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1. 发明申请

WO2007017750A1 BENZOATE SALT OF 4-(5-METHYL-OXAZOLO[4,5-B]PYRIDIN-2-YL)-1,4-DIAZA-BICYCLO[3.2.2]NONANE 审中-公开
标题翻译： 4-（5-甲基 - 氧杂唑并[4,5-b]吡啶-2-基）-1,4-二氮杂双环[3.2.2]壬烷的苯甲酸盐
公开(公告)号：WO2007017750A1
公开(公告)日：2007-02-15
申请号：PCT/IB2006/002219
申请日：2006-08-07
申请人： PFIZER PRODUCTS INC. , DUPLANTIER, Allen, Jacob , KRAUS, Kenneth, George , ROGERS, Bruce, Nelsen
发明人： DUPLANTIER, Allen, Jacob , KRAUS, Kenneth, George , ROGERS, Bruce, Nelsen
IPC分类号： C07D519/00 , A61K31/551
CPC分类号： C07D519/00
摘要： The present invention provides a benzoate salt of Formula (I), is also known as 4-(5-methyloxazolo[4,5-b]pyridine-2-yl)-1 ,4- diazabicyclo[3.2.2]nonane. The benzoate salt of the invention is useful in the treatment of schizophrenia and Alzheimer's Disease. It is particularly of use in the treatment of cognitive deficits associated with schizophrenia, cognitive and attention deficit symptoms of Alzheimer's Disease, and neurodegeneration associated with Alzheimer's Disease.
摘要翻译：本发明提供式（I）的苯甲酸盐，也称为4-（5-甲基恶唑并[4,5-b]吡啶-2-基）-1,4-二氮杂双环[3.2.2]壬烷。本发明的苯甲酸盐可用于治疗精神分裂症和阿尔茨海默病。它特别用于治疗与精神分裂症，阿尔茨海默病的认知和注意缺陷症状以及与阿尔茨海默氏病有关的神经变性相关的认知缺陷。

2. 发明申请

WO2004039815A8 COMPOUNDS HAVING BOTH ALPHA7 NACHR AGONIST AND 5HT ANTAGONIST ACTIVITY FOR TREATMENT OF CNS DISEASES 审中-公开
标题翻译：具有两种ALPHA7 NACHR激动剂和5HT拮抗剂活性以治疗CNS疾病的化合物
公开(公告)号：WO2004039815A8
公开(公告)日：2004-09-23
申请号：PCT/IB0304681
申请日：2003-10-20
申请人： UPJOHN CO , WONG ERIK HO FONG , CORTES-BURGOS LUZ AMPARO , ROGERS BRUCE NELSEN , PIOTROWSKI DAVID WALTER , WALKER DANIEL PATRICK , JACOBSEN ERIC JON , WISHKA DONN GREGORY , ACKER BRAD ALAN
发明人： WONG ERIK HO FONG , CORTES-BURGOS LUZ AMPARO , ROGERS BRUCE NELSEN , PIOTROWSKI DAVID WALTER , WALKER DANIEL PATRICK , JACOBSEN ERIC JON , WISHKA DONN GREGORY , ACKER BRAD ALAN
IPC分类号： C07D453/02 , C07D487/08 , C07D519/00 , A61K31/439
CPC分类号： C07D487/08 , C07D453/02 , Y02P20/55
摘要： The invention discloses compounds that are selective alpha7 nAChR agonists and 5-HT3 antagonists. The compounds are useful for treating many CNS diseases. The compounds have the following Formula (I): Azabicyclo-N(H)-C(=O)-W wherein Azabicyclo is Formula (2) each R1 is independently H, alkyl, or substituted alkyl; R2 is H, alkyl, or substituted alkyl; k is 1 or 2, provided that one R2 is other than H when k is 2; R3 is H, alkyl, or an amino protecting group; W is Formula (3); W is CH or N; W is O, N(R4), N(C(O)R4), or S; W is O, N(R4), N(C(O)R4), or S; R is H, F, Cl, Br, I, alkyl, substituted alkyl, or alkynyl; Alkyl is both straight- and branched-chain moieties having from 1-6 carbon atoms.
摘要翻译：本发明公开了选择性α7nAChR激动剂和5-HT3拮抗剂的化合物。该化合物可用于治疗许多CNS疾病。化合物具有下式（I）：氮杂双环-N（H）-C（= O）-W 0，其中，氮杂双环是式（2），每个R 1独立地是H，烷基或取代的烷基; R2是H，烷基或取代的烷基; k为1或2，条件是当k为2时，一个R2不为H; R3是H，烷基或氨基保护基; W 0是式（3）; W是CH或N; W 1是O，N（R 4），N（C（O）R 4）或S; W 2是O，N（R 4），N（C（O）R 4）或S; R是H，F，Cl，Br，I，烷基，取代的烷基或炔基; 烷基是具有1-6个碳原子的直链和支链部分。

3. 发明申请

WO2004064836A3 TREATMENT OF DISEASES WITH ALPHA-7 NACH RECEPTOR FULL AGONISTS 审中-公开
公开(公告)号：WO2004064836A3
公开(公告)日：2004-08-05
申请号：PCT/IB2004/000115
申请日：2004-01-12
申请人： PHARMACIA & UPJOHN COMPANY , GROPPI, Vincent, Edward, Jr. , ROGERS, Bruce, Nelsen , RUDMANN, Daniel, Gregory
发明人： GROPPI, Vincent, Edward, Jr. , ROGERS, Bruce, Nelsen , RUDMANN, Daniel, Gregory
IPC分类号： A61K31/439
摘要： The present invention relates to compositions and methods to treat diseases or conditions with alpha-7 nicotinic acetylcholine receptor (AChR) full agonists by decreasing levels of tumor necrosis factor-alpha and/or by stimulating vascular angiogenesis.

4. 发明申请

WO2004064836A2 TREATMENT OF DISEASES WITH ALPHA-7 NACH RECEPTOR FULL AGONISTS 审中-公开
标题翻译：用α-7NACH受体全致激素治疗疾病
公开(公告)号：WO2004064836A2
公开(公告)日：2004-08-05
申请号：PCT/IB2004000115
申请日：2004-01-12
申请人： UPJOHN CO , GROPPI VINCENT EDWARD JR , ROGERS BRUCE NELSEN , RUDMANN DANIEL GREGORY
发明人： GROPPI VINCENT EDWARD JR , ROGERS BRUCE NELSEN , RUDMANN DANIEL GREGORY
IPC分类号： A61K31/439 , A61P9/10 , A61P19/02
CPC分类号： A61K31/407 , A61K31/439 , A61K31/4745
摘要： The present invention relates to compositions and methods to treat diseases or conditions with alpha-7 nicotinic acetylcholine receptor (AChR) full agonists by decreasing levels of tumor necrosis factor-alpha and/or by stimulating vascular angiogenesis.
摘要翻译：本发明涉及通过降低肿瘤坏死因子-α水平和/或通过刺激血管血管生成治疗用α-7烟碱乙酰胆碱受体（AChR）完全激动剂治疗疾病或病症的组合物和方法。

5. 发明申请

WO2003093250A3 POSITIVE ALLOSTERIC MODULATORS OF THE NICOTINIC ACETYLCHOLINE RECEPTOR 审中-公开
公开(公告)号：WO2003093250A3
公开(公告)日：2003-11-13
申请号：PCT/US2003/011493
申请日：2003-04-28
申请人： PHARMACIA & UPJOHN COMPANY , PIOTROWSKI, David, W. , ROGERS, Bruce, N. , MCWHORTER, William, W., Jr. , WALKER, Daniel, P. , CORBETT, Jeffrey, W. , GROPPI, Vincent, E., Jr. , RUDMANN, Daniel, G.
发明人： PIOTROWSKI, David, W. , ROGERS, Bruce, N. , MCWHORTER, William, W., Jr. , WALKER, Daniel, P. , CORBETT, Jeffrey, W. , GROPPI, Vincent, E., Jr. , RUDMANN, Daniel, G.
IPC分类号： C07C275/34
摘要： The invention provides compounds of Formula I: (1) these compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.

6. 发明申请

WO2003018585A1 SUBSTITUTED-HETEROARYL-7-AZA[2.2.1]BICYCLOHEPTANES FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：替代异丙基-7-AZA [2.2.1]用于治疗疾病的双环蛋白
公开(公告)号：WO2003018585A1
公开(公告)日：2003-03-06
申请号：PCT/US2002/021326
申请日：2002-08-14
申请人： PHARMACIA & UPJOHN COMPANY , WISHKA, Donn, G. , MYERS, Jason, K. , ROGERS, Bruce, N. , JACOBSEN, Eric, Jon , PIOTROWSKI, David, W. , CORBETT, Jeffrey, W. , BODNAR, Alice, L. , GROPPI, Vincent, E., Jr.
发明人： WISHKA, Donn, G. , MYERS, Jason, K. , ROGERS, Bruce, N. , JACOBSEN, Eric, Jon , PIOTROWSKI, David, W. , CORBETT, Jeffrey, W. , BODNAR, Alice, L. , GROPPI, Vincent, E., Jr.
IPC分类号： C07D487/08
CPC分类号： C07D487/08
摘要： The invention provides compounds of Formula I: compounds of the Formula I: Formula (I), wherein R 1 , R 2 , R 4 , R 6 , X, and W are defined herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 is known to be involved.
摘要翻译：本发明提供了式I化合物：式I化合物：式（I），其中R 1，R 2，R 4，R 6，X和W如本文所定义。这些化合物可以是药物盐或组合物的形式，可以是纯对映体形式或外消旋混合物，并且可用于用于治疗已知α7已知的疾病或病症的药物。

7. 发明申请

WO0217358A3 QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS) 审中-公开
标题翻译：喹诺酮替代治疗疾病（NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS）
公开(公告)号：WO0217358A3
公开(公告)日：2002-05-30
申请号：PCT/US0121139
申请日：2001-08-17
申请人： UPJOHN CO , MYERS JASON K , ROGERS BRUCE N , GROPPI VINCENT E JR , PIOTROWSKI DAVID W , BODNAR ALICE L , JACOBSEN ERIC JON , CORBETT JEFFREY W
发明人： MYERS JASON K , ROGERS BRUCE N , GROPPI VINCENT E JR , PIOTROWSKI DAVID W , BODNAR ALICE L , JACOBSEN ERIC JON , CORBETT JEFFREY W
IPC分类号： A61P25/00 , C07D453/02 , A61K31/439 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D487/08
CPC分类号： C07D453/02
摘要： The invention provides compounds of Formula (I). These compounds may be in the form of pharmaceutical salts or compositions, and racemic mixtures or pure enantiomers thereof. The compounds of Formula (I) are useful in pharmaceuticals in which alpha 7 is known to be involved.
摘要翻译：本发明提供式（I）的化合物。这些化合物可以是药物盐或组合物的形式，以及外消旋混合物或其纯对映异构体。式（I）的化合物可用于已知其中涉及α7的药物。

8. 发明申请

WO2008012622A3 AZABENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR 审中-公开
标题翻译：作为谷氨酸受体的MGLUR2亚型的电位的AZABENZIMIDAZOLYL化合物
公开(公告)号：WO2008012622A3
公开(公告)日：2008-04-03
申请号：PCT/IB2007002030
申请日：2007-07-13
申请人： PFIZER PROD INC , EFREMOV IVAN VIKTOROVICH , ROGERS BRUCE NELSEN , DUPLANTIER ALLEN JACOB , ZHANG LEI , ZHANG QIAN , MAKLAD NOHA SEROUR
发明人： EFREMOV IVAN VIKTOROVICH , ROGERS BRUCE NELSEN , DUPLANTIER ALLEN JACOB , ZHANG LEI , ZHANG QIAN , MAKLAD NOHA SEROUR
IPC分类号： C07D471/04 , A61K31/4523 , A61P25/00 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中化合物具有如说明书中定义的式（I）的结构。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

9. 发明申请

WO2007103582A3 PORTABLE OXYGEN DELIVERY APPARATUS 审中-公开
公开(公告)号：WO2007103582A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/006130
申请日：2007-03-09
申请人： OXYGEN PLUS, INC. , ROGERS, Bruce
发明人： ROGERS, Bruce
IPC分类号： B65D83/00
摘要： A portable breathable gas delivery device including a pressure vessel for storing the breathable gas under pressure and a valve coupled to the pressure vessel through which the breathable gas can be selectively released. The pressure vessel is enclosed in a housing having a first portion that at least partially encloses the pressure vessel and a second portion that partially encloses a chamber coupled to the pressure vessel via the valve into which the breathable gas can be released for breathing by a user. The second portion together with a user's facial structure forms a substantially closed enclosure. The chamber has an opening shaped and formed to interface with the user's facial structure.

10. 发明申请

WO2007103582A2 PORTABLE OXYGEN DELIVERY APPARATUS 审中-公开
标题翻译：便携式氧气输送装置
公开(公告)号：WO2007103582A2
公开(公告)日：2007-09-13
申请号：PCT/US2007006130
申请日：2007-03-09
申请人： OXYGEN PLUS INC , ROGERS BRUCE
发明人： ROGERS BRUCE
IPC分类号： A61M15/08 , A61M16/00
CPC分类号： A61M16/10 , A61M16/06 , A61M16/201 , A61M2016/0027 , A61M2202/0208 , A61M2205/583 , A61M2205/8225
摘要： A portable breathable gas delivery device including a pressure vessel for storing the breathable gas under pressure and a valve coupled to the pressure vessel through which the breathable gas can be selectively released. The pressure vessel is enclosed in a housing having a first portion that at least partially encloses the pressure vessel and a second portion that partially encloses a chamber coupled to the pressure vessel via the valve into which the breathable gas can be released for breathing by a user. The second portion together with a user's facial structure forms a substantially closed enclosure. The chamber has an opening shaped and formed to interface with the user's facial structure.
摘要翻译：一种便携式透气气体输送装置，包括用于储存在压力下的可呼吸气体的压力容器和连接到压力容器的阀，可透气气体可以通过该阀选择性地释放。压力容器被封闭在具有至少部分地包围压力容器的第一部分的壳体中，以及第二部分，其部分地包围通过阀连接到压力容器的腔室，呼吸气体可由用户释放，呼吸用户。第二部分与用户的面部结构一起形成基本封闭的外壳。腔室具有形状并形成为与使用者的面部结构相接合的开口。

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