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    • 11. 发明申请
    • PROCESSES FOR PRODUCING PHARMACEUTICAL EXCIPIENTS FROM LIGNOCELLULOSIC BIOMASS, AND PHARMACEUTICAL EXCIPIENTS OBTAINED THEREFROM
    • 从生物质生物质生产药物制剂的方法及其获得的药物制剂
    • WO2016109479A1
    • 2016-07-07
    • PCT/US2015/067780
    • 2015-12-29
    • API INTELLECTUAL PROPERTY HOLDINGS, LLC
    • NELSON, KimberlyRETSINA, TheodoraPYLKKANEN, Vesa
    • A61K9/20C08B15/08A61K47/38
    • A61K47/38C08B37/0057C08H6/00C08H8/00
    • In some variations, the invention provides a process for producing a microcrystalline cellulose material, comprising: fractionating lignocellulosic biomass feedstock in the presence of an acid, a solvent for lignin, and water, to generate cellulose-rich solids and a liquid containing hemicellulose and lignin; chemically and/or mechanically treating the cellulose-rich solids to form microcrystalline cellulose having an average crystallinity of at least 60%; and recovering the microcrystalline cellulose as a pharmaceutical excipient. The pharmaceutical excipient may function as an antiadherent, a binder, a coating, or a disintegrant. In some embodiments, the pharmaceutical excipient further comprises a lignin-derived lubricant, glidant, sorbent, preservative, or other component. The pharmaceutical excipient may be present in a pill, tablet, capsule, powder, slurry, or other pharmaceutically effective and acceptable form.
    • 在一些变型中,本发明提供了一种用于生产微晶纤维素材料的方法,包括:在酸,木质素和水的溶剂存在下分解木质纤维素生物质原料,以产生富含纤维素的固体和含有半纤维素和木质素的液体 ; 化学和/或机械处理富含纤维素的固体以形成平均结晶度至少为60%的微晶纤维素; 并回收作为药物赋形剂的微晶纤维素。 药物赋形剂可用作抗粘附剂,粘合剂,包衣或崩解剂。 在一些实施方案中,药物赋形剂还包含来自木质素的润滑剂,助流剂,吸附剂,防腐剂或其它组分。 药物赋形剂可以以丸剂,片剂,胶囊,粉末,浆液或其它药学上有效和可接受的形式存在。
    • 13. 发明申请
    • PROCESS FOR THE PRODUCTION OF A MICROFIBRILLATED CELLULOSE COMPOSITION
    • 生产微晶纤维素组合物的方法
    • WO2014202354A1
    • 2014-12-24
    • PCT/EP2014/060958
    • 2014-05-27
    • BASF SE
    • KRÖNER, HubertusACHATZ, PaulKLOKE, Philipp
    • D21H11/18D21H21/36D21H21/52C08B15/08
    • D21H11/18C08B15/08D21B1/066D21B1/08D21H21/36D21H21/52
    • The present invention relates to a process for the production of microfibrillated cellulose composition, wherein the microfibrillated cellulose has an average fiber length in the range from 500 to 1300 µm and a percentage of fiber length in the category≤200 µm of at least 15%, obtained by subjecting an aqueous mixture comprising 30 to 70 % by weight of cellulose containing fibers to mechanical shearing at a temperature in the range of from ≥40°C to ≤120°C in the presence of at least one thermostable biocide, to the microfibrillated cellulose composition obtained in this process and their use in a process for production of paper, card and board comprising draining a paper stock comprising the microfibrillated cellulose composition with sheet formation in the wire.
    • 微纤化纤维素组合物的制造方法技术领域本发明涉及一种微纤化纤维素组合物的制造方法,其中,微纤化纤维素的平均纤维长度为500〜1300μm,纤维长度在≤200μm以内的百分比为15%以上, 通过使含有30〜70重量%的含纤维素纤维的含水混合物在至少一种热稳定性杀生物剂存在下,在≥40℃至≤120℃的温度下进行机械剪切而获得的微纤化 在该方法中获得的纤维素组合物及其在生产纸张,纸板和纸板的方法中的用途,包括将包含微纤化纤维素组合物的纸料在纸丝中形成片材。
    • 20. 发明申请
    • METHOD FOR FORMING CELLULOSE
    • 形成纤维素的方法
    • WO02004524A1
    • 2002-01-17
    • PCT/JP2001/005996
    • 2001-07-11
    • C08B15/02C08B15/08C08B1/00
    • C08B15/08Y02P20/544Y10T428/249921
    • A method for forming II-type cellulose, which comprises introducing together a slurry having water and a I-type cellulose dispersed therein and water in the state of high temperature and high pressure to a tubular reactor (28), contacting the I-type cellulose with a hot water in a supercritical state or subcritical state for a predetermined time in the tubular reactor (28), to thereby decompose a part of the hydrogen bonds in the I-type cellulose and dissolve the I-type cellulose into the water in a supercritical state or subcritical state, cooling a cellulose solution discharged from the tubular reactor (28) in a cooler (30) to room temperature or lower, followed by allowing to stand, to thereby precipitate crystals of II-type cellulose having a molecular weight lower than that of the I-type cellulose, and separating the resultant II-type cellulose from a solvent. The method allows the preparation of pure II-type cellulose by the use of a simple process.
    • 一种形成II型纤维素的方法,其包括将具有水的I型纤维素和I型纤维素分散在一起的高温和高压状态的水引入管状反应器(28),使I型纤维素 在管状反应器(28)中将处于超临界状态或亚临界状态的热水预定时间,从而分解I型纤维素中的一部分氢键,并将I型纤维素溶解在水中 超临界状态或亚临界状态,将冷却器(30)中从管式反应器(28)排出的纤维素溶液冷却至室温以下,然后静置,从而析出分子量较低的II型纤维素的结晶 与I型纤维素的比例,并将所得的II型纤维素与溶剂分离。 该方法允许通过简单的方法制备纯的II型纤维素。