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21. 发明申请

WO2007133722A2 ALLOGRAFT BONE COMPOSITION HAVING A GELATIN BINDER 审中-公开
标题翻译：具有凝胶粘合剂的骨骼组成物（ALLOGRAFT BONE COMPOSITION WITH GELATIN BINDER）
公开(公告)号：WO2007133722A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011491
申请日：2007-05-14
申请人： MUSCULOSKELETAL TRANSPLANT FOUNDATION , SUNWOO, Moon, Hae , GERTZMAN, Arthur, A. , MERBOTH, Barbara, L.
发明人： SUNWOO, Moon, Hae , GERTZMAN, Arthur, A. , MERBOTH, Barbara, L.
IPC分类号： B01D53/14
CPC分类号： A61K6/08 , A61F2/28 , A61F2002/30059 , A61F2002/30153 , A61F2230/0019 , A61L27/222 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L2300/406 , A61L2300/414 , A61L2430/02
摘要： The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition crosslinks the gelatin to form a solid structure and when rehydrated is flexible.
摘要翻译：本发明涉及一种用于骨缺损部位的骨植入物，以在该部位促进新骨生长，其包含与磷酸盐缓冲明胶水混合的脱矿质同种异体移植骨材料的新骨生长诱导组合物，当将其冻干以从组合物将明胶交联以形成固体结构，并且当再水合是柔性时。

22. 发明申请

WO2006113586A3 VERTEBRAL DISC REPAIR 审中-公开
公开(公告)号：WO2006113586A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/014342
申请日：2006-04-17
申请人： MUSCULOSKELETAL TRANSPLANT FOUNDATION , GERTZMAN, Arthur, A. , MERBOTH, Barbara, L. , SCHULER, Michael, J. , STEINER, Anton, J. , SEMLER, Eric, J. , YANNARIELLO-BROWN, Judith, L.
发明人： GERTZMAN, Arthur, A. , MERBOTH, Barbara, L. , SCHULER, Michael, J. , STEINER, Anton, J. , SEMLER, Eric, J. , YANNARIELLO-BROWN, Judith, L.
IPC分类号： A61F2/44
摘要： A sterile implant for treatment of a spinal disc defect comprising an allograft cortical bone demineralized to a Type I collagen having a specific shape which is treated to eliminate osteoinductivity. The implant is lyophilized and compressed into smaller first shape which 20 to 80% from its original shape in at least one dimension and hardened. The implant expanding when hydrated into a second shape having the shape memory of the first shape and expanded in dimensional size from the first compressed shape.

23. 发明申请

WO2006042311A2 CARTILAGE IMPLANT PLUG WITH FIBRIN GLUE AND METHOD FOR IMPLANTATION 审中-公开
标题翻译：软骨植入栓塞纤维蛋白胶和植入方法
公开(公告)号：WO2006042311A2
公开(公告)日：2006-04-20
申请号：PCT/US2005036878
申请日：2005-10-12
申请人： MUSCULOSKELETAL TRANSPLANT , MASSACHUSETTS INST TECHNOLOGY , VUNJAK-NOVAKOVIC GORDANA , TRUNCALE KATHERINE ANN GOMES , SUNWOO MOON HAE , GERTZMAN ARTHUR A
发明人： VUNJAK-NOVAKOVIC GORDANA , TRUNCALE KATHERINE ANN GOMES , SUNWOO MOON HAE , GERTZMAN ARTHUR A
IPC分类号： A61K35/32 , A61B17/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/38 , A61L27/36 , A61L27/38 , A61L27/48 , A61L27/54 , A61L27/56
CPC分类号： A61K35/32 , A61B17/00491 , A61F2/30744 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/2867 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30759 , A61F2210/0004 , A61F2230/0069 , A61F2310/00365 , A61F2310/00383 , A61K38/00 , A61K38/363 , A61K38/4833 , A61L24/0005 , A61L24/0015 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3687 , A61L27/38 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/43 , A61L2300/64 , A61L2430/06 , A61K2300/00
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore and is positioned from the side wall of the bone a distance ranging from 10 microns to 1000 microns and is surrounded by milled cartilage and a fibrin thrombin glue. A method for inserting the assembly into a cartilage defect area is disclosed.
摘要翻译：本发明涉及一种软骨修复组件，其包括软骨下骨的成形结构和整体覆盖的软骨帽，该软骨帽被处理以去除生物可吸收载体中的细胞碎片和蛋白多糖以及碾磨的软骨。该成形结构的尺寸适合于软骨缺损区域中的钻孔，使得当定心在镗孔中时，所述成形骨和软骨帽不接合孔的侧壁并且与骨的侧壁相距一定距离范围从10微米到1000微米，被磨碎的软骨和纤维蛋白凝血酶胶包围。公开了用于将组件插入软骨缺陷区域的方法。

24. 发明申请

WO2004103224A1 CARTILAGE ALLOGRAFT PLUG 审中-公开
标题翻译：卡通铝合金插头
公开(公告)号：WO2004103224A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/010957
申请日：2004-04-21
申请人： MUSCULOSKELETAL TRANSPLANT FOUNDATION , GOMES, Katherine, A. , SUNWOO, Moon Hae , GERTZMAN, Arthur, A. , TOMFORD, William, W.
发明人： GOMES, Katherine, A. , SUNWOO, Moon Hae , GERTZMAN, Arthur, A. , TOMFORD, William, W.
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30062 , A61F2002/30136 , A61F2002/30224 , A61F2002/30233 , A61F2002/3024 , A61F2002/30299 , A61F2002/30327 , A61F2002/30764 , A61F2002/30785 , A61F2210/0004 , A61F2230/0004 , A61F2230/0069 , A61F2230/0093 , A61F2250/0014 , A61F2250/0039 , A61F2310/00365 , A61F2310/00383 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3817 , A61L27/3821 , A61L27/3852 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone (20) with an integral overlying cartilage cap (24) which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap (24) engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
摘要翻译：本发明涉及一种软骨修复组件，其包括具有整体上覆软骨帽（24）的软骨下骨（20）的成形同种异体移植物结构，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和碾磨的同种异体移植软骨。该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得成形骨或软骨盖（24）以过盈配合接合钻孔的侧壁并与铣削的软骨接触，并且生物相容的载体混合物，允许细胞转移到整个缺陷区域。还公开了将成形的同种异体移植结构插入软骨缺损区域的方法。

25. 发明申请

WO2004017731A1 ALLOGRAFT TISSUE PURIFICATION PROCESS FOR CLEANING BONE 审中-公开
标题翻译：用于清洁骨的ALLOGRAFT组织净化过程
公开(公告)号：WO2004017731A1
公开(公告)日：2004-03-04
申请号：PCT/US2003/023272
申请日：2003-08-18
申请人： MUSCULOSKELETAL TRANSPLANT FOUNDATION , DEPAULA, Carl, Alexander , MAHONY, Devin, Joshua , SUNWOO, Moon, Hae , Gertzman, Arthur, A.
发明人： DEPAULA, Carl, Alexander , MAHONY, Devin, Joshua , SUNWOO, Moon, Hae , Gertzman, Arthur, A.
IPC分类号： A01N1/00
CPC分类号： A61L27/365 , A61F2/4644 , A61F2002/2835 , A61F2002/4646 , A61L2/0011 , A61L2/0088 , A61L27/3608 , A61L27/3683 , A61L2430/02
摘要： A method for producing a cleaned bone graft with osteoinductivity above 2.0 suitable for transplantation into a human. The first step is sonicating a bone graft in a nonionic detergent in an ultrasonic cleaner at a temperature ranging from about 33°- C to about 37°- C and for a time period ranging from 15 minutes to 2 hours effective to produce a cleaned bone graft essentially free from bone marrow. The bone graft is sonïcated in purified water in an ultrasonic cleaner at a temperature ranging from about 33-Q C to about 37' C a plurality of times to remove the detergent producing a cleaned bone graft. The bone graft is then sonicated in hydrogen peroxide in an ultrasonic cleaner at a temperature ranging from about 33°- C to about 37°- C for a time period ranging from 10 minutes to about 2 hours effective to retain osteoinductivity of the bone graft and again sonicated in purified water in an ultrasonic cleaner at a temperature ranging from about 33°- C to about 3711 C a plurality of times to produce a cleaned bone graft. The final step is sonicating the bone graft in an alcohol at a temperature ranging from 33°- C to 37°- C for 30 minutes to 2 hours, all of the steps being effective to reduce any initially present viruses at least two logs and bacteria at least ten logs and the bone graft is finally sonicated in purified water to remove the alcohol.
摘要翻译：一种生物活性高于2.0的清洁骨移植物的方法，适用于移植到人体中。第一步是将超声波清洗机中的非离子洗涤剂中的骨移植物在约33℃至约37℃的温度范围内超声波处理15分钟至2小时的时间段，以有效地产生清洁的骨骼移植物基本上不含骨髓。将骨移植物在超声波清洗机中的纯净水中在约33℃至约37℃的温度范围内多次洗脱，以除去产生清洁的骨移植物的洗涤剂。然后将骨移植物在超声清洁器中在约33℃至约37℃的温度范围内在过氧化氢中超声处理持续10分钟至约2小时的时间段，从而有效地保持骨移植物的骨诱导能力，再次在超声波清洗机中，在约33℃至约3711℃的温度范围内，在净化水中超声处理多次以产生清洁的骨移植物。最后一步是在33℃至37℃的温度范围内将骨移植物在醇中超声处理30分钟至2小时，所有步骤都有效地减少任何初始存在的病毒至少两个原木和细菌将至少十个原木和骨移植物最终在纯化水中超声处理以除去醇。

26. 发明申请

WO2011031642A3 TISSUE ENGINEERED MENISCUS REPAIR COMPOSITION 审中-公开
标题翻译：组织工程化的半月板修复组合物
公开(公告)号：WO2011031642A3
公开(公告)日：2011-03-17
申请号：PCT/US2010/047881
申请日：2010-09-03
申请人： MUSCULOSKELETAL TRANSPLANT FOUNDATION INC. , SEMLER, Eric, J. , GERTZMAN, Arthur, A. , HUANG, Yen-chen , YANNARIELLO-BROWN, Judith , TRUNCALE, Katherine, Gomes
发明人： SEMLER, Eric, J. , GERTZMAN, Arthur, A. , HUANG, Yen-chen , YANNARIELLO-BROWN, Judith , TRUNCALE, Katherine, Gomes
IPC分类号： A61L27/22 , A61L27/36 , A61L27/38 , A61L27/48 , A61F2/38 , A61K35/32
摘要： A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 μm to about 500 μm; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.
摘要翻译：提供了用于半月板损伤以促进半月板损伤部位新组织生长的半月板修复组合物。该组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物半月板颗粒; 和包含固体纤维蛋白网基质的载体。当被引入到半月板中的缺陷部位时，组合物不粘附到缺陷部位。修复半月板损伤的方法包括将半月板修复组合物给予损伤部位。

27. 发明申请

WO2011031642A2 TISSUE ENGINEERED MENISCUS REPAIR COMPOSITION 审中-公开
标题翻译：组织工程人工修复组合物
公开(公告)号：WO2011031642A2
公开(公告)日：2011-03-17
申请号：PCT/US2010047881
申请日：2010-09-03
申请人： MUSCULOSKELETAL TRANSPLANT , SEMLER ERIC J , GERTZMAN ARTHUR A , HUANG YEN-CHEN , YANNARIELLO-BROWN JUDITH , TRUNCALE KATHERINE GOMES
发明人： SEMLER ERIC J , GERTZMAN ARTHUR A , HUANG YEN-CHEN , YANNARIELLO-BROWN JUDITH , TRUNCALE KATHERINE GOMES
IPC分类号： A61L27/22
CPC分类号： A61L27/3616 , A61F2/30756 , A61F2/3872 , A61F2002/30762 , A61K35/32 , A61K38/1841 , A61L27/225 , A61L27/3612 , A61L27/3654 , A61L27/38 , A61L27/3817 , A61L27/48 , A61L2430/06 , A61K2300/00
摘要： A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 µm to about 500 µm; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.
摘要翻译：提供一种用于应用于半月板损伤以促进半月板损伤部位新组织生长的半月板修复组合物。组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物弯月面颗粒; 和包含固体纤维蛋白网状基质的载体。当引入弯液面中的缺陷部位时，组合物不粘附于缺陷部位。修复半月板损伤的方法包括向损伤部位施用半月板修复组合物。

28. 发明申请

WO2009105760A3 BIOLOGIC MATRICES COMPRISING ANTI-INFECTIVE, METHODS AND COMPOSITIONS RELATED THERETO 审中-公开
标题翻译：包含抗感染药物的方法和组合物的生物学基础
公开(公告)号：WO2009105760A3
公开(公告)日：2010-06-24
申请号：PCT/US2009034891
申请日：2009-02-23
申请人： MUSCULOSKELETAL TRANSPLANT , DEPAULA CARL ALEXANDER , GERTZMAN ARTHUR A , SUNWOO MOONHAE
发明人： DEPAULA CARL ALEXANDER , GERTZMAN ARTHUR A , SUNWOO MOONHAE
IPC分类号： A61L27/36 , A61L27/54 , A61L31/00 , A61L31/16
CPC分类号： A61K9/70 , A61K31/085 , A61K31/155 , A61K31/191 , A61L27/3633 , A61L27/54 , A61L31/005 , A61L31/16 , A61L2300/202 , A61L2300/404
摘要： Described herein are methods and compositions related to biologic matrices comprising at least one anti-infective. In certain embodiments, the invention relates to a biologic matrix comprising a slowed release anti-infective agent. In a particular embodiment, the invention relates to an acellular dermal matrix comprising a slowed release anti-infective agent, wherein the anti-infective agent is triclosan. In further embodiments, the invention relates to a biologic matrix comprising at least one anti-infective agent, wherein the biologic matrix is suitable for use in surgical procedures, such as, for example, for the replacement of damaged or inadequate integumental tissue or for the repair, reinforcement or supplemental support of soft tissue defects.
摘要翻译：本文描述了与包含至少一种抗感染剂的生物学基质相关的方法和组合物。在某些实施方案中，本发明涉及包含缓释抗感染剂的生物学基质。在一个具体实施方案中，本发明涉及包含缓释抗感染剂的无细胞真皮基质，其中抗感染剂是三氯生。在另外的实施方案中，本发明涉及包含至少一种抗感染剂的生物学基质，其中所述生物学基质适合用于外科手术，例如用于替换损伤或不足的皮肤组织或用于修复，加强或补充支持软组织缺陷。

29. 发明申请

WO2009038676A3 COMPOSITION FOR FILLING BONE DEFECTS 审中-公开
标题翻译：用于填充骨缺损的组合物
公开(公告)号：WO2009038676A3
公开(公告)日：2010-03-25
申请号：PCT/US2008010699
申请日：2008-09-12
申请人： MUSCULOSKELETAL TRANSPLANT , SUNWOO MOON HAE , LIZANO VICTOR A , GERTZMAN ARTHUR A
发明人： SUNWOO MOON HAE , LIZANO VICTOR A , GERTZMAN ARTHUR A
IPC分类号： A61L27/36 , A61L27/44 , A61L27/50 , A61L27/54
CPC分类号： A61L27/446 , A61L27/3608 , A61L27/3804 , A61L27/3847 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/404 , A61L2300/406 , A61L2300/408 , A61L2300/414 , A61L2400/06 , A61L2430/02
摘要： The invention is directed toward an improved formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles ranging from about 100 to 850 microns. The bone particles are mixed in an excipient carrier combination containing carboxymethylcellulose, sodium hyaluronate, and a sodium phosphate saline buffer, the carboxymethylcellulose component of the carrier ranging from about 5.0 to about 11.0% of the composition and the sodium hyaluronate component of the carrier ranging from about 0.3 to about 0.7% of the composition, the composition having a pH between 6.5 -7.5.
摘要翻译：本发明涉及一种改进的可成形骨组合物，用于应用于骨缺损位点，以促进位点处的新骨生长，其包括约100至850微米范围的脱矿质冻干同种异体移植骨颗粒的新骨生长诱导化合物。骨颗粒在含有羧甲基纤维素，透明质酸钠和磷酸钠盐水缓冲液的赋形剂载体组合物中混合，载体的羧甲基纤维素组分范围为组合物的约5.0至约11.0％，载体的透明质酸钠组分范围为约0.3至约0.7％的组合物，该组合物的pH为6.5-7.5。

30. 发明申请

WO2009038676A2 COMPOSITION FOR FILLING BONE DEFECTS 审中-公开
标题翻译：用于填充骨缺损的组合物
公开(公告)号：WO2009038676A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/010699
申请日：2008-09-12
申请人： MUSCULOSKELETAL TRANSPLANT FOUNDATION , SUNWOO, Moon, Hae , LIZANO, Victor, A. , GERTZMAN, Arthur, A.
发明人： SUNWOO, Moon, Hae , LIZANO, Victor, A. , GERTZMAN, Arthur, A.
IPC分类号： A61L27/36 , A61L27/44 , A61L27/50 , A61L27/54
CPC分类号： A61L27/446 , A61L27/3608 , A61L27/3804 , A61L27/3847 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/404 , A61L2300/406 , A61L2300/408 , A61L2300/414 , A61L2400/06 , A61L2430/02
摘要： The invention is directed toward an improved formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles ranging from about 100 to 850 microns. The bone particles are mixed in an excipient carrier combination containing carboxymethylcellulose, sodium hyaluronate, and a sodium phosphate saline buffer, the carboxymethylcellulose component of the carrier ranging from about 5.0 to about 11.0% of the composition and the sodium hyaluronate component of the carrier ranging from about 0.3 to about 0.7% of the composition, the composition having a pH between 6.5 -7.5.
摘要翻译：本发明涉及一种改进的可成形骨组合物，用于应用于骨缺损位点，以促进位点处的新骨生长，其包括约100至850微米范围的脱矿质冻干同种异体移植骨颗粒的新骨生长诱导化合物。骨颗粒在含有羧甲基纤维素，透明质酸钠和磷酸钠盐水缓冲液的赋形剂载体组合物中混合，载体的羧甲基纤维素组分范围为组合物的约5.0至约11.0％，载体的透明质酸钠组分范围为约0.3至约0.7％的组合物，该组合物的pH为6.5-7.5。

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