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1. 发明申请

WO2011130627A3 CHIMPANZEE ADENOVIRAL VECTOR-BASED FILOVIRUS VACCINES 审中-公开
标题翻译： CHIMPANZEE腺病毒载体基于FILOVIRUS疫苗
公开(公告)号：WO2011130627A3
公开(公告)日：2011-12-08
申请号：PCT/US2011032682
申请日：2011-04-15
申请人： US GOV HEALTH & HUMAN SERV , OKAIROS AG , SULLIVAN NANCY J , NABEL GARY J , CLEMENT ASIEDU , CHENG CHENG , NICOSIA ALFREDO , CORTESE RICCARDO , AMMENDOLA VIRGINIA , COLLOCA STEFANO
发明人： SULLIVAN NANCY J , NABEL GARY J , CLEMENT ASIEDU , CHENG CHENG , NICOSIA ALFREDO , CORTESE RICCARDO , AMMENDOLA VIRGINIA , COLLOCA STEFANO
IPC分类号： A61K39/00 , A61K39/12 , A61K39/38 , C12N15/00
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2710/10343 , C12N2760/14134
摘要： This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).
摘要翻译：本发明提供了诱导免疫应答和防止丝状病毒感染的疫苗，用作人类预防性疫苗。具体而言，本发明提供表达来自埃博拉病毒（EBOV）或马尔堡病毒（MARV）的不同毒株的丝状病毒蛋白的黑猩猩腺病毒载体。

2. 发明申请

WO2010086189A3 SIMIAN ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF 审中-公开
标题翻译： SIMIAN ADENOVIRUS核酸和氨基酸序列，含有其的载体及其用途
公开(公告)号：WO2010086189A3
公开(公告)日：2010-09-23
申请号：PCT/EP2010000616
申请日：2010-02-02
申请人： OKAIROS AG SWITZERLAND , COLLOCA STEFANO , NICOSIA ALFREDO , CORTESE RICCARDO , AMMENDOLA VIRGINIA , AMBROSIO MARIA
发明人： COLLOCA STEFANO , NICOSIA ALFREDO , CORTESE RICCARDO , AMMENDOLA VIRGINIA , AMBROSIO MARIA
IPC分类号： C07K14/075 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/861
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/12 , A61K39/235 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10343 , C12N2710/16634 , C12N2740/16134 , C12N2770/24234
摘要： The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.
摘要翻译：本发明涉及具有改善血清阳性率的新型腺病毒株。一方面，本发明涉及腺病毒衣壳蛋白如六邻体，五邻体和纤维蛋白及其片段的分离多肽和编码该多肽的多核苷酸。还提供了包含根据本发明的分离的多核苷酸和包含根据本发明的分离的多核苷酸或多肽的腺病毒的载体和包含所述载体，腺病毒，多肽和/或多核苷酸的药物组合物。本发明还涉及分离的多核苷酸，分离的多肽，载体，腺病毒和/或药物组合物用于治疗或预防疾病的用途。

3. 发明申请

WO2008122769A3 ADENOVIRAL VECTOR ENCODING MALARIA ANTIGEN 审中-公开
标题翻译：腺病毒编码疟原虫
公开(公告)号：WO2008122769A3
公开(公告)日：2009-01-22
申请号：PCT/GB2008001175
申请日：2008-04-10
申请人： ISIS INNOVATION , OKAIROS AG , REYES ARTURO , HILL ADRIAN , O'HARA GERALDINE , COLLOCA STEFANO , CORTESE RICCARDO
发明人： REYES ARTURO , HILL ADRIAN , O'HARA GERALDINE , COLLOCA STEFANO , CORTESE RICCARDO
IPC分类号： A61K39/015 , C07K14/445 , C12N15/861 , C12N15/863
CPC分类号： A61K39/015 , A01K2227/105 , A01K2267/0337 , A61K39/39 , A61K2039/5256 , A61K2039/545 , A61K2039/55561 , C07K14/445 , C07K14/78 , C07K16/205 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , Y10S435/975
摘要： The invention provides recombinant adenoviral vectors which are capable of eliciting immunity against the pre-erythrocytic stage of the life cycle of the malaria parasite. In particular, the invention provides a recombinant, replication deficient simian adenoviral vector which encodes an antigen comprising the thrombospondin-related adhesion protein (TRAP), and also immunogenic compositions (e.g. vaccines) comprising the vector and methods of using such compositions.
摘要翻译：本发明提供能够引发针对疟疾寄生虫生命周期的红细胞前期的免疫的重组腺病毒载体。特别地，本发明提供编码包含血小板反应素相关粘附蛋白（TRAP）的抗原的重组，复制缺陷型猿猴腺病毒载体，以及包含载体的免疫原性组合物（例如疫苗）和使用这些组合物的方法。

4. 发明申请

WO2006133911A2 HEPATITIS C VIRUS NUCLEIC ACID VACCINE 审中-公开
公开(公告)号：WO2006133911A2
公开(公告)日：2006-12-21
申请号：PCT/EP2006005697
申请日：2006-06-13
申请人： ANGELETTI P IST RICHERCHE BIO , LAHM ARMIN , COLLOCA STEFANO , FOLGORI ANTONELLA , NICOSIA ALFREDO
发明人： LAHM ARMIN , COLLOCA STEFANO , FOLGORI ANTONELLA , NICOSIA ALFREDO
IPC分类号： C07K14/18 , A61K39/29 , C12N15/861
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C07K2319/00 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234
摘要： The present invention features nucleic acid constructs that can be used as a HCV nucleic acid vaccine, vaccine component, or in the production of a HCV vaccine. Described constructs include those: (1) encoding for a chimeric HCV polypeptide containing a NS3-4A region based on a first HCV strain and an NS3-NS4A-NS4B-NS5A or an NS3-NS4A-NS4B-NS5A-NS5B region based on a second strain; and (2) a chimpanzee based adenovector encoding an HCV polypeptide.
摘要翻译：本发明具有可用作HCV核酸疫苗，疫苗组分或HCV疫苗生产中的核酸构建体。描述的构建体包括：（1）基于第一个HCV毒株和NS3-NS4A-NS4B-NS5A或NS3-NS4A-NS4B-NS5A-NS5B区域编码含有NS3-4A区域的嵌合HCV多肽，基于第二应变和（2）编码HCV多肽的基于黑猩猩的腺苷酸。

5. 发明申请

WO2005071093A3 CHIMPANZEE ADENOVIRUS VACCINE CARRIERS 审中-公开
公开(公告)号：WO2005071093A3
公开(公告)日：2006-03-30
申请号：PCT/EP2005000558
申请日：2005-01-18
申请人： ANGELETTI P IST RICHERCHE BIO , CIRILLO AGOSTINO , COLLOCA STEFANO , ERCOLE BRUNO BRUNI , MEOLA ANNALISA , NICOSIA ALFREDO , SPORENO ELISABETTA
发明人： CIRILLO AGOSTINO , COLLOCA STEFANO , ERCOLE BRUNO BRUNI , MEOLA ANNALISA , NICOSIA ALFREDO , SPORENO ELISABETTA
IPC分类号： C07K14/075 , A61K38/00 , A61K39/00 , A61K45/06 , A61K48/00 , C07K14/16 , C07K14/18 , C07K14/705 , C12N7/02 , C12N7/04 , C12N15/86 , C12N15/861
CPC分类号： C12N15/86 , A61K38/00 , A61K45/06 , A61K2039/5256 , C07K14/005 , C07K14/70503 , C12N7/00 , C12N2710/10321 , C12N2710/10343 , C12N2710/10351 , C12N2710/10362 , C12N2740/16134 , C12N2770/24222 , C12N2770/24234 , C12N2810/60
摘要： The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.
摘要翻译：本发明提供了源自黑猩猩腺病毒的重组复制缺陷型腺病毒载体和用于在人E1表达细胞系中产生重组腺病毒的方法。本发明还提供了适用于递送和表达编码免疫原的转基因的组合物和方法，其中期望有增强的免疫应答。本发明还提供了产生适合用于人类的临床级矢量种群的方法。在一个具体实施方案中，本发明考虑使用包含在疫苗中编码肿瘤相关抗原的转基因和用于预防和治疗癌症的药物组合物的转基因。

6. 发明申请

WO0028060A2 CELLS FOR THE PRODUCTION OF HELPER DEPENDENT ADENOVIRAL VECTORS, METHOD FOR THE PREPARATION AND USE THEREOF 审中-公开
标题翻译：用于生产依赖性辅助载体的细胞，其制备和使用方法
公开(公告)号：WO0028060A2
公开(公告)日：2000-05-18
申请号：PCT/IT9900356
申请日：1999-11-08
申请人： ANGELETTI P IST RICHERCHE BIO , COLLOCA STEFANO
发明人： COLLOCA STEFANO
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , C07K14/075 , C12N5/10 , C12N15/86
CPC分类号： C12N7/00 , C07K14/005 , C12N2710/10322 , C12N2710/10352
摘要： The present invention relates to cells for the production of helper dependent adenoviral vectors, including at least the following genic units: a first genic unit comprising an adenovirus defective genome having the inverted terminal repeats in head-to-tail configuration, the encapsidation signal inactivated, and at least one of the non-structural regions inactivated; a second genic units comprising at least one inducible promoter and at least one of the regions inactivated in the first genic unit, said regions being under the control of said inducible promoter; whereby following the activation of the inducible promoter of the second genic unit and the infection of the cells with said helper dependent adenoviral vectors, the first genic unit and the second genic unit enable the production of said helper dependent defective adenoviral in said cells in absence of helper.
摘要翻译：本发明涉及用于产生辅助性依赖性腺病毒载体的细胞，其包括至少以下基因单元：第一基因单元，其包含具有头对尾构型中的反向末端重复序列的腺病毒缺陷基因组，所述壳化信号失活，并且至少一个非结构区域失活; 第二基因单元，其包含至少一个诱导型启动子和在第一基因单元中灭活的区域中的至少一个，所述区域在所述诱导型启动子的控制之下; 由此在第二基因单元的诱导型启动子的激活和所述辅助依赖性腺病毒载体的细胞感染之后，第一基因单元和第二基因单元使得能够在所述细胞中产生所述辅助依赖性缺陷型腺病毒，帮手。

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