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1. 发明申请

WO2018085565A2 SHORT BIOACTIVE PEPTIDES BLOCKING ACTIVITY OF ADVANCED GLYCATION END PRODUCTS, COMPOSITIONS, AND METHODS OF USE 审中-公开
标题翻译：短效生物活性肽阻断晚期糖基化终产物，组合物和使用方法的活性
公开(公告)号：WO2018085565A2
公开(公告)日：2018-05-11
申请号：PCT/US2017/059756
申请日：2017-11-02
申请人： HELIX BIOMEDIX, INC.
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K47/69 , A61K38/16
摘要： Advanced glycation end products (AGEs) represent a non-enzymatic post-translational protein modification. AGEs are very stable and the accumulation over time can be used as markers of carbonyl stress which are responsible for the malfunction of bioactive macromolecules in the body. Disclosed herein are a series of short peptides for blocking activity of advanced glycation end products (AGEs), the peptide being derived from a V-region of an sRAGE protein, wherein the V-region is given by SEQ ID NO:61. These peptides effectively inhibit the progress of a Maillard reaction, blocking the AGEs and inhibiting dicarbonyl induced cell apoptosis and death. The peptides can be used as, for example, an anti-glycation agent, a skin anti-aging agent, or an anti-diabetic complication agent.
摘要翻译：晚期糖基化终产物（AGEs）代表非酶促翻译后蛋白质修饰。 AGEs非常稳定，随着时间的推移累积可以用作羰基应激的标记，这是造成体内生物活性大分子故障的原因。本文公开了用于阻断晚期糖基化终产物（AGE）活性的一系列短肽，所述肽源自sRAGE蛋白的V区，其中V区由SEQ ID NO：61给出。这些肽有效抑制美拉德反应的进展，阻断AGEs并抑制二羰基诱导的细胞凋亡和死亡。这些肽可以用作例如抗糖化剂，皮肤抗衰老剂或抗糖尿病并发症剂。

2. 发明申请

WO2014126681A1 SHORT BIO-ACTIVE PEPTIDES FOR PROMOTING WOUND HEALING 审中-公开
标题翻译：短促生物活性肽促进创伤治疗
公开(公告)号：WO2014126681A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/012378
申请日：2014-01-21
申请人： HELIX BIOMEDIX INC.
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K38/16 , C07K14/435
CPC分类号： A61K38/1767 , A61K8/64 , A61K38/00 , A61K2800/74 , A61Q19/00 , A61Q19/08 , C07K5/1013 , C07K5/1021 , C07K7/06 , C07K14/43563 , C12Q1/6876 , G01N33/5014 , G01N33/5044
摘要： Peptides having four to six amino acid residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (MPKEKVFLKIEKMGRNIRN), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory and migratory properties. The inventive peptides comprise four to six contiguous amino acid residues located between position 11 and 16 of HB107 (MPKEKVFLKIEKMGRNIRN), namely EKMGRN. The disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.
摘要翻译：披露具有4-6个氨基酸残基的肽具有生物活性。这些肽构成肽HB-107（MPKEKVFLKIEKMGRNIRN）的短片段，其本身是抗微生物蛋白质天蚕素B的片段，并且具有细胞刺激和迁移性质。本发明的肽包含位于HB107（MPKEKVFLKIEKMGRNIRN）的位置11和16之间的四至六个连续的氨基酸残基，即EKMGRN。所公开的肽包括用于治疗皮肤损伤的有用试剂，例如来自糖尿病性溃疡。这些肽也有效地预防和逆转由各种环境污染引起的皮肤表面损伤。重要的是，肽的治疗效果以等于或大于肽HB-107的浓度表现，因此代表开发有效疗法的较便宜，更通用的手段。还公开了生产和使用这些肽的方法。

3. 发明申请

WO2018085565A3 SHORT BIOACTIVE PEPTIDES BLOCKING ACTIVITY OF ADVANCED GLYCATION END PRODUCTS, COMPOSITIONS, AND METHODS OF USE 审中-公开
公开(公告)号：WO2018085565A3
公开(公告)日：2018-05-11
申请号：PCT/US2017/059756
申请日：2017-11-02
申请人： HELIX BIOMEDIX, INC.
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K38/00 , A61K38/04 , A61K38/06
摘要： Advanced glycation end products (AGEs) represent a non-enzymatic post-translational protein modification. AGEs are very stable and the accumulation over time can be used as markers of carbonyl stress which are responsible for the malfunction of bioactive macromolecules in the body. Disclosed herein are a series of short peptides for blocking activity of advanced glycation end products (AGEs), the peptide being derived from a V-region of an sRAGE protein, wherein the V-region is given by SEQ ID NO:61. These peptides effectively inhibit the progress of a Maillard reaction, blocking the AGEs and inhibiting dicarbonyl induced cell apoptosis and death. The peptides can be used as, for example, an anti-glycation agent, a skin anti-aging agent, or an anti-diabetic complication agent.

4. 发明申请

WO2019108484A3 METHODS AND COMPOSITIONS FOR MODULATING MELANOGENESIS 审中-公开
公开(公告)号：WO2019108484A3
公开(公告)日：2019-06-06
申请号：PCT/US2018/062477
申请日：2018-11-26
申请人： HELIX BIOMEDIX, INC.
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K38/00 , A61K45/06 , A61Q19/00
摘要： Disclosed herein is a composition including a peptide consisting of the sequence of SEQ ID NO: 1 for increasing the production of melanin. The present disclosure provides methods and formulations for the treatment of pigmentation disorders or conditions. In some embodiments, provided herein are compositions and methods for sunless tanning. In other embodiments, the present disclosure is directed to such compositions that are formulated for use as pharmaceuticals and cosmetic products, and to medical devices comprising the disclosed compositions.

5. 发明申请

WO2019108484A2 METHODS AND COMPOSITIONS FOR MODULATING MELANOGENESIS 审中-公开
公开(公告)号：WO2019108484A2
公开(公告)日：2019-06-06
申请号：PCT/US2018/062477
申请日：2018-11-26
申请人： HELIX BIOMEDIX, INC.
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K38/08
摘要： Disclosed herein is a composition including a peptide consisting of the sequence of SEQ ID NO: 1 for increasing the production of melanin. The present disclosure provides methods and formulations for the treatment of pigmentation disorders or conditions. In some embodiments, provided herein are compositions and methods for sunless tanning. In other embodiments, the present disclosure is directed to such compositions that are formulated for use as pharmaceuticals and cosmetic products, and to medical devices comprising the disclosed compositions.

6. 发明申请

WO2014200651A1 TETRAPEPTIDES DERIVED FROM HUMAN C-X-C CHEMOKINES USEFUL FOR TREATMENT OF VARIOUS SKIN CONDITIONS 审中-公开
标题翻译：用于治疗各种皮肤病症的人C-X-C化合物衍生的抗体
公开(公告)号：WO2014200651A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/037978
申请日：2014-05-14
申请人： HELIX BIOMEDIX INC.
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K38/07 , C07K14/52
CPC分类号： A61K38/07 , A61K8/64 , A61K38/00 , A61K2800/74 , A61Q7/02 , A61Q19/02 , A61Q19/08 , C07K14/521
摘要： Tetrapeptides consisting of (I or V)-X1-K-X2, where X1 can be selected from E, Q or K, and X2 can be selected from M, F, I, W, or V, exhibit diverse bioactivities. They are multi-functional effector molecules to stimulate keratinocytes migration; neutralize the proinflammatory effect of bacterial cell wall components such as lipoteichoic acids of the Gram-positive S. aureus; and induce angiogenesis in cultured human umbilical vein endothelial cells. The downregulation of pro-inflammatory condition was also demonstrated using SOR-300-FT psoriasis skin model for representative peptide. The bioactivity was also supported by gene profiling study upon treatment of normal skin tissues using EPIDERM TM skin substitutes. The inventive peptides with diverse bioactivities are useful for treating various skin conditions including, but not limited to, acute or chronic wounds, striae distensae, aging skin, hair control, inflammatory skins such as psoriasis, atopic dermatitis and rosacea and for unwanted hair removal or for conditions such as removal of skin tags.
摘要翻译：由（I或V）-X1-K-X2组成的四肽，其中X1可以选自E，Q或K，X2可以选自M，F，I，W或V，表现出不同的生物活性。它们是多功能效应分子刺激角质细胞迁移; 中和细菌细胞壁组分如革兰氏阳性金黄色葡萄球菌的脂磷壁酸的促炎作用; 并在培养的人脐静脉内皮细胞中诱导血管生成。使用代表性肽的SOR-300-FT牛皮癣皮肤模型也证实了促炎症状的下调。使用EPIDERMTM皮肤替代品治疗正常皮肤组织时，生物活性也得到基因谱学研究的支持。具有不同生物活性的本发明的肽可用于治疗各种皮肤病症，包括但不限于急性或慢性伤口，纹状裂纹，老化皮肤，毛发控制，炎性皮肤如牛皮癣，特应性皮炎和酒渣鼻，以及不需要的毛发去除用于除去皮肤标签等条件。

7. 发明申请

WO2013142088A1 SHORT ANTIMICROBIAL LIPOPEPTIDES 审中-公开
标题翻译：短期抗精神病药
公开(公告)号：WO2013142088A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/029696
申请日：2013-03-07
申请人： HELIX BIOMEDIX INC
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K47/48 , C07K5/09 , A61K38/34
CPC分类号： C07K5/06086 , A61K38/05 , A61K38/06 , A61K38/34 , A61K47/542 , C07K5/0815 , Y02A50/473
摘要： Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri- peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri -peptides, lysine -proline- valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid— KXZ-NH 2 i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH 2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.
摘要翻译：公开了具有生物和治疗活性的肽。特别公开了表现出抗微生物活性的KPV或KdPT的脂化二或三肽类似物。特别地，本发明的肽相对于碱基三肽，赖氨酸 - 脯氨酸 - 缬氨酸和赖氨酸-d-脯氨酸 - 酪氨酸提供增强的抗微生物活性。所公开的肽具有通式C12-18脂质KXZ-NH2i，其中K是赖氨酸; X是脯氨酸，脯氨酸，组氨酸或精氨酸; Z是任选的，如果存在Z是缬氨酸，苏氨酸，丙氨酸或亮氨酸; 并且末端COOH是NH 2酰胺化的。 C12-18脂质优选为月桂酸（C12），肉豆蔻酸（C14），十五烷酸（C15），棕榈酸（C16）或硬脂酸（C18）的脂质部分。本发明还涉及使用这些肽来治疗影响皮肤和其它相关粘膜体表如口腔的各种侮辱，炎症或细菌感染的方法。

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