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11. 发明申请

WO1997002255A1 TRIAZOLINE AND ISOXAZOLINE BIS-OXIME DERIVATIVES AND THEIR USE AS PESTICIDES 审中-公开
标题翻译：三唑和异辛唑双异构体衍生物及其作为杀虫剂的用途
公开(公告)号：WO1997002255A1
公开(公告)日：1997-01-23
申请号：PCT/EP1996002695
申请日：1996-06-21
申请人： CIBA-GEIGY AG , ZIEGLER, Hugo , TRAH, Stephan , ZURFLUH, René , O'SULLIVAN, Anthony, Cornelius
发明人： CIBA-GEIGY AG
IPC分类号： C07D261/12
CPC分类号： C07D261/10 , A01N43/647 , A01N43/80 , C07C251/52 , C07C251/58 , C07C251/60 , C07C265/12 , C07C279/18 , C07C331/28 , C07C335/18 , C07D249/12 , C07D261/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Bis-oxime derivatives of formula (I) in which A is (a) or (b), where W is oxygen or sulfur, and the other substituents defined as follows: R1 = hydrogen, C1-C4alkyl; cyclopropyl; R2 = hydrogen, C1-C6alkyl; halo(C1-C6) alkyl; C2-C6alkoxyalkyl; C3-C6cycloalkyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; cyano; C1-C6alkoxycarbonyl; C1-C6alkyl-S(O)n; substituted or unsubstituted aryl-S(O)n; C1-C6alkoxy; substituted or unsubstituted aryloxy; substituted or unsubstituted heteroaryloxy; unsubstituted or mono- to trimethyl-substituted heterocyclyl; substituted or unsubstituted aryl-C1-C6alkyl; substituted or unsubstituted heteroaryl-C1-C6alkyl; R3 = hydrogen; C1-C6alkyl; C1-C6haloalkyl having 1 to 5 halogen atoms; C1-C4alkoxy-C1-C2-alkyl; unsubstituted or mono- to trihalo-substituted C1-C6alkenyl; C2-C6alkynyl; unsubstituted or mono- to tetrahalo-substituted C3-C6cycloalkyl-C1-C4alkyl; n = 0 to 2; R8 = H, C1-C4alkyl, C1-C4haloalkyl, C3-C6cycloalkyl; X = OR5, SR5, NR6R7, halogen (especially Cl); R6, R7 = independently of one another H, C1-C4alkyl, C3-C4alkenyl, C3-C4alkynyl; R5 = C1-C4alkyl, C1-C3haloalkyl are fungicidal, acaricidal and insecticidal active ingredients for agriculture. They can be employed as formulated crop protection compositions.
摘要翻译：其中A为（a）或（b）的式（I）的双肟衍生物，其中W为氧或硫，其它取代基定义如下：R1 =氢，C1-C4烷基; 环丙基; R2 =氢，C1-C6烷基; 卤代（C 1 -C 6）烷基; C2-C6烷氧基; C3-C6环烷基; 取代或未取代的芳基; 取代或未取代的杂芳基; 氰基; C1-C6烷氧基羰; C1-C6烷基-S（O）n表示取代或未取代的芳基-S（O）n; C1-C6烷氧基; 取代或未取代的芳氧基; 取代或未取代的杂芳氧基; 未取代或单 - 三甲基取代的杂环基; 取代或未取代的芳基-C 1 -C 6烷基; 取代或未取代的杂芳基-C 1 -C 6烷基; R3 =氢; C1-C6烷基; 具有1至5个卤素原子的C 1 -C 6卤代烷基; C1-C4烷氧基，C1-C2烷基; 未取代或单 - 三卤代取代的C 1 -C 6烯基; C2-C6炔基; 未取代或单 - 四卤代取代的C 3 -C 6环烷基-C 1 -C 4烷基; n = 0〜2; R8 = H，C1-C4烷基，C1-C4卤代烷基，C3-C6环烷基; X = OR5，SR5，NR6R7，卤素（特别是Cl）; R6，R7 =彼此独立地为H，C1-C4烷基，C3-C4链烯基，C3-C4炔基; R5 = C1-C4烷基，C1-C3卤代烷基是农业的杀真菌剂，杀螨剂和杀虫活性成分。它们可以用作配制的作物保护组合物。

12. 发明申请

WO1996010556A1 MICROBICIDES 审中-公开
标题翻译：杀菌剂
公开(公告)号：WO1996010556A1
公开(公告)日：1996-04-11
申请号：PCT/EP1995003683
申请日：1995-09-19
申请人： CIBA-GEIGY AG , PFIFFNER, Albert , TRAH, Stephan
发明人： CIBA-GEIGY AG
IPC分类号： C07C69/736
CPC分类号： A01N37/38 , A01N37/50 , C07C69/736 , C07C251/52 , C07C255/61
摘要： Compounds of formula (I) and possible isomers and isomeric mixtures thereof, wherein: a) X is CH2F or CHF2; Y is CH and Z is OMe, or b) X is CH2F or CHF2; Y is a nitrogen atom and Z is OMe or NHCH3, and wherein also m is 0, 1, 2, 3, 4 or 5 and U represents identical or different substituents selected from halogen, cyano, nitro, C1-C12alkyl, C3-C8cycloalkyl, C3-C6alkenyl, C3-C6alkenyloxyiminomethyl, C1-C4alkoxy, C1-C4alkoxyiminomethyl, C1-C2haloalkyl, C1-C2haloalkoxy, unsubstituted or substituted phenyl, unsubstituted or substituted phenoxy and unsubstituted or substituted benzyl or represents substituents at two adjacent positions of the phenyl ring of formula (I) that define a fused hydrocarbon bridge so as to form a larger hydrocarbon ring having up to 14 carbon atoms, are suitable for controlling and preventing microorganisms, insects and Acarina on plants. They can be used in the form of commercially customary formulated compositions.
摘要翻译：式（I）化合物及其可能的异构体和异构体混合物，其中：a）X是CH 2 F或CHF 2; Y是CH，Z是OMe，或b）X是CH 2 F或CHF 2; Y是氮原子，Z是OMe或NHCH 3，其中m是0,1,2,3,4或5，U代表相同或不同的选自卤素，氰基，硝基，C 1 -C 12烷基，C 3 -C 8环烷基 C 3 -C 6烯基氧基亚氨基甲基，C 1 -C 4烷氧基，C 1 -C 4烷氧基亚氨基甲基，C 1 -C 2卤代烷基，C 1 -C 2卤代烷氧基，未取代或取代的苯基，未取代或取代的苯氧基和未取代或取代的苄基或在苯环的两个相邻位置定义稠合烃桥以形成具有至多14个碳原子的较大烃环的式（I）的化合物适用于控制和防止植物上的微生物，昆虫和蜱螨属。它们可以以商业习惯配制的组合物的形式使用。

13. 发明申请

WO1996006072A1 OXIME ETHERS AND THEIR USE AS PESTICIDES 审中-公开
标题翻译： OXIME ETHERS及其作为杀虫剂的用途
公开(公告)号：WO1996006072A1
公开(公告)日：1996-02-29
申请号：PCT/EP1995002898
申请日：1995-07-21
申请人： CIBA-GEIGY AG , PFIFFNER, Albert , TRAH, Stephan
发明人： CIBA-GEIGY AG
IPC分类号： C07C251/60
CPC分类号： A01N37/50 , A01N37/36 , C07C69/734 , C07C251/60 , C07C2601/02 , C07D317/58
摘要： Compounds of formula (I) are suitable for controlling and preventing infestation by micro-organisms, insects and acarina on plants and their possible isomers and mixtures of isomers, wherein (a) X is CH2F or CHF2, Y is CH and Z is OCH3, or (b) X is CH2F or CHF2, Y is a nitrogen atom and Z is OCH3 or NHCH3, and wherein R1 and R2 are each independently of the other hydrogen, cyano, C1-C12alkyl, halo-C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, C3-C6cycloalkyl, cyclopropylmethyl, C1-C4alkoxy, C2-C12alkoxyalkyl, C1-C4alkoxycarbonyl, C1-C4alkylthio, C2-C5alkylthioalkyl; or an unsubstituted or mono- to tri-substituted ring having not more than 15 ring carbon atoms that may be poly-membered and that contains from 0 to 3 hetero atoms selected from N, O and S, it being possible for that ring to be bonded via an aliphatic bridge having at most 4 carbon atoms and/or via CO, oxygen or sulfur, as desired; or wherein R1 and R2 together with their common carbon atom form an unsubstituted or mono- to tri-substituted ring having not more than 15 ring carbon atoms that may be poly-membered and that contains from 0 to 3 hetero atoms selected from N, O and S. They can be used in the form of commercially customary formulated compositions.
摘要翻译：式（I）化合物适用于控制和预防微生物，昆虫和螨虫对植物及其可能的异构体和异构体混合物的侵扰，其中（a）X是CH 2 F或CHF 2，Y是CH，Z是OCH 3，或（b）X是CH 2 F或CHF 2，Y是氮原子，Z是OCH 3或NHCH 3，并且其中R 1和R 2各自独立地是另一个氢，氰基，C 1 -C 12烷基，卤代C 1 -C 12烷基，C 2 -C 12烯基，C 2 -C 12炔基，C 3 -C 6环烷基，环丙基甲基，C 1 -C 4烷氧基，C 2 -C 12烷氧基烷基，C 1 -C 4烷氧基羰基，C 1 -C 4烷硫基，C 2 -C 5烷硫基烷基; 或具有不多于15个环碳原子的未取代或单 - 三取代的环，其可以是多元的并且含有0-3个选自N，O和S的杂原子，该环可能是通过具有至多4个碳原子和/或通过CO，氧或硫的脂族桥键合; 或其中R 1和R 2与它们的共同碳原子一起形成未被取代的或一至三取代的环，其具有不多于15个环碳原子，其可以是多元的并且含有0至3 选自N，O和S的杂原子。它们可以以商业上常规配制的组合物的形式使用。

14. 发明申请

WO1994017060A1 PYRAZOLYL ACRYLIC ACID DERIVATIVES, INTERMEDIATES THERETO, AND THEIR USE AS MICROBICIDES 审中-公开
标题翻译：吡唑丙酸衍生物，其中间体及其作为微生物的用途
公开(公告)号：WO1994017060A1
公开(公告)日：1994-08-04
申请号：PCT/EP1994000103
申请日：1994-01-17
申请人： CIBA-GEIGY AG , TRAH, Stephan
发明人： CIBA-GEIGY AG
IPC分类号： C07D403/12
CPC分类号： C07D401/12 , A01N43/56 , A01N43/66 , C07D231/18 , C07D403/12
摘要： Compounds of formula (I), wherein R1 is hydrogen or methyl, R2 is hydrogen, halogen, OCH3, SCH3 or CN, R3, R4, R5 are each independently of one another hydrogen, halogen, C1-C4alkyl, C1-C4alkoxy, C2-C5alkoxycarbonyl, C1-C5alkanoyl, C1-C4haloalkyl, C1-C4haloalkoxy, CN, NO2, or wherein two of these substituents are adjacent to each other and together are a methylenedioxy or difluoromethylenedioxy radical, K, L, M are each independently of one another CH or N ( = nitrogen atom), but at least one of these three substituents is N, and Y is oxygen or sulfur, are effective microbicides for controlling fungal diseases. They can be used for plant protection by themselves or as formulated compositions.
摘要翻译：式（I）化合物，其中R 1是氢或甲基，R 2是氢，卤素，OCH 3，SCH 3或CN，R 3，R 4，R 5彼此独立地是氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，C 2 -C 5烷氧基羰基，C 1 -C 5烷酰基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，CN，NO 2，或其中两个这些取代基彼此相邻并且一起是亚甲二氧基或二氟亚甲二氧基，K，L，M各自彼此独立地 CH或N（=氮原子），但这三个取代基中的至少一个为N，Y为氧或硫，是控制真菌病害的有效杀微生物剂。它们可以自己或作为配制的组合物用于植物保护。

15. 发明申请

WO1993016986A1 AZO OXIME ETHERS AND THEIR USE AS FUNGICIDES 审中-公开
标题翻译： AZO OXIME ETHERS及其作为防腐剂使用
公开(公告)号：WO1993016986A1
公开(公告)日：1993-09-02
申请号：PCT/EP1993000373
申请日：1993-02-17
申请人： CIBA-GEIGY AG , ZIEGLER, Hugo , TRAH, Stephan
发明人： CIBA-GEIGY AG
IPC分类号： C07C259/20
CPC分类号： C07D213/77 , A01N37/52 , A01N43/40 , C07C259/20 , C07C311/38 , C07C2601/02 , C07D319/18
摘要： Azo oxime ethers of general formula (I), in which X is CH or N, R1 is hydrogen, C1-C3alkyl, trifluoromethyl or cylclopropyl and R2 is aryl or heteroaryl, have an activity against phytopathogenic fungi. They can be used in the form of formulations as crop protection products, seed-dressing products and wood preservatives.
摘要翻译：通式（I）的偶氮肟醚，其中X为CH或N，R 1为氢，C 1 -C 3烷基，三氟甲基或环丙基，R 2为芳基或杂芳基，具有抗植物病原性真菌的活性。它们可以以制剂形式用作作物保护产品，拌种产品和木材防腐剂。

16. 发明申请

WO1993008183A1 2-(2-BENZO(b)THIENYL)-3-METHOXYACRYLATE AND -2-IMINOACETATE DERIVATIVES TO BE USED AS PESTICIDES 审中-公开
标题翻译： 2-（2-苯并（b）噻吩基）-3-甲氧基丙烯酸酯和用作农药的2,3-二氨基乙酸酯衍生物
公开(公告)号：WO1993008183A1
公开(公告)日：1993-04-29
申请号：PCT/EP1992002370
申请日：1992-10-14
申请人： CIBA-GEIGY AG , TRAH, Stephan , GANTZ, François
发明人： CIBA-GEIGY AG
IPC分类号： C07D333/60
CPC分类号： C07D409/12 , A01N43/12 , A01N43/30 , A01N43/32 , A01N43/40 , A01N43/54 , A01N43/58 , A01N43/74 , A01N43/84 , C07D333/60 , C07D417/12
摘要： Compounds of formula (I) in which: X is a nitrogen atom or a group of the formula CH(Ia); R1 is C1-C4alkyl; and either R2 and R3 independently of one another are hydrogen, C1-C4alkyl, halo-C1-C4alkyl, C1-C4alkoxy, C1-C4alkoxymethyl, C1-C4alkylthio, C1-C4alkylthiomethyl, an unsubstituted or substituted aryl, heteroaryl, aryl-C1-C4alkyl, heteroaryl-C1-C4alkyl, aryloxy-C1-C4alkyl, heteroaryloxy-C1-C4alkyl, arylthio-C1-C4alkyl, heteroarylthio-C1C4alkyl, arylcarbonyl or heteroarylcarbonyl group, C2-C4alkenyl, an unsubstituted or substituted aryl-C2-C4alkenyl or heteroaryl-C2-C4alkenyl group, C2-C4alkynyl, C3-C6cycloalkyl or cyano, or R2 and R3 together with the carbon atom to which R2 and R3 are attached are an unsubstituted or substituted saturated or unsaturated, carbo- or heterocyclic 4- to 7-membered ring to which an unsubstituted or substituted benzene ring may be fused; in free form or, if appropriate, in salt form can be used as agrochemical active ingredients.
摘要翻译：式（I）的化合物，其中：X是氮原子或式CH（Ia）的基团; R1是C1-C4烷基; R 2和R 3彼此独立地是氢，C 1 -C 4烷基，卤代C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4烷氧基甲基，C 1 -C 4烷硫基，C 1 -C 4烷硫基甲基，未取代或取代的芳基，杂芳基， C 1 -C 4烷基，杂芳基-C 1 -C 4烷基，芳氧基-C 1 -C 4烷基，杂芳氧基-C 1 -C 4烷基，芳硫基-C 1 -C 4烷基，杂芳基硫代-C 1 -C 4烷基，芳基羰基或杂芳基羰基，C 2 -C 4链烯基，未取代或取代的芳基-C 2 -C 4烯基或杂芳基 C 2 -C 4链烯基，C 2 -C 4炔基，C 3 -C 6环烷基或氰基，或者R 2和R 3与R 2和R 3所连接的碳原子一起是未取代或取代的饱和或不饱和的，可以将未取代或取代的苯环稠合到其上; 游离形式或适当时，盐形式可用作农药活性成分。

17. 发明申请

WO1997011067A1 POLYMER-BOUND FLUOROPHORES AS OPTICAL ION SENSORS 审中-公开
标题翻译：聚对苯二甲酸乙二醇酯作为光离子传感器
公开(公告)号：WO1997011067A1
公开(公告)日：1997-03-27
申请号：PCT/EP1996003954
申请日：1996-09-10
申请人： CIBA-GEIGY AG , ALDER, Alex , BARNARD, Steven, Mark , BECKELMANN, Dirk , BERGER, Joseph , WALDNER, Adrian
发明人： CIBA-GEIGY AG
IPC分类号： C07D311/82
CPC分类号： C07D493/10 , C07D219/08 , C07D311/82 , G01N33/533
摘要： The invention relates to compounds of formula (I), (IIa) or (IIb), wherein R1, R2, R5 and R6 are each independently of one another hydrogen, -SO2-(C1-C6)alkylphenyl, C1-C30alkyl, C1-C30alkyl-CO- or a radical of formula -(CnH2n-O-)m-R10; R3 is hydrogen or -SO2-(C1-C6)alkylphenyl; R4 and R7 are C1-C30 alkylene or a radical of formula -(CnH2n-O-)m-R10; Z is a functional group which is selected from the group consisting of -OH, -SH, -NH2, -COOH, -NCO, -CO-NR8YR9Y, -NH-CO-CH=CH2, -NH-CO-C(CH3)=CH2; R8 and R9 are each independently of the other C1-C30alkylene; R10 is a direct bond or C1-C12alkylene; n is a number from 2 to 6, and m is a number from 1 to 10, with the proviso that the total number of carbon atoms is at most 30; and Y is -OH or -SH. The compounds are used as comonomers for the preparation of copolymer membranes for plasticiser-free ion sensors.
摘要翻译：本发明涉及式（I），（IIa）或（IIb）的化合物，其中R 1，R 2，R 5和R 6各自独立地为氢，-SO 2 - （C 1 -C 6）烷基苯基，C 1 -C 30烷基， -C 30烷基-CO-或式 - （C n H 2n -O-）m -R 10的基团; R3是氢或-SO2-（C1-C6）烷基苯基; R4和R7是C1-C30亚烷基或式 - （CnH2n-O-）m -R10的基团; Z是选自-OH，-SH，-NH2，-COOH，-NCO，-CO-NR8YR9Y，-NH-CO-CH = CH2，-NH-CO-C（CH3 ）= CH 2; R8和R9各自独立地为C 1 -C 30亚烷基; R10是直接键或C1-C12亚烷基; n为2〜6的数，m为1〜10的数，条件是碳原子数为30以下。 Y为-OH或-SH。该化合物用作制备用于不含增塑剂的离子传感器的共聚物膜的共聚单体。

18. 发明申请

WO1997008193A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY 审中-公开
标题翻译：具有细胞信号抑制活性的酰化寡核苷酸衍生物
公开(公告)号：WO1997008193A1
公开(公告)日：1997-03-06
申请号：PCT/EP1996003473
申请日：1996-08-06
申请人： CIBA-GEIGY AG , GARCIA-ECHEVERRIA, Carlos , GAY, Brigitte , FURET, Pascal , RAHUEL, Joseph , CARAVATTI, Giorgio , FRETZ, Heinz , SCHOEPFER, Joseph
发明人： CIBA-GEIGY AG
IPC分类号： C07K05/065
CPC分类号： C07K5/1027 , A61K38/00 , C07K5/0202 , C07K5/0207 , C07K5/06191 , C07K5/0827 , C07K14/71 , Y02P20/55
摘要： The invention relates to an acylated peptide, namely a compound of formula (I), wherein n is 0 to 15, X is arylcarbonyl, cycloalkylcarbonyl, tricycloalkylcarbonyl, arylsulfonyl, heterocyclylcarbonyl, heterocyclylsulfonyl, carbamoyl-lower alkanoyl, aryl-lower alkylcarbonyl, cycloalkyl-lower alkylcarbonyl, aryl-lower alkylsulfonyl, heterocyclyl-lower alkylcarbonyl, heterocyclyl-lower alkylsulfonyl with the proviso that in any of the lower alkyl radicals mentioned a methylene group may be replaced with oxa, aza or thia; heterocyclyl-lower alkenylcarbonyl or aryl-lower alkenylcarbonyl; or, if Y is a secondary or tertiary amino group, is one of the moieties X mentioned above or lower alkanoyl, halo-lower alkanoyl, lower-alkoxycarbonyl, aryl-lower alkoxycarbonyl or cycloalkyl-lower alkoxycarbonyl; PTI is the bivalent radical of tyrosine or (preferably) the bivalent radical of phosphotyrosine or a phosphotyrosine mimic, AA stands for a bivalent radical of a natural or unnatural amino acid, and Y is hydroxy, a C-terminal protecting group or a primary, secondary or tertiary amino group, or a salt thereof, said compound being useful for the treatment of diseases that respond to inhibition of the interaction of (a) protein(s) comprising (an) SH2 domain(s) and a protein tyrosine kinase or a modified version thereof.
摘要翻译：本发明涉及酰化肽，即式（I）化合物，其中n为0至15，X为芳基羰基，环烷基羰基，三环烷基羰基，芳基磺酰基，杂环基羰基，杂环基磺酰基，氨基甲酰基 - 低级烷酰基，芳基 - 低级烷基羰基，环烷基 - 低级烷基羰基，芳基 - 低级烷基磺酰基，杂环基 - 低级烷基羰基，杂环基 - 低级烷基磺酰基，条件是在所提及的任何低级烷基中亚甲基可以被氧杂，氮杂或硫代替代; 杂环基低级烯基羰基或芳基 - 低级烯基羰基; 或者如果Y是仲或叔氨基，则是上述部分X或低级烷酰基，卤代低级烷酰基，低级烷氧基羰基，芳基 - 低级烷氧基羰基或环烷基 - 低级烷氧基羰基之一; PTI是酪氨酸或（优选）磷酸酪氨酸或磷酸酪氨酸模拟物的二价基团的二价基团，AA代表天然或非天然氨基酸的二价基团，Y是羟基，C-末端保护基或伯，仲或叔氨基或其盐，所述化合物可用于治疗响应于（a）包含（a）SH2结构域和蛋白质酪氨酸激酶的蛋白质的相互作用的抑制的疾病，或其修改版本。

19. 发明申请

WO1997005095A1 PROCESS FOR THE HYDROGENATION OF IMINES 审中-公开
标题翻译：加氢方法
公开(公告)号：WO1997005095A1
公开(公告)日：1997-02-13
申请号：PCT/EP1996003143
申请日：1996-07-17
申请人： CIBA-GEIGY AG , JALETT, Hans-Peter , SIEBENHAAR, Bernd
发明人： CIBA-GEIGY AG
IPC分类号： C07C213/02
CPC分类号： C07D333/36 , C07C213/02 , C07C217/08 , C07C209/52 , C07C211/48
摘要： A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts containing diphosphine ligands, with or without an inert solvent, the reaction mixture containing a soluble ammonium chloride, bromide or iodide or a soluble metal chloride, bromide or iodide, wherein the reaction mixture additionally contains at least one solid acid with the exception of ion exchangers. Improved optical yields and high chemical conversion rates are achieved while the catalyst is easily separable.
摘要翻译：在含有二膦配体的铱催化剂存在下，在升高的压力下氢化亚胺的方法，在有或者没有惰性溶剂的情况下，含有可溶性氯化铵，溴化物或碘化物的反应混合物或可溶性金属氯化物，溴化物或碘化物，其中所述反应混合物另外含有除离子交换剂之外的至少一种固体酸。在催化剂容易分离的同时，获得了提高的光学收率和高化学转化率。

20. 发明申请

WO1997001087A1 FLOW CELL 审中-公开
标题翻译：流通池
公开(公告)号：WO1997001087A1
公开(公告)日：1997-01-09
申请号：PCT/EP1996002519
申请日：1996-06-10
申请人： CIBA-GEIGY AG , OROSZLAN, Peter , ERBACHER, Christoph , DUVENECK, Gert, Ludwig , VERPOORTE, Elisabeth
发明人： CIBA-GEIGY AG
IPC分类号： G01N21/05
CPC分类号： G01N21/05 , G01N2021/0346
摘要： A flow cell (1) has in its interior a flow channel (2) and is provided with an inlet opening (3) for the sample and with an outlet opening (4). Also provided are means for producing a sample-free blocked volume located in the flow channel (2). Those means comprise, for example, a further inlet opening (5) for a reference fluid, that inlet opening (5) being so positioned that the reference fluid flows counter to the sample in the flow channel (2). The flow cell (1) is suitable for a sensor apparatus in which one of the boundary surfaces of the flow channel (2) comprises a detection layer that contains selectively sensitive recognition elements for an analyte. The flow cell (1) is also suitable for an optical detection device which preferably utilises luminescence excitation in the evanescent field of an optical waveguide.
摘要翻译：流动池（1）在其内部具有流动通道（2），并且设置有用于样品的入口开口（3）和出口开口（4）。还提供了用于产生位于流动通道（2）中的无样品阻塞体积的装置。这些装置包括例如用于参考流体的另一个入口开口（5），该入口开口（5）被定位成使得参考流体与流动通道（2）中的样品相反。流动池（1）适用于传感器装置，其中流动通道（2）的边界表面之一包括检测层，该检测层包含用于分析物的选择性敏感的识别元件。流动池（1）还适用于光学检测装置，其优选地在光波导的消逝场中利用发光激发。

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