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21. 发明申请

WO2014200651A1 TETRAPEPTIDES DERIVED FROM HUMAN C-X-C CHEMOKINES USEFUL FOR TREATMENT OF VARIOUS SKIN CONDITIONS 审中-公开
标题翻译：用于治疗各种皮肤病症的人C-X-C化合物衍生的抗体
公开(公告)号：WO2014200651A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/037978
申请日：2014-05-14
申请人： HELIX BIOMEDIX INC.
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K38/07 , C07K14/52
CPC分类号： A61K38/07 , A61K8/64 , A61K38/00 , A61K2800/74 , A61Q7/02 , A61Q19/02 , A61Q19/08 , C07K14/521
摘要： Tetrapeptides consisting of (I or V)-X1-K-X2, where X1 can be selected from E, Q or K, and X2 can be selected from M, F, I, W, or V, exhibit diverse bioactivities. They are multi-functional effector molecules to stimulate keratinocytes migration; neutralize the proinflammatory effect of bacterial cell wall components such as lipoteichoic acids of the Gram-positive S. aureus; and induce angiogenesis in cultured human umbilical vein endothelial cells. The downregulation of pro-inflammatory condition was also demonstrated using SOR-300-FT psoriasis skin model for representative peptide. The bioactivity was also supported by gene profiling study upon treatment of normal skin tissues using EPIDERM TM skin substitutes. The inventive peptides with diverse bioactivities are useful for treating various skin conditions including, but not limited to, acute or chronic wounds, striae distensae, aging skin, hair control, inflammatory skins such as psoriasis, atopic dermatitis and rosacea and for unwanted hair removal or for conditions such as removal of skin tags.
摘要翻译：由（I或V）-X1-K-X2组成的四肽，其中X1可以选自E，Q或K，X2可以选自M，F，I，W或V，表现出不同的生物活性。它们是多功能效应分子刺激角质细胞迁移; 中和细菌细胞壁组分如革兰氏阳性金黄色葡萄球菌的脂磷壁酸的促炎作用; 并在培养的人脐静脉内皮细胞中诱导血管生成。使用代表性肽的SOR-300-FT牛皮癣皮肤模型也证实了促炎症状的下调。使用EPIDERMTM皮肤替代品治疗正常皮肤组织时，生物活性也得到基因谱学研究的支持。具有不同生物活性的本发明的肽可用于治疗各种皮肤病症，包括但不限于急性或慢性伤口，纹状裂纹，老化皮肤，毛发控制，炎性皮肤如牛皮癣，特应性皮炎和酒渣鼻，以及不需要的毛发去除用于除去皮肤标签等条件。

22. 发明申请

WO2013142088A1 SHORT ANTIMICROBIAL LIPOPEPTIDES 审中-公开
标题翻译：短期抗精神病药
公开(公告)号：WO2013142088A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/029696
申请日：2013-03-07
申请人： HELIX BIOMEDIX INC
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K47/48 , C07K5/09 , A61K38/34
CPC分类号： C07K5/06086 , A61K38/05 , A61K38/06 , A61K38/34 , A61K47/542 , C07K5/0815 , Y02A50/473
摘要： Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri- peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri -peptides, lysine -proline- valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid— KXZ-NH 2 i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH 2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.
摘要翻译：公开了具有生物和治疗活性的肽。特别公开了表现出抗微生物活性的KPV或KdPT的脂化二或三肽类似物。特别地，本发明的肽相对于碱基三肽，赖氨酸 - 脯氨酸 - 缬氨酸和赖氨酸-d-脯氨酸 - 酪氨酸提供增强的抗微生物活性。所公开的肽具有通式C12-18脂质KXZ-NH2i，其中K是赖氨酸; X是脯氨酸，脯氨酸，组氨酸或精氨酸; Z是任选的，如果存在Z是缬氨酸，苏氨酸，丙氨酸或亮氨酸; 并且末端COOH是NH 2酰胺化的。 C12-18脂质优选为月桂酸（C12），肉豆蔻酸（C14），十五烷酸（C15），棕榈酸（C16）或硬脂酸（C18）的脂质部分。本发明还涉及使用这些肽来治疗影响皮肤和其它相关粘膜体表如口腔的各种侮辱，炎症或细菌感染的方法。

23. 发明申请

WO2007035323A1 HYBRID PORTABLE ORIGIN OF REPLICATION PLASMIDS 审中-公开
标题翻译：复制流体的混合原产地
公开(公告)号：WO2007035323A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/035433
申请日：2006-09-13
申请人： MONSANTO TECHNOLOGY LLC , BOGOSIAN, Gregg , O'NIEL, Julia, P. , SMITH, Hong, Q.
发明人： BOGOSIAN, Gregg , O'NIEL, Julia, P. , SMITH, Hong, Q.
IPC分类号： C12N15/69
CPC分类号： C12N15/69
摘要： The invention relates to modifying plasmid origins of replication to create hybrid origins of replication containing nucleotide sequences from more than one plasmid. The invention also relates to a modified origin of replication cassette that is portable or exchangeable due to the creation of multiple cloning sites flanking the origin of replication. Methods and plasmids for use in exchanging origins of replication are disclosed. Such modified or hybrid plasmids provide useful cloning tools that allow for regulation of the level of expression of a desired protein.
摘要翻译：本发明涉及修饰质粒复制起点以产生含有来自多于一种质粒的核苷酸序列的复制复制起点。本发明还涉及由于产生位于复制起点两侧的多个克隆位点而可移植或可交换的复制盒的修饰起点。公开了用于交换复制起点的方法和质粒。这样的修饰或杂交质粒提供了有用的克隆工具，其允许调节所需蛋白质的表达水平。

24. 发明申请

WO2006047125A2 METHOD FOR IMMOBILIZING MOLECULAR PROBES TO A SEMICONDUCTOR OXIDE SURFACE 审中-公开
标题翻译：用于将分子探针固定到氧化半导体表面的方法
公开(公告)号：WO2006047125A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/037294
申请日：2005-10-17
申请人： BURZYNSKI, Stanislaw, R. , JABS, Harry , WRIGHT, Dennis
发明人： JABS, Harry , WRIGHT, Dennis
IPC分类号： G01N33/543 , G01N33/552 , B01J20/32 , G01N27/414 , C12Q1/58 , C12Q1/68
CPC分类号： G01N33/54373 , B01J20/3219 , B01J20/3242 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , G01N33/54353 , G01N33/5438 , G01N33/552
摘要： A method immobilizing molecules on the surface of a semiconductor oxide substrate by forming stable bonds with hydrazine bound to the surface is disclosed. Also disclosed is a FET sensor for sensing target molecules in a solution. The FET is modified with molecular probes immobilized on the sensor surface via hydrazone bonds. The immobilized molecular probes are available to bind target molecules present in a solution and the FET will respond to the binding event.
摘要翻译：公开了一种通过与结合到表面的肼形成稳定的键而将分子固定在半导体氧化物衬底的表面上的方法。还公开了用于感测溶液中的目标分子的FET传感器。用通过腙键固定在传感器表面上的分子探针修饰FET。固定化分子探针可用于结合溶液中存在的靶分子，并且FET将响应结合事件。

25. 发明申请

WO2005017204A3 USE SINGLE NUCLEOTIDE POLYMORPHSM IN THE CODING REGION OF THE PORCINE LEPTIN RECEPTOR GENE TO ENHANCE PORK PRODUCTION 审中-公开
公开(公告)号：WO2005017204A3
公开(公告)日：2005-02-24
申请号：PCT/US2004/023050
申请日：2004-07-16
申请人： MONSANTO TECHNOLOGY LLC , KOJIMA, Cheryl J. , DU, Fengxing , GROSZ, Michael, D. , BYATT, John, C.
发明人： KOJIMA, Cheryl J. , DU, Fengxing , GROSZ, Michael, D. , BYATT, John, C.
IPC分类号： C12Q1/68
摘要： The instant invention is drawn to the identification and use of information regarding one or more porcine leptin receptor (pLEPR) gene polymorphisms as a marker to identify animals to serve as breeding stock for enhanced pork production. One particular polymorphism of pLEPR gene results in either a methionine or a threonine amino acid residue at position 69 of the protein that the pLEPR genes encodes. The pLEPR gene is located on porcine chromosone 6 and have been shown to be associated with determination of daily feed intake, among other factors.

26. 发明申请

WO2005017167A1 PROMOTER MOLECULES FOR USE IN PLANTS 审中-公开
标题翻译：在植物中使用促进分子
公开(公告)号：WO2005017167A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/024118
申请日：2004-07-27
申请人： MONSANTO TECHNOLOGY LLC , HECK, Gregory, R. , YOU, Jinsong , BAERSON, Scott, R.
发明人： HECK, Gregory, R. , YOU, Jinsong , BAERSON, Scott, R.
IPC分类号： C12N15/82
CPC分类号： C12N15/8223 , C12N15/823 , C12N15/8275
摘要： The present invention relates to polynucleotide molecules for regulating gene expression in plants. In particular, the invention relates to promoters isolated from rice ( Oryza sativa cv Nipponbare) that are useful for regulating gene expression of heterologous polynucleotide molecules in plants. The invention also relates to expression constructs and transgenic plants containing the heterologous polynucleotide molecules.
摘要翻译：本发明涉及用于调节植物中基因表达的多核苷酸分子。特别地，本发明涉及从水稻（Oryza sativa cv Nipponbare）中分离的启动子，其可用于调节植物中异源多核苷酸分子的基因表达。本发明还涉及含有异源多核苷酸分子的表达构建体和转基因植物。

27. 发明申请

WO2004074443A2 GLYPHOSATE RESISTANT CLASS I 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE (EPSPS) 审中-公开
标题翻译：耐肌酸蛋白I类5-烯丙基三磷酸酯-3磷酸酯合成酶（EPSPS）
公开(公告)号：WO2004074443A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/004636
申请日：2004-02-17
申请人： MONSANTO TECHNOLOGY LLC , ALIBHAI, Murtaza, F. , CAJACOB, Claire , FENG, Paul, C., C. , HECK, Gregory, R. , QI, Youlin , FLASINSKI, Stanislaw , STALLINGS, William, C.
发明人： ALIBHAI, Murtaza, F. , CAJACOB, Claire , FENG, Paul, C., C. , HECK, Gregory, R. , QI, Youlin , FLASINSKI, Stanislaw , STALLINGS, William, C.
IPC分类号： C12N
CPC分类号： C12N9/1092 , C12N15/8275
摘要： The compositions and methods disclosed herein provide novel DNA molecules that encode glyphosate resistant EPSPS proteins and plants containing these new proteins. The plants that express the new EPSPS proteins are themselves tolerant to the herbicidal effects of glyphosate.
摘要翻译：本文公开的组合物和方法提供编码抗草甘膦EPSPS蛋白质和含有这些新蛋白质的植物的新型DNA分子。表达新EPSPS蛋白质的植物本身对草甘膦的除草效果具有耐受性。

28. 发明申请

WO2004070020A2 GLYPHOSATE TOLERANT ALFALFA EVENTS AND METHODS FOR DETECTION THEREOF 审中-公开
标题翻译：抗甘油苜蓿事件及其检测方法
公开(公告)号：WO2004070020A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/000812
申请日：2004-01-14
申请人： MONSANTO TECHNOLOGY LLC , FORAGE GENETICS, INC. , BEAZLEY, Kim, A. , FERREIRA, Kenneth, L. , FITZPATRICK, Sharie, N. , MCCASLIN, Mark, H. , REYES, Carlos, C.
发明人： BEAZLEY, Kim, A. , FERREIRA, Kenneth, L. , FITZPATRICK, Sharie, N. , MCCASLIN, Mark, H. , REYES, Carlos, C.
IPC分类号： C12N
CPC分类号： C12Q1/6895 , A01H5/00 , A01H5/10 , C12N15/8275 , C12Q2600/13
摘要： The present invention provides for alfalfa events J-101 and J-163 and DNA molecules unique to these events. The invention also provides methods for detecting the presence of these DNA molecules in a plant sample.
摘要翻译：本发明提供了苜蓿事件J-101和J-163以及这些事件独有的DNA分子。本发明还提供了检测植物样品中这些DNA分子存在的方法。

29. 发明申请

WO2004009761A2 METHODS FOR USING ARTIFICIAL POLYNUCLEOTIDES AND COMPOSITIONS THEREOF TO REDUCE TRANSGENE SILENCING 审中-公开
标题翻译：使用人造多核苷酸及其组合物减少转基因沉默的方法
公开(公告)号：WO2004009761A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/021551
申请日：2003-07-10
申请人： MONSANTO TECHNOLOGY LLC , FLASINSKI, Stanislaw
发明人： FLASINSKI, Stanislaw
IPC分类号： C12N
CPC分类号： C12N15/8275 , C12N9/1029 , C12N9/1092 , C12N15/8218 , C12N15/8277
摘要： The materials and methods disclosed provide for polynucleotide molecules sufficiently divergent from polynucleotides naturally contained in plants, or polynucleotides previously introduced into plants as transgenes to permit trait stacking in plant breeding methods or plant transformation methods. The disclosure also provides for methods and compositions to detect the polynucleotides of the invention in plants.
摘要翻译：所公开的材料和方法提供了与植物中天然包含的多核苷酸或先前作为转基因引入植物以允许在植物育种方法或植物转化方法中性状堆积的多核苷酸充分不同的多核苷酸分子。本公开还提供了检测植物中本发明多核苷酸的方法和组合物。

30. 发明申请

WO2002100163A3 COTTON EVENT MONI5985 AND COMPOSITIONS AND METHODS FOR DETECTION 审中-公开
公开(公告)号：WO2002100163A3
公开(公告)日：2002-12-19
申请号：PCT/US2002/017853
申请日：2002-06-05
申请人： MONSANTO TECHNOLOGY LLC , HUBER, Scott, A. , ROBERTS, James, K. , SHAPPLEY, Zachary, W. , DOHERTY, Sean
发明人： HUBER, Scott, A. , ROBERTS, James, K. , SHAPPLEY, Zachary, W. , DOHERTY, Sean
IPC分类号： A01H1/04
摘要： The present invention provides cotton plants, cotton tissues, and cotton seeds that include the MON15985 event, which confers resistance to Lepidopteran insect damage. Also provided are assays for detecting the presence of the MON15985 event based on the DNA sequence of the recombinant construct inserted into the cotton genome that resulted in the MON15985 event and/or the genomic sequences flanking the insertion site.

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