它们可以制成相对薄壁且紧凑，以与弹簧的线圈部分的尺寸和形状紧密地一致。弹簧壳体的薄壁和小直径使壳体从头发夹持装置突出的程度最小化，从而提高其美学吸引力。

27. 发明申请

WO2004085433A2 POSITIVE ALLOSTERIC MODULATORS OF THE NICOTINIC ACETYLCHOLINE RECEPTOR 审中-公开
标题翻译： NICOTINIC乙酰胆碱受体的阳性免疫调节剂
公开(公告)号：WO2004085433A2
公开(公告)日：2004-10-07
申请号：PCT/IB2004/000838
申请日：2004-03-15
申请人： PHARMACIA & UPJOHN COMPANY , ROGERS, Bruce, Nelsen , PIOTROWSKI, David, Walter , MARGOLIS, Brandon, Jerome , MYERS, Jason, Kenneth , GROPPI, Vincent, Edward, Jr. , RUDMANN, Daniel, Gregory
发明人： ROGERS, Bruce, Nelsen , PIOTROWSKI, David, Walter , MARGOLIS, Brandon, Jerome , MYERS, Jason, Kenneth , GROPPI, Vincent, Edward, Jr. , RUDMANN, Daniel, Gregory
IPC分类号： C07D413/00
CPC分类号： C07D417/12 , C07D413/12 , G01N33/6893 , G01N33/944 , Y02A50/58
摘要： The invention provides compounds of Formula (I). These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.
摘要翻译：本发明提供式（I）的化合物。这些化合物可以是药物盐或组合物的形式，可以是纯对映体形式或外消旋混合物，并且可用于用于治疗其中已知α7nAChR涉及的疾病或病症的药物。

28. 发明申请

WO2004052889A1 COMPOUNDS AS RADIOLIGANDS FOR THE DIAGNOSIS OF DISEASE 审中-公开
标题翻译：化合物作为疾病诊断的放射性物质
公开(公告)号：WO2004052889A1
公开(公告)日：2004-06-24
申请号：PCT/IB2003/005521
申请日：2003-11-24
申请人： PHARMACIA & UPJOHN COMPANY , ROGERS, Bruce, Nelsen , PIOTROWSKI, David, Walter , GROPPI, Vincent, Edward, Jr. , JACOBSEN, Eric, Jon , MYERS, Jason, Kenneth , WALKER, Daniel, Patrick , WISHKA, Donn, Gregory , SKADDAN, Marc, Bradley
发明人： ROGERS, Bruce, Nelsen , PIOTROWSKI, David, Walter , GROPPI, Vincent, Edward, Jr. , JACOBSEN, Eric, Jon , MYERS, Jason, Kenneth , WALKER, Daniel, Patrick , WISHKA, Donn, Gregory , SKADDAN, Marc, Bradley
IPC分类号： C07D453/02
CPC分类号： C07D471/08 , C07B2200/05 , C07D453/02 , C07D487/08
摘要： Radiolabeled ligands useful as probes for determining the relative abundance, receptor occupancy, and/or function of nicotinic acetylcholine receptors. The compounds of Formula I as described herein are labeled with a radioactive isotopic moiety such as 11 C, 18 F, 76 Br, 123 I or 125 I. Disorders are diagnosed by administering to a mammal a detectably labeled compound and detecting the binding of that compound to the nAChR. The compounds that have been administered are detected using methods including, but not limited to, position emission topography and single-photon to emission computed tomography. The present invention is useful in diagnosing a wide variety of diseases and disorders as discussed herein.
摘要翻译：用作确定烟碱乙酰胆碱受体的相对丰度，受体占有率和/或功能的探针的放射性标记配体。如本文所述的式I化合物用放射性同位素部分（例如11 C，18 F，76 Br，123 I或125 I）进行标记。通过向哺乳动物施用可检测标记的化合物并检测该化合物与nAChR的结合来诊断疾病。使用包括但不限于位置发射形貌和单光子到发射计算机断层摄影的方法检测已经施用的化合物。本发明可用于诊断本文所讨论的多种疾病和病症。

29. 发明申请

WO2004052461A1 COMBINATION FOR THE TREATMENT OF ADHD 审中-公开
标题翻译：组合治疗ADHD
公开(公告)号：WO2004052461A1
公开(公告)日：2004-06-24
申请号：PCT/IB2003/005542
申请日：2003-11-28
申请人： PHARMACIA & UPJOHN COMPANY , GROPPI, Vincent, Edward, Jr. , JACOBSEN, Eric, Jon , MYERS, Jason, Kenneth , PIOTROWSKI, David, Walter , ROGERS, Bruce, Nelsen , WALKER, Daniel, Patrick , WISHKA, Donn, Gregory
发明人： GROPPI, Vincent, Edward, Jr. , JACOBSEN, Eric, Jon , MYERS, Jason, Kenneth , PIOTROWSKI, David, Walter , ROGERS, Bruce, Nelsen , WALKER, Daniel, Patrick , WISHKA, Donn, Gregory
IPC分类号： A61P25/00
CPC分类号： A61K45/06 , A61K31/46 , A61K2300/00
摘要： The present invention relates to compositions and methods to treat ADHD with an α7 nAChR full agonist and psychostimulants and/or monoamine reuptake inhibitors.
摘要翻译：本发明涉及用α7nAChR全激动剂和精神兴奋剂和/或单胺再摄取抑制剂治疗ADHD的组合物和方法。

30. 发明申请

WO2003070732A1 FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：用于治疗疾病的双金属N-桥联偶氮类抗氧化剂
公开(公告)号：WO2003070732A1
公开(公告)日：2003-08-28
申请号：PCT/US2003/002687
申请日：2003-02-14
申请人： PHARMACIA & UPJOHN COMPANY , ROGERS, Bruce, N. , PIOTROWSKI, David, W. , WALKER, Daniel, P. , JACOBSEN, Eric, Jon , ACKER, Brad, A. , WISHKA, Donn, G. , GROPPI, Jr. Vincent, E.
发明人： ROGERS, Bruce, N. , PIOTROWSKI, David, W. , WALKER, Daniel, P. , JACOBSEN, Eric, Jon , ACKER, Brad, A. , WISHKA, Donn, G. , GROPPI, Jr. Vincent, E.
IPC分类号： C07D519/00
CPC分类号： C07D519/00
摘要： The invention provides compounds of Formula (I). These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat conditions or diseases in which .α7 is know to be involved.
摘要翻译：本发明提供式（I）的化合物。这些化合物可以是药物盐或组合物的形式，可以是纯对映体形式或外消旋混合物，并且可用于药物以治疗αα7被认为参与的病症或疾病。

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