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11. 发明申请

WO2012012469A2 SIGNAL BIOMARKERS 审中-公开
标题翻译：信号生物标志
公开(公告)号：WO2012012469A2
公开(公告)日：2012-01-26
申请号：PCT/US2011044586
申请日：2011-07-19
申请人： OTAGO INNOVATION LTD , PEMBERTON CHRISTOPHER JOSEPH , RICHARDS ARTHUR MARK , DUFT BRADFORD J
发明人： PEMBERTON CHRISTOPHER JOSEPH , RICHARDS ARTHUR MARK
IPC分类号： G01N33/566 , C07K7/06 , C07K7/08 , C07K16/18 , G01N21/64 , G01N27/72
CPC分类号： C07K16/18 , C07K7/06 , C07K7/08 , C07K16/22 , C07K16/26 , C07K2317/24 , C07K2317/34 , C07K2317/76 , G01N33/74 , G01N33/746 , G01N2333/505 , G01N2333/58 , G01N2800/324 , G01N2800/325 , G01N2800/347 , G01N2800/52
摘要： Diagnostics relating to C-type natriuretic and erythropoietin signal peptides and fragments, and kits, uses and applications therefor.
摘要翻译：涉及C型利尿钠和促红细胞生成素信号肽和片段的诊断，以及试剂盒，用途和应用。

12. 发明申请

WO01083551A1 REAGENT FOR DETECTION OF BIOMOLECULES, AND USE THEREOF 审中-公开
标题翻译：用于检测生物分子的试剂及其用途
公开(公告)号：WO01083551A1
公开(公告)日：2001-11-08
申请号：PCT/SE2001/000941
申请日：2001-05-03
IPC分类号： C07K14/71 , C07K14/72 , G01N33/531 , G01N33/566 , G01N33/74 , C07K14/705 , C07K9/00 , G01N33/53
CPC分类号： C07K14/71 , C07K14/72 , C07K2319/00 , G01N33/531 , G01N33/566 , G01N33/74 , G01N2333/485 , G01N2333/505 , G01N2333/61 , G01N2333/71 , G01N2333/72
摘要： A cell-free reagent for detection of a target molecule is disclosed. Said reagent comprises a binding domain linked to a reporter domain. The binding domain has affinity to the target molecule and will bind to it when brought in contact therewith. The binding of the binding domain to the target molecule will induce dimerization of one reagent molecule with another reagent molecule with a similar binding domain, and as a result the reporter domain will induce a measurable signal. The binding domain may e.g. be the extracellular domain of a receptor, and the reporter molecule may be the intracellular domain of another receptor. Also the use of said receptor for the determination of the presence and/or the level of a target molecule present in a fluid sample and for the screening of potentially pharmaceutical active biomolecules is disclosed.
摘要翻译：公开了一种用于检测靶分子的无细胞试剂。所述试剂包含与报道结构域连接的结合结构域。结合结构域对靶分子具有亲和力，并且当与靶分子接触时与其结合。结合结构域与靶分子的结合将诱导一个试剂分子与具有相似结合结构域的另一个试剂分子的二聚化，结果报告域将诱导可测量的信号。结合域可以例如。是受体的细胞外结构域，并且报告分子可以是另一种受体的细胞内结构域。还公开了所述受体用于测定存在于流体样品中的靶分子的存在和/或水平以及潜在的药物活性生物分子的筛选的用途。

13. 发明申请

WO2005017192A2 SCREENING FOR GESTATIONAL DISORDERS 审中-公开
标题翻译：筛查呕吐障碍
公开(公告)号：WO2005017192A2
公开(公告)日：2005-02-24
申请号：PCT/US2004026484
申请日：2004-08-16
申请人： GEN HOSPITAL CORP , THADHANI RAVI , WOLF MYLES , KNICKERBOCKER TANYA LYNN , MACBEATH GAVIN
发明人： THADHANI RAVI , WOLF MYLES , KNICKERBOCKER TANYA LYNN , MACBEATH GAVIN
IPC分类号： G01N33/53 , G01N33/68 , G06F19/20 , C12Q1/00 , C12Q1/44 , C12Q1/68 , G01N33/543 , G01N33/567
CPC分类号： G01N33/689 , G01N2333/505 , G01N2333/52 , G01N2333/525 , G01N2333/53 , G01N2333/54 , G01N2333/555 , G01N2333/5756 , G01N2333/61 , G01N2800/368 , G06F19/20 , Y10S436/811
摘要： The invention relates to methods and compositions for identifying pregnant subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy, and as early as the first trimester.
摘要翻译：本发明涉及用于鉴定具有妊娠糖尿病，先兆子痫和妊娠高血压患有或倾向于具有妊娠糖尿病，先兆子痫和妊娠高血压的怀孕受试者的方法和组合这些方法适用于尿液和/或血液样品，可以在妊娠前三个月，早在妊娠前期进行。

14. 发明申请

WO0243572A2 ERYTHROPOIETIN AND ERYTHROPOIETIN RECEPTOR EXPRESSION IN HUMAN CANCER 审中-公开
标题翻译：促红细胞生成素和促红细胞生成素受体在人类肿瘤中的表达
公开(公告)号：WO0243572A2
公开(公告)日：2002-06-06
申请号：PCT/US0144950
申请日：2001-11-30
申请人： HENRY M JACKSON FOUNDATION , VERMA AJAY
发明人： VERMA AJAY
IPC分类号： A61K38/00 , A61K38/18 , C12Q1/68 , G01N33/574 , G01N33/74 , A61B
CPC分类号： G01N33/57488 , A61K38/1816 , A61K2039/505 , G01N33/574 , G01N33/746 , G01N2333/505 , G01N2333/71
摘要： The present invention relates to the elucidation of the role of erythropoietin and the erythropoietin receptor in the development and progression of certain solid tumors, including those found in breast, cervical, uterine, ovarian, prostate and brain cancer.
摘要翻译：本发明涉及阐明促红细胞生成素和促红细胞生成素受体在某些实体瘤（包括在乳腺癌，子宫颈癌，子宫癌，卵巢癌，前列腺癌和脑癌中发现的那些）的发展和进展中的作用。

15. 发明申请

WO0107911A3 A NOVEL METHOD FOR THE IMPROVED ISOLATION OF A TARGET CELL POPULATION 审中-公开
标题翻译：改进分离目标细胞群体的新方法
公开(公告)号：WO0107911A3
公开(公告)日：2001-11-08
申请号：PCT/DK0000408
申请日：2000-07-18
申请人： CHRISTENSEN BRITTA , KOELVRAA STEEN , PHILIP JOHN
发明人： CHRISTENSEN BRITTA , KOELVRAA STEEN , PHILIP JOHN
IPC分类号： C12N5/06 , G01N33/569 , G01N33/543 , G01N33/577
CPC分类号： G01N33/56966 , G01N2333/505 , G01N2333/70582
摘要： The present invention relates to a method for the isolation of at least one target cell population from a liquid sample of cells. The method comprises establishing a sample flow over a surface coated with antibodies specific for the target cell population, and allowing the cell sample and surface to be in physical contact. This provides for the cells from the at least one mammalian target cell population to bind to the antibodies on the surface. Then the liquid sample comprising non-bound cells is removed from the surface, and target cells on the surface are identified. The invention further relates to the use of such a method, and to a system for the isolation of target cell populations from a liquid cell sample.
摘要翻译：本发明涉及从细胞的液体样品中分离至少一种靶细胞群的方法。该方法包括在涂覆有针对靶细胞群体的抗体的表面上建立样品流，并允许细胞样品和表面物理接触。这提供了来自至少一个哺乳动物靶细胞群体的细胞结合表面上的抗体。然后从表面除去包含未结合细胞的液体样品，并鉴定表面上的靶细胞。本发明还涉及这种方法的使用，以及用于从液体细胞样品中分离靶细胞群体的系统。

16. 发明申请

WO01077677A1 DETECTION OF ERYTHROPOIETIN AND ERYTHTROPOIETIN RECEPTOR 审中-公开
标题翻译：检测ERYTHROPOIETIN和ERYTHTROPOIETIN受体
公开(公告)号：WO01077677A1
公开(公告)日：2001-10-18
申请号：PCT/US2001/011022
申请日：2001-04-05
IPC分类号： G01N33/53 , C07K14/505 , C07K16/18 , C07K16/22 , C07K16/28 , G01N33/50 , G01N33/563 , G01N33/566 , G01N33/74 , A61K39/395
CPC分类号： G01N33/5005 , G01N33/746 , G01N2333/505 , Y10S436/809
摘要： Methods and kits for simultaneous measurement of erythropoietin and erythropoietin receptor in a biological sample are described.
摘要翻译：描述了用于同时测量生物样品中红细胞生成素和促红细胞生成素受体的方法和试剂盒。

17. 发明申请

WO99026069A1 IMPROVEMENTS IN OR RELATING TO DETECTION OF MOLECULES IN SAMPLES 审中-公开
标题翻译：在样本中检测分子的改进或相关
公开(公告)号：WO99026069A1
公开(公告)日：1999-05-27
申请号：PCT/GB1998/003449
申请日：1998-11-16
IPC分类号： C07K14/505 , C07K14/55 , C07K14/60 , C07K14/61 , C07K14/62 , C12N15/09 , G01N33/58 , G01N33/74
CPC分类号： G01N33/74 , C07K14/505 , C07K14/55 , C07K14/60 , C07K14/61 , C07K14/62 , G01N33/582 , G01N2333/505 , G01N2333/55 , G01N2333/585 , G01N2333/60 , G01N2333/61 , G01N2333/62
摘要： Disclosed is a method of detecting the presence in a sample of a polypeptide exogenously administered to a mammalian subject from whom the sample is obtained, and distinguishing between such an exogenously administered polypeptide and a naturally-occurring endogenous polypeptide present in the sample; the method comprising obtaining a sample from the subject; and subjecting the sample to analysis of fluorescence at a suitable wavelength; wherein the exogenously administered polypeptide is tagged with a greater or lesser amount of fluorescence activity, relative to the untagged endogenous polypeptide, at the wavelength(s) analysed.
摘要翻译：本发明公开了一种检测样品中存在样品中存在样品的方法，所述样品中的多肽外源给予获得样品的哺乳动物受试者，并且区分这样的外源施用的多肽和样品中存在的天然存在的内源性多肽; 所述方法包括从所述受试者获得样品; 并对样品进行适当波长的荧光分析; 其中外源施用的多肽相对于未标记的内源多肽在所分析的波长处被标记有更多或更少量的荧光活性。

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