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21. 发明申请

WO2005067973A2 COMBINATION OF CRF ANTAGONISTS AND 5-HT 1B RECEPTOR ANTAGONISTS 审中-公开
标题翻译： CRF拮抗剂和5-HT 1B受体拮抗剂的组合
公开(公告)号：WO2005067973A2
公开(公告)日：2005-07-28
申请号：PCT/IB2005000012
申请日：2005-01-03
申请人： PFIZER PROD INC , HOWARD HARRY RALPH JR , CHEN YUHPYNG LIANG
发明人： HOWARD HARRY RALPH JR , CHEN YUHPYNG LIANG
IPC分类号： A61K31/513 , A61K31/519 , A61K31/541 , A61K45/06 , A61P1/00 , A61P3/00 , A61P9/00 , A61P15/00 , A61P25/00 , A61P35/00
CPC分类号： A61K31/513 , A61K31/519 , A61K31/541 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition for treating, for example, a disorder or condition selected from the group consisting of hypertension, depression, generalized anxiety disorder, phobias, posttraumatic stress disorder, avoidant personality disorder, sexual dysfunction, eating disorders, obesity, chemical dependencies, cluster headache, migraine, pain, Alzheimer's disease, obsessive-compulsive disorder, panic disorder, memory disorders, Parkinson's diseases, endocrine disorders, cerebellar ataxia, gastrointestinal tract disorders, negative symptoms of schizophrenia, premenstrual syndrome, Fibromyalgia Syndrome, stress incontinence, Tourette syndrome, trichotillomania, kleptomania, male impotence, cancer, chronic paroxysmal hemicrania and headache in a mammal, preferably a human, comprising (i) a corticotropin releasing factor antagonist or a pharmaceutically acceptable salt thereof, (ii) a 5-HT1B receptor antagonist or a pharmaceutically acceptable salt thereof, wherein the 5-HT1B receptor antagonist is selected from the group consisting of (A) a compound of the formula I as described in the specification and (B) a compound of the formula II as described in the specification, and optionally (iii) a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及一种用于治疗例如选自高血压，抑郁症，广泛性焦虑症，恐惧症，创伤后应激障碍，避孕人格障碍，性功能障碍，进食障碍，肥胖症，化学依赖性，丛集性头痛，偏头痛，疼痛，阿尔茨海默病，强迫症，恐慌症，记忆障碍，帕金森病，内分泌紊乱，小脑共济失调，胃肠道疾病，精神分裂症阴性症状，经前综合征，纤维肌痛综合征，压力性尿失禁包括（i）促肾上腺皮质激素释放因子拮抗剂或其药学上可接受的盐，（ii）5-HT1B受体，（ii）5-HT1B受体拮抗剂或其药学上可接受的盐其中所述5-HT1B受体拮抗剂选自（A）如说明书中所述的式I化合物和（B）说明书中所述的式II化合物，和任选地（iii ）药学上可接受的载体。

22. 发明申请

WO2005061491A2 ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES 审中-公开
标题翻译： ARALKYL和ARALKYLIDENE杂环纤维和咪唑
公开(公告)号：WO2005061491A2
公开(公告)日：2005-07-07
申请号：PCT/IB2004/003994
申请日：2004-12-03
申请人： PFIZER PRODUCTS INC. , ELLIOTT, Mark, Leonard , HOWARD, Harry, Ralph, Jr.
发明人： ELLIOTT, Mark, Leonard , HOWARD, Harry, Ralph, Jr.
IPC分类号： C07D413/10
CPC分类号： C07D413/10 , C07D265/32
摘要： The present invention relates to compounds of the formula (I) wherein R 1 , R 2 , R 3 , X, Y and the dashed line are defined in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use as psychotherapeutic agents.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，X，Y和虚线在本说明书中定义为其制备中间体，含有它们和作为心理治疗剂的药用。

23. 发明申请

WO2002083643A1 PHENYL HETEROCYCLYL ETHER DERIVATIVES AS SEROTONIN RE-UPTAKE INHIBITORS 审中-公开
标题翻译：苯基异喹啉酮衍生物作为丝氨酸还原抑制剂
公开(公告)号：WO2002083643A1
公开(公告)日：2002-10-24
申请号：PCT/IB2002/001032
申请日：2002-03-27
申请人： PFIZER LIMITED , PFIZER INC. , ADAM, Mavis, Diane , ANDREWS, Mark, David , GYMER, Geoffrey, Edward , HEPWORTH, David , HOWARD, Harry, Ralph, Jr. , MIDDLETON, Donald, Stuart , STOBIE, Alan
发明人： ADAM, Mavis, Diane , ANDREWS, Mark, David , GYMER, Geoffrey, Edward , HEPWORTH, David , HOWARD, Harry, Ralph, Jr. , MIDDLETON, Donald, Stuart , STOBIE, Alan
IPC分类号： C07D213/65
CPC分类号： C07D213/65 , C07D213/80 , C07D213/82 , C07D241/18 , C07D401/06
摘要： The invention relates to compounds of the formula (I) which exhibit activity as selective serotonin re-uptake inhibitors.
摘要翻译：本发明涉及作为选择性5-羟色胺再摄取抑制剂的活性的式（I）化合物。

24. 发明申请

WO1998014433A1 ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES 审中-公开
标题翻译： ARALKYL和ARALKYLIDENE杂环纤维和咪唑
公开(公告)号：WO1998014433A1
公开(公告)日：1998-04-09
申请号：PCT/IB1997001062
申请日：1997-09-08
申请人： PFIZER INC. , HOWARD, Harry, Ralph
发明人： PFIZER INC.
IPC分类号： C07D233/96
CPC分类号： C07D277/20 , A61K31/135 , A61K31/496 , C07D233/70 , C07D233/96 , C07D241/08 , C07D265/32 , C07D267/10 , C07D273/06 , C07D277/34 , C07D279/12 , C07D281/06 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： Compounds of the formula (I) wherein R is a group of formula G , G , G , G , G , G or G ; Y is an optionally substituted (C1-C4) heteroalkyl bridge that, together with the atoms to which it is attached, forms a five to seven membered heterocycle containing two to four heteroatoms, intermediates for their preparation, pharmaceutical compositions containing them and their medicinal use. These compounds are useful as psychotherapeutic agents.
摘要翻译：式（I）的化合物，其中R 1是式G 1，G 2，G 3，G 4，G 5，G 6或G 7的基团 >; Y是任选取代的（C 1 -C 4）杂烷基桥，其与其连接的原子一起形成含有2至4个杂原子的5至7元杂环，其制备中间体，含有它们的药物组合物及其药物用途。这些化合物可用作心理治疗剂。

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