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11. 发明申请

WO2004067066A1 DRUG INFUSION DEVICE 审中-公开
标题翻译：药物输注装置
公开(公告)号：WO2004067066A1
公开(公告)日：2004-08-12
申请号：PCT/IL2004/000099
申请日：2004-02-02
申请人： SILEX PROJECTS LTD. , GENOSAR, Amir
发明人： GENOSAR, Amir
IPC分类号： A61M5/145
CPC分类号： A61M5/1454 , A61M5/14248 , A61M5/16804 , A61M2005/14204 , A61M2005/14513
摘要： The invention provides a drug delivery infusion device comprising an injection means (18) in fluid connection with a drug reservoir chamber (12) and pressure-generation means (10) coupled to both the drug reservoir (12) and to a liquid filled controlled chamber (13), wherein the coupling is such that the liquid filled control chamber (13) serves to constrain the motion of the pressure-generation means (10), thereby controlling the drug infusion rate, wherein the liquid filled control chamber (13) is associated with means for controlled depletion of the liquid therein whereby depletion of the volume of liquid in the control chamber enables the pressure-generation means to drive the drug in the reservoir chamber therefrom for infusion thereof.
摘要翻译：本发明提供了一种药物递送输注装置，其包括与药物储存室（12）流体连接的注射装置（18）和联接到药物储存器（12）和液体填充的受控腔室（12）的压力产生装置（10）（13），其中所述联接器使得所述液体填充控制室（13）用于约束所述压力产生装置（10）的运动，从而控制药物输注速率，其中所述填充液体的控制室（13）为与其中的液体的控制耗尽的装置相关联，由此在控制室中的液体体积的减少使得压力产生装置能够驱动储存室中的药物用于输注。

12. 发明申请

WO2003037407A1 TRANSDERMAL TRANSPORT DEVICE WITH SUCTION 审中-公开
标题翻译：带吸收的超声波传输装置
公开(公告)号：WO2003037407A1
公开(公告)日：2003-05-08
申请号：PCT/US2002/033830
申请日：2002-10-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： ANGEL, Aimee, B. , HUNTER, Ian, W. , HANSEN, Peter
IPC分类号： A61M5/142
CPC分类号： A61M37/0015 , A61M5/14244 , A61M5/14248 , A61M5/155 , A61M5/1723 , A61M5/425 , A61M5/46 , A61M2005/1405 , A61M2005/14204 , A61M2005/14252 , A61M2005/14268 , A61M2005/1581 , A61M2037/0007 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2205/0266 , A61M2205/50 , A61M2205/8206 , A61M2230/65
摘要： A transdermal transport device includes a reservoir for holding a formulation of an active principle, and one or more needles (14). Each needle has a bore through which the formulation is transported between the reservoir and a biological body, and has an end portion that is substantially algined in a plane parallel to a surfaceof the biological body when the device is placed on the surface. The device also includes a vaccum generator (28) which creates a suction to draw a portion of the surface beyond the plane of the end portions to enable the end portions to penetrate the portion of the surface as the needles are translated along an axis that is substantially parallel to the plane.
摘要翻译：透皮输送装置包括用于保持活性成分的制剂的储存器和一个或多个针14.每个针具有孔，所述制剂通过所述孔在储存器和生物体之间输送，并且具有基本上当装置放置在表面上时，平行于生物体的表面的平面中的内嵌。该装置还包括真空发生器28，该真空发生器28产生抽吸以将表面的一部分拉伸超过端部的平面，以使得当针沿着基本上平行的轴平移时，端部能够穿透表面的该部分到飞机

13. 发明申请

WO02011791A1 LIQUID SUPPLY APPARATUS 审中-公开
标题翻译：液体供应装置
公开(公告)号：WO02011791A1
公开(公告)日：2002-02-14
申请号：PCT/KR2000/001530
申请日：2000-12-23
IPC分类号： A61M5/00 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/168 , A61M5/20 , A61M39/00 , A61M39/02
CPC分类号： A61M5/14526 , A61M5/1452 , A61M5/16831 , A61M39/20 , A61M2005/14204 , A61M2005/14506 , A61M2005/31516 , A61M2039/205 , A61M2205/3592 , A61M2205/50 , A61M2205/7536
摘要： A liquid supply apparatus (10) is provided. The liquid supply apparatus (10) has a cylinder (12), a piston (14) and a piston pushing apparatus . The cylinder (12) is provided with a head portion (20) with outlet (24). The cylinder (12) has a rear end opened. The piston (14) is inserted into the cylinder (12). The piston moves along the longitudinal direction of the cylinder (12) so as to inject liquid contained in the cylinder (12). The piston pushing apparatus (16) pushes the piston (14). The piston pushing apparatus (16) has a moving member contacting the rear portion of the piston (14), a electric motor and a movement transferring mechanism. The movement transferring mechanism converts the rotation of the motor into the linear movement of the moving member.
摘要翻译：提供液体供应装置（10）。液体供给装置（10）具有圆筒（12），活塞（14）和活塞推压装置。气缸（12）设置有具有出口（24）的头部（20）。气缸（12）的后端开口。活塞（14）插入到气缸（12）中。活塞沿着气缸（12）的长度方向移动，以便喷射容纳在气缸（12）中的液体。活塞推动装置（16）推动活塞（14）。活塞推压装置（16）具有与活塞（14）的后部接触的移动部件，电动马达和移动传递机构。运动传递机构将电动机的旋转转换成运动部件的直线运动。

14. 发明申请

WO02007619A1 A NEW SLOW RELEASE DEVICE FOR CONTROLLED DELIVERY OF LIQUID MATERIAL 审中-公开
标题翻译：用于液体材料控制输送的新型缓慢释放装置
公开(公告)号：WO02007619A1
公开(公告)日：2002-01-31
申请号：PCT/IL2001/000625
申请日：2001-07-09
IPC分类号： A61B17/43 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/00
CPC分类号： A61M5/148 , A61B17/43 , A61M5/14593 , A61M2005/14204
摘要： A sterilizable, compact, portable device for dispensing predetermined amount, at a predetermined flow rate, of a selected liquid preparation into a specific target-organ or tissue in a mammalian body, in particular, of a human. Accessories may also be included for assisting in placing, and/or fixing, the device in right position within, or in adjacent to, the desired organ.
摘要翻译：一种可灭菌，紧凑的便携式装置，用于将预定量的预定量的选定液体制剂分配到哺乳动物身体，特别是人的特定靶器官或组织中。也可以包括用于辅助将装置放置和/或固定在所需器官内或附近的正确位置的附件。

15. 发明申请

WO1997041917A1 FLUID DELIVERY APPARATUS AND METHOD 审中-公开
标题翻译：流体输送装置和方法
公开(公告)号：WO1997041917A1
公开(公告)日：1997-11-13
申请号：PCT/US1997007886
申请日：1997-05-07
申请人： CERAMATEC, INC.
发明人： CERAMATEC, INC. , JOSHI, Ashok, V. , DAVIS, James, O. , WOLD, Truman , DI PALMA, Giorgio
IPC分类号： A61M37/00
CPC分类号： A61M5/14593 , A61M5/14244 , A61M5/14248 , A61M35/006 , A61M2005/14204 , A61M2005/14252
摘要： An apparatus (120) useful for, among other things, subcutaneous drug delivery includes a housing (124), a fluid reservoir (154) disposed within the housing for storing the fluid, a pump or pressurized chamber for pressurizing a driving gas and exerting a force on the fluid reservoir to expel the fluid reservoir's contents, and a needle (150) or absorbent pad fluidically communicating with the reservoir. The apparatus may further include a pump activation mechanism such as a button and an electrical circuit such that pushing the button activates a circuit and connecting a battery (138) to a pump (126), and pump control mechanism such as electrical circuitry to control the voltage gradient to a pump to control fluid delivery.
摘要翻译：用于（其中包括）皮下药物递送的装置（120）包括壳体（124），设置在壳体内用于储存流体的流体储存器（154），用于对驱动气体加压并施加压力的泵流体储存器上的力被排出流体储存器的内容物，以及与储存器流体连通的针（150）或吸收垫。该装置还可以包括诸如按钮和电路的泵激活机构，使得按下按钮来激活电路并将电池（138）连接到泵（126），并且泵控制机构例如电路以控制电压梯度到泵以控制流体输送。

16. 发明申请

WO1995015191A1 CONTROLLED RELEASE INFUSION DEVICE 审中-公开
标题翻译：控制释放输液装置
公开(公告)号：WO1995015191A1
公开(公告)日：1995-06-08
申请号：PCT/US1993011660
申请日：1993-12-01
申请人： PHARMETRIX CORPORATION
发明人： PHARMETRIX CORPORATION , ATHAYDE, Amulya, L. , FASTE, Rolf, A.
IPC分类号： A61M37/00
CPC分类号： A61M5/1483 , A61M5/14248 , A61M5/148 , A61M2005/14204 , A61M2005/14513
摘要： A portable infusion device assembly, having two pouches (3, 4) in pressure transmitting relationship, the first (4) containing infusate and the second (3), a driving medium (2). The driving medium (2) is pressurized by activation of osmotic pump, electrochemical reaction, release of pressurized fluid or gas or mechanical means, and the rate of infusion is controlled by a rate controlling means. The infusate pouch is separately manufactured and can be stored apart of the rest of the system.
摘要翻译：一种具有压力传递关系的两个袋（3,4）的便携式输注装置组件，所述第一（4）包含输注物和第二（3），驱动介质（2）。驱动介质（2）通过渗透泵的激活，电化学反应，加压流体或气体或机械装置的释放而被加压，并且输注速率由速率控制装置控制。输液袋是分开制造的，可以在系统的其余部分分开储存。

17. 发明申请

WO2015145264A3 IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2015145264A3
公开(公告)日：2016-03-03
申请号：PCT/IB2015001093
申请日：2015-03-24
申请人： BETA O2 TECHNOLOGIES LTD
发明人： ROTEM AVI , BARKAI URIEL , ZIMERMAN BARUCH , GENDLER ZOHAR
IPC分类号： A61M37/00
CPC分类号： A61M39/0208 , A61F2/022 , A61M5/14276 , A61M2005/14204 , A61M2039/0211 , A61M2202/0007 , A61M2202/0208 , A61M2202/0225 , A61M2209/045
摘要： An implantable medical system that comprises a gas unit for supplying gas that is essentially oxygen and at least one functional cells unit configured to receive oxygen from the gas unit so as to maintain the cells in a viable condition. The cells unit is flexible. Several embodiments are disclosed.
摘要翻译：一种可植入医疗系统，其包括用于供应基本为氧的气体的气体单元和被配置为从气体单元接收氧气的至少一个功能单元单元，以便将细胞维持在可行状态。电池单元是灵活的。公开了几个实施例。

18. 发明申请

WO2014059444A3 CHEMICAL ENGINES AND METHODS FOR THEIR USE, ESPECIALLY IN THE INJECTION OF HIGHLY VISCOUS FLUIDS 审中-公开
标题翻译：化学发动机及其使用方法，特别是注入高粘度流体
公开(公告)号：WO2014059444A3
公开(公告)日：2014-08-21
申请号：PCT/US2013065136
申请日：2013-10-15
申请人： LILLY CO ELI
发明人： HEINTZ AMY , BENNISON CORRIE , MUENZER CHRIS , BLUM TIM , MCKENZIE CHRIS , MADLUND STEVE , ELLIS JEFF , KASEMAN BRIAN
IPC分类号： A61M5/20 , A61M5/19
CPC分类号： A61M5/19 , A61M5/1483 , A61M5/2046 , A61M5/282 , A61M2005/14204 , C06D5/10 , F01B1/01
摘要： Chemical engines and processes for their use and construction are described. The chemical engines can provide powerful and compact devices, especially autoinjectors for the rapid, powered injection of viscous medicines. Novel formulations and designs of chemical engines and delivery technologies employing the chemical engines are described.
摘要翻译：描述了化学发动机及其使用和结构的工艺。化学发动机可以提供强大而紧凑的装置，尤其是用于快速动力注射粘性药物的自动注射器。描述了使用化学发动机的化学发动机和输送技术的新配方和设计。

19. 发明申请

WO2014036112A4 ELECTROCHEMICALLY-ACTUATED MICROFLUIDIC DEVICES 审中-公开
标题翻译：电化学激励微流体器件
公开(公告)号：WO2014036112A4
公开(公告)日：2014-05-30
申请号：PCT/US2013057032
申请日：2013-08-28
申请人： SFC FLUIDICS LLC , UNIV COLORADO
发明人： PAYNE FORREST W , KUMAR SAI RAMAMURTHY , EVANS CHRISTINE E , WASHBURN ANNA , DUNN ANDY , YOUNG BRIAN , BRUTON JOE , DAS CHAMPAK , JEERAGE KAVITA M , KOVAL CARL A , NOBLE RICHARD D
IPC分类号： A61M5/14 , B81B3/00
CPC分类号： A61M5/14224 , A61M5/14244 , A61M5/14248 , A61M5/14593 , A61M2005/14204 , A61M2005/14513 , A61M2205/0244 , F15C3/04
摘要： Electrochemical actuation is disclosed for fluid movement and flow control in microfluidic devices, allowing for miniaturization, minimal power requirements, single-use disposability and engineering of small, complex fluidic networks. In one embodiment, a single-dose fluid delivery device is operable to deliver a bolus dose, in a single extended stroke or in multiple repeated doses. The device uses three electrochemically-actuated chambers, two of the chambers operating as inlet/outlet valves for the device and a third providing both a temporary containment and pumping action. By sequential manipulation of the fluid pressure in the three chambers, fluids may be delivered in precise quantities by the device.
摘要翻译：公开了用于微流体装置中的流体运动和流动控制的电化学致动，从而实现小型化，最小功率要求，单次使用可处置性和工程小型复杂流体网络。在一个实施例中，单剂量流体递送装置可操作以递送单次剂量，单次延长的中风或多次重复剂量。该装置使用三个电化学致动腔室，其中两个腔室用作装置的入口/出口阀，第三个腔室提供临时容纳和泵送动作。通过顺序操纵三个腔室中的流体压力，可以通过该装置以精确的量输送流体。

20. 发明申请

WO2012141776A1 ESTIMATING THE VOLUME OF FLUID IN THERAPEUTIC FLUID DELIVERY DEVICE RESERVOIR 审中-公开
标题翻译：估计治疗流体装置储存中的液体体积
公开(公告)号：WO2012141776A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/023213
申请日：2012-01-31
申请人： MEDTRONIC, INC. , KALPIN, Scott L. , BAUDINO, Michael D.
发明人： KALPIN, Scott L. , BAUDINO, Michael D.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/152 , A61M2005/14204 , A61M2205/3334
摘要： A number of parameters related to the operation of a fluid delivery device are determined based on pressures within the device sensed using multiple pressure sensors. In one example, the volume of therapeutic fluid within a reservoir of a fluid delivery device is estimated based on a measured pressure differential. In another example, the rate at which a therapeutic fluid is added to or removed from the reservoir is estimated based on the measured pressure differential.
摘要翻译：基于使用多个压力传感器感测的装置内的压力来确定与流体输送装置的操作有关的许多参数。在一个示例中，基于测量的压力差估计流体输送装置的储存器内的治疗流体的体积。在另一个实例中，基于所测量的压力差来估计加入到储存器中或从贮存器移除的治疗流体的速率。

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