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11. 发明申请

WO1995035157A1 EMULSION MANUFACTURING METHOD OF EMULSIFIER 审中-公开
标题翻译：乳化剂的乳液制造方法
公开(公告)号：WO1995035157A1
公开(公告)日：1995-12-28
申请号：PCT/JP1995001209
申请日：1995-06-19
申请人： NIPPON SHINYAKU CO., LTD. , SAHEKI, Akira , SEKI, Junzo
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： B01F03/08
CPC分类号： B01F5/0662 , B01F3/0811 , B01F5/0256 , B01F5/0268 , B01F5/0609 , B01F5/0647 , B01F5/0648 , B01F5/0651 , B01F5/068 , Y10S514/941 , Y10S516/923 , Y10S516/928
摘要： An emulsion manufacturing method capable of providing an emulsion which comprises fine emulsion particles with a lower energy supply than in the conventional method of this kind, and providing easily an emulsion comprising uniform fine emulsion particles. The method is characterized in that a back pressure which is not less than 0.2 % and less than 5 % of the pressure applied to point of high-pressure emulsification in a high-pressure emulsification unit is exerted on a raw material during the manufacturing of an emulsion in a high-pressure emulsifier. The back pressure can be obtained by providing a discharge unit with, for example, a device having a pipe the inner diameter of which is smaller than that of a pipe in the discharge unit.
摘要翻译：一种能够提供乳液的乳液制造方法，该乳液包含比常规方法中更低能量供应的细乳液颗粒，并且容易地提供包含均匀的细乳液颗粒的乳液。该方法的特征在于，在制造高压乳化装置时，在原料上施加不低于施加于高压乳化装置的高压乳化点的压力的0.2％且小于5％的背压乳液在高压乳化剂中。背压可以通过设置具有例如具有其内径小于排出单元中的管的管的装置的排出单元来获得。

12. 发明申请

WO1995017883A1 WATER-IN-OIL LOTION CONTAINING A CORTICOSTEROID 审中-公开
标题翻译：包含角质层的油包水
公开(公告)号：WO1995017883A1
公开(公告)日：1995-07-06
申请号：PCT/EP1994004288
申请日：1994-12-22
申请人： GALDERMA S.A. , SATTLER, Henning
发明人： GALDERMA S.A.
IPC分类号： A61K09/107
CPC分类号： A61K9/0014 , A61K31/57 , A61K31/573 , A61K47/02 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/26 , Y10S514/937 , Y10S514/941 , Y10S514/943
摘要： A water-in-oil lotion containing hydrocortisone-21-acetate-17-propionate.
摘要翻译：含有氢化可的松-21-乙酸酯-17-丙酸酯的油包水乳液。

13. 发明申请

WO1995017087A1 OIL IN WATER EMULSIONS 审中-公开
标题翻译：油包水乳液
公开(公告)号：WO1995017087A1
公开(公告)日：1995-06-29
申请号：PCT/EP1994004141
申请日：1994-12-14
申请人： HOECHST AKTIENGESELLSCHAFT , FRISCH, Gerhard , DAMO, Zoltan
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： A01N25/04
CPC分类号： A01N25/04 , Y10S514/941 , Y10S514/975
摘要： The present invention relates to oil in water emulsions with a content of 0.001 to 70 wt % of at least one active agent from the group of phosphoric acid esters, thiophosphoric acid esters and/or carbamates, 0.001 to 30 wt % of one or more tenside compounds from the group of non-ionic tenside compounds or phosphorylised tenside compounds or sulphated tenside compounds or sulphonated tenside compounds and possibly additives and water up to 100 wt %.
摘要翻译：本发明涉及油包水乳液具有0.001内容 - 一种或多种表面活性剂化合物从.- 30％（重量） - 选自磷酸盐，硫代磷酸酯和/或Cabamate，0.001 70重量％的至少一种活性物质的％具有基团的非离子表面活性剂或表面活性剂的磷酸化或硫酸化的表面活性剂化合物或磺化表面活性剂，和任选的添加剂和广告100重量％的水。

14. 发明申请

WO1994010839A1 OIL IN WATER EMULSIONS 审中-公开
标题翻译：油包水乳液
公开(公告)号：WO1994010839A1
公开(公告)日：1994-05-26
申请号：PCT/EP1993003165
申请日：1993-11-11
申请人： HOECHST AKTIENGESELLSCHAFT , FRISCH, Gerhard , DAMO, Zoltan
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： A01N25/04
CPC分类号： A01N25/04 , Y10S514/938 , Y10S514/941
摘要： Oil in water emulsions contain 0.001 to 70 % by weight, preferably 0.5 to 45 % by weight of at least one active substance of the class of the phosphoric acid esters and/or carbamates, 0.001 to 20 % by weight, preferably 0.1 to 10 % by weight of at least one salt of an aryl polyglycol ether-phosphoric acid ester having the formula (I), in which laquelle R stands for hydrogen, C1-24-alkyl, C5-15-cycloalkyl, aryle C8-24 or C6-24-alkaryl; R stands for hydrogen, -O-C1-24-alkyl, -O-C5-15-cycloalkyl or -O-C6-18-aryl or A; M stands for an alkaline metal, an alkaline earth metal or ammonium ion having the formula HN(R )3, in which R stands for hydrogen, C1-4-alkyl, C5-15-cycloalkyl, C6-18-aryl or a group having the formula -(CH2)z-OH, in which z is a number from 1 to 10, x is a number from 0 to 80, y is a number from 0 to 50 and the sum of x and y is different from zero, the remaining percentage being constituted by water and if required solvents and/or additives. These oil in water emulsions are preferably used in agriculture, gardening, the household and hygiene field, and/or in the medical field.

15. 发明申请

WO2010039654A2 TOPICAL TREATMENT OF SKIN INFECTION 审中-公开
标题翻译：皮肤感染的局限性治疗
公开(公告)号：WO2010039654A2
公开(公告)日：2010-04-08
申请号：PCT/US2009/058607
申请日：2009-09-28
申请人： CHIOU, Win, L.
发明人： CHIOU, Win, L.
IPC分类号： A61K31/045 , A61K31/60 , A61P17/10
CPC分类号： A61K9/0014 , A61K31/60 , A61K31/765 , A61K47/10 , Y10S514/852 , Y10S514/859 , Y10S514/863 , Y10S514/884 , Y10S514/941 , Y10S514/944 , A61K2300/00
摘要： The invention relates to an unexpected discovery that propylene glycol is highly effective at killing or inhibiting Propionibacterium acnes in a mammalian skin disorder, as well as to the use of propylene glycol and salicylic acid in a skin- disorder treatment. This invention also relates to compositions containing propylene glycol alone or in combination with salicylic acid for use in killing or inhibiting Propionibacterium acnes.
摘要翻译：本发明涉及意想不到的发现，丙二醇在哺乳动物皮肤病中杀死或抑制痤疮丙酸杆菌以及在皮肤病症治疗中使用丙二醇和水杨酸是非常有效的。本发明还涉及含有丙二醇单独或与水杨酸组合用于杀死或抑制痤疮丙酸杆菌的组合物。

16. 发明申请

WO2002078677A1 SUSPENSION COLLOIDALE DE NANOPARTICULES A BASE D'UN COPOLYMERE AMPHIPHILE 审中-公开
标题翻译：基于AMPHIPHILIC共聚物的纳米颗粒的胶体悬浮液
公开(公告)号：WO2002078677A1
公开(公告)日：2002-10-10
申请号：PCT/FR2002/001045
申请日：2002-03-26
申请人： FLAMEL TECHNOLOGIES , SOULA, Gérard , BRYSON, Nathan
发明人： SOULA, Gérard , BRYSON, Nathan
IPC分类号： A61K9/51
CPC分类号： A61K9/5146 , A61K9/1075 , Y10S514/937 , Y10S514/941
摘要： L'invention concerne une suspension aqueuse, stable en milieu physiologique, de nanoparticules de vectorisation PV de principes actifs PA (par ex.insuline). Ces PV sont à base d'un copolymère tribloc: PolyEthylène-Glycol/polyaminoacide hydrophile/ polyaminoacide hydrophobe . Ces particules de copolymère tribloc peuvent s'associer à un PA sans le dénaturer, puis relarguer ce PA in vivo de façon contrôlée et pendant une très longue durée. Cela assure donc au PA une durée d'action très prolongée.L'invention vise, également, le solide pulvérulent à partir duquel sont issues les PV ainsi que la préparation de ce solide pulvérulent et de cette suspension de PV à base de copolymère tribloc. L'invention concerne les spécialités pharmaceutiques suscepti-bles d'être obtenues à partir de ces particules de vectori-sation chargées en principe actif.
摘要翻译：本发明涉及用于递送活性成分例如胰岛素的纳米颗粒的生物培养基中的水性悬浮液。所述递送颗粒基于三嵌段共聚物：聚乙二醇/亲水性聚氨基酸/疏水性聚氨基酸。所述三嵌段共聚物颗粒可以与活性原子缔合而不使其变性，并且在体内进行所述活性成分的受控和长期释放，从而提供非常延长释放的活性成分。本发明还涉及粉末形式的固体，其衍生为递送颗粒，以及所述粉末形固体和所述基于三嵌段共聚物递送颗粒的悬浮液的制备。本发明还涉及可由填充有活性成分的所述输送颗粒获得的药物特性。

17. 发明申请

WO0170024A3 PROCESS TO PREPARE AQUEOUS FORMULATIONS OF PESTICIDES 审中-公开
标题翻译：制备农药配方的方法
公开(公告)号：WO0170024A3
公开(公告)日：2002-03-28
申请号：PCT/US0109140
申请日：2001-03-21
申请人： FMC CORP , MARTIN TIMOTHY M , LAVIN MARYELLEN
发明人： MARTIN TIMOTHY M , LAVIN MARYELLEN
IPC分类号： A01N25/04 , A01N25/30 , A01N43/653 , A01N43/80 , A01N53/00 , A01N53/06 , A01N53/08 , A01N57/20
CPC分类号： A01N43/80 , A01N25/04 , A01N43/653 , A01N53/00 , A01N57/20 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/94 , Y10S514/941 , Y10S514/942 , Y10S514/943 , Y10S514/97 , Y10S514/973 , A01N25/30 , A01N25/02 , A01N2300/00
摘要： Provided is a method of formulating hydrophobic pesticides comprising emulsifying an aqueous phase and a water-immiscible phase to form a formulation; wherein the aqueous phase is comprised of water and optionally a freeze/thaw agent, one or more emulsifiers, or combinations thereof, and the water-immiscible phase comprises the hydrophobic pesticide and one or more emulsifiers.
摘要翻译：提供了一种配制疏水性农药的方法，包括乳化水相和水不混溶相以形成制剂; 其中水相由水和任选的冷冻/解冻剂，一种或多种乳化剂或其组合组成，并且水不混溶相包含疏水性农药和一种或多种乳化剂。

18. 发明申请

WO02020508A1 POLYOXYETHYLENE-POLYOXYPROPYLENE VITAMIN E AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：聚氧乙烯 - 聚氧丙烯维生素E及其制备方法
公开(公告)号：WO02020508A1
公开(公告)日：2002-03-14
申请号：PCT/KR2000/000948
申请日：2000-08-23
IPC分类号： A61K47/48 , C07D311/72 , C07D311/74 , A61K31/352 , A61K31/355
CPC分类号： C07D311/72 , A61K47/60 , Y10S514/844 , Y10S514/847 , Y10S514/886 , Y10S514/937 , Y10S514/941 , Y10S514/946
摘要： The present invention relates to polyoxyethylene-polyoxypropylene (POE-POP) vitamin E, which is prepared from vitamin E by polyethoxylation and polypropoxylation, and a method for preparing the same. The POE-POP vitamin E has a high surface activity and an excellent safety for the skin, so that the POE-POP vitamin E can be advantageously used in the cosmetic industry, the food industry and the medical industry.
摘要翻译：本发明涉及由维生素E通过聚乙氧基化和聚丙氧基化制备的聚氧乙烯 - 聚氧丙烯（POE-POP）维生素E及其制备方法。 POE-POP维生素E具有高的表面活性和对皮肤的极好的安全性，因此POE-POP维生素E可有利地用于化妆品工业，食品工业和医疗行业。

19. 发明申请

WO01012155A1 COMPOSITIONS AND METHODS FOR ENHANCED ABSORPTION OF HYDROPHILIC THERAPEUTIC AGENTS 审中-公开
标题翻译：用于增强吸收水解治疗药物的组合物和方法
公开(公告)号：WO01012155A1
公开(公告)日：2001-02-22
申请号：PCT/US2000/018807
申请日：2000-07-10
IPC分类号： A61K9/02 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/14 , A61K9/20 , A61K9/22 , A61K9/48 , A61K9/52 , A61K31/155 , A61K31/352 , A61K31/427 , A61K31/4425 , A61K31/522 , A61K31/546 , A61K31/662 , A61K31/663 , A61K31/7036 , A61K31/7048 , A61K31/7052 , A61K31/727 , A61K38/00 , A61K38/11 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K45/00 , A61K45/08 , A61K47/06 , A61K47/30 , A61K47/44 , A61P1/04 , A61P3/02 , A61P3/06 , A61P3/10 , A61P5/16 , A61P5/38 , A61P7/02 , A61P7/10 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/06 , A61P11/14 , A61P17/12 , A61P19/06 , A61P21/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P33/06 , A61P33/10 , A61P35/00 , A61P37/02 , A61P43/00 , A61K9/00 , A61K9/16 , A61K9/28
CPC分类号： A61K9/1075 , A61K9/4858 , A61K9/4891 , Y02A50/463 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/94 , Y10S514/941 , Y10S514/942 , Y10S514/943 , Y10S514/975
摘要： The present invention relates to pharmaceutical compositions, pharmaceutical systems, and methods for enhanced absorption of hydrophilic therapeutic agents. Compositions and systems of the present invention include an absorption enhancing carrier, where the carrier is formed from a combination of at least two surfactants, at least one of which is hydrophilic. A hydrophilic therapeutic agent can be incorporated into the composition, or can be co-administered with the composition as part of a pharmaceutical system. The invention also provides methods of treatment with hydrophilic therapeutic agents using these compositions and systems.
摘要翻译：本发明涉及用于增强亲水治疗剂吸收的药物组合物，药物体系和方法。本发明的组合物和体系包括吸收增强载体，其中载体由至少两种表面活性剂的组合形成，其中至少一种是亲水的。亲水性治疗剂可以掺入组合物中，或者可以作为药物系统的一部分与组合物共同施用。本发明还提供了使用这些组合物和系统用亲水治疗剂治疗的方法。

20. 发明申请

WO1998013069A2 FLUORINATED COPOLYMERIC PHARMACEUTICAL ADJUNCTS 审中-公开
标题翻译：氟化共聚物药用辅料
公开(公告)号：WO1998013069A2
公开(公告)日：1998-04-02
申请号：PCT/US1997016785
申请日：1997-09-09
申请人： SUPRATEK PHARMA, INC. , KABANOV, Alexander V. , VINOGRADOV, Serguei V.
发明人： SUPRATEK PHARMA, INC.
IPC分类号： A61K47/00
CPC分类号： A61K47/18 , A61K9/1075 , A61K47/32 , C08G65/337 , Y10S514/937 , Y10S514/941 , Y10S514/975
摘要： Block copolymers containing a fluorinated hydrocarbon unit, a hydrocarbon unit, and a poly(oxyethylene) unit are useful in fluid formulations of pharmaceutical agents. A typical embodiment is: C11 H23-CONHC2H4NHCO-C8F16-CONHC2H4NHCOO-(C2H4O)34-H.
摘要翻译：包含氟化烃单元，烃单元和聚（氧乙烯）单元的嵌段共聚物可用于药剂的流体配方。典型的实施方案是：C11H23-CONHC2H4NHCO-C8F16-CONHC2H4NHCOO-（C2H4O）34-H。

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