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21. 发明申请

WO2014005643A1 NOVEL PRIME-BOOSTING REGIMENS INVOLVING IMMUNOGENIC POLYPEPTIDES ENCODED BY POLYNUCLEOTIDES 审中-公开
标题翻译：涉及由多核苷酸编码的免疫原性多肽的新型提升方案
公开(公告)号：WO2014005643A1
公开(公告)日：2014-01-09
申请号：PCT/EP2012/063196
申请日：2012-07-05
申请人： OKAIROS AG , NICOSIA, Alfredo , CORTESE, Riccardo , VITELLI, Alessandra
发明人： NICOSIA, Alfredo , CORTESE, Riccardo , VITELLI, Alessandra
IPC分类号： A61K39/155 , C12N15/861 , C12N15/863
CPC分类号： A61K39/155 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , C12N2710/10343 , C12N2710/24143 , C12N2760/18534
摘要： The present invention relates to administration regimens which are particularly suited for vaccine composition comprising polynucleotides which encode immunogenic polypeptides. Said administration regimens involve the repeated administration of a vaccine composition and enhance the immune response against the immunogenic polypeptide.
摘要翻译：本发明涉及特别适用于包含编码免疫原性多肽的多核苷酸的疫苗组合物的施用方案。所述施用方案涉及重复施用疫苗组合物并增强针对免疫原性多肽的免疫应答。

22. 发明申请

WO2011130627A3 CHIMPANZEE ADENOVIRAL VECTOR-BASED FILOVIRUS VACCINES 审中-公开
标题翻译： CHIMPANZEE腺病毒载体基于FILOVIRUS疫苗
公开(公告)号：WO2011130627A3
公开(公告)日：2011-12-08
申请号：PCT/US2011032682
申请日：2011-04-15
申请人： US GOV HEALTH & HUMAN SERV , OKAIROS AG , SULLIVAN NANCY J , NABEL GARY J , CLEMENT ASIEDU , CHENG CHENG , NICOSIA ALFREDO , CORTESE RICCARDO , AMMENDOLA VIRGINIA , COLLOCA STEFANO
发明人： SULLIVAN NANCY J , NABEL GARY J , CLEMENT ASIEDU , CHENG CHENG , NICOSIA ALFREDO , CORTESE RICCARDO , AMMENDOLA VIRGINIA , COLLOCA STEFANO
IPC分类号： A61K39/00 , A61K39/12 , A61K39/38 , C12N15/00
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2710/10343 , C12N2760/14134
摘要： This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).
摘要翻译：本发明提供了诱导免疫应答和防止丝状病毒感染的疫苗，用作人类预防性疫苗。具体而言，本发明提供表达来自埃博拉病毒（EBOV）或马尔堡病毒（MARV）的不同毒株的丝状病毒蛋白的黑猩猩腺病毒载体。

23. 发明申请

WO2010089129A1 INHIBITORS OF VIRAL FUSION AND USES THEREOF 审中-公开
标题翻译： VIVAL FUSION的抑制剂及其用途
公开(公告)号：WO2010089129A1
公开(公告)日：2010-08-12
申请号：PCT/EP2010/000723
申请日：2010-02-05
申请人： CORMUS SRL , CORTESE, Riccardo , PESSI, Antonello
发明人： CORTESE, Riccardo , PESSI, Antonello
IPC分类号： C07K14/08 , A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , A61K47/554 , C12N2760/16122 , C12N2760/16133 , C12N2760/18022 , C12N2760/18033 , C12N2760/18222 , C12N2760/18233 , C12N2760/18522 , C12N2760/18533 , C12N2760/18622 , C12N2760/18633
摘要： The present invention relates to novel inhibitors of viral entry into cells and their use for the prophylaxis and treatment of viral diseases.
摘要翻译：本发明涉及病毒进入细胞的新型抑制剂及其用于预防和治疗病毒性疾病的用途。

24. 发明申请

WO2009146902A1 A VACCINE FOR THE PREVENTION AND THERAPY OF HCV INFECTIONS 审中-公开
标题翻译：用于预防和治疗HCV感染的疫苗
公开(公告)号：WO2009146902A1
公开(公告)日：2009-12-10
申请号：PCT/EP2009/003970
申请日：2009-06-03
申请人： OKAIRÒS AG , CORTESE, Riccardo , NICOSIA, Alfredo
发明人： CORTESE, Riccardo , NICOSIA, Alfredo
IPC分类号： C07K14/18 , A61K39/29 , A61P31/14
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234
摘要： The present invention relates to CD81-binding peptides of the hepatitis virus C (HCV) E2 glycoprotein, which are devoid of or mutated within the amino-terminal 27 amino acids of the mature E2 envelope glycoprotein, or variant thereof which retains the ability to bind to CD81. Furthermore, the present invention provides polypeptides comprising said CD81-binding peptide, polynucleotides encoding the CD81-binding peptide, and expression cassettes and vectors comprising the polynucleotide of the invention. Moreover, the present invention relates to compositions comprising the CD81-binding peptide, the polynucleotide encoding the CD81-binding peptide, the expression cassette, or the vector, and an adjuvant. Furthermore, the present invention provides a pharmaceutical composition comprising the CD81-binding peptide, the polynucleotide, the expression cassette, the vector, or the composition of the invention, and a pharmaceutically acceptable excipient, carrier, or diluent. Moreover, the present invention provides the CD81-binding peptide, the polynucleotide, the expression cassette, the vector, the composition, or the pharmaceutical composition of the invention for induction of an immune response, preferably a broad specificity immune response, against HCV in a mammal, and methods for inducing a therapeutic and/or prophylactic immune response against HCV in a mammal, preferably against HCV of various genotypes.
摘要翻译：本发明涉及在成熟E2包膜糖蛋白的氨基末端27个氨基酸中缺失或突变的肝炎病毒C（HCV）E2糖蛋白的CD81结合肽或其变体，其保持结合能力到CD81。此外，本发明提供了包含所述CD81结合肽，编码CD81结合肽的多核苷酸和包含本发明的多核苷酸的表达盒和载体的多肽。此外，本发明涉及包含CD81结合肽，编码CD81结合肽，表达盒或载体的多核苷酸和佐剂的组合物。此外，本发明提供了包含本发明的CD81结合肽，多核苷酸，表达盒，载体或组合物以及药学上可接受的赋形剂，载体或稀释剂的药物组合物。此外，本发明提供本发明的CD81结合肽，多核苷酸，表达盒，载体，组合物或药物组合物，用于诱导针对HCV的免疫应答，优选广泛的特异性免疫应答哺乳动物和用于在哺乳动物中诱导针对HCV的治疗和/或预防性免疫应答的方法，优选地针对各种基因型的HCV。

25. 发明申请

WO2008122769A3 ADENOVIRAL VECTOR ENCODING MALARIA ANTIGEN 审中-公开
标题翻译：腺病毒编码疟原虫
公开(公告)号：WO2008122769A3
公开(公告)日：2009-01-22
申请号：PCT/GB2008001175
申请日：2008-04-10
申请人： ISIS INNOVATION , OKAIROS AG , REYES ARTURO , HILL ADRIAN , O'HARA GERALDINE , COLLOCA STEFANO , CORTESE RICCARDO
发明人： REYES ARTURO , HILL ADRIAN , O'HARA GERALDINE , COLLOCA STEFANO , CORTESE RICCARDO
IPC分类号： A61K39/015 , C07K14/445 , C12N15/861 , C12N15/863
CPC分类号： A61K39/015 , A01K2227/105 , A01K2267/0337 , A61K39/39 , A61K2039/5256 , A61K2039/545 , A61K2039/55561 , C07K14/445 , C07K14/78 , C07K16/205 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , Y10S435/975
摘要： The invention provides recombinant adenoviral vectors which are capable of eliciting immunity against the pre-erythrocytic stage of the life cycle of the malaria parasite. In particular, the invention provides a recombinant, replication deficient simian adenoviral vector which encodes an antigen comprising the thrombospondin-related adhesion protein (TRAP), and also immunogenic compositions (e.g. vaccines) comprising the vector and methods of using such compositions.
摘要翻译：本发明提供能够引发针对疟疾寄生虫生命周期的红细胞前期的免疫的重组腺病毒载体。特别地，本发明提供编码包含血小板反应素相关粘附蛋白（TRAP）的抗原的重组，复制缺陷型猿猴腺病毒载体，以及包含载体的免疫原性组合物（例如疫苗）和使用这些组合物的方法。

26. 发明申请

WO2008122769A2 ADENOVIRAL VECTOR ENCODING MALARIA ANTIGEN 审中-公开
标题翻译：腺病毒编码疟原虫
公开(公告)号：WO2008122769A2
公开(公告)日：2008-10-16
申请号：PCT/GB2008/001175
申请日：2008-04-10
申请人： ISIS INNOVATION LIMITED , OKAIROS AG , REYES, Arturo , HILL, Adrian , O'HARA, Geraldine , COLLOCA, Stefano , CORTESE, Riccardo
发明人： REYES, Arturo , HILL, Adrian , O'HARA, Geraldine , COLLOCA, Stefano , CORTESE, Riccardo
IPC分类号： A61K39/015 , C07K14/445 , C12N15/861 , C12N15/863
CPC分类号： A61K39/015 , A01K2227/105 , A01K2267/0337 , A61K39/39 , A61K2039/5256 , A61K2039/545 , A61K2039/55561 , C07K14/445 , C07K14/78 , C07K16/205 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , Y02A50/412 , Y10S435/975
摘要： The invention provides recombinant adenoviral vectors which are capable of eliciting immunity against the pre-erythrocytic stage of the life cycle of the malaria parasite. In particular, the invention provides a recombinant, replication deficient simian adenoviral vector which encodes an antigen comprising the thrombospondin-related adhesion protein (TRAP), and also immunogenic compositions ( e.g. vaccines) comprising the vector and methods of using such compositions.
摘要翻译：本发明提供能够引发针对疟疾寄生虫生命周期的红细胞前期的免疫的重组腺病毒载体。特别地，本发明提供编码包含血小板反应素相关粘附蛋白（TRAP）的抗原的重组，复制缺陷型猿猴腺病毒载体，以及包含载体的免疫原性组合物（例如疫苗）和使用该组合物的方法。

27. 发明申请

WO2006005465A1 ANTIGEN BINDING PROTEINS DIRECTED AGAINST SCAVENGER RECEPTOR B1 THAT INHIBIT HCV REPLICATION 审中-公开
标题翻译：针对禁用HCV复制的SCAVENGER受体B1指导的抗原结合蛋白
公开(公告)号：WO2006005465A1
公开(公告)日：2006-01-19
申请号：PCT/EP2005/007160
申请日：2005-07-01
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA , CORTESE, Riccardo , LUZZAGO, Alessandra , NICOSIA, Alfredo , VITELLI, Alessandra
发明人： CORTESE, Riccardo , LUZZAGO, Alessandra , NICOSIA, Alfredo , VITELLI, Alessandra
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4.
摘要翻译：本发明的特征在于抗原结合蛋白，其结合本文鉴定的SR-BI靶区域作为涉及HCV E2结合的区域。鉴定的靶区域是由SEQ ID NO：1,2,3或4的单链抗体结合的区域。

28. 发明申请

WO2003031588A3 HEPATITIS C VIRUS VACCINE 审中-公开
公开(公告)号：WO2003031588A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/032512
申请日：2002-10-10
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI, S.P.A. , EMINI, Emilio, A. , KASLOW, David, C. , BETT, Andrew, J. , SHIVER, John, W. , NICOSIA, Alfredo , LAHM, Armin , LUZZAGO, Alessandra , CORTESE, Riccardo , COLLOCA, Stefano
发明人： EMINI, Emilio, A. , KASLOW, David, C. , BETT, Andrew, J. , SHIVER, John, W. , NICOSIA, Alfredo , LAHM, Armin , LUZZAGO, Alessandra , CORTESE, Riccardo , COLLOCA, Stefano
IPC分类号： C12N15/40
摘要： The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.

29. 发明申请

WO1998022128A1 USE OF CNTF (CILIARY NEUROTROPHIC FACTOR) RECEPTOR ACTIVATORS FOR THE TREATMENT OF OBESITY 审中-公开
标题翻译： CNTF（CILIARY NEUROTROPHIC FACTOR）受体激活剂用于治疗肥胖症的使用
公开(公告)号：WO1998022128A1
公开(公告)日：1998-05-28
申请号：PCT/IT1997000283
申请日：1997-11-18
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , CILIBERTO, Gennaro , COSTA, Patrizia , PAONESSA, Giacomo , LAZZARO, Domenico , GLOAGUEN, Isabelle , DI MARCO, Annalise , DE MARTIS, Anna , LAUFER, Ralph , CORTESE, Riccardo
发明人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.
IPC分类号： A61K38/18
CPC分类号： A61K38/185 , A61K38/2264 , A61K48/00 , A61K2300/00
摘要： The present invention refers to the use of hCNTF (human ciliary neurotrophic factor), mutants thereof or other molecules that activate the CNTF receptor, for the preparation of drugs for the treatment of obesity and associated diseases, for example hyperglycemia. Figure 1 shows the anti-obesity effect of hCNTF and leptin on body weight (left panels) and on food intake (right panels) in genetically obese mice and in mice with diet-induced obesity (DIO).
摘要翻译：本发明涉及hCNTF（人纤维神经营养因子），其突变体或活化CNTF受体的其它分子用于制备用于治疗肥胖症和相关疾病例如高血糖症的药物。图1显示了在遗传肥胖小鼠和饮食诱导的肥胖（DIO）的小鼠中，hCNTF和瘦素对体重（左图）和食物摄取（右图）的抗肥胖作用。

30. 发明申请

WO9426886A3 PROCESS FOR THE PREPARATION OF IMMUNOGENS OR DIAGNOSTIC REAGENTS, AND IMMUNOGENS OR DIAGNOSTIC REAGENTS THEREBY OBTAINABLE 审中-公开
标题翻译：制备免疫原或诊断试剂的方法，以及可获得的免疫原或诊断试剂
公开(公告)号：WO9426886A3
公开(公告)日：1995-03-16
申请号：PCT/IT9400054
申请日：1994-05-05
申请人： ANGELETTI P IST RICHERCHE BIO , FELICI FRANCO , LUZZAGO ALESSANDRA , NICOSIA ALFREDO , MONACI PAOLO , CORTESE RICCARDO
发明人： FELICI FRANCO , LUZZAGO ALESSANDRA , NICOSIA ALFREDO , MONACI PAOLO , CORTESE RICCARDO
IPC分类号： G01N33/53 , A61K35/76 , A61K39/00 , C07K7/08 , C07K14/02 , C07K14/18 , C07K14/47 , C07K16/32 , C09K8/38 , C12N7/00 , C12N15/09 , C12N15/10 , C40B30/06 , C40B40/02 , G01N33/569 , G01N33/576 , A61K39/12 , C12N15/36 , C12N15/51 , C12N15/62 , G01N33/577
CPC分类号： C40B40/02 , A61K39/00 , C07K14/005 , C07K14/4713 , C07K16/32 , C07K2319/40 , C07K2319/735 , C12N15/1037 , C12N2730/10122 , C12N2770/24222 , Y10S436/811
摘要： A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist of the antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.
摘要翻译：一种制备模拟抗原或疾病特异性的致病生物的免疫原或诊断试剂的方法，其基本特征在于以下操作：鉴定与该疾病特异性的抗原或致病生物反应的至少一种抗体; 在使用遗传操作技术（例如，使用为本发明的目的而工程设计的质粒）的引入到编码噬菌体衣壳蛋白的基因的随机序列寡核苷酸插入物表达的衣壳寡肽的表面上显示的噬菌体文库的构建遗传图谱如图所示）; 选择在所述抗体识别的衣壳抗原寡肽的表面上显示的噬菌体; 任选使用选定的噬菌体和/或其片段和/或其衍生物用于制备用于特定病原体的诊断试剂盒，或一般用于该疾病，包括典型的所谓自身免疫性疾病的免疫学疾病，具有已知或未知的病因和/或发病机制; 任选使用所选择的噬菌体和/或其片段和/或其衍生物以诱导对化合物和/或天然或合成制剂的过敏和/或过敏现象的耐受性; 通过所选择的噬菌体和/或其片段和/或其衍生物任选地免疫生物体; 并且可选地验证在免疫生物体的血清中存在识别上述对该疾病特异性的抗原或生物体的抗体。

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