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11. 发明申请

WO2009150565A3 REVERSE DATA RECONSTRUCTION FOR OPTIMAL TIME SAMPLING OF COUNTS IN PHYSIOLOGICAL LIST-MODE NUCLEAR IMAGING 审中-公开
公开(公告)号：WO2009150565A3
公开(公告)日：2009-12-17
申请号：PCT/IB2009/052290
申请日：2009-05-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , UNIVERSITY HOSPITALS MEDICAL GROUP, INC. , GAGNON, Daniel , TIPNIS, Sameer , MUZIC, Raymond
发明人： GAGNON, Daniel , TIPNIS, Sameer , MUZIC, Raymond
IPC分类号： A61B6/03
摘要： A diagnostic imaging device includes detector elements (16) for detecting ƴ-rays indicative of nuclear decay events. Pairs of concurrently detected γ-rays define lines of response (LORs) which are collected, time stamped, and compiled in list-mode. In tissue perfusion studies, it is beneficial to use the data that concurrently maximizes contrast and signal-to-noise ratio in the reconstructed images. Using the list-mode data, events in an adjustable temporal window (33) are reconstructed and the reconstructed images are analyzed to determine a figure of merit based on contrast and signal-to-noise properties of the image. By iteratively adjusting the temporal window, extending its start point (36) backwards in time, and repeating the reconstructing, analyzing, and adjusting steps, an image with an optimal figure of merit is obtained.

12. 发明申请

WO2009138898A1 USING NON-ATTENUATION CORRECTED PET EMISSION IMAGES TO COMPENSATE FOR INCOMPLETE ANATOMIC IMAGES 审中-公开
标题翻译：使用非衰减校正的PET排放图像补偿不完整的解剖图像
公开(公告)号：WO2009138898A1
公开(公告)日：2009-11-19
申请号：PCT/IB2009/051825
申请日：2009-05-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HU, Zhiqiang , GAGNON, Daniel , TUNG, Chia-Hua
发明人： HU, Zhiqiang , GAGNON, Daniel , TUNG, Chia-Hua
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , G06T2211/424 , G06T2211/432
摘要： When compensating for truncated patient scan data acquired by a multi¬ modal PET/CT or PET/MR imaging system (14, 16), such as occurs when a patient is larger than a field of view for an anatomical imaging device, a segmented contour of a non- attenuation-corrected (NAC) PET image is used to identify a contour of the truncated region. An appropriate tissue type is used to fill in truncated regions of a truncated CT or MR image for the attenuation map. The corrected attenuation map is then used to generate an attenuation-corrected PET image of the patient or a region of interest. Alternatively, the system can be employed in PET/CT or PET/MR imaging scenarios where two modalities are performed sequentially (e.g., not simultaneously), and thus the contour derived from the PET scan can be compared to the CT or MR image to infer potential subject motion between the PET and CT or MR scans. Additionally, the system can be employed in PET imaging scenarios where the contour derived from the NAC PET image is used as emission boundary for scatter correction using single-scatter simulation, in which a tail-fitting procedure utilizes an emission boundary to define pure-scatter tails (e.g., in the absence of true coincidence events).
摘要翻译：当补偿由多模PET / CT或PET / MR成像系统（14,16）获取的截断的患者扫描数据时，例如当患者大于解剖成像装置的视野时发生，分段轮廓使用非衰减校正（NAC）PET图像来识别截断区域的轮廓。使用适当的组织类型来填充用于衰减图的截断的CT或MR图像的截断区域。然后校正的衰减图用于产生患者或感兴趣区域的衰减校正的PET图像。或者，该系统可以用于PET / CT或PET / MR成像场合，其中顺序执行两种模式（例如，不同时执行），因此可以将从PET扫描导出的轮廓与CT或MR图像进行比较以推断 PET和CT或MR扫描之间的潜在主体运动。此外，该系统可以用于PET成像场景，其中从NAC PET图像导出的轮廓用作使用单分散模拟的散射校正的发射边界，其中尾部拟合过程利用发射边界来定义纯散射尾巴（例如，没有真正的巧合事件）。

13. 发明申请

WO2009125309A2 MODULAR MULTI-GEOMETRY PET SYSTEM 审中-公开
标题翻译：模块化多元几何PET系统
公开(公告)号：WO2009125309A2
公开(公告)日：2009-10-15
申请号：PCT/IB2009/051190
申请日：2009-03-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel , MCKNIGHT, Douglas, B.
发明人： GAGNON, Daniel , MCKNIGHT, Douglas, B.
CPC分类号： G01T1/2985 , A61B6/037 , G01R33/481
摘要： When performing positron emission tomography (PET) scanning and image reconstruction, a primary PET system (10) with a primary PET detector array (12) is used to image a patient or subject, and a secondary PET detector array (14) is coupled to the system at specific input points to mitigate unnecessary duplication of system components. The primary system (10) provides PET data processing and reconstruction for the secondary array (14), in addition to the first array (12). An adjustable array (120) includes radially movable detectors (122) and stationary detectors (124) with different crystal resolutions. The movable detectors (122) are alternately positioned with the stationary detectors (124) at a first radius to form a large detector ring, or are positioned at a second, smaller radius without the stationary detectors (124) to form a small detector ring.
摘要翻译：当进行正电子发射断层扫描（PET）扫描和图像重建时，使用具有主要PET检测器阵列（12）的主要PET系统（10）对患者或受试者进行成像，并且将辅助PET检测器阵列（14）耦合到该系统在特定的输入点，以减轻不必要的系统组件重复。除了第一阵列（12）之外，主系统（10）还为次级阵列（14）提供PET数据处理和重建。可调节阵列（120）包括具有不同晶体分辨率的径向可移动探测器（122）和固定探测器（124）。移动检测器（122）与第一半径处的固定式检测器（124）交替定位以形成大的检测器环，或者定位在第二较小的半径处，而没有固定的检测器（124）以形成小的检测器环。

14. 发明申请

WO2007046013A2 PATIENT SCAN TIME OPTIMIZATION FOR PET/SPECT IMAGING 审中-公开
标题翻译：患者扫描时间优化PET / SPECT成像
公开(公告)号：WO2007046013A2
公开(公告)日：2007-04-26
申请号：PCT/IB2006/053317
申请日：2006-09-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , NARAYANAN, Manoj , BAKKER, Bart , GAGNON, Daniel , FISCHER, Alexander , SPIES, Lothar
发明人： NARAYANAN, Manoj , BAKKER, Bart , GAGNON, Daniel , FISCHER, Alexander , SPIES, Lothar
CPC分类号： A61B6/00 , A61B6/037
摘要： An imaging system (10) comprises a data device (30), which controls radiation data acquisition from a subject positioned in an examination region (18) for an examination. A rebinning processor (40) bins the acquired data periodically into a histogram (42). A transform (70) transforms the histogram (42) into individual independent or uncorrelated components, each component including a signal content and a noise content. A stopping determining device (52) compares an aspect of at least one selected component to a predetermined threshold (TH) and, based on the comparison, terminates the data acquisition.
摘要翻译：成像系统（10）包括数据装置（30），其控制从位于检查区域（18）中的被摄体进行检查的辐射数据采集。重组处理器（40）将获取的数据周期性地存储到直方图（42）中。变换（70）将直方图（42）变换为独立的或不相关的分量，每个分量包括信号内容和噪声内容。停止确定装置（52）将至少一个所选择的组件的方面与预定阈值（TH）进行比较，并且基于该比较，终止数据采集。

15. 发明申请

WO2005040854A2 METHOD AND APPARATUS FOR REVERSING PERFORMANCE DEGRADATION IN SEMI-CONDUCTOR DETECTORS 审中-公开
标题翻译：用于在半导体探测器中反转性能退化的方法和设备
公开(公告)号：WO2005040854A2
公开(公告)日：2005-05-06
申请号：PCT/IB2004/052001
申请日：2004-10-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel , GRIESMER, Jerome, J.
发明人： GAGNON, Daniel , GRIESMER, Jerome, J.
IPC分类号： G01T1/24
CPC分类号： G01T1/249 , G01T1/24
摘要： A system reverses degraded energy resolution of semiconductor radiation detection elements (44) which are used in a radiation detector assembly. A means (38) identifies semiconductor elements which exhibit degraded energy resolution as compared to an initial level of energy resolution after application of the forward bias. A means (40) restores the degraded semiconductor elements to the initial level of energy resolution by applying the reverse bias. A heater (74) accelerates the restoration process by supplying an elevated ambient temperature. A screening means (48) screens new semiconductor elements to identify the elements which are susceptible to degradation. A forward bias is applied by a forward bias means (50) to induce the degradation. A heater (52) increases an ambient temperature to accelerate the performance degradation in the new semiconductor. elements. The identified degradable elements are treated with a reverse bias prior to installation in the detector.
摘要翻译：系统逆转在辐射检测器组件中使用的半导体辐射检测元件（44）的退化能量分辨率。装置（38）识别在施加正向偏置之后与能量分辨率的初始水平相比表现出降低的能量分辨率的半导体元件。装置（40）通过施加反向偏压将退化的半导体元件恢复到能量分辨率的初始水平。加热器（74）通过提供升高的环境温度来加速恢复过程。筛选装置（48）筛选新的半导体元件以识别易受降解影响的元素。正向偏压由正向偏压装置（50）施加以引起退化。加热器（52）增加环境温度以加速新半导体中的性能下降。元素。确定的可降解元件在安装在检测器中之前用反向偏压进行处理。

16. 发明申请

WO2004061477A1 CONSTANT RADIUS SINGLE PHOTON EMISSION TOMOGRAPHY 审中-公开
标题翻译：恒定半径单光子发射测量
公开(公告)号：WO2004061477A1
公开(公告)日：2004-07-22
申请号：PCT/IB2003/006242
申请日：2003-12-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GAGNON, Daniel
发明人： GAGNON, Daniel
IPC分类号： G01T1/164
CPC分类号： A61B6/037 , A61B6/032 , A61B6/5235 , G01T1/1603 , G01T1/1611 , G01T1/1644 , G01T1/1648 , G01T1/2985
摘要： A nuclear camera (10) includes four or more gamma detectors (20, 20', 20'', 201, 202, 203, 204, 205, 206) arranged on a generally circular rotatable gantry (12, 12', 12'', 12''') around an imaging region that emits emission radiation. The gamma detectors are each disposed at a fixed equal distance (R, R2, R3, R5) from an imaging isocenter (22, 22', 22'', 22''') to rotate in a fixed radius circular orbit. Each gamma detector includes a radiation sensitive surface (72) that responds to the emission radiation and a slat collimator (70) that spins about an axis 88. Resolution and sensitivity at the fixed radius are selected by selecting collimator slat height (Wz) and spacing (G) and radiation sensitive surface width (Cy). The gamma detectors and rotating gantry are enclosed in an optically opaque toroidal housing (14) that defines a generally circular bore (16) that admits imaging subjects over a range of sizes.
摘要翻译：核相机（10）包括布置在大致圆形可旋转机架（12,12'，12“）上的四个或更多个伽马检测器（20,20'，20”，201,202,203,204,205,206），12“'）围绕发射发射辐射的成像区域。伽马检测器各自以与成像等角点（22,22'，22“，22”“）相等的固定距离（R，R2，R3，R5）设置，以固定的半径圆形轨道旋转。每个伽马检测器包括响应于发射辐射的辐射敏感表面（72）和围绕轴线88旋转的平板准直器（70）。通过选择准直器板条高度（Wz）和间距来选择固定半径处的分辨率和灵敏度（G）和辐射敏感表面宽度（Cy）。 γ检测器和旋转台架被封闭在光学不透明的环形壳体（14）中，该环形壳体限定大致圆形的孔（16），允许成像对象在一定尺寸范围内。

17. 发明申请

WO2010082101A1 REGIONAL RECONSTRUCTION AND QUANTITATIVE ASSESSMENT IN LIST MODE PET IMAGING 审中-公开
标题翻译：列表模式PET成像中的区域重建和定量评估
公开(公告)号：WO2010082101A1
公开(公告)日：2010-07-22
申请号：PCT/IB2009/055948
申请日：2009-12-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel , MANIAWSKI, Piotr, J.
发明人： GAGNON, Daniel , MANIAWSKI, Piotr, J.
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , A61B6/037
摘要： A method for reconstructing list mode data comprises: reconstructing all list mode data of a list mode data set (30, 160) to generate a first reconstructed image (32, 62); selecting a sub-set of the list mode data set; and reconstructing the sub-set of the list mode data set to generate an enhanced reconstructed image (84, 86). An image generation system comprises: a reconstruction module (24) configured to perform a standard reconstruction of a list mode data set to generate a standard reconstructed image (32, 62); and a re-reconstruction module (24, 70, 80, 82, 150, 152, 154) configured to perform a reconstruction other than the standard reconstruction of at least a portion of the list mode data set to generate an enhanced reconstructed image (84, 86).
摘要翻译：重建列表模式数据的方法包括：重建列表模式数据集（30,160）的所有列表模式数据，以生成第一重建图像（32,62）; 选择列表模式数据集的子集; 以及重建列表模式数据集的子集以生成增强的重建图像（84,86）。一种图像生成系统包括：重建模块（24），被配置为执行列表模式数据集的标准重建以生成标准重建图像（32,62）; 以及重建重建模块（24,70,80,82,150,152,154），其被配置为执行不同于所述列表模式数据集的至少一部分的标准重建的生成增强重建图像（84 ，86）。

18. 发明申请

WO2010041191A2 ENCLOSURE FOR HYGROSCOPIC SCINTILLATION CRYSTAL FOR NUCLEAR IMAGING 审中-公开
标题翻译：用于核成像的羟基化学晶体的外观
公开(公告)号：WO2010041191A2
公开(公告)日：2010-04-15
申请号：PCT/IB2009/054351
申请日：2009-10-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel
发明人： GAGNON, Daniel
CPC分类号： G01T1/2018 , Y10T29/49002
摘要： When employing hygroscopic scintillation crystals (32) in a nuclear detector (e.g., PET or SPECT), Silicon photomultiplier (SiPM) sensors (34) are coupled to each scintillation crystal (32) to improve scintillation event detection and reduce scatter. The crystals (32) and sensors (34) are hermetically sealed in a detector housing (50) using a sealant layer (51). Electrical contacts (60) from each sensor (34) extend through the sealant layer (51) or are bused together such that the bus extends through the sealant layer (51). In this manner, hygroscopic scintillation crystals (e.g., LaBr, NaI, etc.) are protected from humidity and light scatter is reduced by direct coupling of the sensors (34) and crystals (32).
摘要翻译：当在核检测器（例如PET或SPECT）中使用吸湿闪烁晶体（32）时，硅光电倍增管（SiPM）传感器（34）耦合到每个闪烁晶体（32），以改善闪烁事件检测并减少散射。晶体（32）和传感器（34）使用密封剂层（51）气密地密封在检测器壳体（50）中。来自每个传感器（34）的电触头（60）延伸穿过密封剂层（51），或者被连接在一起，使得总线延伸穿过密封剂层（51）。以这种方式，吸湿性闪烁晶体（例如LaBr，NaI等）被保护免受湿度，并且通过传感器（34）和晶体（32）的直接耦合来减少光散射。

19. 发明申请

WO2008135873A1 HYBRID MR/PET WITH CORRECTION FOR RADIATION ABSORPTION BY MR COIL 审中-公开
标题翻译：混合MR / PET与MR线圈的辐射吸收校正
公开(公告)号：WO2008135873A1
公开(公告)日：2008-11-13
申请号：PCT/IB2008/051475
申请日：2008-04-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , MORICH, Michael, A. , DEMEESTER, Gordon, D. , GAGNON, Daniel
发明人： MORICH, Michael, A. , DEMEESTER, Gordon, D. , GAGNON, Daniel
IPC分类号： G01R33/48 , G01T1/161
CPC分类号： G01R33/481 , G01R33/4808 , G01T1/1603 , G01T1/1647
摘要： An imaging method comprises: acquiring magnetic resonance data of a subject using a magnetic resonance component (30, 30') disposed with the subject; acquiring nuclear imaging data of the subject with the magnetic resonance component disposed with the subject; determining a position of the magnetic resonance component respective to a frame of reference of the nuclear imaging data; and reconstructing the nuclear imaging data (60) to generate a nuclear image (62) of at least a portion of the subject. The reconstructing includes adjusting at least one of the nuclear imaging data and the nuclear image based on a density map (46) of the magnetic resonance component and the determined position of the magnetic resonance component respective to the frame of reference of the nuclear imaging data to correct the nuclear image for radiation absorption by the magnetic resonance component.
摘要翻译：一种成像方法包括：使用与受检者一起设置的磁共振成分（30,30'）来获取对象的磁共振数据; 用设置在对象的磁共振成分获取对象的核成像数据; 确定所述磁共振成分相对于所述核成像数据的参考系的位置; 以及重构所述核成像数据（60）以产生所述受试者的至少一部分的核图像（62）。重建包括基于磁共振分量的密度图（46）和与核成像数据的参考系的相应的磁共振分量的确定的位置来调整核成像数据和核图像中的至少一个，通过磁共振成分校正核图像的辐射吸收。

20. 发明申请

WO2008096285A2 MOTION ESTIMATION IN TREATMENT PLANNING 审中-公开
标题翻译：治疗计划运动估计
公开(公告)号：WO2008096285A2
公开(公告)日：2008-08-14
申请号：PCT/IB2008/050279
申请日：2008-01-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , BRINKS, Ralph , MEYER, Carsten , FISCHER, Alexander , GAGNON, Daniel , BUSCH, Marc
发明人： BRINKS, Ralph , MEYER, Carsten , FISCHER, Alexander , GAGNON, Daniel , BUSCH, Marc
IPC分类号： A61B6/03
CPC分类号： A61B6/032 , A61B5/055 , A61B5/721 , A61B5/7289 , A61B6/037 , A61B6/527 , A61N5/103 , A61N5/1037 , A61N5/1067 , A61N2005/1052
摘要： An apparatus includes a scanner (102, 104) and a scanning motion monitor (100). A motion modeler (116) uses data from the scanning motion monitor (100) and the scanner (102, 104) to generate a motion model which describes motion of a region of interest of an object. A treatment planner (112) uses image data from the scanner (102, 104) to establish a treatment plan for the object. A treatment device 114, which operates in conjunction with a treatment motion monitor (108), uses the motion model to compensate for motion of the object during application of the treatment.
摘要翻译：一种装置包括扫描仪（102,104）和扫描运动监视器（100）。运动建模器（116）使用来自扫描运动监视器（100）和扫描器（102,104）的数据来生成描述对象感兴趣区域的运动的运动模型。治疗计划器（112）使用来自扫描器（102,104）的图像数据来建立对象的治疗计划。与治疗运动监视器（108）一起操作的治疗装置114使用运动模型来补偿在施用治疗期间物体的运动。

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