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1. 发明申请

WO2007063385A2 SPIROCYCLIC AMINE HISTAMINE-3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：螺旋胺组胺3受体拮抗剂
公开(公告)号：WO2007063385A2
公开(公告)日：2007-06-07
申请号：PCT/IB2006/003355
申请日：2006-11-20
申请人： PFIZER PRODUCTS INC. , ELLIOTT, Mark, Leonard , HOWARD, Harry, Ralph, Jr.
发明人： ELLIOTT, Mark, Leonard , HOWARD, Harry, Ralph, Jr.
CPC分类号： C07D491/10
摘要： This invention is directed to compounds of the formula I as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the Gl tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.
摘要翻译：本发明涉及本文定义的式I化合物或其药学上可接受的盐; 含有式I化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向需要这种治疗的哺乳动物施用如上所述的式I化合物，以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD），精神障碍，睡眠中的障碍或病症的方法过敏反应，过敏性鼻炎，鼻充血，过敏充血，充血，低血压，心血管疾病，胃肠道疾病，超低运动性和酸性分泌胃肠道，该方法包括向需要这种治疗的哺乳动物施用化合物我如上所述。

2. 发明申请

WO2005066165A1 N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES 审中-公开
标题翻译： N-取代的哌啶和哌嗪衍生物
公开(公告)号：WO2005066165A1
公开(公告)日：2005-07-21
申请号：PCT/IB2004/004239
申请日：2004-12-20
申请人： WARNER-LAMBERT COMPANY LLC , CHO, Stephen, Sung, Yong , GREGORY, Tracy, Fay , GUZZO, Peter, Robert , HOWARD, Harry, Ralph, Jr. , NIKAM, Sham, Shridhar , SURMAN, Matthew, David , WALTERS, Michael, Anthony
发明人： CHO, Stephen, Sung, Yong , GREGORY, Tracy, Fay , GUZZO, Peter, Robert , HOWARD, Harry, Ralph, Jr. , NIKAM, Sham, Shridhar , SURMAN, Matthew, David , WALTERS, Michael, Anthony
IPC分类号： C07D417/14
CPC分类号： C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： This invention relates to compounds of the formula 1 wherein R 1 , R 2 , R 7 , R 8 , R 9 , U, V, Z, A, W, X, M, E, L, T and D are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.
摘要翻译：本发明涉及式1的化合物，其中R 1，R 2，R 7，R 8，R 9，U，V，Z，A，W，X，M，E L，T和D如说明书中所定义，含有它们的药物组合物及其在治疗中枢神经系统和其它疾病中的用途。

3. 发明申请

WO1992008718A1 4-(1,2-BENZISOXAZOLYL)PIPERIDINE ANTIPSYCHOTIC AGENTS 审中-公开
标题翻译： 4-（1,2-BZZOXOXAZOLYL）哌啶类抗生素代谢物
公开(公告)号：WO1992008718A1
公开(公告)日：1992-05-29
申请号：PCT/US1991005593
申请日：1991-08-16
申请人： PFIZER INC. , HOWARD, Harry, Ralph, Jr.
发明人： PFIZER INC.
IPC分类号： C07D413/14
CPC分类号： C07D413/14 , C07D417/14
摘要： Certain 1-substituted 4-(1,2-benzisoxazolyl)piperidine compounds exhibit neuroleptic activity and are useful in the treatment of psychosis and anxiety.

4. 发明申请

WO2007138431A2 AZABICYCLIC ETHER HISTAMINE-3 ANTAGONISTS 审中-公开
标题翻译：亚硫酸钙组胺组胺3拮抗剂
公开(公告)号：WO2007138431A2
公开(公告)日：2007-12-06
申请号：PCT/IB2007/001367
申请日：2007-05-18
申请人： PFIZER PRODUCTS INC. , BERKE, Helen , HOWARD, Harry, Ralph, Jr.
发明人： BERKE, Helen , HOWARD, Harry, Ralph, Jr.
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention is directed to compounds of the formula (I) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula (I), a method of treatment of a disorder or condition that may be treated by antagonizing histamine H 3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above.
摘要翻译：本发明涉及本文定义的式（I）化合物或其药学上可接受的盐; 含有式（I）化合物的药物组合物，治疗可以通过拮抗组胺H 3受体治疗的病症或病症的方法，所述方法包括向需要这样的受体的哺乳动物施用治疗如上所述的式（I）化合物，以及治疗选自以下的疾病或病症的方法：抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默病，注意力缺陷障碍（ADD），注意力过敏反应，过敏性鼻炎，鼻塞，过敏性充血，充血，低血压，心血管疾病，过敏反应，过敏反应，过敏反应，胃肠道疾病，胃肠道的超低运动性和酸性分泌，该方法包括向需要这种治疗的哺乳动物施用如上所述的式（I）化合物。

5. 发明申请

WO2007063385A3 SPIROCYCLIC AMINE HISTAMINE-3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：螺环胺胺组胺3受体拮抗剂
公开(公告)号：WO2007063385A3
公开(公告)日：2007-10-04
申请号：PCT/IB2006003355
申请日：2006-11-20
申请人： PFIZER PROD INC , ELLIOTT MARK LEONARD , HOWARD HARRY RALPH JR
发明人： ELLIOTT MARK LEONARD , HOWARD HARRY RALPH JR
IPC分类号： C07D491/10 , A61K31/4747 , A61P3/04 , A61P25/28 , A61P37/08
CPC分类号： C07D491/10
摘要： This invention is directed to compounds of the formula I as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the Gl tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.
摘要翻译：本发明涉及如本文所定义的式I化合物或其药学上可接受的盐; 含有式I化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括对需要所述治疗的哺乳动物施用如上所述的式I化合物，以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意力缺陷多动障碍（ADHD），精神病性障碍，睡眠障碍肥胖，头晕，癫痫，晕动病，呼吸系统疾病，变态反应，过敏引起的气道反应，过敏性鼻炎，鼻塞，过敏性充血，充血，低血压，心血管疾病，胃肠道疾病，过度运动和酸性胃肠道分泌的方法，所述方法包括向需要这种治疗的哺乳动物施用用于治疗的化合物如上所述。

6. 发明申请

WO2007099423A1 1-PYRROLIDINE INDANE DERIVATIVES AS HISTAMINE-3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为组胺-3受体拮抗剂的1-吡咯烷吲哚衍生物
公开(公告)号：WO2007099423A1
公开(公告)日：2007-09-07
申请号：PCT/IB2007/000414
申请日：2007-02-19
申请人： PFIZER PRODUCTS INC. , HOWARD, Harry, Ralph, Jr.
发明人： HOWARD, Harry, Ralph, Jr.
IPC分类号： C07D295/08 , A61K31/445 , A61P25/00
CPC分类号： C07D295/08 , C07D295/088
摘要： The invention is directed to compounds of the formula (I) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula (I), a method of treatment of a disorder or condition that may be treated by antagonizing histamine H 3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the Gl tract, hyper and hypo motility of the gastrointestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above.
摘要翻译：本发明涉及本文定义的式（I）化合物或其药学上可接受的盐; 含有式（I）化合物的药物组合物，治疗可以通过拮抗组胺H 3受体治疗的病症或病症的方法，所述方法包括向需要这样的受体的哺乳动物施用治疗如上所述的式（I）化合物，以及治疗选自以下的疾病或病症的方法：抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默病，注意力缺陷障碍（ADD），注意力过敏反应，过敏性鼻炎，鼻塞，过敏性充血，充血，低血压，心血管疾病，过敏反应，过敏反应，过敏反应， GI道的疾病，胃肠道的超低运动性，所述方法包括向需要这种治疗的哺乳动物施用式（I ）如上所述。

7. 发明申请

WO2007036781A1 DIPHENYL ETHER MONOAMINE REUPTAKE INHIBITOR 审中-公开
标题翻译：二苯醚单体反应抑制剂
公开(公告)号：WO2007036781A1
公开(公告)日：2007-04-05
申请号：PCT/IB2006/002650
申请日：2006-09-18
申请人： PFIZER PRODUCTS INC. , HOWARD, Harry, Ralph, Jr.
发明人： HOWARD, Harry, Ralph, Jr.
IPC分类号： C07C217/58 , A61K31/135 , A61P9/12 , A61P25/24
CPC分类号： C07C217/58
摘要： The present invention relates to a compound of the formula (I) wherein R 1 is hydrogen or C 1 -C 6 alkyl; X and Y are independently selected from the group consisting of fluoro, chloro and bromo; its enantiomers, racemate and mixtures of enantiomers and the pharmaceutically acceptable salts thereof, which exhibit activity as serotonin, norepinephrine and dopamine reuptake inhibitors, and are therefore useful in the treatment of central nervous system and other disorders.
摘要翻译：本发明涉及式（I）化合物，其中R 1是氢或C 1 -C 6烷基; X和Y独立地选自氟，氯和溴; 其对映异构体，外消旋体和对映异构体及其药学上可接受的盐的混合物，其表现出作为血清素，去甲肾上腺素和多巴胺再摄取抑制剂的活性，因此可用于治疗中枢神经系统和其他疾病。

8. 发明申请

WO2005105744A1 HISTAMINE-3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：组胺-3受体拮抗剂
公开(公告)号：WO2005105744A1
公开(公告)日：2005-11-10
申请号：PCT/IB2005/001038
申请日：2005-04-18
申请人： PFIZER PRODUCTS INC. , HOWARD, Harry, Ralph, Jr. , WLODECKI, Bishop
发明人： HOWARD, Harry, Ralph, Jr. , WLODECKI, Bishop
IPC分类号： C07D213/38
CPC分类号： C07D213/38 , A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/506 , A61K45/06 , C07C215/30 , C07C233/43 , C07C237/30 , C07C255/58 , C07C311/37 , C07C317/32 , C07C323/32 , C07D207/09 , C07D209/08 , C07D211/26 , C07D213/61 , C07D217/02 , C07D231/12 , C07D239/26 , C07D239/30 , C07D239/34 , C07D239/36 , C07D239/42 , C07D239/52 , C07D261/08 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/52 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/58 , A61K2300/00
摘要： This invention is directed to a compound of the formula (I) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy- induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro- intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.
摘要翻译：本发明涉及本文定义的式（I）化合物或其药学上可接受的盐; 含有式I化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向需要这种治疗的哺乳动物施用如上所述的式I化合物，以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD），精神障碍，睡眠中的障碍或病症的方法过敏反应，过敏性鼻炎，鼻塞，过敏性充血，充血，低血压，心血管疾病，胃肠道疾病，超低运动性和酸性分泌胃肠道，该方法包括向需要这种治疗的哺乳动物施用f 如上所述。

9. 发明申请

WO2005082370A1 COMBINATIONS OF AN ATYPICAL ANTIPSYCHOTIC AND AN AMINOMETHYLPYRIDYLOXYMETHYL/BENZISOXAZOLE AZABICYCLIC DERIVATIVES FOR TREATING CNS DISORDERS 审中-公开
标题翻译：复方抗惊厥药与用于治疗中枢神经系统疾病的氨基甲基吡咯烷基甲基苯甲酸唑烷偶联衍生物的组合
公开(公告)号：WO2005082370A1
公开(公告)日：2005-09-09
申请号：PCT/IB2005/000106
申请日：2005-01-17
申请人： PFIZER PRODUCTS INC. , BRODNEY, Michael, Aaron , HOWARD, Harry, Ralph, Jr.
发明人： BRODNEY, Michael, Aaron , HOWARD, Harry, Ralph, Jr.
IPC分类号： A61K31/498
CPC分类号： A61K31/496 , A61K31/498 , A61K31/551 , A61K31/5513 , A61K2300/00
摘要： An aminomethylpyridyloxymethyl/benzisoxazole substituted azabicyclic compound, a pharmaceutical composition same, and a method of treating one or more CNS or other disorders, including concurrent treatment of disorders such as a schizophrenia and depression.
摘要翻译：氨基甲基吡啶氧基甲基/苯并异恶唑取代的氮杂双环化合物，其药物组合物，以及治疗一种或多种CNS或其它病症的方法，包括同时治疗诸如精神分裂症和抑郁症等疾病。

10. 发明申请

WO2005067973A3 COMBINATION OF CRF ANTAGONISTS AND 5-HT 1B RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2005067973A3
公开(公告)日：2005-07-28
申请号：PCT/IB2005/000012
申请日：2005-01-03
申请人： PFIZER PRODUCTS INC. , HOWARD, Harry, Ralph, Jr. , CHEN, Yuhpyng, Liang
发明人： HOWARD, Harry, Ralph, Jr. , CHEN, Yuhpyng, Liang
IPC分类号： A61K45/06
摘要： The present invention relates to a pharmaceutical composition for treating, for example, a disorder or condition selected from the group consisting of hypertension, depression, generalized anxiety disorder, phobias, posttraumatic stress disorder, avoidant personality disorder, sexual dysfunction, eating disorders, obesity, chemical dependencies, cluster headache, migraine, pain, Alzheimer's disease, obsessive-compulsive disorder, panic disorder, memory disorders, Parkinson's diseases, endocrine disorders, cerebellar ataxia, gastrointestinal tract disorders, negative symptoms of schizophrenia, premenstrual syndrome, Fibromyalgia Syndrome, stress incontinence, Tourette syndrome, trichotillomania, kleptomania, male impotence, cancer, chronic paroxysmal hemicrania and headache in a mammal, preferably a human, comprising (i) a corticotropin releasing factor antagonist or a pharmaceutically acceptable salt thereof, (ii) a 5-HT 1B receptor antagonist or a pharmaceutically acceptable salt thereof, wherein the 5-HT 1B receptor antagonist is selected from the group consisting of (A) a compound of the formula I as described in the specification and (B) a compound of the formula II as described in the specification, and optionally (iii) a pharmaceutically acceptable carrier.

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