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11. 发明申请

WO2005022129A1 SENSOR FOR DETECTING A TARGET SUBSTANCE IN A FLUID 审中-公开
标题翻译：用于检测流体中目标物质的传感器
公开(公告)号：WO2005022129A1
公开(公告)日：2005-03-10
申请号：PCT/JP2004/012790
申请日：2004-08-27
申请人： CANON KABUSHIKI KAISHA , YANO, Koji , OKAMOTO, Kohei , YAMAZAKI, Takeo , SHIOTSUKA, Hidenori , SUGITA, Mitsuro , IMAMURA, Takeshi , OUCHI, Toshihiko , KURODA, Ryo
发明人： YANO, Koji , OKAMOTO, Kohei , YAMAZAKI, Takeo , SHIOTSUKA, Hidenori , SUGITA, Mitsuro , IMAMURA, Takeshi , OUCHI, Toshihiko , KURODA, Ryo
IPC分类号： G01N21/35
CPC分类号： G02B6/02385 , B82Y20/00 , G01N21/21 , G01N21/253 , G01N21/39 , G01N21/774 , G01N33/54373 , G02B6/02347 , G02B6/0239 , G02B6/1225
摘要： A device for detecting a target substance in a fluid is provided. This device comprises a periodic structure having a vacant portion for passing the fluid containing the target substance and a solid portion arranged regularly and capable of transmitting an electromagnetic wave, an electromagnetic wave-projecting means for projecting the electromagnetic wave to the periodic structure, and a detecting means for measuring the magnetic wave emitted from the periodic structure to detect a change in periodic distribution of a refractive index. This sensor is highly sensitive in a small size.
摘要翻译：提供了一种用于检测流体中的目标物质的装置。该装置包括周期性结构，其具有用于使含有目标物质的流体通过的空白部分和规则地排列并能够传输电磁波的固体部分，用于将电磁波投射到周期性结构的电磁波投影装置，以及用于测量从周期性结构发射的磁波以检测折射率的周期性分布的变化的检测装置。该传感器在小尺寸下非常灵敏。

12. 发明申请

WO2005003715A2 INFORMATION ACQUISITION METHOD, INFORMATION ACQUISITION APPARATUS AND DISEASE DIAGNOSIS METHOD 审中-公开
标题翻译：信息获取方法，信息获取装置和疾病诊断方法
公开(公告)号：WO2005003715A2
公开(公告)日：2005-01-13
申请号：PCT/JP2004/009788
申请日：2004-07-02
申请人： CANON KABUSHIKI KAISHA , HASHIMOTO, Hiroyuki , KUGE, Katsuaki , KOMATSU, Manabu , NAKAMURA, Kumi , BAN, Kazuhiro , IMAMURA, Takeshi , KOBAYASHI, Shin
发明人： HASHIMOTO, Hiroyuki , KUGE, Katsuaki , KOMATSU, Manabu , NAKAMURA, Kumi , BAN, Kazuhiro , IMAMURA, Takeshi , KOBAYASHI, Shin
IPC分类号： G01N
CPC分类号： G01N33/6848 , H01J49/04 , H01J49/40
摘要： An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.
摘要翻译：一种用于获取关于目标对象的信息的信息获取方法，包括使用促进目标对象的电离的物质促进目标物体的离子化以使目标对象发射的步骤，以及获取关于物体的信息的步骤的步骤的飞行目标物体使用飞行时间二次离子质谱法。

13. 发明申请

WO2004009226A1 METHOD AND APPARATUS FOR CHEMICAL ANALYSIS 审中-公开
标题翻译：化学分析方法与装置
公开(公告)号：WO2004009226A1
公开(公告)日：2004-01-29
申请号：PCT/JP2003/008760
申请日：2003-07-10
申请人： CANON KABUSHIKI KAISHA , YAMAZAKI, Takeo , MIHASHI, Naoto , IMAMURA, Takeshi , OMIZU, Satoko
发明人： YAMAZAKI, Takeo , MIHASHI, Naoto , IMAMURA, Takeshi , OMIZU, Satoko
IPC分类号： B01F13/00
CPC分类号： B01F13/0059 , B01F7/00291 , B01F13/02 , B01F15/00487 , B01F15/00551 , B01F2215/0431 , B01F2215/044 , B01F2215/0477
摘要： A method of mixing plural liquids in a liquid chamber is provided which comprises steps of introducing plural liquids into the liquid chamber, and repeating expansion and shrinkage of a bubble in the liquids in the liquid chamber. In this method, the liquid may be heated to produce the bubble. A liquid-mixing apparatus for mixing plural liquids in a liquid chamber to obtain a liquid mixture is also provided. The liquid-mixing apparatus comprises a liquid chamber (103); flow channels (104) for introducing the plural liquids into the liquid chamber; a heating part (106) placed in the liquid chamber for heating the liquid mixture in the liquid chamber; and an energy-supplying means for causing expansion and shrinkage of a bubble in the liquid mixture in the liquid chamber.
摘要翻译：提供了一种在液体室中混合多种液体的方法，其包括以下步骤：将多种液体引入液体室，并且重复液体室中的液体中的气泡的膨胀和收缩。在该方法中，可以加热液体以产生气泡。还提供了用于在液体室中混合多种液体以获得液体混合物的液体混合装置。液体混合装置包括液体室（103）; 用于将多种液体引入液体室的流路（104）放置在所述液体室中用于加热所述液体室中的液体混合物的加热部分（106）以及用于引起液体室中的液体混合物中的气泡的膨胀和收缩的能量供应装置。

14. 发明申请

WO2004012864A1 LIQUID TRANSFER APPARATUS AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：液体转运装置及其制造方法
公开(公告)号：WO2004012864A1
公开(公告)日：2004-02-12
申请号：PCT/JP2003/009923
申请日：2003-08-05
申请人： CANON KABUSHIKI KAISHA , IMAMURA, Takeshi , YAMAZAKI, Takeo
发明人： IMAMURA, Takeshi , YAMAZAKI, Takeo
IPC分类号： B01L3/00
CPC分类号： B01F13/0079 , B01F13/1013 , B01F13/1016 , B01J19/0093 , B01J2219/00783 , B01J2219/00804 , B01J2219/00819 , B01J2219/00867 , B01J2219/00889 , B01J2219/00891 , B01L3/5027 , B01L2200/027 , B01L2300/0861 , B01L2400/0439 , B01L2400/0442 , B01L2400/0605 , Y10T436/2575
摘要： A liquid transfer apparatus comprises a liquid containing section for containing liquid, a liquid introducing section for introducing liquid into the liquid containing section and a liquid leading out section for leading out the liquid introduced into the liquid containing section. When a number of such liquid transfer apparatuses are connected together, the liquid introducing section and the liquid leading out section of such liquid transfer apparatus are arranged such that the liquid leading out section of a liquid transfer apparatus communicates with the liquid introducing section of another liquid transfer apparatus.
摘要翻译：液体传送装置包括用于容纳液体的液体容纳部分，用于将液体引入液体容纳部分的液体引入部分和用于引出引入液体容纳部分的液体的液体引出部分。当多个这样的液体传送装置连接在一起时，液体传送装置的液体导入部分和液体导出部分被布置成使得液体传送装置的液体引出部分与另一种液体的液体导入部分连通传送装置。

15. 发明申请

WO2004012863A1 LIQUID TRANSPORT DEVICE AND LIQUID-TRANSPORTING METHOD 审中-公开
标题翻译：液体运输装置和液体运输方法
公开(公告)号：WO2004012863A1
公开(公告)日：2004-02-12
申请号：PCT/JP2003/009909
申请日：2003-08-05
申请人： CANON KABUSHIKI KAISHA , YAMAZAKI, Takeo , IMAMURA, Takeshi
发明人： YAMAZAKI, Takeo , IMAMURA, Takeshi
IPC分类号： B01L3/00
CPC分类号： B01F15/0255 , B01F13/0059 , B01F15/0203 , B01L3/0241 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/0605 , B01L2300/0816 , B01L2400/0439 , B01L2400/0442 , Y10T436/2575
摘要： A liquid transport device capable of introducing and transporting a liquid and preventing a backward flow of the liquid in a small-sized analysis system is provided. The liquid transport device has a substrate 201, a ejection orifice 205 which is formed integrally with the substrate 201 and through which a liquid is ejected, a space portion 210 which is formed so as to communicate with the ejection orifice 205 and through which the liquid ejected from the ejection orifice flies, and a flow channel 204 which communicates with the space portion 210 and which is positioned within such a distance range that the flying liquid can reach the flow channel.
摘要翻译：提供一种能够引入和输送液体并防止液体在小型分析系统中反向流动的液体输送装置。液体输送装置具有基板201，与基板201一体形成并喷射有液体的喷射孔205，形成为与喷射孔205连通的空间部210，液体从喷射口喷射的飞行物，以及与空间部分210连通并且位于飞行液体可以到达流动通道的距离范围内的流动通道204。

16. 发明申请

WO2007114512A1 METHOD FOR DETECTING TARGET SUBSTANCE AND TARGET-SUBSTANCE DETECTION KIT 审中-公开
标题翻译：检测目标物质和目标物质检测试剂盒的方法
公开(公告)号：WO2007114512A1
公开(公告)日：2007-10-11
申请号：PCT/JP2007/057712
申请日：2007-03-30
申请人： CANON KABUSHIKI KAISHA , OGAWA, Miki , MINAMI, Masato , IMAMURA, Takeshi , IKEDA, Takashi , NAKAHAMA, Kazumichi
发明人： OGAWA, Miki , MINAMI, Masato , IMAMURA, Takeshi , IKEDA, Takashi , NAKAHAMA, Kazumichi
IPC分类号： G01N27/72 , G01N33/543
CPC分类号： G01N33/54373 , Y10S436/807
摘要： The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ 1 of the magnetic label in the sample solution, the surface potential ψ 2 of the detecting part, and the surface potential ψ 3 of the non-detecting part satisfy any one of the following relationships i) to iv): i) ψ 1 ψ 3 > 0 and ψ 2 = 0, ii) ψ 1 ψ 2 3 = 0, iii) ψ 1 ψ 2 2 ψ 3 > 0, and |ψ 2 | > |ψ 3 |, and iv) ψ 1 ψ 2 2 ψ 3
摘要翻译：本发明提供了一种通过使样品溶液与包括检测部分和非检测部分的检测元件接触来检测样品溶液中目标物质的存在或浓度来检测目标物质的方法，或存在于检测部件表面附近的磁性标签（磁性标记）的数量，并提供目标物质检测套件。样品溶液中的磁性标签的表面电位ψ1 N 1，检测部分的表面电位ψ2 2和表面电位？3 的非检测部分满足以下关系中的任何一个：i）至iv）：i）＆lt; 1＆gt;＆lt; 3＆lt; 3＆gt; 0＆ SUB> = 0，ii）？1 <？？>，iii iii？？？？？SUB SUB SUB SUB SUB SUB SUB 0≤n≤2 2，＆lt; 2＆gt;＆lt; 2＆gt;＆lt;＆lt; 3 <0; 并且由磁性标签承载的目标物质由被检测部分承载的主要捕获体俘获，或者由被检测部分承载的主要捕获体捕获的目标物质被由磁性标签承载的二次捕获体俘获。

17. 发明申请

WO2007026972A3 BINDING PROTEIN MOLECULE 审中-公开
公开(公告)号：WO2007026972A3
公开(公告)日：2007-03-08
申请号：PCT/JP2006/317808
申请日：2006-09-01
申请人： CANON KABUSHIKI KAISHA , IMAMURA, Takeshi , SHIOTSUKA, Hidenori , BAN, Kazuhiro , IBII, Takahisa
发明人： IMAMURA, Takeshi , SHIOTSUKA, Hidenori , BAN, Kazuhiro , IBII, Takahisa
IPC分类号： C07K16/40 , C07K16/18 , C07K16/44 , C07K17/14 , G01N33/553
摘要： A binding protein molecule, characterized in that it has a first domain having a binding site to an inhibitor of non-specific adsorption in which the domain comprises a part of the variable region of an antibody as the binding site and a second domain having a binding site to a target substance in which the domain comprises a part of the variable region of an antibody as the binding site, wherein the first and second domains are bound via a linker.

18. 发明申请

WO2007004600A2 TARGET SUBSTANCE-CAPTURING BODY, DEVICE FOR CAPTURING TARGET SUBSTANCE, AND INSTRUMENT, KIT AND METHOD FOR DETECTING TARGET SUBSTANCE BY USE OF THEM 审中-公开
标题翻译：目标物质捕获体，用于捕获目标物质的装置，以及用于通过使用目标物质检测目标物质的仪器，工具包和方法
公开(公告)号：WO2007004600A2
公开(公告)日：2007-01-11
申请号：PCT/JP2006/313195
申请日：2006-06-27
申请人： CANON KABUSHIKI KAISHA , SHIOTSUKA, Hidenori , IMAMURA, Takeshi
发明人： SHIOTSUKA, Hidenori , IMAMURA, Takeshi
IPC分类号： G01N33/531 , G01N33/68 , C12N15/62
CPC分类号： G01N33/531 , G01N33/6854
摘要： It is intended to provide a target substance-capturing body comprising: a base consisting of a soluble protein; and two or more functional domains capable of binding to different target substances.
摘要翻译：旨在提供一种靶物质捕获体，其包含：由可溶性蛋白质组成的碱; 以及能够结合不同靶物质的两个或更多个功能结构域。

19. 发明申请

WO2005085806A1 RECOGNITION CHIP FOR TARGET SUBSTANCE, AND DETECTION METHOD AND DEVICE FOR THE SAME 审中-公开
标题翻译：目标物质的识别芯片及其相关的检测方法和装置
公开(公告)号：WO2005085806A1
公开(公告)日：2005-09-15
申请号：PCT/JP2005/004029
申请日：2005-03-02
申请人： CANON KABUSHIKI KAISHA , YAMAMICHI, Junta , OGAWA, Miki , HANDA, Yoichiro , IMAMURA, Takeshi , UTSUNOMIYA, Norihiko , NISHIUMA, Satoru
发明人： YAMAMICHI, Junta , OGAWA, Miki , HANDA, Yoichiro , IMAMURA, Takeshi , UTSUNOMIYA, Norihiko , NISHIUMA, Satoru
IPC分类号： G01N21/05
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate (103) comprising a plurality of objects (105) of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means (101, 107) for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output (106) when the objects are irradiated with light (102), wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译：一种检测装置，包括：基板（103），包括由于与目标物质的接触而改变其特性的多个物体（105），使目标物质与物体接触的装置，以及装置（101,107）用于当物体被照射光（102）时，基于光输出（106）检测当目标物质与物体接触时引起的物体的性质变化，其中多个物体位于照射光的行进方向，检测装置是用于根据在照射光时从多个物体输出的光的总和来检测特性变化的装置。

20. 发明申请

WO2006009890A9 METHODS AND COMPOSITIONS FOR PRODUCING INSULIN SENSITIZATION 审中-公开
公开(公告)号：WO2006009890A9
公开(公告)日：2006-01-26
申请号：PCT/US2005/021560
申请日：2005-06-17
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , OLEFSKY, Jerrold, M. , USIU, Isao , IMAMURA, Takeshi
发明人： OLEFSKY, Jerrold, M. , USIU, Isao , IMAMURA, Takeshi
IPC分类号： G01N33/566 , G01N33/53 , C12Q1/68 , C12P21/08 , C07K16/00 , C07H21/02
摘要： The invention herein provides a mode of treating metabolic syndrome, which includes Type 2 diabetes mellitus and insulin resistance in human and other subjects by identifying and administering an insulin sensitizing compound which modulates GRK2 function in the insulin signaling pathway. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable insulin sensitizing aspects are achieved by various embodiments of the present invention.

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