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11. 发明申请

WO2016128353A1 SYSTEM AND METHOD FOR DETERMINING A QUANTITY OF MAGNETIC PARTICLES 审中-公开
标题翻译：用于确定磁性颗粒数量的系统和方法
公开(公告)号：WO2016128353A1
公开(公告)日：2016-08-18
申请号：PCT/EP2016/052625
申请日：2016-02-08
申请人： PEPRIC NV
发明人： VERBIEST, Joeri
IPC分类号： G01N24/10 , G01R33/60 , G01R33/28
CPC分类号： G01N24/10 , G01R33/281 , G01R33/60
摘要： Quantification of a particular element comprised in magnetic particles enclosed in a volume is described. Applying a first time-varying magnetic field, B o (t) to said volume, having a first magnitude and a first frequency, f Bo and applying a second time varying magnetic field, B 1 (t), not parallel with the first magnetic field B o (t) for causing precession of the magnetized particles is performed. The second magnetic field is an RF field having a second frequency, f B1 equal to the Larmor-frequency, f L of said particular element. Thereafter the resultant magnetization, M(t), originating from the volume and modulated by the time-varying field is measured, and at least one frequency component f B1 ±nf BO ,n=1,3,5,... of the resultant magnetization is determined. A power and/or voltage of the at least one frequency component is calculated and a quantity of the magnetic particles enclosed in the volume is determined based thereon.
摘要翻译：描述包含在体积中的磁性颗粒中的特定元素的定量。将具有第一幅度和第一频率的第一时变磁场Bo（t）施加到所述体积，并且施加与第一磁场B 1（t）不平行的第二时变磁场B1（t） t）用于引起磁化颗粒的进动。第二磁场是具有等于所述特定元件的拉莫尔频率fL的第二频率fB1的RF场。此后，测量由体积产生并由时变场调制的所得磁化强度M（t），并且所得磁化的至少一个频率分量fB1±nfBO，n = 1,3,5，... 决心，决意，决定。计算出至少一个频率分量的功率和/或电压，并且基于此确定包围在体积中的磁性颗粒的量。

12. 发明申请

WO2015015172A1 SENSITIVE DETECTOR 审中-公开
标题翻译：敏感探测器
公开(公告)号：WO2015015172A1
公开(公告)日：2015-02-05
申请号：PCT/GB2014/052289
申请日：2014-07-25
申请人： THE UNIVERSITY OF WARWICK
发明人： MORLEY, Gavin William , NEWTON, Mark Edward
IPC分类号： G01N24/08 , G01R33/60 , G01R33/62
CPC分类号： G01N24/08 , G01N24/087 , G01R33/60 , G01R33/62
摘要： Detectors and methods for detecting electromagnetic radiation and/or EPR/NMR are disclosed, which exploit the electron-spin-dependent fluorescence of a colour centre in a solid. In one example, a detector comprises a substrate arranged to receive an input radiation to be detected and comprising a colour centre of a type that exhibits electron-spin-dependent fluorescence, and a spin measurement section for probing the spin state of the colour centre using fluorescence, thereby detecting input radiation that is such as to change the spin state of the colour centre.
摘要翻译：公开了用于检测电磁辐射和/或EPR / NMR的检测器和方法，其利用固体中的颜色中心的电子自旋依赖性荧光。在一个示例中，检测器包括布置成接收待检测的输入辐射的基板，并且包括具有电子自旋依赖性荧光的类型的颜色中心，以及用于利用以下方式探测颜色中心的自旋状态的自旋测量部分荧光，从而检测输入辐射，以改变色心的旋转状态。

13. 发明申请

WO2014049093A1 METHODS AND SYSTEMS FOR DETERMINING A PARTICLE DISTRIBUTION BY MEANS OF ELECTRON PARAMAGNETIC RESONANCE DATA 审中-公开
标题翻译：通过电子参考共振数据确定粒子分布的方法和系统
公开(公告)号：WO2014049093A1
公开(公告)日：2014-04-03
申请号：PCT/EP2013/070136
申请日：2013-09-26
申请人： PEPRIC NV
发明人： CREVECOEUR, Guillaume , COENE, Annelies , DUPRÉ, Luc , VAES, Peter
IPC分类号： G01N24/10 , G01R33/60
CPC分类号： G01R33/60 , G01N24/10 , G01R33/385
摘要： Methods and systems for determining a particle distribution A system (100) for determining a reconstruction of a particle distribution in an object based on electron paramagnetic resonance (EPR) measurement data of the object comprising the distribution of particles is described. The system (100) comprises a data obtaining means (110) for obtaining electron paramagnetic resonance measurement data of the object under study. The system also comprises a processor (120) for processing the obtained data by applying a numerical model for solving a numerical inverse problem of deriving from the electron paramagnetic resonance measurement data a reconstruction of the particle distribution. The system furthermore comprises an output means (130) for outputting data based on the derived reconstruction of the particle distribution.
摘要翻译：用于确定粒子分布的方法和系统描述用于基于包括粒子分布的物体的电子顺磁共振（EPR）测量数据确定物体中的粒子分布的重建的系统（100）。系统（100）包括用于获得被研究对象的电子顺磁共振测量数据的数据获取装置（110）。该系统还包括处理器（120），用于通过应用数值模型来处理所获得的数据，所述数值模型用于求解从电子顺磁共振测量数据导出粒子分布重建的数值反问题。该系统还包括输出装置（130），用于基于所导出的粒子分布的重建来输出数据。

14. 发明申请

WO2012149473A3 COMPOSITIONS AND METHODS TO ASSESS THE CAPACITY OF HDL TO SUPPORT REVERSE CHOLESTEROL TRANSPORT 审中-公开
标题翻译：评估HDL支持反向胆固醇运输能力的组合物和方法
公开(公告)号：WO2012149473A3
公开(公告)日：2012-12-27
申请号：PCT/US2012035663
申请日：2012-04-27
申请人： CHILDRENS HOSP & RES CT OAK , ODA MICHAEL N
发明人： ODA MICHAEL N
IPC分类号： G01N24/12 , G01N24/10 , G01R33/24 , G01R33/60 , G01R33/62
CPC分类号： G01N33/92 , G01N24/10 , G01N2333/775 , G01N2800/324 , G01N2800/50 , G01N2800/52 , G01R33/60
摘要： The invention provides compositions and methods for assessing the capacity of high density lipoprotein (HDL) to support reverse cholesterol transport in blood by measuring exchange if HDL- specific spin-labeled lipoprotein probes and electron paramagnetic spectroscopy. The invention also provides methods to identify individuals at risk for cardiovascular disease, to monitor the treatment of cardiovascular disease and in the development of therapies to treat cardiovascular disease. The invention also provides methods to identify individuals at risk for Alzheimer's disease, to monitor the treatment of Alzheimer's disease and in the development of therapies to treat Alzheimer's disease.
摘要翻译：本发明提供用于评估高密度脂蛋白（HDL）通过如果HDL特异性自旋标记的脂蛋白探针和电子顺磁光谱法测量交换来支持血液中的反向胆固醇转运的能力的组合物和方法。本发明还提供了鉴定患有心血管疾病风险的个体，监测心血管疾病的治疗和治疗心血管疾病的疗法的方法。本发明还提供了鉴定处于阿尔茨海默病风险的个体，监测阿尔茨海默氏病的治疗和开发治疗阿尔茨海默氏病的疗法的方法。

15. 发明申请

WO2012159896A1 DIAMOND SENSORS, DETECTORS, AND QUANTUM DEVICES 审中-公开
标题翻译：钻石传感器，探测器和量子设备
公开(公告)号：WO2012159896A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/058682
申请日：2012-05-10
申请人： ELEMENT SIX LIMITED , TWITCHEN, Daniel, James , MARKHAM, Matthew, Lee
发明人： TWITCHEN, Daniel, James , MARKHAM, Matthew, Lee
IPC分类号： G01N24/10 , G01R33/60 , C30B29/04 , H01L21/04 , G06N99/00 , B82Y10/00 , G01R33/24 , G01R33/30
CPC分类号： H01L29/1602 , B82Y10/00 , C30B29/04 , C30B29/64 , C30B31/22 , C30B33/08 , G01N24/10 , G01R33/24 , G01R33/302 , G01R33/60 , G06N99/002 , H01L21/0405 , H01L29/157 , H01L29/167
摘要： A thin plate of synthetic single crystal diamond material, the thin plate of synthetic single crystal diamond material having: a thickness in a range 100 nm to 50 μιη; a concentration of quantum spin defects greater than 0.1 ppb (parts-per-billion); a concentration of point defects other than the quantum spin defects of below 200 ppm (parts-per-million); and wherein at least one major face of the thin plate of synthetic single crystal diamond material comprises surface termination species which have zero nuclear spin and/or zero electron spin.
摘要翻译：合成单晶金刚石材料的薄板，合成单晶金刚石材料的薄板具有：厚度在100nm至50μΩ的范围内; 量子自旋缺陷的浓度大于0.1ppb（十亿分之一）; 量子自旋缺陷以外的点缺陷浓度低于200ppm（百万分之一）; 并且其中所述合成单晶金刚石材料薄板的至少一个主面包括具有零核自旋和/或零电子自旋的表面终止物质。

16. 发明申请

WO2012034924A1 A MICROFLUIDIC CELL AND A SPIN RESONANCE DEVICE FOR USE THEREWITH 审中-公开
标题翻译：一种微流控细胞和一种用于其的旋转共振装置
公开(公告)号：WO2012034924A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065573
申请日：2011-09-08
申请人： ELEMENT SIX LIMITED , TWITCHEN, Daniel James , MARKHAM, Matthew Lee
发明人： TWITCHEN, Daniel James , MARKHAM, Matthew Lee
IPC分类号： G01R33/30 , B01L9/00 , G01R33/465 , G01R33/60
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2300/0663 , G01R33/24 , G01R33/302 , G01R33/323 , G01R33/465 , G01R33/60
摘要： A microfluidic cell comprising: a microfluidic channel (32) for receiving a fluid sample; and a sensor (30) located adjacent the microfluidic channel; wherein the sensor comprises a diamond material comprising one or more quantum spin defects (34). In use, a fluid sample is loaded into the microfluidic cell and the fluid is analysed via magnetic resonance using the quantum spin defects.
摘要翻译：一种微流体细胞，包括：用于接收流体样品的微流体通道（32）和位于所述微流体通道附近的传感器（30）; 其中所述传感器包括包含一个或多个量子自旋缺陷（34）的金刚石材料。在使用中，将流体样品装载到微流体细胞中，并通过使用量子自旋缺陷的磁共振来分析流体。

17. 发明申请

WO2010037801A9 PULSED EPR DETECTION 审中-公开
公开(公告)号：WO2010037801A9
公开(公告)日：2010-04-08
申请号：PCT/EP2009/062723
申请日：2009-09-30
申请人： IMEC , VAES, Peter , TEUGHELS, Stephanie
发明人： VAES, Peter , TEUGHELS, Stephanie
IPC分类号： G01R33/60 , G01N24/10 , G01R33/28
摘要： A method and system for performing pulsed electron paramagnetic resonance is disclosed. The method comprises generating an excitation pulse train for applying to an object comprising probes and detecting from the probes an echo response induced by the excitation pulse train.

18. 发明申请

WO2010037801A1 PULSED EPR DETECTION 审中-公开
标题翻译：脉冲EPR检测
公开(公告)号：WO2010037801A1
公开(公告)日：2010-04-08
申请号：PCT/EP2009/062723
申请日：2009-09-30
申请人： IMEC , VAES, Peter , TEUGHELS, Stephanie
发明人： VAES, Peter , TEUGHELS, Stephanie
IPC分类号： G01R33/60 , G01N24/10 , G01R33/28
CPC分类号： G01N24/10 , G01R33/281 , G01R33/60
摘要： A method and system for performing pulsed electron paramagnetic resonance is disclosed. The method comprises generating an excitation pulse train for applying to an object comprising probes and detecting from the probes an echo response induced by the excitation pulse train.
摘要翻译：公开了一种用于执行脉冲电子顺磁共振的方法和系统。该方法包括产生用于施加到包括探针的物体的激发脉冲串，并且从探测器检测由激励脉冲序列引起的回波响应。

19. 发明申请

WO2009027645A3 IMPROVEMENTS IN THE PREPARATION OF A SAMPLE (E.G. INVOLVING DYNAMIC NUCLEAR POLARISATION) FOR ANALYSIS (E.G. BY NMR OR MRI) 审中-公开
标题翻译：制备用于分析的样品（E.G.涉及动态核偏振）的改进（通过NMR或MRI鉴定）
公开(公告)号：WO2009027645A3
公开(公告)日：2009-04-23
申请号：PCT/GB2008002855
申请日：2008-08-22
申请人： UNIVERSTIY OF NOTTINGHAM , UNIV ST ANDREWS , OXFORD INSTR MOLECULAR BIOTOOL , KOCKENBERGER WALTER FRIEDRICH , SMITH GRAHAM MURRAY , SLADE ROBERT ANDREW , TOWNSEND MARTIN CHARLES , STRANGE DANIEL ROBERT , STABLES GARY
发明人： KOCKENBERGER WALTER FRIEDRICH , SMITH GRAHAM MURRAY , SLADE ROBERT ANDREW , TOWNSEND MARTIN CHARLES , STRANGE DANIEL ROBERT , STABLES GARY
IPC分类号： G01R33/28 , G01R33/30 , G01R33/60 , G01R33/62
CPC分类号： G01R33/282 , G01R33/307 , G01R33/445 , G01R33/4808 , G01R33/60 , G01R33/62
摘要： A method of preparation of a sample for analysis (such as a sample for dynamic unclear polarisation with subsequent analysis by NMR or MRI) comprises providing a sample (10) in a solid state at a first location (12); moving the sample (10) in the solid state to a second location (18); converting the sample (10) to a liquid state at. the second location (18); and performing an analysis on the sample (10) after conversion to the liquid state. Also according to the invention, sample preparation apparatus comprises: a sample preparation station (12) operable to prepare a sample (10) in a solid state; a conversion station (18) operable to convert a prepared sample (10) to a liquid state; a transport mechanism (19) operable to transport a sample (10) in a solid state from the sample preparation station (12) to the conversion station (18); and an analysis station (22) operable to perform an analysis on a sample (10) after conversion to the liquid state by the conversion station (18).
摘要翻译：制备用于分析的样品的方法（例如用于动态不清楚的极化的样品，随后通过NMR或MRI分析）包括在第一位置（12）提供固态的样品（10）; 将固体样品（10）移动到第二位置（18）; 将样品（10）转换成液体状态。第二位置（18）; 并且在转换成液体状态之后对样品（10）进行分析。根据本发明，样品制备装置包括：样品制备站（12），其可操作以制备固态样品（10）; 转换站（18），其可操作以将制备的样品（10）转换成液态; 可操作以将固体样品（10）从样品制备站（12）输送到转化站（18）的输送机构（19）; 以及分析台（22），其可操作以在由所述转换站（18）转换为液体状态之后对样品（10）进行分析。

20. 发明申请

WO2005103659A3 METHOD FOR DETERMINING AN INTEGRAL SUN PROTECTION FACTOR ENCOMPASSING UVA AND UVB RADIATION 审中-公开
标题翻译：确定一体化防晒因子对UVA和UVB辐射的影响的方法
公开(公告)号：WO2005103659A3
公开(公告)日：2006-03-09
申请号：PCT/EP2005004148
申请日：2005-04-14
申请人： COTY BV , FERRERO LOUIS , ZASTROW LEONHARD , GOLZ-BERNER KARIN , GROTH NORBERT , HERRLING THOMAS
发明人： FERRERO LOUIS , ZASTROW LEONHARD , GOLZ-BERNER KARIN , GROTH NORBERT , HERRLING THOMAS
IPC分类号： G01R33/60
CPC分类号： G01R33/60
摘要： The invention relates to a method for determining an integral sun protection factor (ò SPF or iSPF) which encompasses both UVA and UVB radiation and can be used for classifying cosmetic and dermatological sunscreens. The method comprises the steps of applying a defined amount of the sunscreen onto a defined area of a skin substrate impregnated with a spin trap, exposing the skin substrate to a defined amount of UVA- and UVB rays by a sun simulator, subjecting the skin substrate exposed to radiation to an electron spin resonance (ESR) measurement, recording the number of free radicals trapped as a real number x 1012 free radicals / mg of skin sample, and determining the integral sun protection factor ò SPF according to the equations (1) and (2) and (8).
摘要翻译：本发明涉及一种用于确定包含UVA和UVB辐射两者的整体防晒系数（òSPF或iSPF）的方法，可用于对化妆品和皮肤病防晒剂进行分类。该方法包括以下步骤：将限定量的防晒剂施加到浸渍有自旋阱的皮肤基底的限定区域上，通过太阳模拟器将皮肤基底暴露于规定量的UVA和UVB射线，使皮肤基底暴露于辐射至电子自旋共振（ESR）测量，记录被捕获的自由基数量为实数x 1012自由基/ mg皮肤样品，并根据等式（1）确定积分防晒因子òSPF 和（2）和（8）。

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