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11. 发明申请

WO1998019595A1 APPARATUS AND METHODS FOR PROCEDURES RELATED TO THE ELECTROPHYSIOLOGY OF THE HEART 审中-公开
标题翻译：与心脏电生理相关的程序的装置和方法
公开(公告)号：WO1998019595A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020067
申请日：1997-11-06
申请人： NOVOSTE CORPORATION
发明人： NOVOSTE CORPORATION , LARSEN, Charles, E. , TRIP, Roelof , JOHNSON, Cheryl, R.
IPC分类号： A61B05/0402
CPC分类号： H01L35/00 , A61B5/0422 , A61B18/02 , A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2018/00047 , A61B2018/00083 , A61B2018/00095 , A61B2018/00797 , A61B2018/00821 , A61B2018/0212 , A61B2018/0237 , A61B2018/0243 , A61N1/28
摘要： Methods and apparatus are disclosed for use in procedures related to the electrophysiology of the heart, such as identifying or evaluating the electrical activity of the heart, diagnosing and/or treating conditions associated with the electrophysiology of the heart. An apparatus (200) having thermocouple elements (206, 208) of different electromotive potential conductively connected at a junction (210) is introduced into the interior of the heart and a section of heart tissue is contacted with the junction (210). An electrical current is passed through the thermocouple elements (206, 208) to reduce the temperature of the junction in accordance with the Peltier effect and thereby cool contacted heart tissue. The effect of the cooling may be monitored and, if desired, the section of heart tissue may be treated.
摘要翻译：公开了用于与心脏电生理学有关的方法的方法和装置，例如鉴定或评估心脏的电活动，诊断和/或治疗与心脏的电生理学相关的病症。具有在结（210）处导电连接的不同电动势的热电偶元件（206,208）的装置（200）被引入到心脏的内部，心脏组织的一部分与结点（210）接触。电流通过热电偶元件（206,208），以根据珀尔帖效应降低结点的温度，从而冷却接触的心脏组织。可以监测冷却的效果，并且如果需要，可以处理心脏组织的部分。

12. 发明申请

WO1997006727A1 A MULTIPOLAR TRANSMURAL PROBE 审中-公开
标题翻译：多媒体传输探测器
公开(公告)号：WO1997006727A1
公开(公告)日：1997-02-27
申请号：PCT/AU1996000489
申请日：1996-08-02
申请人： CARDIAC CRC NOMINEES PTY. LTD. , SODHI, Chris , DALY, Michael , ROSS, David , KOVOOR, Pramesh , KOEVSKI, Ilija
发明人： CARDIAC CRC NOMINEES PTY. LTD.
IPC分类号： A61B05/04
CPC分类号： A61B5/0422 , A61B5/6848 , A61B2017/00044 , A61B2017/00243 , A61B2018/1253 , A61B2562/0209 , A61B2562/043 , A61N1/06
摘要： The present invention relates to a needle-like probe (1) for use in electrical potential sensing and RF ablation of tissue, a method of making such probes (1), and a probe array comprising a number of such probes (1). The probe (1) has an elongated body (2, 22) with one end (9, 29) adapted for penetration of tissue. The body (2, 22) has sufficient rigidity to be inserted into the tissue. The elongated body (2, 22) also comprises two or more electrodes (7, 27) separated and spaced apart from each other along the elongated body (2, 22) by insulative material (8, 28). Each electrode (7, 27) has at least one electrical conductor (10, 11) coupled to the electrode (7, 27). The electrode (7, 27) is capable of delivering RF energy to the tissue surrounding the electrode (7, 27) and sensing the electrical potential of the tissue. Preferably, the two or more electrodes (7, 27) each comprise a metal band incorporated in the elongated body (2, 22) and optionally include a thermal sensing means for measuring the temperature at the interface between the electrode (7, 27) and the tissue. Still further, the elongated body (2, 22) can internally incorporate an elongated rigid member (14) for providing structural stiffening of the probe (1). The elongated rigid member (14) can be comprised of metal and is rigidly fixed to at least the one end (9, 29) adapted for penetration of the tissue. Preferably, the two or more electrodes (7, 27) and the insulative material (8, 28) form a tubular structure and the interior cavity of the tubular structure if filled with matrix material (16). Preferably, the probe (1) comprises at least four electrodes (7, 27) and at least three insulative portions (8, 28) interleaved therewith. Optionally, the elongated body (2, 22) has a substantially arcuate or curved form.
摘要翻译：本发明涉及用于组织的电位感测和RF消融的针状探针（1），制造这种探针的方法（1）和包括多个这种探针（1）的探针阵列。探针（1）具有细长体（2,22），其一端（9,29）适于穿透组织。身体（2,22）具有足够的刚性以插入组织。细长体（2,22）还包括通过绝缘材料（8,28）沿着细长体（2,22）彼此间隔开并隔开的两个或更多个电极（7,27）。每个电极（7,27）具有耦合到电极（7,27）的至少一个电导体（10,11）。电极（7,27）能够将RF能量传递到围绕电极（7,27）的组织并感测组织的电位。优选地，两个或更多个电极（7,27）各自包括结合在细长体（2,22）中的金属带，并且可选地包括热敏装置，用于测量电极（7,27）和组织。此外，细长主体（2,22）可以内部包括用于提供探针（1）的结构加强的细长刚性构件（14）。细长的刚性构件（14）可以由金属构成，并刚性地固定在适于穿透组织的至少一端（9,29）上。优选地，两个或更多个电极（7,27）和绝缘材料（8,28）形成管状结构，并且如果填充有基体材料（16），则管状结构的内腔。优选地，探针（1）包括与其交错的至少四个电极（7,27）和至少三个绝缘部分（8,28）。可选地，细长体（2,22）具有基本上弧形或弯曲形状。

13. 发明申请

WO2017044775A1 THERMOREGULATORY MANIPULATION OF SYSTEMIC BLOOD PRESSURE 审中-公开
标题翻译：系统血液压力的温度调节
公开(公告)号：WO2017044775A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/050988
申请日：2016-09-09
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： DILLER, Kenneth R. , KHOSHNEVIS, Sepideh , HEMMEN, Laura
IPC分类号： A47C21/04 , A61F7/00 , A61F7/02 , A61F7/08 , A61H7/00 , A61H9/00 , A61H23/04
CPC分类号： A47C21/048 , A47C21/044 , A61B2017/00044 , A61B2017/00075 , A61B2017/00084 , A61F7/00 , A61F7/02 , A61F7/08 , A61F2007/0002 , A61F2007/0018 , A61F2007/0029 , A61F2007/0039 , A61F2007/0054 , A61F2007/0075 , A61F2007/0076 , A61F2007/0095
摘要： A system and/or method for proactively inducing a significant drop in blood pressure during sleep is provided herein. The system includes a blood pressure monitor and a stimulating device that provides stimulation to at least a portion of the person's body. For example, the stimulating device may stimulate a portion of the person's body corresponding to the person's peripheral thermoregulatory control tissue. The stimulation increases or maintains blood flow in the person's glabrous tissue. Additionally, the stimulating device provides stimulation in response to the person's blood pressure being above a predetermined threshold.
摘要翻译：本文提供了一种主动诱导睡眠期间血压明显下降的系统和/或方法。该系统包括血压监测器和刺激装置，其向身体的至少一部分提供刺激。例如，刺激装置可以刺激与人的周边体温调节组织相对应的人体的一部分。刺激增加或维持人的无毛组织中的血液流动。此外，刺激装置响应于人的血压高于预定阈值而提供刺激。

14. 发明申请

WO2017004093A1 OPEN-IRRIGATED ABLATION CATHETER 审中-公开
标题翻译：开放式抽油烟机
公开(公告)号：WO2017004093A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/039915
申请日：2016-06-28
申请人： BOSTON SCIENTIFIC SCIMED INC.
发明人： MIRIGIAN, Mark D. , KIM, Isaac J. , FORREST, Mark D. , CHEUNG, Desmond , HARVEY, Guy R. , KURSE, Ravi , ORTIZ, Ofelia , VELILLA, Simplicio A. , NGUYEN, Oanh , WYLIE, Bryan , ESHEIM, Taiki
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/0422 , A61B5/0464 , A61B5/055 , A61B5/6852 , A61B5/7217 , A61B2017/00044 , A61B2018/00029 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/00708 , A61B2018/00839 , A61B2018/00875 , A61B2018/1467 , A61B2217/007 , A61B2218/002
摘要： An open-irrigated catheter system includes a catheter body and a tip assembly, coupled to a distal end of the catheter body. The tip assembly includes an exterior wall that is conductive for delivering radio frequency (RF) energy for an RF ablation procedure, and that defines an interior region. The exterior wall includes a number of proximal irrigation ports and a number of distal irrigation ports. At least one fluid chamber is defined within the interior region and is in fluid communication with at least one of the proximal irrigation ports and the distal irrigation ports. At least one fluid lumen extends from a fluid source, through the catheter body, to the tip assembly, and is in fluid communication with the at least one fluid chamber.
摘要翻译：开放灌注的导管系统包括导管本体和与导管主体的远端连接的末端组件。尖端组件包括导电的外壁，用于为RF消融过程传送射频（RF）能量，并且限定内部区域。外墙包括多个近端冲洗口和多个远端冲洗口。至少一个流体室限定在内部区域内，并与近端冲洗口和远端冲洗口中的至少一个流体连通。至少一个流体腔从流体源延伸穿过导管主体到尖端组件，并且与至少一个流体室流体连通。

15. 发明申请

WO2014182822A1 UTILIZATION OF ELECTRODE SPATIAL ARRANGEMENTS FOR CHARACTERIZING CARDIAC CONDUCTION CONDITIONS 审中-公开
标题翻译：用于表征心脏导管条件的电极空间安排的应用
公开(公告)号：WO2014182822A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/037160
申请日：2014-05-07
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.
发明人： BALACHANDRAN, Ram K. , DENO, D. Curtis
IPC分类号： A61B5/042 , A61B5/06 , A61B19/00 , A61B18/14 , A61B5/0452
CPC分类号： A61B5/0422 , A61B5/0452 , A61B5/061 , A61B5/062 , A61B5/7203 , A61B5/7239 , A61B18/1492 , A61B34/20 , A61B2017/00039 , A61B2017/00044 , A61B2017/00053 , A61B2018/00577 , A61B2018/00839 , A61B2034/2051 , A61B2034/2053 , A61B2218/002
摘要： A system and method are provided for determining electrophysiological data. The system comprises an electronic control unit that is configured to receive electrical signals from a set of electrodes, receive position and orientation data for the set of electrodes from a mapping system, compensate for position and orientation artifacts of the set of electrodes, compose cliques of a subset of neighboring electrodes in the set of electrodes, determine catheter orientation independent information of a target tissue, and output the orientation independent information to a display. The method comprising receiving electrogram data for a set of electrodes (80), compensating for artifacts in sensor positions in the mapping system (81), resolving the bipolar signals into a 3D vector electrogram in the mapping system coordinates (82), manipulating observed unipolar voltage signals and the tangent component of the e-field to estimate the conduction velocity vector (83), and outputting the catheter orientation independent information (84).
摘要翻译：提供了一种用于确定电生理数据的系统和方法。该系统包括电子控制单元，其被配置为从一组电极接收电信号，从映射系统接收用于该组电极的位置和取向数据，补偿该组电极的位置和取向伪像，电极组中的相邻电极的子集，确定目标组织的导管取向独立信息，并将取向独立信息输出到显示器。该方法包括接收用于一组电极（80）的电描记图数据，补偿映射系统（81）中的传感器位置中的伪像，将双极性信号解析为映射系统坐标（82）中的3D矢量电描记图，操纵观察到的单极性电压信号和电场的切线分量来估计传导速度矢量（83），并输出导管取向独立信息（84）。

16. 发明申请

WO2014100631A1 REAL-TIME FEEDBACK FOR ELECTRODE CONTACT DURING MAPPING 审中-公开
标题翻译：映射期间电极接触的实时反馈
公开(公告)号：WO2014100631A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/077019
申请日：2013-12-20
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： MASKARA, Barun , THAKUR, Pramodsingh H. , ARCOT-KRISHNAMURTHY, Shantha , SHOME, Shibaji , SAHA, Sunipa , SHUROS, Allan C. , MEYER, Scott A.
IPC分类号： A61B5/00 , A61B5/042 , A61B5/0424 , A61B5/107 , A61B18/14
CPC分类号： A61B5/0538 , A61B5/0422 , A61B5/0424 , A61B5/044 , A61B5/6858 , A61B5/6885 , A61B18/1492 , A61B2017/00044 , A61B2017/00053 , A61B2018/00267 , A61B2018/00678 , A61B2018/00839 , A61B2090/065
摘要： A catheter system includes a mapping catheter including a plurality of mapping electrodes, each mapping electrode configured to sense signals associated with an anatomical structure. The catheter system further includes a processor operatively coupled to the plurality of mapping electrodes and configured to receive the signals sensed by the plurality of mapping electrodes, characterize the signals sensed by the plurality of mapping electrodes based on amplitudes of the sensed signals, and generate an output of a quality of contact of the plurality of mapping electrodes with the anatomical structure based on the signal characterization.
摘要翻译：导管系统包括包括多个映射电极的映射导管，每个映射电极被配置为感测与解剖结构相关联的信号。导管系统还包括可操作地耦合到多个映射电极并且被配置为接收由多个映射电极感测的信号的处理器，基于感测信号的幅度表征由多个映射电极感测的信号，并且生成基于信号表征，输出多个映射电极与解剖结构的接触质量。

17. 发明申请

WO2014047068A1 MAP AND ABLATE CLOSED-LOOP COOLED ABLATION CATHETER 审中-公开
标题翻译： MAP和ABLATE闭环冷却吸管
公开(公告)号：WO2014047068A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060183
申请日：2013-09-17
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： TUN, Zaya , KIM, Isaac , KOBLISH, Josef V. , CAO, Minhchau N , HA, Steve
IPC分类号： A61B18/14 , A61B18/00 , A61B17/00
CPC分类号： A61B5/6853 , A61B5/04012 , A61B5/0422 , A61B5/4836 , A61B18/1206 , A61B18/1492 , A61B18/18 , A61B2017/00044 , A61B2018/00023 , A61B2018/00136 , A61B2018/00791 , A61B2018/00839 , A61M5/00
摘要： A system for performing mapping and ablation functions includes a catheter sized and shaped for vascular access. The catheter includes an elongate body extending between a proximal end and a distal end. A tip section positioned at the distal end of the catheter body and includes a proximal portion and a distal portion. One or more electrode structures are formed on an exterior surface of the tip section. The one or more electrode structures each includes a mapping electrode at the distal portion of the tip section and a contact pad electrically coupled to the mapping electrode.
摘要翻译：用于执行测绘和消融功能的系统包括尺寸和形状用于血管通路的导管。导管包括在近端和远端之间延伸的细长体。位于导管主体的远端的尖端部分，包括近端部分和远端部分。一个或多个电极结构形成在尖端部分的外表面上。所述一个或多个电极结构各自包括在所述尖端部分的远端部分处的映射电极和电耦合到所述映射电极的接触焊盘。

18. 发明申请

WO2012031204A3 DEVICES AND METHODS FOR ANCHORING TISSUE 审中-公开
标题翻译：用于锚固组织的装置和方法
公开(公告)号：WO2012031204A3
公开(公告)日：2012-04-26
申请号：PCT/US2011050331
申请日：2011-09-02
申请人： GUIDED DELIVERY SYSTEMS INC , SERINA EUGENE , TAM TAMMY Y , HENDERSON JENNIFER
发明人： SERINA EUGENE , TAM TAMMY Y , HENDERSON JENNIFER
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B5/0002 , A61B5/686 , A61B5/6877 , A61B5/6882 , A61B17/0644 , A61B17/068 , A61B17/3478 , A61B18/14 , A61B2017/00022 , A61B2017/00039 , A61B2017/00044 , A61B2017/00221 , A61B2017/00305 , A61B2017/00849 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00893 , A61B2017/0409 , A61B2017/0417 , A61B2017/0427 , A61B2017/0464 , A61B2017/0649 , A61B2017/22038 , A61B2090/3904 , A61B2090/3966 , A61F2/2442 , A61M25/04 , A61N1/05
摘要： Described herein are devices and methods for delivering implants that comprise multiple coupled anchors. The anchors have an elongate form following a curved arcuate path in a single turning direction. Each anchor has two legs arranged to diverge away from each other, where each leg has a substantially non-constant radius of curvature and a substantially straight distal tip. The anchors are secured to tissue using a multi-opening guide tunnel that is configured to releasably retain one or more portions of the implant located between two of the anchors. The releasable retention of one or more intervening portions of the implant maintains the position of the implant and the guide tunnel until the implant is secured to the tissue. One variation of a multi-opening guide tunnel comprises releasable retention flaps and an aperture capable of deploying a fluid contrast medium into a patient without interfering with anchor delivery.
摘要翻译：这里描述了用于输送包括多个连接的锚的植入物的装置和方法。锚固件具有沿着单个转动方向的弯曲弧形路径的细长形式。每个锚具有布置成彼此远离的两个腿，其中每个腿具有基本上不恒定的曲率半径和基本上直的远侧末端。使用多开口引导隧道将锚定件固定到组织，所述多开口引导通道构造成可释放地保持位于两个锚固件之间的植入物的一个或多个部分。植入物的一个或多个中间部分的可释放保留维持植入物和引导通道的位置，直到植入物固定到组织。多开口引导通道的一个变体包括可释放的保持翼片和能够将流体造影剂部署到患者体内而不干扰锚定器输送的孔。

19. 发明申请

WO2009120953A3 NAVIGATION AND TISSUE CAPTURE SYSTEMS AND METHODS 审中-公开
标题翻译：导航和组织捕获系统和方法
公开(公告)号：WO2009120953A3
公开(公告)日：2010-02-18
申请号：PCT/US2009038544
申请日：2009-03-27
申请人： MAYO FOUNDATION , AEGIS MEDICAL INNOVATIONS INC , FRIEDMAN PAUL A , BRUCE CHARLES J , ASIRVATHAM SAMUEL J , MCCAW TREVOR A , HONG ELLIOT Y K
发明人： FRIEDMAN PAUL A , BRUCE CHARLES J , ASIRVATHAM SAMUEL J , MCCAW TREVOR A , HONG ELLIOT Y K
IPC分类号： A61B17/29 , A61B5/042 , A61B18/14 , A61M25/00
CPC分类号： A61B17/29 , A61B5/042 , A61B5/06 , A61B5/063 , A61B17/0218 , A61B17/122 , A61B17/1285 , A61B18/02 , A61B18/1445 , A61B18/1492 , A61B18/20 , A61B2017/00044 , A61B2017/00243 , A61B2017/0034 , A61B2017/2905 , A61B2017/2926 , A61B2017/2946 , A61B2018/00214 , A61B2018/00351 , A61B2018/00839 , A61B2018/00898 , A61B2018/0212 , A61B2018/1407
摘要： Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
摘要翻译：描述使用所选择的组织和/或其他组织的先天电活动导航和/或捕获选定组织的导航和组织捕获系统和方法。在左心耳闭合的情况下，系统和方法可用于导航到左心耳并捕获/控制附肢，同时将闭合器械（缝合线，夹子，环）放置在附件上并收紧或闭合关闭方法（消融，低温手术，装订等）进行闭合左心耳。用于导航装置的先天电活动的使用可以与身体的其他组织和/或区域结合使用。

20. 发明申请

WO2009003138A1 APPARATUS AND METHOD FOR ENDOVASCULAR DEVICE GUIDING AND POSITIONING USING PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：使用生理参数进行血管内装置引导和定位的装置和方法
公开(公告)号：WO2009003138A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/068422
申请日：2008-06-26
申请人： VASONOVA, INC. , GRUNWALD, Sorin , SANDER, Fiona, Maria , SAMSON, Wilfred, J. , HILL, Bradley , CHENG, E., Tina
发明人： GRUNWALD, Sorin , SANDER, Fiona, Maria , SAMSON, Wilfred, J. , HILL, Bradley , CHENG, E., Tina
IPC分类号： A61B5/042 , A61B8/06 , A61B5/06 , A61B8/08 , A61B5/0476 , A61B5/0472 , A61B5/0452 , A61B5/0215 , A61B17/00
CPC分类号： A61B8/463 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0456 , A61B5/0472 , A61B5/0476 , A61B5/0488 , A61B5/06 , A61B5/061 , A61B5/065 , A61B5/1459 , A61B5/6853 , A61B5/7405 , A61B5/742 , A61B7/04 , A61B8/02 , A61B8/06 , A61B8/08 , A61B8/0841 , A61B8/12 , A61B8/42 , A61B8/445 , A61B8/461 , A61B8/465 , A61B8/488 , A61B8/565 , A61B34/20 , A61B34/25 , A61B2017/00044 , A61B2017/00106 , A61B2017/00115 , A61B2017/22067 , A61B2034/2051 , A61B2034/2055 , A61B2034/252 , A61B2090/062 , A61B2090/064 , A61B2090/378 , G06F19/00 , G09B23/288
摘要： An endovascular access and guidance system (100) has an elongate body (105) with a proximal end (110) and a distal end (115); a non-imaging ultrasound transducer (120) on the elongate body configured to provide in vivo non-image based ultrasound information of the vasculature of the patient; an endovascular electrogram lead (130) on the elongate body in a position that, when the elongate body is in the vasculature, the endovascular electrogram lead electrical sensing segment provides an in vivo electrogram signal of the patient; a processor (140) configured to receive and process a signal from the non-imaging ultrasound transducer and a signal from the endovascular electrogram lead; and an output device configured to display a result of information processed by the processor.
摘要翻译：血管内通路和引导系统（100）具有带有近端（110）和远端（115）的细长主体（105）。所述细长主体上的非成像超声换能器（120）被配置成提供患者的脉管系统的体内基于非图像的超声信息; 细长体上的血管内电描记线（130），当细长体处于脉管系统中时，血管内电描记图导线电传感段提供患者的体内电描记图信号; 处理器（140），被配置为接收和处理来自所述非成像超声换能器的信号和来自所述血管内电针引线的信号; 以及输出装置，被配置为显示由处理器处理的信息的结果。

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