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21. 发明申请

WO2006065918A2 METHODS OF PROVIDING BIOCHEMICAL ANALYSES 审中-公开
标题翻译：提供生物化学分析方法
公开(公告)号：WO2006065918A2
公开(公告)日：2006-06-22
申请号：PCT/US2005045269
申请日：2005-12-14
申请人： BIOPROCESSORS CORP , ZARUR ANDREY J , RODGERS SETH T
发明人： ZARUR ANDREY J , RODGERS SETH T
CPC分类号： C12M41/48 , B01J2219/00283 , B01J2219/00481 , B01J2219/00585 , B01J2219/00599 , B01J2219/00743 , C12M41/00 , C12P1/00
摘要： A method of providing information regarding a bioreaction is provided. Information obtained from operation of microbioreactors can be used to design and/or alter and/or operate large-scale bioreactors and large-scale bioreactions.
摘要翻译：提供了提供关于生物反应的信息的方法。从微生物反应器的操作获得的信息可用于设计和/或改变和/或操作大规模生物反应器和大规模生物反应。

22. 发明申请

WO2006044368A1 MICROREACTORS INCORPORATING INTERPENETRATING AND/OR SEMI-INTERPENETRATING POLYMERS 审中-公开
标题翻译：混合和/或半嵌段聚合物的微生物
公开(公告)号：WO2006044368A1
公开(公告)日：2006-04-27
申请号：PCT/US2005/036508
申请日：2005-10-12
申请人： BIOPROCESSORS CORP. , LEROUX, Denis, F. , MILLER, Scott, E.
发明人： LEROUX, Denis, F. , MILLER, Scott, E.
IPC分类号： B01J19/00 , B01L3/00
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00862 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00905 , B01J2219/00957 , B01J2219/00966 , B01J2219/00986 , B01L3/502707 , B01L3/502746 , B01L2200/028 , B01L2300/0654 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/10 , B01L2300/12 , B01L2400/046 , B01L2400/086
摘要： The present disclosure includes description of chemical, biological, and/or biochemical reactor chips and/or reaction systems such as a microreactor systems having interpenetrating and/or semi-interpenetrating polymer networks, as well as methods for constructing and using such systems. In some cases, the interpenetrating and/or semi-interpenetrating polymer networks may be used to determine analytes, for example, by the incorporation of a reaction entity to a interpenetrating and/or semi-interpenetrating polymer network able to interact with the analytes, which may be physically included within the network (for example, physically entagled), or chemically bonded to a polymer within the network (for example, cross-linked) in some cases. In certain embodiments, a chip and/or a reaction system may be constructed so as to promote cell growth within it. In some embodiments, the chip and/or reaction system may include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In certain embodiments, a chip and/or reaction system is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO 2 concentration, O 2 concentration, relative humidity, pH, etc., associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In certain embodiments, the disclosed devices can employ light-interacting components. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本公开内容包括化学，生物和/或生物化学反应堆芯片和/或反应系统的描述，例如具有互穿和/或半互穿聚合物网络的微反应器系统，以及用于构建和使用这种系统的方法。在一些情况下，互穿和/或半互穿聚合物网络可以用于确定分析物，例如通过将反应实体并入能够与分析物相互作用的互穿和/或半互穿聚合物网络，其中可能物理上包括在网络内（例如，物理上陷入困境），或者在某些情况下化学键合到网络内的聚合物（例如交联）。在某些实施方案中，可以构建芯片和/或反应系统以促进细胞内的细胞生长。在一些实施方案中，芯片和/或反应系统可以包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在某些实施方案中，芯片和/或反应系统能够检测，测量和/或控制环境因素，例如温度，压力，CO

23. 发明申请

WO2004016729A3 SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS 审中-公开
标题翻译：控制pH和其他反应器环境条件的系统和方法
公开(公告)号：WO2004016729A3
公开(公告)日：2005-06-30
申请号：PCT/US0325907
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
发明人： MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

24. 发明申请

WO2004069983A9 MICROREACTOR ARCHITECTURE AND METHODS 审中-公开
标题翻译：微波炉结构和方法
公开(公告)号：WO2004069983A9
公开(公告)日：2005-02-03
申请号：PCT/US0325943
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12M
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

25. 发明申请

WO2004112946A3 REACTOR WITH MEMORY COMPONENT 审中-公开
公开(公告)号：WO2004112946A3
公开(公告)日：2004-12-29
申请号：PCT/US2004/018637
申请日：2004-06-07
申请人： BIOPROCESSORS CORP. , ZARUR, Andrey, J. , MACGREGOR, Ian, K. , BASQUE, Todd, A. , RODGERS, Seth, T. , RUSSO, A., Peter , LEBLANC, Sean, J.
发明人： ZARUR, Andrey, J. , MACGREGOR, Ian, K. , BASQUE, Todd, A. , RODGERS, Seth, T. , RUSSO, A., Peter , LEBLANC, Sean, J.
IPC分类号： B01J19/00
摘要： The present invention provides techniques for conveniently and reliably storing and/or retrieving data associated with a chemical, biological, or biochemical chip, reactor, or reaction system. The data can pertain to the reactor; to chemical, biological, or biochemical species introduced into, taken from, or otherwise associated with the reactor; to conditions to which the reactor and/or some or all of its contents has been, is being, or will be exposed to, or the like. Various aspects of the present invention relate to memory and data storage components suitable for use in chips or other reaction systems. These components may include silicon integrated circuits, magnetic media, optical media, radio-frequency tags, smart cards, bar-codes and other kinds of data storage devices. The chip may contain a reaction site having a volume of less than about 2 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light activated in certain cases. Other facilitated reactions may include the production and/or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, and/or more than one reaction site.

26. 发明申请

WO2004069983A2 MICROREACTOR ARCHITECTURE AND METHODS 审中-公开
标题翻译：微波炉结构和方法
公开(公告)号：WO2004069983A2
公开(公告)日：2004-08-19
申请号：PCT/US0325943
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12M
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

27. 发明申请

WO2004016727B1 DETERMINATION AND/OR CONTROL OF REACTOR ENVIRONMENTAL CONDITIONS 审中-公开
标题翻译：确定和/或控制反应堆环境条件
公开(公告)号：WO2004016727B1
公开(公告)日：2004-07-08
申请号：PCT/US0325956
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
发明人： MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12Q1/00
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, 02 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生物化学反应器芯片和其他反应系统，例如微反应器系统，以及用于构建和使用此类装置的系统和方法。在一个方面，可以构建芯片或其他反应系统以促进其内的细胞生长。在某些实施方案中，本发明的木片或其他反应体系包括一个或多个反应位点。反应位点可以非常小，例如体积小于约1ml。在本发明的一个方面中，芯片能够检测，测量和/或控制与一个或多个反应位点相关的环境因素，例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。另一方面，本发明涉及具有湿度和/或气体控制的材料和系统，例如用于芯片。这样的材料可以具有高的透氧性和/或低的水蒸汽渗透性。再一方面，本发明总体上涉及适用于芯片和其他反应器系统的光交互部件。这些部件可以包括波导，光纤，光源，光电探测器，光学元件等。

28. 发明申请

WO03103813A2 MATERIALS AND REACTOR SYSTEMS HAVING HUMIDITY AND GAS CONTROL 审中-公开
标题翻译：具有湿度和气体控制的材料和反应器系统
公开(公告)号：WO03103813A2
公开(公告)日：2003-12-18
申请号：PCT/US0317816
申请日：2003-06-05
申请人： BIOPROCESSORS CORP
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD , ZARUR ANDREY J
IPC分类号： C12M1/04 , B01D69/02 , B01D69/10 , B01D69/12 , B01D71/26 , B01D71/28 , B01D71/32 , B01D71/70 , B01J19/00 , B01L3/00 , C12M3/06 , C12N5/06 , C40B60/14 , C12M1/00
CPC分类号： C12M29/04 , B01D69/02 , B01D69/12 , B01J19/0093 , B01J2219/00317 , B01J2219/00743 , B01J2219/00783 , B01J2219/00833 , B01J2219/00907 , B01J2219/00957 , B01J2219/00981 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/10 , B01L2400/046 , C12M23/12 , C12M23/22 , C12M23/24 , C12M25/02 , C12M41/34 , C40B60/14
摘要： The present invention is directed to materials and reactor systems having humidity and/or gas control. The material may have high oxygen permeability and/or low water vapor permeability. In some cases, the material may have sufficient permeance and/or permeability to allow cell culture to occur in a chip or other reactor system using the material. In certain embodiments, the material may be positioned adjacent to or abut a reaction site within a chip or reactor; in other embodiments, the material may be positioned such that it is in fluidic communication with the reaction site. The material may also be porous and/or transparent in some cases. In one set of embodiments, the material include a polymer that is branched, and/or contains bulky side groups that allow the polymer to have a more open structure. In some cases, the material may include two or more layers. Each layer may have a desired property, which may include, for example, permeability, transparency, cytophilicity, biophilicity, hydrophilicity, or a structural feature. In some embodiments, the material may be chosen so as to promote cell growth within the chip or reactor.
摘要翻译：本发明涉及具有湿气和/或气体控制的材料和反应器系统。该材料可能具有高的透氧性和/或低水蒸气渗透性。在一些情况下，该材料可具有足够的渗透性和/或渗透性，以允许细胞培养在使用该材料的芯片或其它反应器系统中发生。在某些实施方案中，材料可以位于与芯片或反应器内的反应位置相邻或邻接的位置; 在其它实施方案中，材料可以被定位成使其与反应部位流体连通。在某些情况下，材料也可以是多孔的和/或透明的。在一组实施方案中，材料包括分支的聚合物和/或包含允许聚合物具有更开放结构的庞大的侧基。在一些情况下，材料可以包括两层或更多层。每个层可以具有期望的性质，其可以包括例如渗透性，透明度，细胞毒性，生物亲和力，亲水性或结构特征。在一些实施方案中，可以选择材料以促进芯片或反应器内的细胞生长。

29. 发明申请

WO2006138743A2 FLUID TRANSFER DEVICE 审中-公开
标题翻译：流体传输装置
公开(公告)号：WO2006138743A2
公开(公告)日：2006-12-28
申请号：PCT/US2006/024529
申请日：2006-06-23
申请人： BIOPROCESSORS CORP. , LEBLANC, Sean, J. , MACGREGOR, Ian, K. , AUMOND, Bernardo , VELLA, George, J. , RUSSO, A., Peter , RODGERS, Seth, T. , ZARUR, Andrey, J.
发明人： LEBLANC, Sean, J. , MACGREGOR, Ian, K. , AUMOND, Bernardo , VELLA, George, J. , RUSSO, A., Peter , RODGERS, Seth, T. , ZARUR, Andrey, J.
IPC分类号： B01L3/02
CPC分类号： B01L3/0275 , B01L2200/026 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0672 , B01L2300/0681
摘要： Fluid transfer devices described herein can include a body portion and a tip portion. A fluid pathway extends through the body and tip portions through which fluid may be transferred, for example, from a fluid-dispensing apparatus to a fluidic chamber of a microreactor. In some embodiments, the fluid transfer device is connected to the fluid-dispensing apparatus with an engaging element. The engaging element may be part of the body, and can enable the dispensing apparatus to repeatedly engage the body at one predetermined position. The body is capable of storing the fluid received from the dispensing apparatus. The tip portion may be formed of a rigid material (e.g., a metal), and/or may be configured to repeatedly pierce a septum without damaging either the tip or the body. Advantageously, in certain embodiments, the fluid transfer device can controllably transfer small volumes of fluid (e.g., 1 μL) with a high degree of accuracy.
摘要翻译：本文所述的流体输送装置可以包括主体部分和尖端部分。流体通道延伸穿过主体和尖端部分，流体可通过该尖端部分例如从流体分配装置传送到微反应器的流体室。在一些实施例中，流体输送装置用接合元件连接到流体分配装置。接合元件可以是主体的一部分，并且能够使得分配装置能够在一个预定位置反复地接合身体。身体能够储存从分配装置接收的流体。尖端部分可以由刚性材料（例如，金属）形成，和/或可以构造成反复刺穿隔膜而不损坏尖端或者身体。有利地，在某些实施方案中，流体转移装置可以高度准确地可控地传递小体积的流体（例如1μL）。

30. 发明申请

WO2005121310A3 CREATION OF SHEAR IN A REACTOR 审中-公开
公开(公告)号：WO2005121310A3
公开(公告)日：2005-12-22
申请号：PCT/US2005/020081
申请日：2005-06-07
申请人： BIOPROCESSORS CORP. , JOHNSON, Timothy, J. , AUMOND, Bernardo , BENOIT, Brian, O. , VELLA, George, J. , RODGERS, Seth, T. , ZARUR, Andrey, J.
发明人： JOHNSON, Timothy, J. , AUMOND, Bernardo , BENOIT, Brian, O. , VELLA, George, J. , RODGERS, Seth, T. , ZARUR, Andrey, J.
IPC分类号： B01F13/00
摘要： An apparatus for performing a biological or biochemical reaction that, in certain embodiments, has the ability to apply shear stress to a component of a liquid sample and includes a biological or biochemical reactor comprising a container having a volume of less than about 2 mL and containing a liquid sample, and a shear-generating element, the shear-generating element being contained within the apparatus and constructed and arranged so that the entire shear-generating element moves along a selected path of motion intersecting a first location within the apparatus and a second location within the apparatus, with or without rotational movement is described. A method of applying shear stress to a component of a liquid sample that includes moving a liquid or gaseous shear-generating element within an apparatus along a selected path of motion to create a reproducible and controllable level of shear stress at a selected location within the liquid sample is also disclosed.

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